Ultrastructural Changes of Mitochondria in the Skeletal Muscle of Patients with Amyotrophic Lateral Sclerosis
Abstract
Functional defects and morphological changes of mitochondria have been reported to be in the skeletal muscle of patients with amyotrophic lateral sclerosis (ALS). Recent studies suggested that mitochondrial abnormalities are related to the pathogenesis of ALS. The purpose of this study is to evaluate the ultrastructural changes of muscle mitochondria in ALS patients. The authors examined 49 cases of diagnostic muscle biopsy samples with definite or probable ALS by electron microscopy. Of the 49 cases, 5 (10%) had ultrastructural abnormalities of muscle mitochondria, including giant mitochondria, paracrystalline inclusions, and abnormal cristae. These abnormal mitochondria were mainly observed among subsarcolemmal mitochondrial aggregates.
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Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS.
“Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS [281–285].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [282]
Cites
Wong, P. C., Pardo, C. A., Borchelt, D., Lee, M. K., Copeland, N. G., Jenkins, N. A., Sisodia, S. S., Cleveland, D. W., & Price, D. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90259-7 · Cited by 1,439 · see citing works
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
Klivenyi, P., Ferrante, R. J., Matthews, R. T., Bogdanov, M. B., Klein, A. M., Andreassen, O. A., Mueller, G., Wermer, M., Kaddurah-Daouk, R., & Beal, M. F. (1999) · Nature Medicine · doi:10.1038/6568 · Cited by 682 · see citing works
Bowling, A. C., Schulz, J. B., Brown, R. H., & Beal, M. F. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07478.x · Cited by 629 · see citing works
Vielhaber, S. (2000) · Brain · doi:10.1093/brain/123.7.1339 · Cited by 260 · see citing works
Cytochrome c Oxidase subunit I microdeletion in a patient with motor neuron disease
Comi, G. P., Bordoni, A., Salani, S., Franceschina, L., Sciacco, M., Prelle, A. C., Fortunato, F., Zeviani, M., Napoli, L., Bresolin, N., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410430119 · Cited by 247 · see citing works
Mourelatos, Z., Gonatas, N. K., Stieber, A., Gurney, M. E., & Canto, M. C. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5472 · Cited by 224 · see citing works
Mitochondria in Sporadic Amyotrophic Lateral Sclerosis
Swerdlow, R. H., Parks, J. K., Cassarino, D. S., Trimmer, P. A., Miller, S. W., Maguire, D., Sheehan, J. P., Maguire, R. S., Pattee, G. L., Juel, V. C., et al. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6866 · Cited by 180 · see citing works
Sasaki, S., & Iwata, M. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12314-4 · Cited by 173 · see citing works
Molecular analysis of the muscle pathology associated with mitochondrial DNA deletions
Moraes, C. T., Ricci, E., Petruzzella, V., Shanske, S., DiMauro, S., Schon, E. A., & Bonilla, E. (1992) · Nature Genetics · doi:10.1038/ng0892-359 · Cited by 164 · see citing works
Hepatic Ultrastructural Changes and Liver Dysfunction in Amyotrophic Lateral Sclerosis
Nakano, Y., Hirayama, K., & Terao, K. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520130079022 · Cited by 138 · see citing works
Vielhaber, S., Winkler, K., Kirches, E., Kunz, D., Büchner, M., Feistner, H., Elger, C. E., Ludolph, A. C., Riepe, M. W., & Kunz, W. S. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00236-1 · Cited by 121 · see citing works
Mitochondrial DNA deletions in inclusion body myositis
Oldfors, A., Larsson, N., Lindberg, C., & Holme, E. (1993) · Brain · doi:10.1093/brain/116.2.325 · Cited by 115 · see citing works
Stadhouders, A. M., Jap, P. H. K., Winkler, H., Eppenberger, H. M., & Wallimann, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5089 · Cited by 94 · see citing works
Functional Imaging of Mitochondria in Saponin-permeabilized Mice Muscle Fibers
Kuznetsov, A. V., Mayboroda, O. A., Kunz, D., Winkler, K., SCHUBERT, W. J., & Kunz, W. S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.5.1091 · Cited by 88 · see citing works
Kaal, E. C. A., Vlug, A. S., Versleijen, M. W. J., Kuilman, M. E. M., Joosten, E. A. J., & Bär, P. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.741158.x · Cited by 86 · see citing works
Eppenberger-Eberhardt, M., Riesinger, I., Messerli, M. A., Schwarb, P., Müller, M. M., Eppenberger, H. M., & Wallimann, T. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.2.289 · Cited by 83 · see citing works
The effects of glucocorticoids on red and white muscles in the rat.
Tice, L. W., & Engel, A. G. (1967) · PubMed Central · Cited by 75 · see citing works
Experimental mitochondrial myopathy produced by in vivo uncoupling of oxidative phosphorylation
Melmed, C., Karpati, G., & Carpenter, S. (1975) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(75)90204-x · Cited by 49 · see citing works
Human skeletal muscle metabolism and morphology after temporary incomplete ischaemia
Sjöstróm, M., Neglen, P. N., Fridén, J. O., & Eklöf, B. (1982) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1982.tb00941.x · Cited by 46 · see citing works
Neuromuscular Disorders with Abnormal Muscle Mitochondria
Kamieniecka, Z., & Schmalbruch, H. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)61964-6 · Cited by 34 · see citing works
Molnár, M. J., & Schröder, J. M. (1998) · Acta Neuropathologica · doi:10.1007/s004010050858 · Cited by 27 · see citing works
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Cited by
Sorted by citations
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
Boillée, S., Velde, C. V., & Cleveland, D. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.018 · Cited by 1,426 · see citing works
A comprehensive review of amyotrophic lateral sclerosis
Zarei, S., Carr, K., Reiley, L. E., Diaz, K., Guerra, O., Altamirano, P., Pagani, W., Lodin, D., Orozco, G., & Chinea, A. R. (2015) · Surgical Neurology International · doi:10.4103/2152-7806.169561 · Cited by 737 · see citing works
Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity
Dobrowolny, G., Aucello, M., Rizzuto, E., Beccafico, S., Mammucari, C., Bonconpagni, S., Belia, S., Wannenes, F., Nicoletti, C., Del Prete, Z., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.002 · Cited by 513 · see citing works
Cristae formation—linking ultrastructure and function of mitochondria
Zick, M., Rabl, R., & Reichert, A. S. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.06.013 · Cited by 484 · see citing works
Transcranial magnetic stimulation and amyotrophic lateral sclerosis: pathophysiological insights
Vucic, S., Ziemann, U., Eisen, A., Hallett, M., & Kiernan, M. C. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304019 · Cited by 270 · see citing works
Mitochondrial Medicine for Aging and Neurodegenerative Diseases
Reddy, P. H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8044-z · Cited by 230 · see citing works
Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases
Reddy, P. H., & Reddy, T. P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745401 · Cited by 227 · see citing works
Ultrastructure of blood–brain barrier and blood–spinal cord barrier in SOD1 mice modeling ALS
Garbuzova-Davis, S., Haller, E., Saporta, S., Kolomey, I., Nicosia, S. V., & Sanberg, P. R. (2007) · Brain Research · doi:10.1016/j.brainres.2007.04.044 · Cited by 239 · see citing works
The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis
Loeffler, J., Picchiarelli, G., Dupuis, L., & de Aguilar, J. G. (2016) · Brain Pathology · doi:10.1111/bpa.12350 · Cited by 201 · see citing works
Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works
Mitochondria in Amyotrophic Lateral Sclerosis: A Trigger and a Target
Dupuis, L., de Aguilar, J. G., Oudart, H., de Tapia, M., Barbeito, L., & Loeffler, J. (2004) · Neurodegenerative Diseases · doi:10.1159/000085063 · Cited by 150 · see citing works
Mitochondrial dysfunction in amyotrophic lateral sclerosis – a valid pharmacological target?
Muyderman, H., & Chen, T. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12476 · Cited by 134 · see citing works
Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis
Verma, S., Khurana, S., Vats, A., Sahu, B., Ganguly, N. K., Chakraborti, P., Gourie-Devi, M., & Taneja, V. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02658-6 · Cited by 122 · see citing works
Amyotrophic Lateral Sclerosis: A Neurodegenerative Motor Neuron Disease With Ocular Involvement
Rojas, P., Ramirez, A. I., Fernández‐Albarral, J. A., López‐Cuenca, I., Salobrar‐García, E., Cadena, M., Elvira‐Hurtado, L., Salazar, J. J., de Hoz, R., & Ramirez, J. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.566858 · Cited by 116 · see citing works
Methods for imaging mammalian mitochondrial morphology: A prospective on MitoGraph
Harwig, M. C., Viana, M. P., Egner, J. M., Harwig, J. J., Widlansky, M. E., Rafelski, S. M., & Hill, R. B. (2018) · Analytical Biochemistry · doi:10.1016/j.ab.2018.02.022 · Cited by 98 · see citing works
Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting
Amin, A., Perera, N. D., Beart, P. M., Turner, B. J., & Shabanpoor, F. (2020) · Cells · doi:10.3390/cells9112413 · Cited by 96 · see citing works
OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation
Barrera, M., Koob, S., Dikov, D., Vogel, F., & Reichert, A. S. (2016) · FEBS Letters · doi:10.1002/1873-3468.12384 · Cited by 94 · see citing works
Mitochondrial Inhibition and Oxidative Stress: Reciprocating Players in Neurodegeneration
Zeevalk, G. D., Bernard, L. P., Song, C., Gluck, M. J., & Ehrhart, J. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1117 · Cited by 87 · see citing works
Proteotoxicity and Neurodegenerative Diseases
Ruz, C., Alcantud, J. L., Montero, F. V., Durán, R., & Bandrés‐Ciga, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165646 · Cited by 81 · see citing works
Amyotrophic Lateral Sclerosis and Skeletal Muscle: An Update
Pansarasa, O., Rossi, D., Berardinelli, A. L., & Cereda, C. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8578-4 · Cited by 79 · see citing works
What is “Hyper” in the ALS Hypermetabolism?
Ferri, A., & Coccurello, R. (2017) · Mediators of Inflammation · doi:10.1155/2017/7821672 · Cited by 77 · see citing works
The effects of diet and sex in amyotrophic lateral sclerosis
Pape, J. A., & Grose, J. H. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2019.09.008 · Cited by 70 · see citing works
Mitochondrial Involvement in Amyotrophic Lateral Sclerosis: Trigger or Target?
Bacman, S. R., Bradley, W. G., & Moraes, C. T. (2006) · Molecular Neurobiology · doi:10.1385/mn:33:2:113 · Cited by 64 · see citing works
Dysregulated mitochondrial Ca2+ and ROS signaling in skeletal muscle of ALS mouse model
Zhou, J., Li, A., Li, X., & Yi, J. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.01.024 · Cited by 58 · see citing works
Piemonte, F., Rossi, F., & Carletti, B. (2011) · Current Neuropharmacology · doi:10.2174/157015911795596603 · Cited by 59 · see citing works
Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases
Joshi, A. U., & Mochly‐Rosen, D. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.08.010 · Cited by 57 · see citing works
Ioakeimidis, F., Ott, C., Kozjak‐Pavlovic, V., Violitzi, F., Rinotas, V. E., Makrinou, E., Eliopoulos, E., Fasseas, C., Kollias, G. A., & Douni, E. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104237 · Cited by 54 · see citing works
Vucic, S., & Kiernan, M. C. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53497-2.00045-0 · Cited by 47 · see citing works
TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis
Lépine, S., Castellanos‐Montiel, M. J., & Durcan, T. M. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00331-z · Cited by 43 · see citing works
Cappello, V., Vezzoli, E., Righi, M., Fossati, M., Mariotti, R., Crespi, A., Patruno, M., Bentivoglio, M., Pietrini, G., & Francolini, M. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.07.003 · Cited by 42 · see citing works
Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy
Stacchiotti, A., Favero, G., Lavazza, A., García-Gómez, R., Monsalve, M., & Rezzani, R. (2018) · Cells · doi:10.3390/cells8010005 · Cited by 41 · see citing works
Fabbrizio, P., Apolloni, S., Bianchi, A., Salvatori, I., Valle, C., Lanzuolo, C., Bendotti, C., Nardo, G., & Volonté, C. (2019) · Brain Pathology · doi:10.1111/bpa.12774 · Cited by 41 · see citing works
ALS-related misfolded protein management in motor neurons and muscle cells
Galbiati, M., Crippa, V., Rusmini, P., Cristofani, R., Cicardi, M. E., Giorgetti, E., Onesto, E., Messi, E., & Poletti, A. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.10.007 · Cited by 40 · see citing works
Badu-Mensah, A., Guo, X., McAleer, C. W., Rumsey, J. W., & Hickman, J. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70510-3 · Cited by 39 · see citing works
Magrì, A., Lipari, C. L. R., Risiglione, P., Zimbone, S., Guarino, F., Caccamo, A., & Messina, A. A. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05643-0 · Cited by 39 · see citing works
de Aguilar, J. G., Dupuis, L., Oudart, H., & Loeffler, J. (2005) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2005.03.003 · Cited by 39 · see citing works
New Neuroprotective Effect of Lemon IntegroPectin on Neuronal Cellular Model
Nuzzo, D., Picone, P., Giardina, C., Scordino, M., Mudò, G., Pagliaro, M., Scurria, A., Meneguzzo, F., Ilharco, L. M., Fidalgo, A. M., et al. (2021) · Antioxidants · doi:10.3390/antiox10050669 · Cited by 38 · see citing works
Belosludtseva, N. V., Matveeva, L. A., & Belosludtsev, K. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316833 · Cited by 39 · see citing works
The neuroprotective role of attractin in neurodegeneration
Paz, J. P., Yao, H., Lim, H. S., Lu, X., & Zhang, W. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.014 · Cited by 37 · see citing works
New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders
Wilkins, H., & Morris, J. K. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612822666161230144517 · Cited by 34 · see citing works
What skeletal muscle has to say in amyotrophic lateral sclerosis: Implications for therapy
Manzano, R., Toivonen, J. M., Moreno‐Martínez, L., de la Torre, M., Moreno‐García, L., López‐Royo, T., Molina, N., Zaragoza, P., Calvo, A. C., & Osta, R. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15276 · Cited by 32 · see citing works
Deterministic Ratchet for Sub-micrometer (Bio)particle Separation
Kim, D., Luo, J., Arriaga, E. A., & Ros, A. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03774 · Cited by 34 · see citing works
Mitochondrial Dysfunction in Skeletal Muscle of Amyloid Precursor Protein-overexpressing Mice
Boncompagni, S., Moussa, C., Levy, E., Pezone, M. J., Lopez, J. R., Protasi, F., & Shtifman, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.359588 · Cited by 34 · see citing works
Day, W. A., Koishi, K., Nukuda, H., & McLennan, I. S. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.010 · Cited by 32 · see citing works
Quessada, C., Bouscary, A., René, F., Valle, C., Ferri, A., Ngo, S. T., & Loeffler, J. (2021) · Cells · doi:10.3390/cells10061449 · Cited by 32 · see citing works
The Human G93A-Superoxide Dismutase-1 Mutation, Mitochondrial Glutathione and Apoptotic Cell Death
Muyderman, H., Hutson, P. G., Matusica, D., Rogers, M., & Rush, R. A. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9974-z · Cited by 32 · see citing works
Altered Bioenergetics and Metabolic Homeostasis in Amyotrophic Lateral Sclerosis
Nelson, A. T., & Trotti, D. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01262-3 · Cited by 31 · see citing works
Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases
Rodolfo, C., Ciccosanti, F., Giacomo, G. D., Piacentini, M., & Fimia, G. M. (2010) · Expert Review of Proteomics · doi:10.1586/epr.10.43 · Cited by 28 · see citing works
Targeting common disease pathomechanisms to treat amyotrophic lateral sclerosis
Faller, K. M. E., Chaytow, H., & Gillingwater, T. H. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-024-01049-4 · Cited by 28 · see citing works
The Drosophila inner-membrane protein PMI controls cristae biogenesis and mitochondrial diameter
Macchi, M., Fissi, N. E., Tufi, R., Bentobji, M., Liévens, J.-C., Martins, L. M., Royet, J., & Rival, T. (2012) · Journal of Cell Science · doi:10.1242/jcs.115675 · Cited by 26 · see citing works
Palencia, P., QUIROZ‐ROTHE, E., & Rivero, J. L. L. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0940-1 · Cited by 26 · see citing works
Lanznaster, D., Bruno, C., Bourgeais, J., Emond, P., Zemmoura, I., Lefèvre, A., Reynier, P., Eymieux, S., Blanchard, E., Vourc’h, P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10061307 · Cited by 24 · see citing works
Shanmukha, S., Narayanappa, G., Nalini, A., Alladi, P. A., & Raju, T. R. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031997 · Cited by 21 · see citing works
Marini, C., Cossu, V., Bonifacino, T., Bauckneht, M., Torazza, C., Bruno, S., Castellani, P., Ravera, S., Milanese, M., Venturi, C. B., et al. (2020) · EJNMMI Research · doi:10.1186/s13550-020-00666-6 · Cited by 20 · see citing works
Lysosomes Dysfunction Causes Mitophagy Impairment in PBMCs of Sporadic ALS Patients
Bordoni, M., Pansarasa, O., Scarian, E., Cristofani, R., Leone, R., Fantini, V., Garofalo, M., Diamanti, L., Bernuzzi, S., Gagliardi, S., et al. (2022) · Cells · doi:10.3390/cells11081272 · Cited by 19 · see citing works
Mitochondriopathy as a differential diagnosis of amyotrophic lateral sclerosis
Finsterer, J. (2002) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/146608202760839008 · Cited by 19 · see citing works
An overview about neurological diseases in India – A theranostics approach
Vellingiri, B. (2023) · Aging and Health Research · doi:10.1016/j.ahr.2023.100177 · Cited by 16 · see citing works
Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle
Tarantino, N., Canfora, I., Camerino, G. M., & Pierno, S. (2022) · Cells · doi:10.3390/cells11030415 · Cited by 14 · see citing works
Légaré, V. P., Rampal, C. J., Gurberg, T. J. N., Aaltonen, M. J., Janer, A., Zinman, L. H., Shoubridge, E. A., & Armstrong, G. A. B. (2023) · Developmental Neurobiology · doi:10.1002/dneu.22909 · Cited by 13 · see citing works
Parvanovova, P., Evinová, A., Grofik, M., Hnilicová, P., Tatarková, Z., & Koprušáková, M. T. (2024) · Biomedicines · doi:10.3390/biomedicines12061294 · Cited by 13 · see citing works
A Phase I safety study of hyperbaric oxygen therapy for amyotrophic lateral sclerosis
Steele, J., Matos, L. A., Lopez, E., Pérez‐Pinzón, M. A., Prado, R., Busto, R., Arheart, K. L., & Bradley, W. G. (2004) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820410021285 · Cited by 12 · see citing works
Charrasse, S., Racine, V., Saint-Omer, C., Poquillon, T., Lionnard, L., Ledru, M., Gonindard, C., Delaunois, S., Kissa, K., Frye, R. E., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301372 · Cited by 10 · see citing works
MitoCellPhe reveals mitochondrial morphologies in single fibroblasts and clustered stem cells
Bakare, A. B., Meshrkey, F., Lowe, B., Molder, C., Rao, R. R., Zhan, J., & Iyer, S. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00231.2021 · Cited by 11 · see citing works
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Zhong, R., Rua, M. T., & Wei‐LaPierre, L. (2023) · The Journal of Physiology · doi:10.1113/jp284143 · Cited by 10 · see citing works
Multiple Mitochondrial Alterations in a Case of Myopathy
Fujioka, H., Tandler, B., Cohen, M. L., Koontz, D., & Hoppel, C. L. (2014) · Ultrastructural Pathology · doi:10.3109/01913123.2014.888114 · Cited by 10 · see citing works
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Dorn, G. W. (2023) · Cells · doi:10.3390/cells12081188 · Cited by 8 · see citing works
Is there mitochondrial dysfunction in amyotrophic lateral sclerosis skeletal muscle?
Vielhaber, S., Kudin, A. P., Winkler, K., Wiedemann, F. R., Schröder, R., Feistner, H., Heinze, H., Elger, C. E., & Kunz, W. S. (2003) · Annals of Neurology · doi:10.1002/ana.10564 · Cited by 8 · see citing works
Belosludtseva, N. V., Ilzorkina, A. I., Dubinin, M. V., Mikheeva, I. B., & Belosludtsev, K. N. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl28260 · Cited by 7 · see citing works
Zhong, R., Dionela, D. L. A., Kim, N. H., Harris, E. N., Geisler, J. G., & Wei‐LaPierre, L. (2024) · Annals of Neurology · doi:10.1002/ana.27140 · Cited by 6 · see citing works
Massopust, R. T., Juros, D., Shapiro, D., Lopes, M. C., Haldar, S. M., Taetzsch, T., & Valdez, G. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105583 · Cited by 5 · see citing works
Couturier, N., Hörner, S. J., Nürnberg, E., Joazeiro, C. A. P., Hafner, M., & Rudolf, R. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1429759 · Cited by 3 · see citing works
Yang, E. J., & Lee, S. H. (2025) · Mediators of Inflammation · doi:10.1155/mi/1999953 · Cited by 3 · see citing works
Neuroprotective and Mitoprotective Effects of Lemon IntegroPectin on SH-SY5Y CellsPreprint
Nuzzo, D., Picone, P., Giardina, C., Scordino, M., Mudò, G., Pagliaro, M., Scurria, A., Meneguzzo, F., Ilharco, L. M., Fidalgo, A. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.09.430380 · Cited by 3 · see citing works
Mitochondrial Function and Neurodegenerative Diseases
Wilkins, H. M., Weidling, I., Koppel, S., Wang, X., von Schulze, A., & Swerdlow, R. H. (2018) · The Molecular and Cellular Basis of Neurodegenerative Diseases · doi:10.1016/b978-0-12-811304-2.00013-4 · Cited by 2 · see citing works
Review of the Pathology of Muscle in Amyotrophic Lateral Sclerosis
Katz, M., Robertson, T., Ngo, S. T., Yarlagadda, S., Henderson, R. D., McCombe, P., & Noakes, P. G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062802 · Cited by 2 · see citing works
Neurotoxicity and ALS: Insights into Pathogenesis
Vucic, S., & Kiernan, M. C. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_138-1 · Cited by 1 · see citing works
Légaré, V. P., Rampal, C. J., Aaltonen, M. J., Janer, A., Zinman, L. H., Shoubridge, E. A., & Armstrong, G. A. B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.02.488746 · Cited by 1 · see citing works
Scala, F. D. (2006) · edoc (University of Basel) · doi:10.5451/unibas-004071740
Acevedo, L. M., Finol, H. J., & Sucre, L. (2009) · Revista Científica de la Facultad de Ciencias Veterinarias
Duobles, T. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2013.tde-09082013-140206
Wilson, M. (2011) · D-Scholarship@Pitt (University of Pittsburgh)
The role of the corticomotorneurons in pathogenesis of amyotrophic lateral sclerosis
Menon, P. (2014) · The Sydney eScholarship Repository (The University of Sydney)
Acevedo, L. M., Finol, H. J., & Sucre, L. (2009)
Cognitive Sub-groups in ALS: Neuroanatomical Associations and Theory of Mind Impairments
Chenji, S. (2018) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3st7fc7m
Neurotoxicity and ALS: Insights into Pathogenesis
Vucic, S., & Kiernan, M. C. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_138
Compromised mitophagy in aging and neurodegenerative diseases
Lagartos-Donate, M. J., Cao, S., & Fang, E. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00017-x
Marini, C., Cossu, V., Bonifacino, T., Bauckneht, M., Torazza, C., Bruno, S., Castellani, P., Ravera, S., Milanese, M., Venturi, C., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12623217
Marini, C., Cossu, V., Bonifacino, T., Bauckneht, M., Torazza, C., Bruno, S., Castellani, P., Ravera, S., Milanese, M., Venturi, C., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12623223
Marini, C., Cossu, V., Bonifacino, T., Bauckneht, M., Torazza, C., Bruno, S., Castellani, P., Ravera, S., Milanese, M., Venturi, C., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12623226
Phytomedicinal Approaches to Mitigating Neurological Disorder
Ansari, T., Shukla, R., Shrivastava, S., & Soni, R. K. (2025) · IGI Global eBooks · doi:10.4018/979-8-3373-4627-4.ch015
Wei‐LaPierre, L., Zhong, R., Rastelli, G., Ainbinder, A., Thome, T., Kim, K., Cort, T. A., Brandt, Z., Harris, E. N., Rua, M. T., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-8825893/v1
Khalil, B. (2016) · theses.fr (ABES) · doi:10.70675/4446111fz4182z4737zae76z7f117887a893
Wooten, S. V., Wang, F., Liu, G., Jeyabal, P., Zigler, C. M., Zhou, Y., Livingston, J. A. A., Roth, M. E., Amini, B., & Kleinerman, E. S. (2026) · Scientific Reports · doi:10.1038/s41598-026-45296-5
A brief critique of excitotoxicity in amyotrophic lateral sclerosis
Odierna, G. L. (2026) · Academia Biology · doi:10.20935/acadbiol8371
Martynova, E., Mukhamedyarov, M., Kabwe, E., Khaiboullina, S. F., Simwalangana, O., Markelova, M., Rizvanov, A. A., Arkhipova, S. S., & Salafutdinov, I. I. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198604
- Authors
- Chung, M. J., & Suh, Y.-L.
- Affiliations
- Jeonbuk National University Hospital (KR)
- Samsung Medical Center (KR)
- Venue
- Ultrastructural Pathology
- Publisher
- Informa UK Limited
- Published
- 2002-01
- Volume
- 26
- Issue
- 1
- Pages
- 3-7
- ISSN
- 0191-3123 (ISSN-L)
- 1521-0758
- OpenAlex
- W2108072121
- Cited by
- 96
- References
- 21
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 2 · 2018: 7 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ultrastructural Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- amyotrophic lateral sclerosis, mitochondrial ultrastructure, skeletal muscle, mitochondrial abnormalities, giant mitochondria, paracrystalline inclusions, muscle biopsy, ALS pathogenesis
- MeSH terms
- Adult, Aged, Amyotrophic Lateral Sclerosis, Biopsy, Humans, Middle Aged, Mitochondria, Muscle, Mitochondrial Myopathies, Muscle, Skeletal
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