Cited by 48Probiotics and Fermented FoodsCarcinogens and Genotoxicity AssessmentFood and Agricultural Sciences

Antigenotoxic Effect of Kefir and Ayran Supernatants on Fecal Water-Induced DNA Damage in Human Colon Cells

Grishina, Anna, Kulikova, Irina, Alieva, Ludmila, Dodson, Andrew, Rowland, Ian, Jin, Jing·2011·Nutrition and Cancer

Abstract

Fermented dairy products and their component bacteria have been shown to possess health-promoting functions in consumers and recently have been suggested to reduce the risk of colorectal cancer. Kefir and ayran are two popular fermented milk drinks that have their origins in the Caucasus region of Russia. The present study aimed to evaluate their potential anticancer properties in colon cells in vitro. The comet assay and transepithelial resistance assay were used to assess the effect of kefir and ayran supernatants on genotoxicity of fecal water samples and on intestinal tight junction integrity. Their antioxidant capacity was measured by trolox equivalent antioxidant capacity assay and compared with that of unfermented milk. The results showed that DNA damage induced by 2 of 4 fecal water samples was significantly decreased by kefir and ayran supernatants and with ayran the effect was dose-dependent. However no effect on intestinal tight junctions was observed. The supernatants of kefir and ayran contained high amounts of acetic and lactic acid but only a very small quantity of caproic and butyric acid, and they showed significantly greater antioxidant capacity than milk. These findings suggest kefir and ayran can reduce DNA damage, which might be due to their antioxidant capacities.

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Registry

Crossref · 10.1080/01635581.2010.516873

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  • Kefir has the ability to inhibit proliferation and induce apoptosis in HT 29 and Caco 2 colorectal cancer cells.

    “Also, Khoury et al. (86) showed the ability of kefir to inhibit proliferation and induce apoptosis in HT 29 and Caco 2 colorectal cancer cells.”

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Authors
Grishina, A., Kulikova, I., Alieva, L., Dodson, A., Rowland, I., & Jin, J.
Affiliations
  • North Caucasus State Technical University
  • University of Reading (GB)
Venue
Nutrition and Cancer
Published
2010-12-15
Volume
63
Issue
1
Pages
73-79
ISSN
  • 0163-5581 (ISSN-L)
  • 1532-7914
OpenAlex
W2042386967
Cited by
48
References
31
Citations by year
2025: 3 · 2024: 3 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 3 · 2019: 8 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 3 · 2014: 1 · 2013: 1
FWCI
0.49
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition and Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • CentAUR (University of Reading) (submittedVersion)
Funders
University of Reading
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
Keywords
kefir, ayran, fermented milk beverages, antigenotoxicity, DNA damage, fecal water, colon cells, colorectal cancer prevention, antioxidant capacity, intestinal tight junctions, lactic acid, acetic acid
MeSH terms
Antioxidants, Colonic Neoplasms, DNA Damage, Fatty Acids, Feces, Humans, Anticarcinogenic Agents, Cultured Milk Products

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