Key variables associated with gastroparesis in diabetes patients with gastroparesis-like symptoms
Open accessAbstract
BACKGROUND/AIMS: Gastroparesis is a late complication of diabetes mellitus characterized by delayed gastric emptying and upper gastrointestinal symptoms. The disorder substantially impacts the quality of life, glycemic stability, nutrition and absorption of orally administered drugs. Since symptom severity is a poor predictor of gastric emptying status, the clinician has little to aid them in whom to refer for gastric emptying testing. In this study, we aim to identify clinical characteristics associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms. MATERIALS AND METHODS: Diabetes patients consecutively referred to Haukeland University Hospital for assessment of gastroparesis-like symptoms underwent gastric emptying scintigraphy, blood samples and questionnaires for assessing gastrointestinal symptoms (Gastrointestinal Symptom Rating Scale), neuroticism (Eysenck Personality Questionnaire-Short Form), and symptoms of anxiety and depression (Hospital Anxiety & Depression Scale). Seventy-one patients were included in the study, of which 28 displayed delayed gastric emptying. Delayed gastric emptying was characterized by having type 1 diabetes, younger age, lower BMI, presence of other late complications including distal symmetric polyneuropathy and retinopathy, higher Hb1Ac levels and lower albumin and hemoglobin levels. Symptoms were not related to gastric emptying status. CONCLUSION: We identified several clinical variables associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms. These variables are commonly assessed during a medical consultation and may be used to aid the clinician in choosing who to refer for gastric emptying testing.
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Risk correlates for DGP include long disease duration, poor glycemic control, presence of other diabetic complications (especially peripheral and autonomic neuropathy), prior bariatric surgery, and female sex.
“Risk correlates include long disease duration [8, 11, 12], poor glycemic control [3, 13], presence of other diabetic complications (especially peripheral and autonomic neuropathy) [4, 13], prior bariatric surgery [14, 15], and female sex [16, 17]”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [13]
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Diabetic gastroparesis: pathophysiology and impact on insulin timing choices
Galeano, F., Tumminia, A., Oteri, V., Le Moli, R., Piticchio, T., Scilletta, S., Di Marco, M., Di Pino, A., & Frasca, F. (2026) · Endocrine · doi:10.1007/s12020-026-04693-6
“Risk correlates include long disease duration [8, 11, 12], poor glycemic control [3, 13], presence of other diabetic complications (especially peripheral and autonomic neuropathy) [4, 13], prior bariatric surgery [14, 15], and female sex [16, 17], while psychological factors (anxiety, depression,…”
Zhou, Z., Zhou, S., Xu, W., Liu, L., Zhu, W., Chen, H., Zhou, J., & Zhang, Z. (2026) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2026.07.652
- Authors
- Bekkelund, M., Steinsvik, E. K., Valeur, J., Søfteland, E., Dimcevski, G., & Sangnes, D. A.
- Affiliations
- University of Oslo (NO)
- Haukeland University Hospital (NO)
- Corresponding author
- Valeur, Jørgen
- ORCID
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 2025-07-12
- Volume
- 60
- Issue
- 9
- Pages
- 865-873
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W4412360019
- Cited by
- 2
- References
- 33
- Citations by year
- 2026: 2
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Lovisenberg Diakonal Hospital, Norwegian Competence Centre for Functional Gastrointestinal Disorders and Haukeland University Hospital
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- diabetic gastroparesis, delayed gastric emptying, diabetes mellitus, type 1 diabetes, late complications of diabetes, distal symmetric polyneuropathy, retinopathy, HbA1c, albumin, hemoglobin, neuroticism, anxiety, depression, gastrointestinal symptoms, risk factors, gastric emptying scintigraphy
- MeSH terms
- Adult, Age Factors, Aged, Anxiety, Depression, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Gastric Emptying, Glycated Hemoglobin, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Radionuclide Imaging, Body Mass Index, Gastroparesis, Diabetes Complications
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