Preparation and swelling properties of pH-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release
Abstract
A series of pH-sensitive composite hydrogel beads, chitosan-g-poly (acrylic acid)/vermiculite/sodium alginate (CTS-g-PAA/VMT/SA), was prepared using CTS-g-PAA/VMT composite and SA by Ca(2+) as the crosslinking agent. The structure and morphologies of the developed composite hydrogel beads were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The swelling properties and pH-sensitivity of the beads were investigated. In addition, the drug loading and controlled release behaviors of the beads were also evaluated using diclofenac sodium (DS) as the model drug in stimulated gastric fluids (pH 2.1) and intestinal fluids (pH 6.8). The results indicate that the composite hydrogel beads showed good pH-sensitivity. The release rate of the drug from the composite hydrogel beads is remarkably slowed down, which indicated that incorporating VMT into the composite hydrogel beads can improve the burst release effect of the drug.
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At lower pH, the lower swelling ratio of PAG-co-AA hydrogels is attributed to protonation of ionized -COO- and hydrogen bond formation in -OH, -COOH, and -NHCO groups of polymer chains.
“At lower pH, less swelling ratio is attributed to the protonation of ionized -COO -and hydrogen bond formation in -OH, -COOH, and -NHCO groups of polymer chains.”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Wang et al., 2010
At pH 7.4, ionization of -COOH groups and hydrogen bond breaking leads to electrostatic repulsion in polymer chains, resulting in higher water absorption and increased swelling of PAG-co-AA hydrogels.
“Contrarily, at 7.4 pH ionization of -COOH groups and hydrogen bond breaking leads to electrostatic repulsion in polymer chains resulting in higher water absorption and increased swelling (Wang et al., 2010).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Wang et al., 2010
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“4 pH ionization of -COOH groups and hydrogen bond breaking leads to electrostatic repulsion in polymer chains resulting in higher water absorption and increased swelling (Wang et al., 2010).”
Background
- Authors
- Wang, Q., Xie, X., Zhang, X., Zhang, J., & Wang, A.
- Affiliations
- Chinese Academy of Sciences (CN)
- First Hospital of Lanzhou University (CN)
- Corresponding author
- Wang, Aiqin
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 46
- Issue
- 3
- Pages
- 356-362
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W1999176000
- Cited by
- 162
- References
- 35
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 11 · 2019: 16 · 2018: 11 · 2017: 12 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 11 · 2012: 15
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Lanzhou University Institutional Repository (submittedVersion)
- Funders
- Bijzonder Onderzoeksfonds UGent
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Polymer-Based Agricultural Enhancements
- Keywords
- vermiculite, sodium alginate, composite hydrogels, diclofenac sodium, controlled release, swelling power, calcium crosslinking, burst release, gastrointestinal drug delivery
- MeSH terms
- Acrylic Resins, Alginates, Aluminum Silicates, Delayed-Action Preparations, Diclofenac, Hexuronic Acids, Hydrogen-Ion Concentration, Microscopy, Electron, Scanning, Microspheres, Spectroscopy, Fourier Transform Infrared, Hydrogel, Polyethylene Glycol Dimethacrylate, Glucuronic Acid, Chitosan
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