Cited by 173Amyotrophic Lateral Sclerosis ResearchNeuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Ultrastructural study of synapses in the anterior horn neurons of patients with amyotrophic lateral sclerosis

Sasaki, Shoichi, Iwata, Makoto·1996·Neuroscience Letters

Abstract

This report concerns an ultrastructural examination of the synapses present on the surface of somata of anterior horn neurons of the lumbar spinal cord of seven patients with amyotrophic lateral sclerosis (ALS). Specimens from six age-matched, neurologically normal control individuals were included for comparison. Examination of presynaptic terminals revealed a wide range of changes not only in degenerated neurons (central chromatolytic neurons), but, to a lesser extent, in normal-appearing neurons. The alterations included dense conglomerates of aggregated dark mitochondria and presynaptic vesicles, bundles of neurofilaments, as well as marked increase of presynaptic vesicles. Our observations suggest that in patients with ALS a substantial synaptic alteration does take place in the early stages of anterior horn neuron degeneration and degeneration of axosomatic synapses of anterior horn neurons in ALS may be of consequence on lower motor neuron degeneration.

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Crossref · 10.1016/0304-3940(96)12314-4

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28 of 28 references verified0 citation errors · 0 not checkable

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  • Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS.

    “Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS [281–285].”

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Authors
Sasaki, S., & Iwata, M.
Affiliations
Tokyo Women's Medical University (JP)
Corresponding author
Sasaki, Shoichi
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
1996-02
Volume
204
Issue
1-2
Pages
53-56
ISSN
0304-3940 (ISSN-L)
OpenAlex
W2092390300
Cited by
173
References
28
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 2 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 10 · 2012: 8
FWCI
3.72
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
amyotrophic lateral sclerosis, anterior horn neurons, synapses, presynaptic terminals, synaptic ultrastructure, presynaptic vesicles, mitochondrial aggregation, neurofilaments, lower motor neuron degeneration, lumbar spinal cord
MeSH terms
Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Anterior Horn Cells, Astrocytes, Axons, Humans, Microscopy, Electron, Middle Aged, Mitochondria, Nerve Fibers, Synapses, Synaptic Vesicles, Presynaptic Terminals

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