The DOI matches its Crossref record; 79 of the 80 references it cites were found in a registry or an index.
Non-esterified fatty acids (NEFA) in dairy cattle. A review
Abstract
The objective of this report is to review the literature on elevated blood concentrations of nonesterified fatty acids (NEFA) before and after parturition in high-yielding dairy cows. It highlights the factors that influence serum NEFA production and their circulation before and after parturition, such as adaptation for nutrient partitioning for fetal needs, onset of lactogenesis, stress of calving and numerous changes in physiological, metabolic, and endocrine status to accommodate parturition and lactogenesis. The role of NEFA in the liver and peripheral tissues and its toxic effects when in excess are discussed. The cow's adaptive physiologic mechanisms to prevent or decrease excessive values of serum NEFA and preventive and therapeutic interventions to enhance these mechanisms are categorized as natural and artificial antidotes respectively. Feeding systems during the dry period and daily exercise or walking activity which may burn excessive NEFA through beta-oxidation in the muscles are considered as more useful antidotes to managing the NEFA metabolism. This will minimize accumulation of lipids in the liver during early lactation and alleviate the negative effects of plasma NEFA leading to more optimal metabolic health and productivity of dairy cows.
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In the citing paper
“An increase in BHBA and NEFA is observed when their dietary sources of energy are depleted, resulting in a negative energy balance”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Adewuyi et al., 2005
In the citing paper
“When calves deplete their dietary sources of energy, BHB and NEFA increase and glucose decreases, indicating a state of negative energy balance (Adewuyi et al., 2005).”
From A randomized controlled trial evaluating the effect of providing a rest period during long-distance transportation of surplus dairy calves: Part II. Effect on hematological variables (2024) · cites this paper as Adewuyi et al., 2005
In the citing paper
“Limited research is available regarding associations between negative energy balance, NEFA, and BHB in young calves, however, as mentioned above, calves mobilize adipose tissue to cope with challenges such as fasting.”
From A randomized controlled trial evaluating the effect of providing a rest period during long-distance transportation of surplus dairy calves: Part II. Effect on hematological variables (2024) · cites this paper as Adewuyi et al., 2005
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Metadata
- Authors
- Adewuyi, A. A., Gruys, E., & van Eerdenburg, F. J. C. M.
- Affiliations
- Utrecht University (NL)
- Venue
- Veterinary Quarterly
- Publisher
- Informa UK Limited
- Published
- 2005-09
- Volume
- 27
- Issue
- 3
- Pages
- 117-126
- ISSN
- 0165-2176 (ISSN-L)
- 1875-5941
- OpenAlex
- W2049628589
- Cited by
- 343
- References
- 80
- Citations by year
- 2026: 19 · 2025: 30 · 2024: 22 · 2023: 34 · 2022: 26 · 2021: 32 · 2020: 33 · 2019: 24 · 2018: 21 · 2017: 18 · 2016: 9 · 2015: 16 · 2014: 20 · 2013: 8 · 2012: 6
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Quarterly (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
- Keywords
- free fatty acids, dairy cattle, childbirth, lactogenesis, hepatic lipid accumulation, fatty acid beta-oxidation, dry period feeding, physical activity, endocrine changes, antidotes
- MeSH terms
- Adaptation, Physiological, Animals, Cattle, Fatty Acids, Nonesterified, Female, Lactation, Nutritional Requirements, Pregnancy, Parturition
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