Polyphenols and Their Potential Role in Preventing Skeletal Muscle Atrophy
Abstract
Skeletal muscle atrophy is the consequence of various conditions, such as disuse, denervation, fasting, aging, and disease. Even if the underlying molecular mechanisms are still not fully understood, an elevated oxidative stress related to mitochondrial dysfunction has been proposed as one of the major contributors to skeletal muscle atrophy. Researchers have described various forms of nutritional supplementation to prevent oxidative stress-induced muscle wasting. Among a variety of nutrients, attention has also focused on polyphenols, a wide range of plant-based compounds with antioxidant and inflammatory properties, many of which have beneficial effects on human health and might retard skeletal muscle loss and function impairment. The purpose of this review is to describe polyphenol actions in skeletal muscle atrophy prevention. Published articles from the last 10 years were searched on PubMed and other databases. Polyphenols are important molecules that should be considered when discussing possible strategies against muscle atrophy. In particular, the collected studies describe, for each polyphenol subclass, the beneficial effect on muscle mass preservation in various skeletal muscle disorders. In these examples, the polyphenol compounds appear to mainly act by reversing mitochondrial dysfunction. Given that the current information on polyphenols is mostly restricted to basic studies, more comprehensive research and additional studies should be performed to clarify their mechanisms of action in improving skeletal muscle functions during atrophy.
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Evidence from preclinical studies reveals nutraceuticals play a significant role in maintaining muscle health and are potential therapeutic agents in a broad range of muscle atrophy models.
“Evidence from various preclinical studies has revealed that nutraceuticals play a significant role in maintaining muscle health and emerge as potential therapeutic agents in a broad range of muscle atrophy models [17,18].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [18]
Phytochemicals play an essential role in the prevention and treatment of muscle atrophy, especially in reducing muscle protein degradation and promoting muscle protein synthesis.
“Collectively, phytochemicals play an essential role in the prevention and treatment of muscle atrophy, especially in reducing muscle protein degradation and promoting muscle protein synthesis [17,18].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [18]
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- Authors
- Salucci, S., & Falcieri, E.
- Affiliations
- University of Urbino (IT)
- Corresponding author
- Salucci, Sara
- Venue
- Nutrition Research
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 74
- Pages
- 10-22
- ISSN
- 0271-5317 (ISSN-L)
- OpenAlex
- W2990972406
- Cited by
- 83
- References
- 134
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 11 · 2023: 13 · 2022: 19 · 2021: 8 · 2020: 10
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- polyphenols, skeletal muscle atrophy, oxidative stress, mitochondrial dysfunction, antioxidant activity, anti-inflammatory activity, dietary supplementation, muscle mass preservation, disuse atrophy, aging
- MeSH terms
- Acids, Carbocyclic, Animals, Anti-Inflammatory Agents, Antioxidants, Diet, Flavonoids, Fruit, Humans, Mitochondria, Muscle, Muscular Atrophy, Stilbenes, Vegetables, Muscle, Skeletal, Dietary Supplements, Polyphenols
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