Resveratrol Attenuates Denervation-Induced Muscle Atrophy Due to the Blockade of Atrogin-1 and p62 Accumulation
Open accessAbstract
Decrease in activity stress induces skeletal muscle atrophy. A previous study showed that treatment with resveratrol inhibits muscular atrophy in mdx mice, a model of DMD. However, almost all studies using resveratrol supplementation have only looked at adaptive changes in the muscle weight. The present study was designed to elucidate whether the resveratrol-inducing attenuation of skeletal muscle actually reflects the adaptation of muscle fibers themselves, based on the modulation of atrogin-1- or p62-dependent signaling. Mice were fed either a normal diet or 0.5% resveratrol diet. One week later, the right sciatic nerve was cut. The wet weight, mean fiber area, and amount of atrogin-1 and p62 proteins were examined in the gastrocnemius muscle at 14 days after denervation. The 0.5% resveratrol diet significantly prevented denervation-induced decreases in both the muscle weight and fiber atrophy. In addition, dietary resveratrol suppressed the denervation-induced atrogin-1 and p62 immunoreactivity. In contrast, 0.5% resveratrol supplementation did not significantly modulate the total protein amount of atrogin-1 or p62 in the denervated muscle of mice. Resveratrol supplementation significantly prevents muscle atrophy after denervation in mice, possibly due to the decrease in atrogin-1 and p62-dependent signaling.
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Dietary resveratrol attenuates denervation-induced muscle atrophy via downregulation of MAFbx and p62 in ICR mice.
“Moreover, Asami et al. found that dietary resveratrol attenuates muscle atrophy induced by denervation via the downregulation of MAFbx and p62 in institute of cancer research (ICR) mice [88].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [88]
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- Authors
- Asami, Y., Aizawa, M., Kinoshita, M., Ishikawa, J., & Sakuma, K.
- Affiliations
- Toyohashi University of Technology (JP)
- Tokyo Institute of Technology (JP)
- Corresponding author
- Sakuma, Kunihiro
- ORCID
- Sakuma, Kunihiro
- Venue
- International Journal of Medical Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2018
- Volume
- 15
- Issue
- 6
- Pages
- 628-637
- ISSN
- 1449-1907 (ISSN-L)
- PMC
- PMC5930465
- OpenAlex
- W2802977116
- Cited by
- 33
- References
- 38
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 5
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- International Journal of Medical Sciences (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (17K01755)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- resveratrol, skeletal muscle atrophy, denervation, atrogin-1, p62, muscle fiber atrophy, gastrocnemius, sciatic nerve transection, dietary supplementation, muscle fiber area
- MeSH terms
- Resveratrol, Animals, Humans, Muscle Denervation, Muscle Proteins, Muscular Atrophy, Stilbenes, Transcription Factors, Signal Transduction, Mice, Inbred mdx, Muscle Fibers, Skeletal, Dietary Supplements, SKP Cullin F-Box Protein Ligases, Transcription Factor TFIIH
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