Use of a β-Agonist to Alter Fat and Muscle Deposition in Steers1

Ricks, Catherine A.; Dalrymple, R. H.; Baker, Pamela K.; Ingle, D. L.

doi:10.2527/jas1984.5951247x

Cited by 294Pharmacological Effects and AssaysMeat and Animal Product QualityRuminant Nutrition and Digestive Physiology

Use of a β-Agonist to Alter Fat and Muscle Deposition in Steers1

Ricks, Catherine A., Dalrymple, R. H., Baker, Pamela K., Ingle, D. L.·1984·Journal of Animal Science

DOI 10.2527/jas1984.5951247x

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Abstract

The effect of a β-agonist, clenbuterol [benzyl alcohol, 4-amino-α-(t-butylamino)methyl-3, 5-dichloro] on carcass composition, performance criteria and clinical blood chemistry was evaluated in 24 finishing Hereford steers assigned to three treatment groups. Clenbuterol was administered in the feed at 0, 10 or 500 mg•head−1•d−1 for 98 d. Carcass evaluation showed that the 10 and 500 mg•head−1•d−1 treatment groups had 11 (P≤.05) and 16% (P≤.01) larger 12th rib longissimus muscle areas, 35 (P≤.01) and 42% (P≤.01) less 12th rib fat depths, 23 (P≤.05) and 33% (P≤.01) less kidney, pelvic and heart fat and improved USDA yield grades of 1.0 and 1.5 grade points, respectively. Chemical analysis of the 9th to 11th rib section from these carcasses indicated that they had 13 (P≤.01) and 14% (P≤.01) higher protein contents, 20 (P≤.01) and 30% (P≤.01) less fat and 10 (P≤.05) and 16% (P≤.01) more water, respectively. Clinical chemistry measurements were within normal physiological ranges. Blood urea N levels (mg/dl) for the 0, 10 and 500 mg clen-buterol•head−1•d−1 were 9.6, 8.5 and 5.9 (P≤.01), respectively, indicating that clenbuterol may have increased N retention. Rate of gain was not altered at 10 mg•head−1•d−1, but was reduced (P≤.05) by the high drug level. There were no differences among treatments in feed efficiency. The data demonstrate that significant improvements in muscle accretion with concomitant reductions in fat deposition can be achieved by feeding clenbuterol to finishing steers.

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Some repartitioning treatments such as β-adrenergic agonists act on skeletal muscle and adipose tissue at the same time.
“However, some repartitioning treatments such as β-adrenergic agonists act on skeletal muscle and adipose tissue at the same time.”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [170]
β-adrenergic agonists stimulate skeletal muscle hypertrophy and adipose lipolysis by acting on adrenergic receptors expressed by both tissues.
“A key example is β-adrenergic agonists, which stimulate skeletal muscle hypertrophy and adipose lipolysis by acting on adrenergic receptors expressed by both tissues [170, 183].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [170]

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Authors: Ricks, C. A., Dalrymple, R. H., Baker, P. K., & Ingle, D. L.
Affiliations: Apnimed (United States) (US)
Venue: Journal of Animal Science
Publisher: Oxford University Press (OUP)
Published: 1984-11-01
Volume: 59
Issue: 5
Pages: 1247-1255
ISSN: 0021-8812 (ISSN-L)
1525-3163
DOI: 10.2527/jas1984.5951247x
OpenAlex: W2547271346
Cited by: 294
References: 0
Citations by year: 2026: 4 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 8 · 2017: 9 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 9 · 2012: 4
FWCI: 18.79
Type: journal article
Language: en
Open access: closed
Locations: Journal of Animal Science (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Pharmacological Effects and Assays
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
Keywords: clenbuterol, beta-adrenergic agonists, Hereford steers, carcass composition, fat deposition, muscle deposition, loin eye area, USDA yield grade, blood urea nitrogen, nitrogen retention, weight gain, feed efficiency, finishing cattle

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Use of a β-Agonist to Alter Fat and Muscle Deposition in Steers1

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