Ultrastructural study of synapses in the anterior horn neurons of patients with amyotrophic lateral sclerosis
Abstract
This report concerns an ultrastructural examination of the synapses present on the surface of somata of anterior horn neurons of the lumbar spinal cord of seven patients with amyotrophic lateral sclerosis (ALS). Specimens from six age-matched, neurologically normal control individuals were included for comparison. Examination of presynaptic terminals revealed a wide range of changes not only in degenerated neurons (central chromatolytic neurons), but, to a lesser extent, in normal-appearing neurons. The alterations included dense conglomerates of aggregated dark mitochondria and presynaptic vesicles, bundles of neurofilaments, as well as marked increase of presynaptic vesicles. Our observations suggest that in patients with ALS a substantial synaptic alteration does take place in the early stages of anterior horn neuron degeneration and degeneration of axosomatic synapses of anterior horn neurons in ALS may be of consequence on lower motor neuron degeneration.
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Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS.
“Accumulations of dysmorphic and enlarged mitochondria, many with deficiencies of critical oxidative enzymes, in anterior horn cells, intramuscular nerves, and skeletal muscle are characteristic of sALS [281–285].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [284]
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- Authors
- Sasaki, S., & Iwata, M.
- Affiliations
- Tokyo Women's Medical University (JP)
- Corresponding author
- Sasaki, Shoichi
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1996-02
- Volume
- 204
- Issue
- 1-2
- Pages
- 53-56
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2092390300
- Cited by
- 173
- References
- 28
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 2 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 10 · 2012: 8
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- amyotrophic lateral sclerosis, anterior horn neurons, synapses, presynaptic terminals, synaptic ultrastructure, presynaptic vesicles, mitochondrial aggregation, neurofilaments, lower motor neuron degeneration, lumbar spinal cord
- MeSH terms
- Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Anterior Horn Cells, Astrocytes, Axons, Humans, Microscopy, Electron, Middle Aged, Mitochondria, Nerve Fibers, Synapses, Synaptic Vesicles, Presynaptic Terminals
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