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Cited by 41Muscle metabolism and nutritionCardiovascular and exercise physiologySports Performance and Training

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Pro- and macroglycogenolysis during repeated exercise: roles of glycogen content and phosphorylase activation

Shearer, J., Marchand, I., Tarnopolsky, M. A., Dyck, D. J., Graham, T. E.·2001·Journal of Applied Physiology
DOI 10.1152/jappl.2001.90.3.880
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Abstract

This study examined the relationship between preexercise muscle glycogen content and glycogen utilization in two physiological pools, pro- (PG) and macroglycogen (MG). Male subjects (n = 6) completed an exercise and dietary protocol before the experiment that resulted in one leg with high glycogen (HL) and one with low glycogen (LL). Preexercise PG levels were 312 +/- 29 and 208 +/- 31 glucosyl units/kg dry wt (dw) (P < or = 0.05) in the HL and LL, respectively, and the corresponding values for MG were 125 +/- 37 and 89 +/- 43 mmol glucosyl units/kg dw (P < or = 0.05). Subjects then performed two 90-s exercise bouts at 130% maximal oxygen uptake separated by a 10-min rest period. Biopsies were obtained at rest and after each exercise bout. Preexercise glycogen concentration was correlated to net glycogenolysis for both PG and MG for bout 1 and bouts 1 and 2 (r < or = 0.60). In bout 1, there was no difference in the rate of PG or MG catabolism between HL and LL despite a 26% increase (P < or = 0.05) in glycogen phosphorylase transformation (phos a %) in the HL. In the second bout, more PG was catabolized in the HL vs. LL (38 +/- 9 vs. 9 +/- 6 mmol glucosyl units. kg dw(-1). min(-1)) (P < or = 0.05) with no difference between legs in phos a %. phos a % was increased in HL vs. LL but does not necessarily increase glycogenolysis in either PG or MG. Despite both legs performing the same exercise and having identical metabolic demands, the HL catabolized 2.3 (P < or = 0.05) times more PG and 1.5 (P < or = 0.05) times more MG vs. LL in bouts 1 and 2, indicating that preexercise glycogen concentration is a regulator of glycogenolysis.

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Crossref · 10.1152/jappl.2001.90.3.880

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41 of 41 references verified0 citation errors · 0 not checkable

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  • Increasing the glycogen content in one leg accelerated glycogenolysis twofold compared with the control leg with low glycogen content.

    “In support of this, increasing the glycogen content in one leg was shown to accelerate glycogenolysis twofold compared with the control leg with low glycogen content”

    From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [71]

  • Women tend to have lower resting muscle glycogen concentrations.

    “More recent evidence demonstrates that women tend to have lower resting muscle glycogen concentrations”

    From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [71]

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Research works printed but not linked: 1

  1. Boobis LH, 1983, J Physiol (Lond), 342, 36

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Metadata

Authors
Shearer, J., Marchand, I., Tarnopolsky, M. A., Dyck, D. J., & Graham, T. E.
Affiliations
  • University of Guelph (CA)
  • McMaster University (CA)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2001-03-01
Volume
90
Issue
3
Pages
880-888
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.2001.90.3.880
OpenAlex
W2173763762
Cited by
41
References
41
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2015: 1 · 2014: 1 · 2012: 2
FWCI
1.24
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
glycogenolysis, glycogen phosphorylase, muscle glycogen content, repeated exercise, glycogen catabolism
MeSH terms
Adult, Diet, Enzyme Activation, Physical Exertion, Glycogen, Phosphorylases, Glycolysis, Humans, Kinetics, Leg, Male, Oxygen Consumption, Exercise, Muscle, Skeletal

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