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Antibiotics: a risk factor for irritable bowel syndrome in a population-based cohort
Abstract
Objectives Use of antibiotics affects the composition of the gut microbiome. The microbiome is thought to play a role in development of irritable bowel syndrome (IBS), but antibiotics as a possible risk factor for IBS has not been clarified. We aimed to explore if antibiotics is a risk factor for IBS by investigating use of antibiotics and development of IBS in a cohort from the Danish background population. Materials and methods An internet-based web panel representative of the Danish background population was invited to participate in a survey regarding the epidemiology of IBS in 2010, 2011 and 2013. A questionnaire based on the Rome III criteria for IBS were answered at all three occasions. In 2013, a question regarding use of antibiotics in the past year was included. Results In 2013, use of antibiotics was reported by 22.4% (624/2781) of the population. A higher proportion of individuals with IBS reported use of antibiotics compared with asymptomatic controls [29.0% (155/534) vs. 17.9% (212/1,184), p Conclusions Antibiotics is a risk factor for IBS in asymptomatic individuals. Possible mechanisms should be investigated in future studies.
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Small intestinal bacterial overgrowth has also been implicated, but its role is controversial due, in large part, to limitations of available diagnostic tests, such as glucose and lactulose breath tests and culture of jejunal aspirates.
“Small intestinal bacterial overgrowth (SIBO), has also been implicated, 44 but its role is controversial due, in large part, to limitations of available diagnostic tests, such as glucose and lactulose breath tests 45 and culture of jejunal aspirates. 46”
From Irritable bowel syndrome (2020) · cites this paper as [46]
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Cites
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939
Shifting the balance: antibiotic effects on host–microbiota mutualism
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747
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Research works printed but not linked: 12
- 10.1136/gutjnl-2013-306434 · DOI
- 10.1073/pnas.1000087107 · DOI · Paper page
- 10.1099/mic.0.040618-0 · DOI · Paper page
- 10.1097/00042737-199801000-00011 · DOI
- 10.1111/nmo.12655 · DOI
- 10.1111/nmo.12986 · DOI
- 10.3109/00365521.2013.775328 · DOI · Paper page
- 10.1038/ajg.2012.131 · DOI
- 10.1053/j.gastro.2009.02.074 · DOI · Paper page
- 10.1053/j.gastro.2016.12.039 · DOI · Paper page
- 10.1111/apt.12938 · DOI · Paper page
- Villarreal A, 2012, Wmj, 111, 17
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Ford, A. C., Sperber, A. D., Corsetti, M., & Camilleri, M. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31548-8 · Cited by 818
Phan, J., Nair, D., Jain, S., Montagne, T., Flores, D. V., Nguyen, A., Dietsche, S., Gombar, S., & Cotter, P. (2021) · mSystems · doi:10.1128/msystems.01215-21 · Cited by 33
Al Helo, A., & Department of family medicine, J. M. O. H. (2019) · Journal of Gastroenterology and Hepatology Research · doi:10.17554/j.issn.2224-3992.2019.08.818 · Cited by 3
Metadata
- Authors
- Krogsgaard, L. R., Engsbro, A. L., & Bytzer, P.
- Affiliations
- Zealand University Hospital Køge (DK)
- Hvidovre Hospital (DK)
- University of Copenhagen (DK)
- Corresponding author
- Krogsgaard, Laura Rindom
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 2018-09-02
- Volume
- 53
- Issue
- 9
- Pages
- 1027-1030
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2889847873
- Cited by
- 33
- References
- 2
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 4
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- University of Copenhagen
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- irritable bowel syndrome, antibiotics, gut microbiota, risk factors, antibiotic use, asymptomatic individuals, Rome III criteria, population-based cohort
- MeSH terms
- Gastrointestinal Microbiome, Adolescent, Adult, Anti-Bacterial Agents, Denmark, Drug Utilization, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Risk Factors, Cohort Studies, Logistic Models, Irritable Bowel Syndrome, Young Adult, Asymptomatic Diseases
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