Cited by 747Gut microbiota and healthAntibiotic Use and ResistanceOral microbiology and periodontitis research

Shifting the balance: antibiotic effects on host–microbiota mutualism

Willing, Benjamin P., Russell, Shannon L., Finlay, B. Brett·2011·Nature Reviews Microbiology

Abstract

Antibiotics have been used effectively as a means to treat bacterial infections in humans and animals for over half a century. However, through their use, lasting alterations are being made to a mutualistic relationship that has taken millennia to evolve: the relationship between the host and its microbiota. Host-microbiota interactions are dynamic; therefore, changes in the microbiota as a consequence of antibiotic treatment can result in the dysregulation of host immune homeostasis and an increased susceptibility to disease. A better understanding of both the changes in the microbiota as a result of antibiotic treatment and the consequential changes in host immune homeostasis is imperative, so that these effects can be mitigated.

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Crossref · 10.1038/nrmicro2536

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Authors
Willing, B. P., Russell, S. L., & Finlay, B. B.
Affiliations
University of British Columbia (CA)
Corresponding author
Finlay, B. Brett
Venue
Nature Reviews Microbiology
Published
2011-02-28
Volume
9
Issue
4
Pages
233-243
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W2134985690
Cited by
747
References
121
Citations by year
2026: 24 · 2025: 56 · 2024: 68 · 2023: 45 · 2022: 77 · 2021: 62 · 2020: 86 · 2019: 47 · 2018: 38 · 2017: 42 · 2016: 36 · 2015: 31 · 2014: 53 · 2013: 32 · 2012: 37
FWCI
3.92
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
antibiotics, host-microbiota interactions, gut microbiota, immune homeostasis, dysbiosis, disease susceptibility, antibiotic resistance
MeSH terms
Animals, Anti-Bacterial Agents, Bacteria, Bacterial Infections, Disease Susceptibility, Enterocolitis, Pseudomembranous, Fatty Acids, Volatile, Homeostasis, Humans, Biomass, Immunity, Mucosal, Gastrointestinal Tract, Host-Pathogen Interactions, Metagenome, Microbial Interactions

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