Regulation of virulence genes in Listeria

Kreft, Jürgen; Vázquez-Boland, José A.

doi:10.1078/1438-4221-00111

Cited by 140Listeria monocytogenes in Food SafetyBacterial Genetics and BiotechnologyProbiotics and Fermented Foods

Regulation of virulence genes in Listeria

Kreft, Jürgen, Vázquez-Boland, José A.·2001·International Journal of Medical Microbiology

DOI 10.1078/1438-4221-00111

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Abstract

As in all pathogenic bacteria, virulence of the facultative intracellular Listeria species is a multifactorial trait. The expression of the bacterial genes involved in the different steps of the infectious process--invasion, intracellular multiplication and spreading--is temporally and spatially controlled, thus ensuring the presence of the respective gene products at the right moment and place. So far, one network which is involved in the regulation of listerial virulence, the PrfA regulon, has been characterized rather well. The key element of this regulon, PrfA, belongs to the Crp/Fnr family of transcriptional regulators. Its synthesis and activity are influenced by a variety of physico-chemical signals outside and inside of eukaryotic host cells. The analysis of virulence gene expression in vivo, i.e. in infected host cells, indicates that yet uncharacterized bacterial factors other than PrfA, and possibly also host factors, modulate the expression of the PrfA regulon. Essentially nothing is known about the signal transduction pathways involved in the observed differential expression of virulence genes. Fermentable carbon sources seem to have a particular role in virulence gene regulation. In addition to the PrfA regulon, the Clp stress proteins have an impact on Listeria virulence. These two regulons interact with each other by an unknown mechanism.

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Expression of Fur is negatively regulated by PerR, a Fur homologue involved in oxidative stress response.
“It has been shown that expression of Fur is negatively regulated by PerR, a Fur homologue that is involved in the oxidative stress response.”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [57]
Fourteen Fur-regulated genes have been identified in L. monocytogenes, including genes encoding Fe2+ transporters, ferrichrome ABC transporters, and Fe storage proteins.
“Fourteen Fur-regulated genes have been identified in L. monocytogenes, including genes that encode Fe2+ transporters and ferrichrome ABC transporters and proteins involved in Fe storage [56, 57].”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [57]

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Karunasagar, I., Lampidis, R., Goebel, W., & Kreft, J. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1997.tb10209.x · Cited by 19 · see citing works
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Internalization of Listeria monocytogenes by Nonprofessional and Professional Phagocytes
Kuhn, M., & Goebel, W. (2000) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4757-4580-1_16 · Cited by 18 · see citing works

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The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776 · see citing works
Listeria monocytogenes lineages: Genomics, evolution, ecology, and phenotypic characteristics
Orsi, R. H., den Bakker, H. C., & Wiedmann, M. (2010) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2010.05.002 · Cited by 733 · see citing works
Listeria monocytogenes: a multifaceted model
Hamon, M. A., Bierne, H., & Cossart, P. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1413 · Cited by 613 · see citing works
Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs
Körner, H., Sofia, H. J., & Zumft, W. G. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00066-4 · Cited by 456 · see citing works
Control of key metabolic intersections in Bacillus subtilis
Sonenshein, A. L. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1772 · Cited by 424 · see citing works
Listeriolysin O: a phagosome-specific lysin
Schnupf, P., & Portnoy, D. A. (2007) · Microbes and Infection · doi:10.1016/j.micinf.2007.05.005 · Cited by 361 · see citing works
Transcriptome analysis of Listeria monocytogenes identifies three groups of genes differently regulated by PrfA
Milohanic, E., Glaser, P., Coppée, J., Frangeul, L., Vega, Y., Vázquez‐Boland, J. A., Kunst, F., Cossart, P., & Buchrieser, C. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03413.x · Cited by 325 · see citing works
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Human Listeriosis
Koopmans, M. M., Brouwer, M. C., Vázquez‐Boland, J. A., & van de Beek, D. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00060-19 · Cited by 304 · see citing works
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Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria
Chico‐Calero, I., Suárez, M., González‐Zorn, B., Scortti, M. M., Slaghuis, J., Goebel, W., & Vázquez‐Boland, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012363899 · Cited by 270 · see citing works
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Molecular Determinants ofListeria monocytogenesVirulence
Dussurget, O., Pizarro‐Cerdá, J., & Cossart, P. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.57.030502.090934 · Cited by 269 · see citing works
The RNA-Binding Protein Hfq ofListeria monocytogenes: Role in Stress Tolerance and Virulence
Klitgaard, J. K., Larsen, M., Ingmer, H., Søgaard‐Andersen, L., & Kallipolitis, B. H. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.11.3355-3362.2004 · Cited by 255 · see citing works
The PrfA virulence regulon
Scortti, M. M., Monzó, H. J., Lacharme‐Lora, L., LEWIS, D. A., & Vázquez‐Boland, J. A. (2007) · Microbes and Infection · doi:10.1016/j.micinf.2007.05.007 · Cited by 251 · see citing works
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Identification ofLactobacillus plantarumGenes That Are Induced in the Gastrointestinal Tract of Mice
Bron, P. A., Grangette, C., Mercenier, A., de Vos, W. M., & Kleerebezem, M. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.17.5721-5729.2004 · Cited by 239 · see citing works
How the Bacterial Pathogen Listeria monocytogenes Mediates the Switch from Environmental Dr. Jekyll to Pathogenic Mr. Hyde
Gray, M. J., Freitag, N. E., & Boor, K. J. (2006) · Infection and Immunity · doi:10.1128/iai.74.5.2505-2512.2006 · Cited by 193 · see citing works
Identification ofListeria monocytogenesGenes Expressed in Response to Growth at Low Temperature
Liu, S., Graham, J. E., Bigelow, L. J., Morse, P. D., & Wilkinson, B. J. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.4.1697-1705.2002 · Cited by 193 · see citing works
Exploration of host-pathogen interactions using Listeria monocytogenes and Drosophila melanogaster
Mansfield, B. E., Dionne, M., Schneider, D. S., & Freitag, N. E. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00329.x · Cited by 186 · see citing works
Comparative Analysis of the σB-Dependent Stress Responses inListeria monocytogenesandListeria innocuaStrains Exposed to Selected Stress Conditions
Raengpradub, S., Wiedmann, M., & Boor, K. J. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00951-07 · Cited by 167 · see citing works
A role for ActA in epithelial cell invasion by Listeria monocytogenes
Suárez, M., González‐Zorn, B., Vega, Y., Chico‐Calero, I., & Vázquez‐Boland, J. A. (2001) · Cellular Microbiology · doi:10.1046/j.1462-5822.2001.00160.x · Cited by 155 · see citing works
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FbpA, a novel multifunctional Listeria monocytogenes virulence factor
Dramsi, S., Bourdichon, F., Cabanes, D., Lecuit, M., Fsihi, H., & Cossart, P. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04138.x · Cited by 141 · see citing works
Glycerol Metabolism and PrfA Activity inListeria monocytogenes
Joseph, B., Mertins, S., Stoll, R., Schär, J., Umesha, K. R., Luo, Q., Müller‐Altrock, S., & Goebel, W. (2008) · Journal of Bacteriology · doi:10.1128/jb.00259-08 · Cited by 135 · see citing works
Identification of Drosophila Mutants Altering Defense of and Endurance to Listeria monocytogenes Infection
Ayres, J. S., Freitag, N. E., & Schneider, D. S. (2008) · Genetics · doi:10.1534/genetics.107.083782 · Cited by 128 · see citing works
The CtsR regulator of Listeria monocytogenes contains a variant glycine repeat region that affects piezotolerance, stress resistance, motility and virulence
Karatzas, K. A. G., Wouters, J. A., Gahan, C. G. M., Hill, C., Abee, T., & Bennik, M. H. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03636.x · Cited by 121 · see citing works
Listeria monocytogenesσBModulates PrfA-Mediated Virulence Factor Expression
Ollinger, J., Bowen, B. M., Wiedmann, M., Boor, K. J., & Bergholz, T. M. (2009) · Infection and Immunity · doi:10.1128/iai.01205-08 · Cited by 111 · see citing works
Isolation of Listeria monocytogenes mutants with high‐level in vitro expression of host cytosol‐induced gene products
Shetron‐Rama, L. M., Mueller, K. J., Bravo, J. M., Bouwer, H. G. A., Way, S. S., & Freitag, N. E. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03534.x · Cited by 108 · see citing works
Blue and Red Light Modulates SigB-Dependent Gene Transcription, Swimming Motility and Invasiveness in Listeria monocytogenes
Ondrusch, N., & Kreft, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016151 · Cited by 103 · see citing works
Self-citation
Plant-derived antimicrobials reduce Listeria monocytogenes virulence factors in vitro, and down-regulate expression of virulence genes
Upadhyay, A., Johny, A. K., Amalaradjou, M. A. R., Baskaran, S. A., Kim, K. S., & Venkitanarayanan, K. (2012) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2012.04.018 · Cited by 102 · see citing works
Negative control of Listeria monocytogenes virulence genes by a diffusible autorepressor
Ermolaeva, S. A., Novella, S., Vega, Y., Ripio, M. T., Scortti, M. M., & Vázquez‐Boland, J. A. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04003.x · Cited by 91 · see citing works
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The Listeria monocytogenes Virulence Factor InlJ Is Specifically Expressed In Vivo and Behaves as an Adhesin
Sabet, C., Toledo‐Arana, A., Personnic, N., Lecuit, M., Dubrac, S., Poupel, O., Gouin, E., Nahori, M., Cossart, P., & Bierne, H. (2008) · Infection and Immunity · doi:10.1128/iai.01519-07 · Cited by 89 · see citing works
SigB-Dependent In Vitro Transcription ofprfAand Some Newly Identified Genes ofListeria monocytogenesWhose Expression Is Affected by PrfA In Vivo
Rauch, M., Luo, Q., Müller‐Altrock, S., & Goebel, W. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.2.800-804.2005 · Cited by 87 · see citing works
pbp2229 -Mediated Nisin Resistance Mechanism in Listeria monocytogenes Confers Cross-Protection to Class IIa Bacteriocins and Affects Virulence Gene Expression
Gravesen, A., Kallipolitis, B. H., Holmstrøm, K., Høiby, P. E., Ramnath, M., & Knøchel, S. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.3.1669-1679.2004 · Cited by 86 · see citing works
Isolation, Potential Virulence, and Population Diversity of Listeria monocytogenes From Meat and Meat Products in China
Chen, M., Cheng, J., Zhang, J., Chen, Y., Zeng, H., Xue, L., Lei, T., Pang, R., Wu, S., Wu, H., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00946 · Cited by 86 · see citing works
Cross Talk between SigB and PrfA in Listeria monocytogenes Facilitates Transitions between Extra- and Intracellular Environments
Gaballa, A., Guariglia-Oropeza, V., Wiedmann, M., & Boor, K. J. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-19 · Cited by 84 · see citing works
Characterization of DegU, a response regulator inListeria monocytogenes, involved in regulation of motility and contributes to virulence
Knudsen, G. M., Olsen, J. E., & Dons, L. E. (2004) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2004.09.039 · Cited by 83 · see citing works
Mechanism of polarization of Listeria monocytogenes surface protein ActA
Rafelski, S. M., & Theriot, J. A. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05025.x · Cited by 82 · see citing works
Contribution of Chitinases to Listeria monocytogenes Pathogenesis
Chaudhuri, S., Bruno, J. C., Alonzo, F., Xayarath, B., Cianciotto, N. P., & Freitag, N. E. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01338-10 · Cited by 81 · see citing works
New Listeria monocytogenes prfA* mutants, transcriptional properties of PrfA* proteins and structure–function of the virulence regulator PrfA
Vega, Y., Rauch, M., Banfield, M. J., Ermolaeva, S. A., Scortti, M. M., Goebel, W., & Vázquez‐Boland, J. A. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04052.x · Cited by 79 · see citing works
Self-citation
Comparative Genomics Analysis of Streptococcus Isolates from the Human Small Intestine Reveals their Adaptation to a Highly Dynamic Ecosystem
van den Bogert, B., Boekhorst, J., Herrmann, R., Smid, E. J., Zoetendal, E. G., & Kleerebezem, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083418 · Cited by 74 · see citing works
Construction and Characterization of Listeria monocytogenes Mutants with In-Frame Deletions in the Response Regulator Genes Identified in the Genome Sequence
Williams, T., Bauer, S., Beier, D., & Kuhn, M. (2005) · Infection and Immunity · doi:10.1128/iai.73.5.3152-3159.2005 · Cited by 74 · see citing works
A Novel Mutation within the CentralListeria monocytogenesRegulator PrfA That Results in Constitutive Expression of Virulence Gene Products
Wong, K. K. Y., & Freitag, N. E. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.18.6265-6276.2004 · Cited by 70 · see citing works
Overexpression of PrfA Leads to Growth Inhibition of Listeria monocytogenes in Glucose-Containing Culture Media by Interfering with Glucose Uptake
Marr, A. K., Joseph, B., Mertins, S., Ecke, R., Müller‐Altrock, S., & Goebel, W. (2006) · Journal of Bacteriology · doi:10.1128/jb.01978-05 · Cited by 69 · see citing works
Response regulator DegU ofListeria monocytogenesregulates the expression of flagella-specific genes
Williams, T., Joseph, B., Beier, D., Goebel, W., & Kuhn, M. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.09.011 · Cited by 69 · see citing works
Prevalence, Characterization, and Antimicrobial Resistance of Listeria monocytogenes Isolates from Bovine Hides and Carcasses
Wieczorek, K., Dmowska, K., & Osek, J. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.07156-11 · Cited by 71 · see citing works
Strain dependent expression of stress response and virulence genes of Listeria monocytogenes in meat juices as determined by microarray
Rantsiou, K., Greppi, A., Garosi, M., Acquadro, A., Mataragas, M., & Cocolin, L. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.08.009 · Cited by 66 · see citing works
Listeria monocytogenes at the interface between ruminants and humans: A comparative pathology and pathogenesis review
Bagatella, S., Tavares-Gomes, L., & Oevermann, A. (2021) · Veterinary Pathology · doi:10.1177/03009858211052659 · Cited by 65 · see citing works
The Alternative Sigma Factor σBand the Virulence Gene Regulator PrfA Both Regulate Transcription ofListeria monocytogenesInternalins
McGann, P., Wiedmann, M., & Boor, K. J. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02664-06 · Cited by 65 · see citing works
Modulation of PrfA activity in Listeria monocytogenes upon growth in different culture media
Stoll, R., Mertins, S., Joseph, B., Müller‐Altrock, S., & Goebel, W. (2008) · Microbiology · doi:10.1099/mic.0.2008/018283-0 · Cited by 65 · see citing works
Comparative Chemical and Biological Characterization of the Lipopolysaccharides of Gastric and Enterohepatic Helicobacters
Hynes, S. O., Ferris, J. A., Szponar, B., Wadström, T., Fox, J. G., O’Rourke, J., Larsson, L., Yaquian, E., Ljungh, Å., Clyne, M., et al. (2004) · Helicobacter · doi:10.1111/j.1083-4389.2004.00237.x · Cited by 65 · see citing works
A spontaneous genomic deletion in Listeria ivanovii identifies LIPI‐2, a species‐specific pathogenicity island encoding sphingomyelinase and numerous internalins
Domínguez‐Bernal, G., Müller‐Altrock, S., González‐Zorn, B., Scortti, M. M., Herrmann, P., Monzó, H. J., Lacharme‐Lora, L., Kreft, J., & Vázquez‐Boland, J. A. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04955.x · Cited by 64 · see citing works
Self-citation
Multi-Virulence-Locus Sequence Typing Clarifies Epidemiology of Recent Listeriosis Outbreaks in the United States
Chen, Y., Zhang, W., & Knabel, S. J. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.10.5291-5294.2005 · Cited by 62 · see citing works
Inducible Control of Virulence Gene Expression in Listeria monocytogenes : Temporal Requirement of Listeriolysin O during Intracellular Infection
Dancz, C. E., Haraga, A., Portnoy, D. A., & Higgins, D. E. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.21.5935-5945.2002 · Cited by 62 · see citing works
RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression
Lebreton, A., & Cossart, P. (2016) · RNA Biology · doi:10.1080/15476286.2016.1189069 · Cited by 61 · see citing works
Listeria monocytogenes: Pathogenesis and Host Response
Goldfine, H., & Shen, H. (2007) · Springer eBooks · doi:10.1007/978-0-387-49376-3 · Cited by 61 · see citing works
Evidence implicating the 5′ untranslated region ofListeria monocytogenes actAin the regulation of bacterial actin-based motility
Wong, K. K. Y., Bouwer, H. G. A., & Freitag, N. E. (2004) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00348.x · Cited by 58 · see citing works
Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment
Portman, J. L., Dubensky, T. B., Peterson, B. N., Whiteley, A. T., & Portnoy, D. A. (2017) · mBio · doi:10.1128/mbio.01595-17 · Cited by 57 · see citing works
Listeria monocytogenes and the Genus Listeria
Khelef, N., Lecuit, M., Buchrieser, C., Cabanes, D., Dussurget, O., & Cossart, P. (2006) · Springer eBooks · doi:10.1007/0-387-30744-3_11 · Cited by 52 · see citing works
Strategies of intracellular pathogens for obtaining iron from the environment
Leon-Sicairos, N., Reyes-Cortes, R., Guadrón-Llanos, A. M., Madueña-Molina, J., Leon-Sicairos, C., & Canizalez-Román, A. (2015) · BioMed Research International · doi:10.1155/2015/476534 · Cited by 51 · see citing works
“genes that encode Fe transporters and ferrichrome ABC transporters and proteins involved in Fe storage [56, 57].”
Background
Pleiotropic Enhancement of Bacterial Pathogenesis Resulting from the Constitutive Activation of theListeria monocytogenesRegulatory Factor PrfA
Mueller, K. J., & Freitag, N. E. (2005) · Infection and Immunity · doi:10.1128/iai.73.4.1917-1926.2005 · Cited by 51 · see citing works
EXPRESSION OF VIRULENCE GENES OF LISTERIA MONOCYTOGENES IN FOOD
Rantsiou, K., Mataragas, M., Alessandria, V., & Cocolin, L. (2011) · Journal of Food Safety · doi:10.1111/j.1745-4565.2011.00363.x · Cited by 49 · see citing works
Susceptibility ofListeria monocytogenesto antimicrobial peptides
López‐Solanilla, E., González‐Zorn, B., Novella, S., VÃ¡zquez-Boland, J. A., & Rodríguez‐Palenzuela, P. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00579-2 · Cited by 49 · see citing works
Self-citation
The Chitinolytic Activity ofListeria monocytogenesEGD Is Regulated by Carbohydrates but Also by the Virulence Regulator PrfA
Larsen, M., Leisner, J. J., & Ingmer, H. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00297-10 · Cited by 45 · see citing works
Listeria monocytogenes and Salmonella enterica Enteritidis Biofilms Susceptibility to Different Disinfectants and Stress-Response and Virulence Gene Expression of Surviving Cells
Rodrigues, D., Cerca, N., Teixeira, P., Oliveira, R., Ceri, H., & Azeredo, J. (2011) · Microbial Drug Resistance · doi:10.1089/mdr.2010.0183 · Cited by 45 · see citing works
Dynamics of competitive population abundance of Lactobacillus plantarum ivi gene mutants in faecal samples after passage through the gastrointestinal tract of mice
Bron, P. A., Meijer, M., Bongers, R. S., de Vos, W. M., & Kleerebezem, M. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03376.x · Cited by 40 · see citing works
The fruRBA Operon Is Necessary for Group A Streptococcal Growth in Fructose and for Resistance to Neutrophil Killing during Growth in Whole Human Blood
Valdes, K. M., Sundar, G. S., Vega, L. A., Belew, A. T., Islam, E., Binet, R., El-Sayed, N. M., Breton, Y. S. L., & McIver, K. S. (2016) · Infection and Immunity · doi:10.1128/iai.01296-15 · Cited by 38 · see citing works
A phylogenomic analysis of bacterial helix–turn–helix transcription factors
Santos, C. L., Tavares, F., Thioulouse, J., & Normand, P. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00154.x · Cited by 37 · see citing works
Deregulation of Listeria monocytogenes virulence gene expression by two distinct and semi-independent pathways
Milenbachs, A. A., Mueller, K. J., Freitag, N. E., & Youngman, P. J. (2004) · Microbiology · doi:10.1099/mic.0.26718-0 · Cited by 36 · see citing works
Fibronectin‐binding protein, FbpA, is the adhesin responsible for pathogenesis of Listeria monocytogenes infection
Osanai, A., Li, S., Asano, K., Sashinami, H., Hu, D., & Nakane, A. (2013) · Microbiology and Immunology · doi:10.1111/1348-0421.12030 · Cited by 35 · see citing works
Listeria monocytogenes adapts to long-term stationary phase survival without compromising bacterial virulence
Bruno, J. C., & Freitag, N. E. (2011) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2011.02373.x · Cited by 34 · see citing works
Variable Carbon Source Utilization, Stress Resistance, and Virulence Profiles Among Listeria monocytogenes Strains Responsible for Listeriosis Outbreaks in Switzerland
Muchaamba, F., Eshwar, A. K., Stevens, M. J. A., von Ah, U., & Tasara, T. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00957 · Cited by 32 · see citing works
Contributions of a LysR Transcriptional Regulator to Listeria monocytogenes Virulence and Identification of Its Regulons
Abdelhamed, H., Ramachandran, R., Narayanan, L., Ozdemir, O., Cooper, A., Olivier, A. K., Karsi, A., & Lawrence, M. L. (2020) · Journal of Bacteriology · doi:10.1128/jb.00087-20 · Cited by 31 · see citing works
Characterization and Antimicrobial Resistance of Listeria monocytogenes Isolated from Retail Beef Meat in Poland
Wieczorek, K., Dmowska, K., & Osek, J. (2012) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2012.1137 · Cited by 31 · see citing works
Genetic Separation of Listeria monocytogenes Causing Central Nervous System Infections in Animals
Aguilar-Bultet, L., Nicholson, P., Rychener, L., Dreyer, M., Gözel, B., Origgi, F., Oevermann, A., Frey, J., & Falquet, L. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00020 · Cited by 24 · see citing works
σ B - and PrfA-Dependent Transcription of Genes Previously Classified as Putative Constituents of the Listeria monocytogenes PrfA Regulon
Ollinger, J., Wiedmann, M., & Boor, K. J. (2008) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2008.0079 · Cited by 30 · see citing works
From Hot Dogs to Host Cells: How the Bacterial Pathogen Listeria Monocytogenes Regulates Virulence Gene Expression
Freitag, N. E. (2006) · Future Microbiology · doi:10.2217/17460913.1.1.89 · Cited by 30 · see citing works
A novel prfA mutation that promotes Listeria monocytogenes cytosol entry but reduces bacterial spread and cytotoxicity
Miner, M. D., Port, G. C., Bouwer, H. G. A., Chang, J. C., & Freitag, N. E. (2008) · Microbial Pathogenesis · doi:10.1016/j.micpath.2008.06.006 · Cited by 29 · see citing works
Eugenol in combination with lactic acid bacteria attenuates Listeria monocytogenes virulence in vitro and in invertebrate model Galleria mellonella
Upadhyay, A., Upadhyaya, I., Mooyottu, S., & Venkitanarayanan, K. (2016) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000251 · Cited by 30 · see citing works
Comparison of PI-PLC based assays and PCR along with in vivo pathogenicity tests for rapid detection of pathogenic Listeria monocytogenes
Aurora, R., Prakash, A., Prakash, S., Rawool, D. B., & Barbuddhe, S. B. (2007) · Food Control · doi:10.1016/j.foodcont.2007.07.002 · Cited by 28 · see citing works
Lineage specific recombination and positive selection in coding and intragenic regions contributed to evolution of the main Listeria monocytogenes virulence gene cluster
Orsi, R. H., Maron, S. B., Nightingale, K. K., Jerome, M., Tabor, H., & Wiedmann, M. (2008) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2008.04.006 · Cited by 28 · see citing works
A simple method for the differentiation of Listeria monocytogenes based on induction of lecithinase activity by charcoal
Ermolaeva, S. A., Карпова, Т. И., Novella, S., Wagner, M., Scortti, M. M., Tartakovskii, I. S., & Vázquez‐Boland, J. A. (2003) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(02)00399-9 · Cited by 27 · see citing works
Self-citation
Molecular Characterization and Phylogenetic Analysis of Listeria monocytogenes Isolated from Milk and Milk Products in Kaduna, Nigeria
Usman, U., Kwaga, J. K. P., Kabir, J., Olonitola, O. S., Radu, S., & Bande, F. (2016) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2016/4313827 · Cited by 27 · see citing works
Probing the Role of Protein Surface Charge in the Activation of PrfA, the Central Regulator of Listeria monocytogenes Pathogenesis
Xayarath, B., Volz, K. W., Smart, J. I., & Freitag, N. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023502 · Cited by 26 · see citing works
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Authors: Kreft, J., & Vázquez-Boland, J. A.
Affiliations: University of Würzburg (DE)
Corresponding author: Kreft, Jürgen
Venue: International Journal of Medical Microbiology
Publisher: Elsevier BV
Published: 2001
Volume: 291
Issue: 2
Pages: 145-157
ISSN: 1438-4221 (ISSN-L)
DOI: 10.1078/1438-4221-00111
OpenAlex: W2073528230
Cited by: 140
References: 80
Citations by year: 2026: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 4
FWCI: 8.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: International Journal of Medical Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission (BMH4-CT96-0659)
Deutsche Forschungsgemeinschaft (KR 1206/3-2)
Dirección General de Enseñanza Superior e Investigación Científica (BMC2000-0553, DGESIC PB97-0327-C03-01)
Verband der Chemischen Industrie
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Listeria monocytogenes in Food Safety
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: Listeria, virulence gene regulation, intracellular bacterial pathogens, signal transduction, carbon source regulation, host-pathogen interaction
MeSH terms: Bacterial Proteins, Listeria monocytogenes, Peptide Termination Factors, Virulence, Trans-Activators, Gene Expression Regulation, Bacterial, Molecular Chaperones

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Regulation of virulence genes in Listeria

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