The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Stimulation of muscle growth by clenbuterol: lack of effect on muscle protein biosynthesis
Open accessAbstract
1. Young rats were offered to appetite a semi-synthetic diet either alone or containing the β 2-selective agonist clenbuterol (4-amino-α[t-butylamino) methyl]-3, 5-dichlorobenzyl alcohol). 3. Male rats (starting weight 53 g) received clenbuterol at a daily oral dose of 200 pg/kg body-weight per d. Animals were slaughtered after 0, 4, 8, 11, 18, 21 and 25 d of treatment. At 4, 11, 21 and 25 d muscle protein synthesis was measured by the method of Garlick et al.(1980). Although clenbuterol increased the rate of protein and RNA accretion in gastrocnemius and soleus muscles, protein synthesis was not increased. 4. The results suggested that the drug had a rapid, perhaps direct, inhibitory effect on protein degradation. It is concluded that the growth-promoting effect of clenbuterol may be specific to muscle and that the drug may act in a novel manner which circumvents the physiological mechanisms responsible for the control of muscle growth.
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Cites
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Use of a β-Agonist to Alter Fat and Muscle Deposition in Steers1
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Chronic effects of β2 agonists on body composition and protein synthesis in the rat
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Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410
Multiple actions of β-adrenergic agonists on skeletal muscle and adipose tissue
Yang, Y. T., & McElligott, M. A. (1989) · Biochemical Journal · doi:10.1042/bj2610001 · Cited by 281
Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol
Kline, W. O., Panaro, F. J., Yang, H., & Bodine, S. C. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00873.2006 · Cited by 177
Technologies for the control of fat and lean deposition in livestock
Sillence, M. N. (2004) · The Veterinary Journal · doi:10.1016/j.tvjl.2003.10.020 · Cited by 142
MacLennan, P. A., & Edwards, R. H. (1989) · Biochemical Journal · doi:10.1042/bj2640573 · Cited by 119
Metadata
- Authors
- Reeds, P. J., Hay, S. M., Dorwood, P. M., & Palmer, R. M.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 1986-07
- Volume
- 56
- Issue
- 1
- Pages
- 249-258
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2132057788
- Cited by
- 309
- References
- 19
- FWCI
- 29.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Reeds, P. J., Hay, S. M., Dorwood, P. M., & Palmer, R. M. (1986). Stimulation of muscle growth by clenbuterol: lack of effect on muscle protein biosynthesis. British Journal of Nutrition. https://doi.org/10.1079/bjn19860104
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
