Cited by 33Muscle Physiology and DisordersSirtuins and Resveratrol in MedicineNutrition and Health in Aging

Resveratrol Attenuates Denervation-Induced Muscle Atrophy Due to the Blockade of Atrogin-1 and p62 Accumulation

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Asami, Yuka, Aizawa, Miki, Kinoshita, Masakazu, Ishikawa, Junji, Sakuma, Kunihiro·2018·International Journal of Medical Sciences

Abstract

Decrease in activity stress induces skeletal muscle atrophy. A previous study showed that treatment with resveratrol inhibits muscular atrophy in mdx mice, a model of DMD. However, almost all studies using resveratrol supplementation have only looked at adaptive changes in the muscle weight. The present study was designed to elucidate whether the resveratrol-inducing attenuation of skeletal muscle actually reflects the adaptation of muscle fibers themselves, based on the modulation of atrogin-1- or p62-dependent signaling. Mice were fed either a normal diet or 0.5% resveratrol diet. One week later, the right sciatic nerve was cut. The wet weight, mean fiber area, and amount of atrogin-1 and p62 proteins were examined in the gastrocnemius muscle at 14 days after denervation. The 0.5% resveratrol diet significantly prevented denervation-induced decreases in both the muscle weight and fiber atrophy. In addition, dietary resveratrol suppressed the denervation-induced atrogin-1 and p62 immunoreactivity. In contrast, 0.5% resveratrol supplementation did not significantly modulate the total protein amount of atrogin-1 or p62 in the denervated muscle of mice. Resveratrol supplementation significantly prevents muscle atrophy after denervation in mice, possibly due to the decrease in atrogin-1 and p62-dependent signaling.

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  • Dietary resveratrol attenuates denervation-induced muscle atrophy via downregulation of MAFbx and p62 in ICR mice.

    “Moreover, Asami et al. found that dietary resveratrol attenuates muscle atrophy induced by denervation via the downregulation of MAFbx and p62 in institute of cancer research (ICR) mice [88].”

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Authors
Asami, Y., Aizawa, M., Kinoshita, M., Ishikawa, J., & Sakuma, K.
Affiliations
  • Toyohashi University of Technology (JP)
  • Tokyo Institute of Technology (JP)
Corresponding author
Sakuma, Kunihiro
Venue
International Journal of Medical Sciences
Published
2018
Volume
15
Issue
6
Pages
628-637
ISSN
1449-1907 (ISSN-L)
OpenAlex
W2802977116
Cited by
33
References
38
Citations by year
2026: 2 · 2025: 1 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 5
FWCI
1.16
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • International Journal of Medical Sciences (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Japan Society for the Promotion of Science (17K01755)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
resveratrol, skeletal muscle atrophy, denervation, atrogin-1, p62, muscle fiber atrophy, gastrocnemius, sciatic nerve transection, dietary supplementation, muscle fiber area
MeSH terms
Resveratrol, Animals, Humans, Muscle Denervation, Muscle Proteins, Muscular Atrophy, Stilbenes, Transcription Factors, Signal Transduction, Mice, Inbred mdx, Muscle Fibers, Skeletal, Dietary Supplements, SKP Cullin F-Box Protein Ligases, Transcription Factor TFIIH

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