The DOI matches its Crossref record, with a small difference in title or year; 21 of the 21 references it cites were found in a registry or an index.
Design and in vitro evaluation of pH-sensitive crosslinked chitosan-grafted acrylic acid copolymer (CS- co -AA) for targeted drug delivery
Abstract
In current research study, novel chitosan-based hydrogel was formulated via crosslinking graft copolymerization of acrylic acid (AA) and chitosan. Potassium persulfate was used as free radical generator in the presence of crosslinker (methylene bis acrylamide (MBA)). FTIR spectroscopy was employed to elucidate structure of hydrogel. Moreover, sample morphology was examined by scanning electron microscopy (SEM) and thermal analysis was conducted by using thermogravimetric analysis (DSC/TGA). The influence of reaction variables such as concentration of chitosan (CS), acrylic acid (AA) and MBA was optimized to attain hydrogel with significant swelling capacity. Chitosan-g-AA hydrogel depicted pH responsive attributes and swelling–deswelling pulsatile behavior was recorded at pHs 1.2 and 7.4. This on–off switching makes hydrogel ideal candidate for controlled drug delivery.
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The relaxation of the polymer network during swelling causes diffusion of drug from PAG-co-AA hydrogels.
“The relaxation of polymer network during swelling cause diffusion of drug (Ijaz et al., 2022).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Ijaz et al., 2022
Citations
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Research works printed but not linked: 1
- Anwar, M.; Pervaiz, F.; Shoukat, H.; Noreen, S.; Shabbir, K.; Majeed, A.; Ijaz, S. Formulation and Evaluation of Interpenetrating Network of Xanthan Gum and Polyvinylpyrrolidone as a Hydrophilic Matrix for Controlled Drug Delivery System. Polym. Bull. 2020, 1–13.
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Noureen, S., Noreen, S., Ghumman, S. A., Abdelrahman, E. A., Batool, F., Aslam, A., Mehdi, M., Shirinfar, B., & Ahmed, N. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106555 · Cited by 28
Metadata
- Authors
- Ijaz, H., Tulain, U. R., Minhas, M. U., Mahmood, A., Sarfraz, R. M., Erum, A., & Danish, Z.
- Affiliations
- University of Sargodha (PK)
- University of Lahore (PK)
- University of the Punjab (PK)
- Corresponding author
- Ijaz, Hira
- ORCID
- Venue
- International Journal of Polymeric Materials and Polymeric Biomaterials
- Publisher
- Informa UK Limited
- Published
- 2020-10-15
- Volume
- 71
- Issue
- 5
- Pages
- 336-348
- ISSN
- 0091-4037 (ISSN-L)
- 1563-535X
- OpenAlex
- W3097183777
- Cited by
- 42
- References
- 21
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 5 · 2023: 12 · 2022: 6 · 2021: 3
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Polymeric Materials (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Polymer-Based Agricultural Enhancements
- Keywords
- chitosan hydrogel, pH-responsive hydrogels, graft copolymerization, potassium persulfate initiator, swelling-deswelling behavior, controlled drug delivery, hydrogel morphology, thermal stability
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