Muscle glycogen and metabolic regulation

Hargreaves, Mark

doi:10.1079/pns2004344

Cited by 72Muscle metabolism and nutritionMetabolism, Diabetes, and CancerCardiovascular and exercise physiology

Muscle glycogen and metabolic regulation

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Hargreaves, Mark·2004·Proceedings of The Nutrition Society

DOI 10.1079/pns2004344

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Abstract

Muscle glycogen is an important fuel for contracting skeletal muscle during prolonged strenuous exercise, and glycogen depletion has been implicated in muscle fatigue. It is also apparent that glycogen availability can exert important effects on a range of metabolic and cellular processes. These processes include carbohydrate, fat and protein metabolism during exercise, post-exercise glycogen resynthesis, excitation-contraction coupling, insulin action and gene transcription. For example, low muscle glycogen is associated with reduced muscle glycogenolysis, increased glucose and NEFA uptake and protein degradation, accelerated glycogen resynthesis, impaired excitation-contraction coupling, enhanced insulin action and potentiation of the exercise-induced increases in transcription of metabolic genes. Future studies should identify the mechanisms underlying, and the functional importance of, the association between glycogen availability and these processes.

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Glycogen availability prior to exercise may modulate its metabolism during subsequent exercise.
“This demonstrates that glycogen availability prior to exercise may modulate its metabolism during subsequent exercise [72].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [72]

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Gollnick PD, Piehl K, Saubert CW, Armstrong RB & Saltin B (1972) Diet, exercise and muscle glycogen. Journal of Applied Physiology 33, 421-425.

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“This demonstrates that glycogen availability prior to exercise may modulate its metabolism during subsequent exercise [72].”
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Authors: Hargreaves, M.
Affiliations: Deakin University (AU)
Corresponding author: Hargreaves, Mark
ORCID: Hargreaves, Mark
Venue: Proceedings of The Nutrition Society
Publisher: Cambridge University Press (CUP)
Published: 2004-05
Volume: 63
Issue: 2
Pages: 217-220
ISSN: 0029-6651 (ISSN-L)
1475-2719
DOI: 10.1079/pns2004344
OpenAlex: W2171510273
Cited by: 72
References: 40
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2017: 1 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 2
FWCI: 0.17
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 1038 d)
Locations: Proceedings of The Nutrition Society (publishedVersion)
PubMed (publishedVersion)
Own your potential (DEAKIN) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: muscle glycogen, glycogen depletion, muscle fatigue, skeletal muscle metabolism, physical activity, glycogen resynthesis, glycogenolysis, glucose uptake, protein degradation, excitation-contraction coupling, insulin action, gene transcription, metabolic regulation
MeSH terms: Energy Metabolism, Glycogen, Humans, Insulin, Muscle Contraction, Exercise, Muscle, Skeletal

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