Cited by 95Metabolism, Diabetes, and CancerMuscle metabolism and nutritionAdipose Tissue and Metabolism

Role of glycogen concentration and epinephrine on glucose uptake in rat epitrochlearis muscle.

Jensen, J., Aslesen, R., Ivy, J. L., Brors, O.·1997·American Journal of Physiology-Endocrinology and Metabolism

Abstract

The effects of diet-manipulated variations in muscle glycogen concentration and epinephrine on glucose uptake were studied in epitrochlearis muscles from Wistar rats. Both basal and insulin-stimulated glucose uptake [measured with a tracer amount of 2-[1,2-3H(N)]deoxy-D-glucose] inversely correlated with initial glycogen concentration (glycogen concentration vs. basal glucose uptake: Spearman's rho = -0.76, n = 84, P < 0.000001; glycogen concentration vs. insulin-stimulated glucose uptake: Spearman's rho = -0.67, n = 44, P < 0.00001). Two fasting-refeeding procedures were used that resulted in differences in muscle glycogen concentrations, although with similar treatment for the last 48 h before the experiment. In the rats with the lower glycogen concentration, basal as well as insulin-stimulated glucose uptake was elevated. The muscle glycogen concentration had no effect on epinephrine-stimulated glycogenolysis. Epinephrine, however, was found to reduce basal glucose uptake in all groups. These results suggest that 1) the glycogen concentration participates in the regulation of both basal and insulin-stimulated glucose uptake in skeletal muscle, 2) the magnitude of epinephrine-stimulated glycogen breakdown is independent of the glycogen concentration, and 3) epinephrine inhibits basal glucose uptake at all glycogen concentrations.

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Crossref · 10.1152/ajpendo.1997.272.4.e649

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Authors
Jensen, J., Aslesen, R., Ivy, J. L., & Brors, O.
Affiliations
  • University of Oslo (NO)
  • Department of Anatomy, Institute of Basic Medical Sciences, Universityof Oslo, Norway.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Published
1997-04-01
Volume
272
Issue
4
Pages
E649-E655
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
OpenAlex
W2122488312
Cited by
95
References
24
Citations by year
2025: 2 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 1
FWCI
1.90
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
muscle glycogen, epinephrine, glucose uptake, epitrochlearis muscle, skeletal muscle, insulin-stimulated glucose uptake, glycogenolysis, fasting and refeeding
MeSH terms
Animals, Animal Feed, Epinephrine, Fasting, Forelimb, Glucose, Glycogen, Male, Osmolar Concentration, Rats, Wistar, Muscle, Skeletal, Glucose-6-Phosphate, Rats, In Vitro Techniques

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