Neuropharmacology of an Extract derived from Convolvulus microphyllus
Open accessAbstract
Neuropharmacological activities of the methanol extract of the whole plant of Shankhapushpi, Convolvulus microphyllus Sieb ex Spreng (Convolvulaceae), were studied in experimental animals. The extract was found to produce alterations in the general behaviour pattern, reduction in spontaneous motor activity, hypothermia, potentiation of pentobarbitone-sleeping time, reduction in exploratory behavioural pattern, and suppression of aggressive behaviour. The extract also showed an inhibitory effect on conditioned avoidance response and antagonism to amphetamine toxicity. These findings explicitly suggest that the whole plant extract of C. microphyllus possesses a potential CNS-depressant activity.
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C. microphyllus, another plant of the same family, had the LD50 of 1250 mg/kg after oral administration of the whole plant extract.
“C. microphyllus, another plant of the same family had the LD50 of 1250 mg/kg after oral administration of the whole plant extract [245].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [245]
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- Authors
- Pawar, S. A., Dhuley, J. N., & Naik, S. R.
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 39
- Issue
- 4
- Pages
- 253-258
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2101204030
- Cited by
- 17
- References
- 14
- Citations by year
- 2021: 1 · 2020: 1 · 2018: 3 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmaceutical Biology (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- methanol plant extracts, neuropharmacology, CNS depressant activity, hypothermia, motor activity, exploratory behavior, aggression, conditioned avoidance response
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