The DOI matches its Crossref record; 112 of the 113 references it cites were found in a registry or an index.
The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells
Abstract
Cancer remains a second leading cause of deaths and major public health problem. It occurs due to extensive DNA damage caused by ultraviolet radiations, ionizing radiations, environmental agents, therapeutic agents, etc. Among all cancers, the most frequently diagnosed cancers are lung (12.7%), breast (10.9%), colorectal (9.7%), and gastric cancer (7.81%). Natural compounds are most favorable against cancer on the count of their anti-cancerous ability, easy to avail and efficient. Among natural compounds, polyphenols (flavonoids, catechin, hesperetin, flavones, quercetin, phenolic acids, ellagic acid, lignans, stilbenes, etc.) represent a large and diverse group used in the prevention and treatment of cancer. Natural flavonoids are derived from different plant sources and from various medicinal plants including Petroselinum crispum, Apium graveolens, Flemingia vestita, Phyllanthus emblica, etc. Natural flavonoids possess antioxidant, anti-inflammation, as well as anti-cancerous activities through multiple pathways, they induce apoptosis in breast, colorectal, and prostate cancers, lower the nucleoside diphosphate kinase-B activity in lung, bladder and colon cancers, inhibit cell-proliferation and cell cycle arrest by suppressing the NF-kB pathway in various cancers, etc. The current review summarized the anticancer activities of natural polyphenols and their mechanisms of action.
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“تیواضی ؾطعاى ٍ الساهات زضهاًی هطتَعِ تأحیطات ضٍاى قٌاذتی لاتل تَرْی ضا زض ایي تیواضاى ایزاز هی وٌٌس، زض حالی وِ زیاتت اگطچِ فَاضو تقضاً ًاتَاى وٌٌسُ ای زاضز، اها زض همایؿِ تا ؾطعاى ٍ ًیع زض همایؿِ زضهاى ّای تیواضی زیاتت تا ؾطعاى، تاض ضٍاًی ووتطی تِ تیواضاى ٍاضز هی قَز )53( .”
From Effectiveness of Mindfulness Training in Emotion Regulation and Distress Tolerance among Breast Cancer Patients (2024) · cites this paper as [53]
In the citing paper
“Antioxidant capacity depends on different solvents such as acetone, acetyl acetate, chloroform, ethanol, methanol and n-hexane by several antioxidant potential determining assays including diphenyle-1-picrylhydrazyl assay (DPPH), ferric reducing antioxidant power (FRAP), metal chelating activity, 2,2'-azinobis”
From Functional, nutritional and medicinal potential of banana peel (2023) · cites this paper as [86]
In the citing paper
“Mechanistic characteristics of bioactive components may inhibit ulcer through a number of mechanisms, including antioxidant activity, repression of cell growth, activation of apoptosis, repression of cell invasion and intracellular signaling pathways 86].”
From Functional, nutritional and medicinal potential of banana peel (2023) · cites this paper as [86]
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Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women
Ko, S., & Kim, H. (2020) · Nutrients · doi:10.3390/nu12010202 · Cited by 561
“The food sources of phenolic acids are coffee beans, fruits (apples, blueberries, cherries, grapes, oranges, pears, and prunes), oats, potatoes, and soybeans [176].”
BackgroundRudrapal, M., Rakshit, G., Singh, R. P., Garse, S., Khan, J., & Chakraborty, S. (2024) · Antioxidants · doi:10.3390/antiox13040429 · Cited by 302
“…potencies among others [53], and play a vital role in the control of diseases [54]. are mainly found in , , , Mushrooms have been reported to be one of the major sources of phenolic acids, which substantially account for their therapeutic activities such as antioxidant, antimicrobial, and…”
BackgroundAnticancer Activity of Natural and Synthetic Chalcones
Constantinescu, T., & Lungu, C. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111306 · Cited by 197
Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
Anik, M. I., Mahmud, N., Masud, A. A., Khan, M. I., Islam, M. N., Uddin, S., & Hossain, M. K. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00411 · Cited by 163
Nutraceuticals and Cancer: Potential for Natural Polyphenols
Maiuolo, J., Gliozzi, M., Carresi, C., Musolino, V., Oppedisano, F., Scarano, F., Nucera, S., Scicchitano, M., Bosco, F., Macrì, R., et al. (2021) · Nutrients · doi:10.3390/nu13113834 · Cited by 164
Metadata
- Authors
- Hazafa, A., Rehman, K.-U., Jahan, N., & Jabeen, Z.
- Affiliations
- University of Agriculture Faisalabad (PK)
- Corresponding author
- Hazafa, Abu
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2019-07-09
- Volume
- 72
- Issue
- 3
- Pages
- 386-397
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W2961940793
- Cited by
- 388
- References
- 113
- Citations by year
- 2026: 42 · 2025: 61 · 2024: 99 · 2023: 66 · 2022: 76 · 2021: 29 · 2020: 15
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition and Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Keywords
- polyphenols, flavonoids, anticancer activity, natural compounds, apoptosis, NF-κB signaling, cell cycle arrest, DNA damage, antioxidant activity, anti-inflammatory activity, quercetin, catechins, ellagic acid, medicinal plants, cancer prevention
- MeSH terms
- Anthocyanins, Antineoplastic Agents, Antioxidants, Flavonoids, Humans, Neoplasms, Plants, Edible, Plants, Medicinal, Quercetin, Tea, Anticarcinogenic Agents, Apoptosis, Cell Line, Tumor, Cell Proliferation, Polyphenols
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