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Combining Results of Multiple Search Engines in Proteomics
Open accessAbstract
A crucial component of the analysis of shotgun proteomics datasets is the search engine, an algorithm that attempts to identify the peptide sequence from the parent molecular ion that produced each fragment ion spectrum in the dataset. There are many different search engines, both commercial and open source, each employing a somewhat different technique for spectrum identification. The set of high-scoring peptide-spectrum matches for a defined set of input spectra differs markedly among the various search engine results; individual engines each provide unique correct identifications among a core set of correlative identifications. This has led to the approach of combining the results from multiple search engines to achieve improved analysis of each dataset. Here we review the techniques and available software for combining the results of multiple search engines and briefly compare the relative performance of these techniques.
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Mass spectrometry-based proteomics
Aebersold, R., & Mann, M. (2003) · Nature · doi:10.1038/nature01511 · Cited by 6,955
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Self-citationProline: an efficient and user-friendly software suite for large-scale proteomics
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The 5300-year-old Helicobacter pylori genome of the Iceman
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Self-citationJUMP: a tag-based database search tool for peptide identification with high sensitivity and accuracy
Wang, X., Li, Y., Wu, Z., Wang, H., Tan, H., & Peng, J. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o114.039586 · Cited by 194
Metadata
- Authors
- Shteynberg, D., Nesvizhskii, A. I., Moritz, R. L., & Deutsch, E. W.
- Venue
- Molecular & Cellular Proteomics
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 12
- Issue
- 9
- Pages
- 2383-2393
- ISSN
- 1535-9476 (ISSN-L)
- OpenAlex
- W2103345380
- Cited by
- 187
- References
- 1
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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