Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India
Open accessAbstract
BACKGROUND: Shankhpushpi is an Ayurvedic drug, widely used for its actions on the central nervous system, especially to improve intellect and boost memory. Four botanicals viz. Canscora decussata Schult. (CD), Clitorea ternatea Linn. (CT), Convolvulus pluricaulis Choisy. (CP) and Evolvulus alsinoides Linn. (EA) are considered as sources of Shankhpushpi by Indian practitioners on the basis of their morphological descriptions given in ancient texts. OBJECTIVE: The present study was undertaken to evaluate the neuropharmacological effect of four herbs commonly identified as source of Shankhpushpi. MATERIALS AND METHODS: Methanol extracts of all four varieties were tested and evaluated in vitro and in vivo for their neuropharmacological effects. Experiments such as protection against β-amyloid induced neurotoxicity on brain cell line (Neuro 2A), antioxidant potential, AchE (acetylcholinesterase enzyme) inhibition, and 5-LOX (lipoxygenase) enzyme inhibition were conducted for in vitro evaluation. For in vivo evaluation, scopolamine (0.3 mg/kg i.p.) induced memory retrieval using pole climbing apparatus and Morris water maze were performed in rat models. RESULTS: It was found that protective effects of EA and CD against β-amyloid induced neurotoxicity in Neuro 2A cells were significantly higher than CT and CP. EA proved to be superior than other varieties on the basis of antioxidant activity, AchE inhibitory and LOX inhibitory activities. The preventive activity of EA on scopolamine induced memory retrieval in pole climbing and Morris water maze task in rats was found to be higher than that of CD, CT and CP. CONCLUSION: EA has remarkable neuropharmacological effect as compared to other three varieties of Shankhpushpi. This effect may be attributed due to the presence of steroids (stigmasterol and betulinic acid), coumarins (scopoletin) and flavonoids (β-carotene and chlorogenic acid). Hence it can be used as a promising lead in development and management of neuronal disorders including Alzheimer's disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous studies indicated the memory enhancing effect of E. alsinoides in the experimental model of amnesia.
“Previous studies also indicated the memory enhancing effect of E. alsionoides in the experimental model of amnesia [191,192].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [191]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works
Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity
Vinutha, B., Prashanth, D., Salma, K., Sreeja, S. L., Pratiti, D., Padmaja, R. J., Radhika, S., Amit, A., Venkateshwarlu, K., & Deepak, M. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.06.014 · Cited by 389 · see citing works
The Relation Between Antioxidants and Memory Performance in the Old and Very Old
Perrig, W. J., Perrig, P., & Stähelin, H. B. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb01476.x · Cited by 344 · see citing works
Potential medicinal plants for CNS disorders: an overview
Kumar, V. (2006) · Phytotherapy Research · doi:10.1002/ptr.1970 · Cited by 268 · see citing works
LePage, K. T., DICKEY, R. W., Gerwick, W. H., Jester, E. L. E., & Murray, T. F. (2005) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v17.i1.20 · Cited by 162 · see citing works
Hoi, C. P., Ho, Y. P., Baum, L., & Chow, A. H. L. (2010) · Phytotherapy Research · doi:10.1002/ptr.3178 · Cited by 154 · see citing works
The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease
Czapski, G. A., Czubowicz, K., Strosznajder, J. B., & Strosznajder, R. P. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1776-x · Cited by 133 · see citing works
An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine
Sethiya, N. K. (2009) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20091101 · Cited by 127 · see citing works
Self-citationPlant-based Rasayana drugs from Ayurveda
Balasubramani, S. P., Venkatasubramanian, P., Kukkupuni, S. K., & Patwardhan, B. (2011) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-011-0659-5 · Cited by 125 · see citing works
Nootropic, anxiolytic and CNS-depressant studies on different plant sources ofshankhpushpi
Malik, J., Karan, M., & Vasisht, K. (2011) · Pharmaceutical Biology · doi:10.3109/13880209.2011.584539 · Cited by 89 · see citing works
Protective Effects of Anthocyanins against Amyloid β-Peptide-Induced Damage in Neuro-2A Cells
Shih, P., Wu, C., Yeh, C., & Yen, G. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103822h · Cited by 75 · see citing works
Nahata, A., Patil, U. K., & Dixit, V. K. (2008) · Natural Product Research · doi:10.1080/14786410802214199 · Cited by 74 · see citing works
Self-citationMcIntyre, C. K., Ragozzino, M. E., & Gold, P. E. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00161-7 · Cited by 69 · see citing works
Sethiya, N. K., Trivedi, A., Patel, M., & Mishra, S. H. (2010) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/0110-5558.76437 · Cited by 66 · see citing works
Self-citationSethiya, N. K., Trivedi, A., & Mishra, S. (2014) · Biomedicine & Preventive Nutrition · doi:10.1016/j.bionut.2014.03.007 · Cited by 60 · see citing works
Self-citationEffect of Evolvulus alsinoides Linn. on learning behavior and memory enhancement activity in rodents
Nahata, A., Patil, U. K., & Dixit, V. K. (2009) · Phytotherapy Research · doi:10.1002/ptr.2932 · Cited by 58 · see citing works
Self-citationAnxiolytic activity of<i>Evolvulus alsinoides</i>and<i>Convulvulus pluricaulis</i>in rodents
Nahata, A., Patil, U. K., & Dixit, V. K. (2009) · Pharmaceutical Biology · doi:10.1080/13880200902822596 · Cited by 57 · see citing works
Sethiya, N. K., Raja, M. K. M. M., & Mishra, S. (2013) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/2231-4040.107497 · Cited by 40 · see citing works
Self-citationSethiya, N. K., & Mishra, S. H. (2014) · Journal of Biologically Active Products from Nature · doi:10.1080/22311866.2014.921121 · Cited by 39 · see citing works
Self-citationAli, E. H. A., & Arafa, N. M. S. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.01.016 · Cited by 37 · see citing works
Sethiya, N. K., Trivedi, A., & Mishra, S. H. (2015) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2015.04.002 · Cited by 35 · see citing works
Self-citationSiddiqui, N. A., Ahmad, N., Musthaq, N., Chattopadhyaya, I., Kumria, R., & Gupta, S. (2011) · The Open Neurology Journal · doi:10.2174/1874205x01408010011 · Cited by 29 · see citing works
Brain neurotransmitter receptor binding and nootropic studies on Indian Hypericum perforatum Linn.
Kumar, V., Khanna, V., Seth, P. K., et al. (2002) · Phytotherapy Research · doi:10.1002/ptr.1101 · Cited by 29 · see citing works
Sethiya, N. K., & Mishra, S. (2014) · Journal of Chromatographic Science · doi:10.1093/chromsci/bmu111 · Cited by 29 · see citing works
Self-citationMelamed, J., de Jesus, F. M., Maior, R. S., & Barros, M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00395 · Cited by 27 · see citing works
Anxiolytic Activity of Canscora decussata in Albino Rats
Sethiya, N. K., Nahata, A., & Dixit, V. K. (2010) · Journal of Complementary and Integrative Medicine · doi:10.2202/1553-3840.1263 · Cited by 21 · see citing works
Self-citationComparative nootropic effect of evolvulus alsinoides and convolvulus pluricaulis.
Rawat, M. S., & Kothiyal, P. (2011) · International Journal of Pharma and Bio Sciences · Cited by 18 · see citing works
Neuropharmacology of an Extract derived from Convolvulus microphyllus
Pawar, S. A., Dhuley, J. N., & Naik, S. R. (2001) · Pharmaceutical Biology · doi:10.1076/phbi.39.4.253.5920 · Cited by 17 · see citing works
Dixit, V. K. (2011) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/2231-4040.82948 · Cited by 12 · see citing works
Sethiya, N. K., Keluskar, P., Ingle, S., et al. (2014) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(14)60612-5 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [24]Sethiya N.K. Dixit V.K. Investigation on South Indian Shankhpushpi vol. 1 2012 LAP Lambert Academic Publishing Germany 116
- [25]Sethiya N.K. Dube B. Mishra S.H. Herbs in metal health vol. 1 2012 LAP Lambert Academic Publishing Germany 75
Cited by
Sorted by citations
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108 · see citing works
Sharma, R., Singla, R. K., Banerjee, S., Sinha, B., Shen, B., & Sharma, R. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104795 · Cited by 81 · see citing works
Pradhan, P., Majhi, O., Biswas, A., Joshi, V. K., & Sinha, D. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-02942-8 · Cited by 44 · see citing works
- Authors
- Sethiya, N. K., Nahata, A., Singh, P. K., & Mishra, S. H.
- Affiliations
- Maharaja Sayajirao University of Baroda (IN)
- Dr. Hari Singh Gour University (IN)
- National Innovation Foundation (IN)
- Corresponding author
- Sethiya, Neeraj K.
- Venue
- Journal of Ayurveda and Integrative Medicine
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 10
- Issue
- 1
- Pages
- 25-31
- ISSN
- 0975-9476 (ISSN-L)
- PMC
- PMC6470306
- OpenAlex
- W2789323218
- Cited by
- 58
- References
- 30
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 14 · 2022: 11 · 2021: 7 · 2020: 5 · 2018: 2
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Ayurveda and Integrative Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Shankhpushpi, Evolvulus alsinoides, Convolvulus pluricaulis, neuropharmacology, amyloid-beta toxicity, acetylcholinesterase inhibition, lipoxygenase inhibition, antioxidant activity, scopolamine-induced amnesia, memory retrieval, Alzheimer's disease, Ayurvedic herbs, stigmasterol, betulinic acid, scopoletin, flavonoids, coumarins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
