Apolipoprotein D in the aging brain and in Alzheimer’s dementia
Abstract
Apolipoprotein D (apoD) levels were examined in the temporal cortex as well as an assessment of the location of apoD positive cells within the brain by immunohistochemical and biochemical methods in young control (YC), aged control (AC), and Alzheimer's demented (AD) probands. Scattered apoD positive astrocytes and oligodendrocytes were found throughout the white matter by immunohistochemistry. ApoD immunoreactivity was also observed in the cerebellar oligodendrocytes of the YC group. There was faint positive apoD staining in scattered cortical astrocytes and a few neurons in the same group. In contrast, some of the AC and all of the AD probands had intense and frequent apoD immunostained cortical astrocytes and pyramidal neurons. The cortical senile plaques and neurofibrillary tangles were apoD immunonegative. No quantitative differences were found between the cortical apoD levels in the AC and AD groups, determined by immunoblotting. ApoD detected in the brain tissue was different in molecular weight (29 kDal) from that seen in CSF or in the serum (32 kDal). Our results indicate apoD is present in the human brain, especially in glial cells, and has increased abundance in the elderly and AD subjects.
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Apolipoprotein D expression is induced in the brains of individuals with Alzheimer's disease.
“Moreover, apolipoprotein D expression is induced in the brains of individuals with Alzheimer’s disease (25).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [25]
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- Authors
- Kalman, K., McConathy, W., Araoz, C., Kasa, P., & Lacko, A. G.
- Affiliations
- University of North Texas Health Science Center (US)
- ORCID
- Lacko, Andras G.
- Venue
- Neurological Research
- Publisher
- Informa UK Limited
- Published
- 2000-06
- Volume
- 22
- Issue
- 4
- Pages
- 330-336
- ISSN
- 0161-6412 (ISSN-L)
- 1743-1328
- OpenAlex
- W22062734
- Cited by
- 107
- References
- 30
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 3 · 2021: 8 · 2020: 4 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apolipoprotein D, Alzheimer's disease, brain aging, temporal cortex, astrocytes, oligodendrocytes, white matter, amyloid plaques, neurofibrillary tangles, cerebellum, glial cells
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Apolipoproteins, Astrocytes, Brain, Brain Chemistry, Humans, Immunohistochemistry, Middle Aged, Oligodendroglia, Blotting, Western, Pyramidal Cells, Apolipoproteins D
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