Cited by 96Amyotrophic Lateral Sclerosis ResearchMitochondrial Function and PathologyMuscle Physiology and Disorders

Ultrastructural Changes of Mitochondria in the Skeletal Muscle of Patients with Amyotrophic Lateral Sclerosis

Chung, Myoung Ja, Suh, Yeon-Lim·2002·Ultrastructural Pathology

Abstract

Functional defects and morphological changes of mitochondria have been reported to be in the skeletal muscle of patients with amyotrophic lateral sclerosis (ALS). Recent studies suggested that mitochondrial abnormalities are related to the pathogenesis of ALS. The purpose of this study is to evaluate the ultrastructural changes of muscle mitochondria in ALS patients. The authors examined 49 cases of diagnostic muscle biopsy samples with definite or probable ALS by electron microscopy. Of the 49 cases, 5 (10%) had ultrastructural abnormalities of muscle mitochondria, including giant mitochondria, paracrystalline inclusions, and abnormal cristae. These abnormal mitochondria were mainly observed among subsarcolemmal mitochondrial aggregates.

Integrity signals

Registry

Crossref · 10.1080/01913120252934260

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS.

    “Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS [281–285].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Chung, M. J., & Suh, Y.-L.
Affiliations
  • Jeonbuk National University Hospital (KR)
  • Samsung Medical Center (KR)
Venue
Ultrastructural Pathology
Published
2002-01
Volume
26
Issue
1
Pages
3-7
ISSN
  • 0191-3123 (ISSN-L)
  • 1521-0758
OpenAlex
W2108072121
Cited by
96
References
21
Citations by year
2026: 5 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 2 · 2018: 7 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 6 · 2013: 4 · 2012: 4
FWCI
1.77
Type
journal article
Language
en
Open access
closed
Locations
  • Ultrastructural Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
amyotrophic lateral sclerosis, mitochondrial ultrastructure, skeletal muscle, mitochondrial abnormalities, giant mitochondria, paracrystalline inclusions, muscle biopsy, ALS pathogenesis
MeSH terms
Adult, Aged, Amyotrophic Lateral Sclerosis, Biopsy, Humans, Middle Aged, Mitochondria, Muscle, Mitochondrial Myopathies, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review