Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo.
Open accessAbstract
The mechanism by which cancer mediates muscle atrophy has been delineated in the past 3 decades and includes a prominent role of tumor-derived cytokines, such as IL-6, TNFα, and IL-1. These cytokines interact with their cognate receptors on muscle to activate the downstream transcription factor NF-κB and induce sarcomere proteolysis. Experimentally, inhibiting NF-κB signaling largely prevents cancer-induced muscle wasting, indicating its prominent role in muscle atrophy. Resveratrol, a natural phytoalexin found in the skin of grapes, has recently been shown to inhibit NF-κB in cancer cells, which led us to hypothesize that it might have a protective role in cancer cachexia. Therefore, we investigated whether daily oral resveratrol could protect against skeletal muscle loss and cardiac atrophy in an established mouse model. We demonstrate resveratrol inhibits skeletal muscle and cardiac atrophy induced by C26 adenocarcinoma tumors through its inhibition of NF-κB (p65) activity in skeletal muscle and heart. These studies demonstrate for the first time the utility of oral resveratrol therapy to provide clinical benefit in cancer-induced atrophy through the inhibition of NF-κB in muscle. These findings may have application in the treatment of diseases with parallel pathophysiologies such as muscular dystrophy and heart failure.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RSV has been reported to prevent muscle atrophy in several catabolic conditions, including cancer, diabetes, chronic kidney disease and disuse.
“RSV has been reported to prevent muscle atrophy in several catabolic conditions, including cancer, diabetes, chronic kidney disease and disuse [27–30].”
From Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway (2019) · cites this paper as [27]
Resveratrol inhibits protein degradation and attenuates skeletal muscle fiber atrophy in different disease models, including cancer, diabetes, and denervation.
“Resveratrol (3, 5, 4′-trihydroxystilbene), a natural antioxidant found mainly in grape skin, and especially red wine, has been shown to inhibit protein degradation and attenuate skeletal muscle fiber atrophy in the different disease model, including cancer, diabetes, and denervation [86,87].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [87]
Oral resveratrol treatment alleviates muscle atrophy induced by C26 adenocarcinoma through inhibition of NF-κB in CD2F1 mice.
“Oral resveratrol treatment alleviates muscle atrophy induced by C26 adenocarcinoma through the inhibition of NF-κB in CD2F1 mice [87].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [87]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works
Regulation and Function of NF-κB Transcription Factors in the Immune System
Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,578 · see citing works
Stitt, T. N., Drujan, D., Clarke, B. A., Panaro, F., Timofeyva, Y., Kline, W. O., Gonzalez, M., Yancopoulos, G. D., & Glass, D. J. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00211-4 · Cited by 1,964 · see citing works
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., & Walle, U. K. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000885 · Cited by 1,893 · see citing works
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works
Tisdale, M. J. (2009) · Physiological Reviews · doi:10.1152/physrev.00016.2008 · Cited by 1,192 · see citing works
Skeletal muscle hypertrophy and atrophy signaling pathways
Glass, D. J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.04.018 · Cited by 1,106 · see citing works
Tisdale, M. J. (2002) · Nature reviews. Cancer · doi:10.1038/nrc927 · Cited by 983 · see citing works
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
Zhou, X., Wang, J. L., Lu, J., Song, Y., Kwak, K. S., Jiao, Q., Rosenfeld, R., Chen, Q., Boone, T. C., Simonet, W. S., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.011 · Cited by 941 · see citing works
Boocock, D. J., Faust, G. E. S., Patel, K. R., Schinas, A. M., Brown, V. A., Ducharme, M. P., Booth, T. D., Crowell, J. A., Perloff, M., Gescher, A. J., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0022 · Cited by 827 · see citing works
Sacheck, J. M., Ohtsuka, A., McLary, S. C., & Goldberg, A. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2004 · Cited by 606 · see citing works
Cohen, S., Brault, J. J., Gygi, S. P., Glass, D. J., Valenzuela, D. M., Gartner, C. A., Latres, E., & Goldberg, A. L. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200901052 · Cited by 584 · see citing works
Corbett, T. H., Griswold, D. P., Roberts, B. J., Peckham, J. C., & Schabel, F. M. (1975) · PubMed · Cited by 584 · see citing works
Cancer cachexia is regulated by selective targeting of skeletal muscle gene products
Acharyya, S., Ladner, K. J., Nelsen, L., Damrauer, J. S., Reiser, P. J., Swoap, S. J., & D, D. C. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20174 · Cited by 541 · see citing works
Holmes-McNary, M. Q., & Baldwin, A. S. (2019) · PubMed · doi:10.17615/wdcc-wb89 · Cited by 442 · see citing works
Nuclear factor-kappa B signaling in skeletal muscle atrophy
Li, H., Malhotra, S., & Kumar, A. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0373-8 · Cited by 442 · see citing works
Acharyya, S., Villalta, S. A., Bakkar, N., Bupha‐Intr, T., Janssen, P. M. L., Carathers, M., Li, Z.-W., Beg, A. A., Ghosh, S., Sahenk, Z., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30556 · Cited by 436 · see citing works
THE IMMEDIATE CAUSES OF DEATH IN CANCER
Warren, S. (1932) · The American Journal of the Medical Sciences · doi:10.1097/00000441-193211000-00002 · Cited by 424 · see citing works
Bhardwaj, A., Sethi, G., Vadhan-Raj, Bueso-Ramos, C., Takada, Y., Gaur, U., Nair, A. S., Shishodia, S., & Aggarwal, B. B. (2007) · Blood · doi:10.1182/blood-2006-02-003988 · Cited by 395 · see citing works
Waddell, D. S., Baehr, L. M., van den Brandt, J., Johnsen, S. A., Reichardt, H. M., Furlow, J. D., & Bodine, S. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00646.2007 · Cited by 360 · see citing works
Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial
Gordon, J., Trebble, T. M., Ellis, R. D., Duncan, H. D., Johns, T., & Goggin, P. M. (2005) · Gut · doi:10.1136/gut.2004.047563 · Cited by 322 · see citing works
May, P. E., Barber, A. E., D'Olimpio, J. T., Hourihane, A., & Abumrad, N. N. (2002) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)00823-1 · Cited by 318 · see citing works
Acharyya, S., Butchbach, M. E. R., Sahenk, Z., Wang, H., Saji, M., Carathers, M., Ringel, M. D., Skipworth, R. J. E., Fearon, K. C. H., Hollingsworth, M. A., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.004 · Cited by 316 · see citing works
Mourkioti, F., Kratsios, P., Luedde, T., Song, Y.-H., Delafontaine, P., Adami, R., Parente, V., Bottinelli, R., Pasparakis, M., & Rosenthal, N. A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28721 · Cited by 315 · see citing works
Black, P. H. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.04.008 · Cited by 276 · see citing works
Lundholm, K., Gélin, J., Hyltander, A. G., Lönnroth, C., Sandström, R., Svaninger, G., Körner, U., Gulich, M. P., Kärrefors, I., & Norli, B. (1994) · PubMed · Cited by 269 · see citing works
Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy
Hunter, R. B., & Kandarian, S. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21696 · Cited by 249 · see citing works
Evaluation of a Quantitative Magnetic Resonance Method for Mouse Whole Body Composition Analysis
Tinsley, F. C., Taicher, G. Z., & Heiman, M. L. (2004) · Obesity Research · doi:10.1038/oby.2004.20 · Cited by 244 · see citing works
Rosen, G., Wollner, N., Tan, C. R. C., Wu, S., Hajdu, S. I., Cham, W., D’Angio, G. J., & Murphy, M. L. (1974) · Cancer · doi:10.1002/1097-0142(197402)33:2 · Cited by 230 · see citing works
Body-composition changes in patients who gain weight while receiving megestrol acetate.
Loprinzi, C. L., Schaid, D. J., Dose, A. M., Burnham, N. L., & Jensen, M. D. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.1.152 · Cited by 230 · see citing works
Safety studies conducted on high-purity trans-resveratrol in experimental animals
Williams, L. D., Burdock, G. A., Edwards, J. A., Beck, M., & Bausch, J. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.06.002 · Cited by 223 · see citing works
Interleukin-6 as a Key Regulator of Muscle Mass during Cachexia
Carson, J., & Baltgalvis, K. A. (2010) · Exercise and sport sciences reviews · doi:10.1097/jes.0b013e3181f44f11 · Cited by 217 · see citing works
Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma
Bishayee, A., Politis, T., & Darvesh, A. S. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.10.002 · Cited by 205 · see citing works
Wyke, S. M., Russell, S. T., & Tisdale, M. J. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602165 · Cited by 184 · see citing works
Pallàs, M., Casadesús, G., Smith, M. A., Coto‐Montes, A. M., Pelegrı́, C., Vilaplana, J., & Camins, A. (2009) · Current Neurovascular Research · doi:10.2174/156720209787466019 · Cited by 183 · see citing works
Aulino, P., Berardi, E., Cardillo, V., Rizzuto, E., Perniconi, B., Ramina, C., Padula, F., Spugnini, E. P., Baldi, A., Faiola, F., et al. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-363 · Cited by 177 · see citing works
Tisdale, M. J. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283347e77 · Cited by 174 · see citing works
Cardiac alterations in cancer-induced cachexia in mice
Belury (2010) · International Journal of Oncology · doi:10.3892/ijo_00000683 · Cited by 145 · see citing works
The pivotal role of cytokines in muscle wasting during cancer
Argilés, J. M. A., Busquets, S., & López-Soriano, F. J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.03.014 · Cited by 142 · see citing works
Smith, H. J., Wyke, S. M., & Tisdale, M. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1760 · Cited by 132 · see citing works
Wyke, S. M., & Tisdale, M. J. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602402 · Cited by 130 · see citing works
Muscle cachexia is regulated by a p53–PW1/Peg3-dependent pathwayPreprint
Schwarzkopf, M., Coletti, D., Sassoon, D. A., & Marazzi, G. (2006) · Genes & Development · doi:10.1101/gad.412606 · Cited by 123 · see citing works
Altered expression of skeletal muscle myosin isoforms in cancer cachexia
Diffee, G. M., Kalfas, K., Al‐Majid, S., & McCarthy, D. O. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00154.2002 · Cited by 113 · see citing works
Fearon, K. C. H., & Moses, A. G. W. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00235-8 · Cited by 103 · see citing works
Muscle ring finger 1 mediates cardiac atrophy in vivo
Willis, M. S., Rojas, M., Li, L., Selzman, C. H., Tang, R., Stansfield, W. E., Rodriguez, J., Glass, D. J., & Patterson, C. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00660.2008 · Cited by 101 · see citing works
Self-citationThe IκB kinases IKKα and IKKβ are necessary and sufficient for skeletal muscle atrophy
Gammeren, D. V., Damrauer, J. S., Jackman, R. W., & Kandarian, S. C. (2008) · The FASEB Journal · doi:10.1096/fj.08-114249 · Cited by 100 · see citing works
Yasumoto, K., Mukaida, N., Harada, A., Kuno, K., Akiyama, M., Nakashima, E., Fujioka, N., Mai, M., Kasahara, T., & Fujimoto-Ouchi, K. (1995) · PubMed · Cited by 88 · see citing works
(2008) · PubMed · Cited by 84 · see citing works
Role of NF-κB and cytokine in experimental cancer cachexia
Zhou, W., Jiang, Z.-W., Tian, J., Jiang, J., Li, N., & Li, J.-S. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i7.1567 · Cited by 74 · see citing works
Enhanced radiation-induced apoptosis of cancer cell lines after treatment with resveratrol
Baatout, S., Derradji, H., Jacquet, P., Ooms, D., Michaux, A., & Mergeay, M. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.13.6.895 · Cited by 63 · see citing works
Are Tumoral Factors Responsible for Host Tissue Wasting in Cancer Cachexia?
Tisdale, M. J. (2010) · Future Oncology · doi:10.2217/fon.10.20 · Cited by 62 · see citing works
Soda, K., Kawakami, M., Kashii, A., & Miyata, M. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910620317 · Cited by 59 · see citing works
Cancer cachexia: from experimental models to patient management
Costelli, P., & Baccino, F. M. (2000) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200005000-00003 · Cited by 57 · see citing works
Weyermann, P., Dallmann, R., Magyar, J. P., Anklin, C., Hufschmid, M., Dubach‐Powell, J., Courdier-Fruh, I., Henneböhle, M., Nordhoff, S., & Mondadori, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004774 · Cited by 53 · see citing works
Metabolomic analysis of cancer cachexia reveals distinct lipid and glucose alterations
O’Connell, T. M., Ardeshirpour, F., Asher, S. A., Winnike, J. H., Yin, X., George, J. R., D, D. C. G., He, W., Wysong, A. S., Willis, M. S., et al. (2008) · Metabolomics · doi:10.1007/s11306-008-0113-7 · Cited by 47 · see citing works
Self-citationResveratrol does not ameliorate muscle wasting in different types of cancer cachexia models
Busquets, S., Fuster, G., Ametller, E., Oliván, M., Figueras, M., Costelli, P., Carbó, N., Argilés, J. M. A., & López-Soriano, F. J. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2006.12.001 · Cited by 46 · see citing works
Eley, H. L., Russell, S. T., & Tisdale, M. J. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603704 · Cited by 46 · see citing works
Soda, K., Kawakami, M., Kashii, A., & Miyata, M. (1994) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1994.tb02917.x · Cited by 45 · see citing works
Effects of tumor-load and malnutrition on myocardial function in the isolated working rat heart*
Drott, C., Ekman, L. G., HOLM, S., Waldenström, A. P., & Lundholm, K. (1986) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(86)80042-6 · Cited by 36 · see citing works
Skeletal muscle is enriched in hematopoietic stem cells and not inflammatory cells in cachectic mice
Berardi, E., Aulino, P., Murfuni, I., Toschi, A., Padula, F., Scicchitano, B. M., Coletti, D., & Adamo, S. (2008) · Neurological Research · doi:10.1179/174313208x281046 · Cited by 32 · see citing works
Is there a common mechanism linking muscle wasting in various disease types?
Tisdale, M. J. (2007) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3282f35238 · Cited by 30 · see citing works
In vivo gene transfer of murine interleukin-4 inhibits colon-26-mediated cancer cachexia in mice.
Šturlan, S., Beinhauer, B. G., Oberhuber, G., Huang, L., Aasen, A. O., & Rogy, M. A. (2002) · PubMed · Cited by 10 · see citing works
[Role of NF-kappa B in cancer cachexia].
Zhou, W., Jiang, Z., Jiang, J., Li, N., & Li, J. (2004) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cancer cachexia: molecular mechanisms and treatment strategies
Setiawan, T., Sari, I. N., Wijaya, Y., Julianto, N. M., Muhammad, J. A., Lee, H.-Y., Ji, H.-O.-C., & Kwon, H. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01454-0 · Cited by 300 · see citing works
Inflammation: Roles in Skeletal Muscle Atrophy
Ji, Y., Li, M., Chang, M., Liu, R., Qiu, J., Wang, K., Deng, C., Shen, Y., Zhu, J., Wang, W., et al. (2022) · Antioxidants · doi:10.3390/antiox11091686 · Cited by 311 · see citing works
Prevention of liver cancer cachexia-induced cardiac wasting and heart failure
Springer, J., Tschirner, A., Haghikia, A., von Haehling, S., Lal, H., Grzesiak, A., Kaschina, E., Palus, S., Poetsch, M. S., von Websky, K., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht302 · Cited by 211 · see citing works
The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia
Kasprzak, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041565 · Cited by 187 · see citing works
Wang, D., Yin, Y., Yang, Y., Lv, P.-J., Shi, Y. Q., Lu, L., & Wei, L.-B. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.02.002 · Cited by 176 · see citing works
Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action
Dutt, V., Gupta, S. K., Dabur, R., Injeti, E. R., & Mittal, A. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.010 · Cited by 174 · see citing works
Huang, Y., Zhu, X., Chen, K., Lang, H., Zhang, Y., Hou, P., Ran, L., Zhou, M., Zheng, J., Yi, L., et al. (2019) · Aging · doi:10.18632/aging.101910 · Cited by 167 · see citing works
Polyphenols and Their Effects on Muscle Atrophy and Muscle Health
Nikawa, T., Ulla, A., & Sakakibara, I. (2021) · Molecules · doi:10.3390/molecules26164887 · Cited by 140 · see citing works
Dolinsky, V. W., Rogan, K. J., Sung, M. M., Zordoky, B. N., Haykowsky, M. J., Young, M. E., Jones, L. W., & Dyck, J. R. B. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00044.2013 · Cited by 133 · see citing works
The pathogenesis and treatment of cardiac atrophy in cancer cachexia
Murphy, K. T. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00720.2015 · Cited by 115 · see citing works
Potential of resveratrol in the treatment of heart failure
Raj, P., Louis, X. L., Thandapilly, S. J., Movahed, A., Zieroth, S. R., & Netticadan, T. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.12.011 · Cited by 109 · see citing works
Wang, D., Sun, H., Song, G., Yang, Y., Zou, X., Han, P., & Li, S. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700941 · Cited by 102 · see citing works
Frazzi, R., Valli, R., Tamagnini, I., Casali, B., Latruffe, N., & Merli, F. (2012) · International Journal of Cancer · doi:10.1002/ijc.27748 · Cited by 97 · see citing works
Martin, A., & Freyssenet, D. G. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12678 · Cited by 97 · see citing works
Alamdari, N., Aversa, Z., Castillero, E., Gurav, A., Petkova, V., Tizio, S., & Hasselgren, P.-O. J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.154 · Cited by 98 · see citing works
Cancer-induced cardiac cachexia: Pathogenesis and impact of physical activity
Belloum, Y., Rannou‐Bekono, F., & Favier, F. B. (2017) · Oncology Reports · doi:10.3892/or.2017.5542 · Cited by 90 · see citing works
Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models
van de Worp, W. R. P. H., Schols, A. M. W. J., Theys, J., van Helvoort, A., & LANGEN, R. C. J. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.601329 · Cited by 92 · see citing works
Cancer cachexia update in head and neck cancer: Definitions and diagnostic features
Couch, M. E., Dittus, K. L., Toth, M. J., Willis, M. S., D, D. C. G., George, J. R., Barnes, C. A., Gourin, C. G., & Der‐Torossian, H. (2014) · Head & Neck · doi:10.1002/hed.23599 · Cited by 85 · see citing works
Self-citationSIRT1–NOX4 signaling axis regulates cancer cachexia
Dasgupta, A., Shukla, S. K., Vernucci, E., King, R. J., Abrego, J., Mulder, S. E., Mullen, N. J., Graves, G., Buettner, K. B., Thakur, R. K., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190745 · Cited by 84 · see citing works
Polyphenols and Their Potential Role in Preventing Skeletal Muscle Atrophy
Salucci, S., & Falcieri, E. (2020) · Nutrition Research · doi:10.1016/j.nutres.2019.11.004 · Cited by 83 · see citing works
Concurrent evolution of cancer cachexia and heart failure: bilateral effects exist
Kazemi-Bajestani, S., Becher, H., Fassbender, K., Chu, Q., & Baracos, V. (2014) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-014-0137-y · Cited by 74 · see citing works
Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration
Beltrà, M., Pin, F., Ballarò, R., Costelli, P., & Penna, F. (2021) · Cells · doi:10.3390/cells10113150 · Cited by 76 · see citing works
Nuclear factor‐κB signalling and transcriptional regulation in skeletal muscle atrophy
Jackman, R. W., Cornwell, E. W., Wu, C., & Kandarian, S. C. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.063321 · Cited by 73 · see citing works
Experimental cancer cachexia: Evolving strategies for getting closer to the human scenario
Penna, F., Busquets, S., & Argilés, J. M. A. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.09.002 · Cited by 72 · see citing works
Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
Der‐Torossian, H., Wysong, A. S., Shadfar, S., Willis, M. S., McDunn, J. E., & Couch, M. E. (2013) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0101-7 · Cited by 56 · see citing works
Self-citationPassey, S. L., Hansen, M. J., Bozinovski, S., McDonald, C. F., Holland, A. E., & Vlahos, R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.06.013 · Cited by 57 · see citing works
Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia
Coletti, D., Aulino, P., Pigna, E., Barteri, F., Moresi, V., Annibali, D., Adamo, S., & Berardi, E. (2015) · Stem Cells International · doi:10.1155/2016/6729268 · Cited by 55 · see citing works
da Costa, R. M. G., Aragão, S., Moutinho, M., Alvarado, A., Carmo, D., Casaca, F., da Silva, S. R. A., Ribeiro, J., de Sousa, H. M. L., Ferreira, R. M., et al. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.10.031 · Cited by 54 · see citing works
Sukari, A. W., Muqbil, I., Mohammad, R. M., Philip, P. A., & Azmi, A. S. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.01.002 · Cited by 50 · see citing works
Phytochemicals suppress nuclear factor-κB signaling
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834d3ae7 · Cited by 50 · see citing works
Bae, T., Jang, J., Lee, H., Song, J., Chae, S., Park, M., Son, C., Yoon, S., & Yoon, Y. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112222 · Cited by 45 · see citing works
Nutraceuticals and Exercise against Muscle Wasting during Cancer Cachexia
Aquila, G., Cecconi, A. D. R., Brault, J., Corli, O., & Piccirillo, R. (2020) · Cells · doi:10.3390/cells9122536 · Cited by 41 · see citing works
Amirazodi, F., Mehrabi, A., Amirazodi, M., Parsania, S., Rajizadeh, M. A., & Esmaeilpour, K. (2020) · Experimental Aging Research · doi:10.1080/0361073x.2020.1754015 · Cited by 44 · see citing works
C26 Cancer-Induced Muscle Wasting Is IKKβ-Dependent and NF-kappaB-Independent
Cornwell, E. W., Mirbod, A., Wu, C., Kandarian, S. C., & Jackman, R. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087776 · Cited by 42 · see citing works
The Redox Balance: A Target for Interventions Against Muscle Wasting in Cancer Cachexia?
Penna, F., Ballarò, R., & Costelli, P. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8041 · Cited by 41 · see citing works
Annunziata, G., Jiménez‐García, M., Tejada, S., Moranta, D., Arnone, A., Ciampaglia, R., Tenore, G. C., Sureda, A., Novellino, E., & Capó, X. (2020) · Nutrients · doi:10.3390/nu12051280 · Cited by 39 · see citing works
Resveratrol ameliorates muscle atrophy in chronic kidney disease via the axis of SIRT1/FoxO1
Wang, R., Yuan, W., Li, L., Lu, F., Zhang, L., Gong, H., & Huang, X. (2022) · Phytotherapy Research · doi:10.1002/ptr.7499 · Cited by 38 · see citing works
Moutinho, M., Aragão, S., CARMO, D., Casaca, F., da Silva, S. R. A., Ribeiro, J., de Sousa, H. M. L., Pires, I. C. R., QUEIROGA, F. L., Colaço, B., et al. (2018) · Anticancer Research · doi:10.21873/anticanres.12371 · Cited by 38 · see citing works
Dinardo, M. M., Camerino, G. M., Mele, A., Latorre, R., Camerino, D. C., & Tricarico, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040235 · Cited by 37 · see citing works
Sun, L.-J., Sun, Y.-N., Chen, S.-J., Liu, S., & Jiang, G.-R. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.022 · Cited by 35 · see citing works
Research on cachexia, sarcopenia and skeletal muscle in cardiology
Coats, A. J. S. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0090-6 · Cited by 35 · see citing works
Guo, X., Li, J., Tang, J., & Li, D. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1349076 · Cited by 35 · see citing works
Natural products and skeletal muscle health
Qu, Z., Zhou, S., Li, P., Liu, C., Yuan, B., Zhang, S., & Liu, A. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108619 · Cited by 35 · see citing works
Exercise Training as Therapy for Cancer-Induced Cardiac Cachexia
Antunes, J. M. M., Ferreira, R. M., & Moreira‐Gonçalves, D. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.06.002 · Cited by 35 · see citing works
Capozzi, A., Saucier, C., Bisbal, C., & Lambert, K. (2022) · Molecules · doi:10.3390/molecules27196594 · Cited by 37 · see citing works
Asami, Y., Aizawa, M., Kinoshita, M., Ishikawa, J., & Sakuma, K. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.22723 · Cited by 33 · see citing works
Targeting Mitochondria and Oxidative Stress in Cancer- and Chemotherapy-Induced Muscle Wasting
Huot, J. R., Baumfalk, D. R., Resendiz, A., Bonetto, A., Smuder, A. J., & Penna, F. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0149 · Cited by 35 · see citing works
The Janus‐Faced Role of Antioxidants in Cancer Cachexia: New Insights on the Established Concepts
Assi, M., & Rébillard, A. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9579868 · Cited by 30 · see citing works
Oxidative Stress, Inflammation and Connexin Hemichannels in Muscular Dystrophies
González‐Jamett, A. M., Vásquez, W., Cifuentes-Riveros, G., Martínez-Pando, R., Sáez, J. C., & Cárdenas, A. M. (2022) · Biomedicines · doi:10.3390/biomedicines10020507 · Cited by 29 · see citing works
Li, B., Wan, L., Li, Y., Yu, Q., Chen, P., Gan, R., Yang, Q., Han, Y., & Guo, C. (2014) · Tumor Biology · doi:10.1007/s13277-014-2558-9 · Cited by 28 · see citing works
Mechanisms underlying the cross‐talk between heart and cancer
Brancaccio, M., Pirozzi, F., Hirsch, E., & Ghigo, A. (2019) · The Journal of Physiology · doi:10.1113/jp276746 · Cited by 27 · see citing works
Lee, H., Lee, S.-J., Bae, G.-U., Baek, N.-I., & Ryu, J.-H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122748 · Cited by 26 · see citing works
Yang, H., Li, Y., Wang, G., Xie, J., Kaneko, G., & Yu, E. (2023) · Aquaculture Reports · doi:10.1016/j.aqrep.2023.101878 · Cited by 24 · see citing works
How progressive cancer endangers the heart: an intriguing and underestimated problem
Ausoni, S., Calamelli, S., Saccà, S., & Azzarello, G. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09869-8 · Cited by 25 · see citing works
Ye, D., Zhu, J., Su, S., Yu, Y., Zhang, J., Yin, Y., Lin, C., Xie, X., Qin, X., & Yu, R. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1571767 · Cited by 22 · see citing works
Salomão, R. A. S., de Paula, T. G., Zanella, B. T. T., de Carvalho, P. L. P. F., Duran, B. O. D. S., Valente, J. S., Fantinatti, B. E. A., Fernandes, A. A. H., Barros, M. M., Mareco, E. A., et al. (2019) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2019.05.002 · Cited by 21 · see citing works
Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
Vudatha, V., Devarakonda, T., Liu, C., Freudenberger, D. C., Riner, A. N., Herremans, K. M., & Trevino, J. (2022) · Cells · doi:10.3390/cells11061040 · Cited by 21 · see citing works
Cardiac Remodeling in Cancer-Induced Cachexia: Functional, Structural, and Metabolic Contributors
Wiggs, M. P., Beaudry, A. G., & Law, M. L. (2022) · Cells · doi:10.3390/cells11121931 · Cited by 19 · see citing works
Natural constituents from food sources: potential therapeutic agents against muscle wasting
Shen, S., Yu, H., Gan, L., Yang, Y., & Lin, L. (2019) · Food & Function · doi:10.1039/c9fo00912d · Cited by 20 · see citing works
Phytochemicals: A potential therapeutic intervention for the prevention and treatment of cachexia
Zarifi, S. H., Bagherniya, M., Banach, M., Johnston, T. P., & Sahebkar, A. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.11.009 · Cited by 17 · see citing works
Cardiac wasting in patients with cancer
Anker, M. S., Rashid, A. M., Butler, J., & Khan, M. S. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-024-01079-5 · Cited by 16 · see citing works
Archer-Lahlou, É., Lan, C., & Jagoe, R. T. (2018) · Physiological Reports · doi:10.14814/phy2.13726 · Cited by 16 · see citing works
Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia
Li, W., Swiderski, K., Murphy, K. T., & Lynch, G. S. (2022) · Antioxidants · doi:10.3390/antiox11020183 · Cited by 16 · see citing works
Pay attention to cardiac remodeling in cancer cachexia
Zheng, Y., Chen, H., Li, X., & Sun, Y. (2016) · Supportive Care in Cancer · doi:10.1007/s00520-016-3222-2 · Cited by 16 · see citing works
Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice
Berent, T. E., Dorschner, J. M., Meyer, T., Craig, T. A., Wang, X., Kunz, H., Jatoi, A., Lanza, I. R., Chen, H., & Kumar, R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226440 · Cited by 14 · see citing works
Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
Li, W., Trieu, J., Blazev, R., Parker, B. L., Murphy, K. T., Swiderski, K., & Lynch, G. S. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00025.2022 · Cited by 13 · see citing works
Sakata, Y., Okamoto, T., Oshio, K., Nakamura, H., Iwamoto, H., Namba, K., Takeda, Y., & Yoshizawa, F. (2016) · SpringerPlus · doi:10.1186/s40064-016-2427-7 · Cited by 13 · see citing works
Translational implications of novel findings in cancer cachexia
Der‐Torossian, H., Gourin, C. G., & Couch, M. E. (2012) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328359b695 · Cited by 12 · see citing works
Self-citationChen, G., Chen, B., Wu, Y., Nie, H., Zhong, Z., Yang, S., Qin, R., Kang, W., Zhang, C., Wang, N., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02379-7 · Cited by 13 · see citing works
Jang, J., Lee, H., Song, J., Bae, T., Park, M., Kwon, Y. V., Lee, D., & Yoon, Y. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113403 · Cited by 11 · see citing works
Simulated microgravity accelerates aging in Saccharomyces cerevisiae
Fukuda, A. P. M., Camandona, V. D. L., Francisco, K. J. M., Rios-Anjos, R. M., do Lago, C. L., & Ferreira-Júnior, J. R. (2020) · Life Sciences in Space Research · doi:10.1016/j.lssr.2020.12.003 · Cited by 11 · see citing works
Shoura, S. M. S., Naghsh, N., Moslemi, E., Kavyani, Z., Moridpour, A. H., Musazadeh, V., & Dehghan, P. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105360 · Cited by 11 · see citing works
Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases
Svensson, K., & Handschin, C. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.02.013 · Cited by 13 · see citing works
Muscle loss in cancer cachexia: what is the basis for nutritional support?
Faiad, J. Z., Andrade, M. F., de Castro, G. S., de Resende, J., Coêlho, M. D. C., de Aquino, G. P., & Seelaender, M. C. L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1519278 · Cited by 10 · see citing works
Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice
Clark, Y. Y., Wold, L. E., Szalacha, L. A., & McCarthy, D. O. (2014) · Biological Research For Nursing · doi:10.1177/1099800414543822 · Cited by 10 · see citing works
Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
Moresi, V., Renzini, A., Cavioli, G., Seelaender, M. C. L., Coletti, D., Gigli, G., & Cedola, A. (2022) · Metabolites · doi:10.3390/metabo12111149 · Cited by 9 · see citing works
Ogilvie, L. M., Coyle‐Asbil, B., Brunt, K. R., Petrik, J., & Simpson, J. A. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00795.2023 · Cited by 9 · see citing works
Samadi, M., Daryanoosh, F., Mojtahedi, Z., Pour, A. S., Nobarı, H., Zarifkar, A. H., & Khoramipour, K. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01491-7 · Cited by 8 · see citing works
Does Myocardial Atrophy Represent Anti-Arrhythmic Phenotype?
Bačová, B. S., Andelová, K. O., Sýkora, M., Beňová, T. E., Barančı́k, M., Kurahara, L. H., & Tribulová, N. (2022) · Biomedicines · doi:10.3390/biomedicines10112819 · Cited by 7 · see citing works
Resveratrol aggravated H2O2-induced the HK-2 cell damage by inhibiting AKT phosphorylation
Luo, S., Chen, Y., Ma, X., Tian, F., & He, X. (2025) · PLoS ONE · doi:10.1371/journal.pone.0327135 · Cited by 5 · see citing works
Cellular mechanisms promoting cachexia and how they are opposed by sirtuins
Samant, S. A., Pillai, V. B., & Gupta, M. P. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0479 · Cited by 5 · see citing works
A Review of Nutraceuticals in Cancer Cachexia
Caeiro, L., Gandhay, D., Anderson, L. J., & Garcia, J. M. (2023) · Cancers · doi:10.3390/cancers15153884 · Cited by 4 · see citing works
Muscle quality index correlates with arthritis: a cross-sectional study from NHANES 2011–2014
Wang, C., Xu, H. E., Wang, L., Huang, S., Pan, B., Pan, H., Jia, H., & Tang, S. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1573729 · Cited by 3 · see citing works
Chitti, S. V., Marzan, A. L., Shahi, S. K., Kang, T., Fonseka, P., & Mathivanan, S. (2021) · Biology · doi:10.3390/biology10080700 · Cited by 3 · see citing works
Role of NF-KB in Loss of Skeletal Muscle Mass in Cancer Cachexia and its Therapeutic Targets
Srivastava, D. S., & Dhaulakhandi, D. B. (2013) · Cited by 3 · see citing works
Sun, Y., Huang, Z.-Y., Huang, S.-T., Tang, H., Li, Z., Ma, X., & Liu, L. (2025) · Innovations in Acupuncture and Medicine · doi:10.1186/s44424-025-00041-z · Cited by 2 · see citing works
Tastekin, B., Pelit, A., Sapmaz, T., Çelenk, A., Majeed, M. A., Mundkur, L., & Nagabhushanam, K. (2023) · Journal of Diabetes Research · doi:10.1155/2023/6657869 · Cited by 3 · see citing works
Nutraceuticals Approach as a Treatment for Cancer Cachexia
Chiocchetti, G. D. M. E., Viana, L. R., Lopes‐Aguiar, L., Miyaguti, N. A. D. S., & Gomes‐Marcondes, M. C. C. (2022) · doi:10.1002/9781119746843.ch14 · Cited by 2 · see citing works
Phytotherapy and oncology. A short review
Sannia, A. (2021) · Integrative Cancer Science and Therapeutics · doi:10.15761/icst.1000353 · Cited by 1 · see citing works
Skeletal muscle regeneration and the role of Sirtuin 1
Bennett, B. T. (2013) · doi:10.33915/etd.4952
اسماعیلی, ب. ا., عبدی, ا., عباسی دلویی, آ., & فرزانگی, پ. (2020) · مجله علمی دانشگاه علوم پزشکی بیرجند · doi:10.32592/jbirjandunivmedsci.2020.27.2.103
(2012) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e32835ad036
اسماعیلی, ب. ا., عبدی, ا., دلویی, آ. ع., & فرزانگی, پ. (2020) · مجله علمی دانشگاه علوم پزشکی بیرجند · doi:10.32592/jbirjandunimedsci.2020.27.2.103
van de Worp, W. R. P. H. (2022) · doi:10.26481/dis.20221214ww
Polyphenols-Enriched Diet Prevents Muscle Atrophy in an Inflamed Zebrafish (Danio Rerio) ModelPreprint
Orso, G., Matuozzo, M., Rocco, M., Hoseinifar, S. H., Ashouri, G., Scaloni, A., Paolucci, M., DˈAmbrosio, C., & Imperatore, R. (2025) · Preprints.org · doi:10.20944/preprints202508.1585.v1
- Authors
- Shadfar, S., Couch, M. E., McKinney, K. A., Weinstein, L. J., Yin, X., Rodríguez, J. E., Guttridge, D. C., & Willis, M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Willis, Monte
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2011-07
- Volume
- 63
- Issue
- 5
- Pages
- 749-762
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- PMC
- PMC3623008
- OpenAlex
- W2137590405
- Cited by
- 98
- References
- 64
- Citations by year
- 2025: 7 · 2024: 3 · 2023: 4 · 2022: 15 · 2021: 8 · 2020: 12 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 6
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nutrition and Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- American Heart Association
- University of North Carolina at Chapel Hill
- National Heart, Lung, and Blood Institute (R01HL104129)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- resveratrol, cancer cachexia, skeletal muscle atrophy, cardiac atrophy, NF-κB signaling, tumor-derived cytokines, interleukin-6, TNF-α, interleukin-1, oral supplementation, muscle atrophy, heart failure, muscular dystrophy
- MeSH terms
- Tripartite Motif Proteins, Resveratrol, Adenocarcinoma, Administration, Oral, Animals, Body Composition, Cachexia, Dose-Response Relationship, Drug, Echocardiography, Female, Heart, Muscle Proteins, Muscular Atrophy, Myocardium, Neoplasm Transplantation, Random Allocation, RNA, Messenger, Stilbenes, Weight Loss, Gene Expression Regulation, Enzymologic, Muscle, Skeletal, Ubiquitin-Protein Ligases, Cell Line, Tumor, Mice, Transcription Factor RelA
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
