Oral conjugated linoleic acid supplementation enhanced glycogen resynthesis in exercised human skeletal muscle
Abstract
Present study examined the effects of conjugated linoleic acid (CLA) supplementation on glycogen resynthesis in exercised human skeletal muscle. Twelve male participants completed a cross-over trial with CLA (3.8 g/day for 8 week) or placebo supplements by separation of 8 weeks. CLA is a mixture of trans-10 cis-12 and cis-9 trans-11 isomers (50:50). On experiment day, all participants performed 60-min cycling exercise at 75% VO2 max, then consumed a carbohydrate meal immediately after exercise and recovered for 3 h. Biopsied muscle samples from vastus lateralis were obtained immediately (0 h) and 3 h following exercise. Simultaneously, blood and gaseous samples were collected for every 30 min during 3-h recovery. Results showed significantly increased muscle glycogen content with CLA after a single bout of exercise (P < 0.05). Muscle glucose transporter type 4 expression was significantly elevated immediately after exercise, and this elevation was continued until 3 h after exercise in CLA trial. However, P-Akt/Akt ratio was not significantly altered, while glucose tolerance was impaired with CLA. Gaseous exchange data showed no beneficial effect of CLA on fat oxidation, instead lower non-esterified fatty acid and glycerol levels were found at 0 h. Our findings conclude that CLA supplementation can enhance the glycogen resynthesis rate in exercised human skeletal muscle.
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In healthy males, prior conjugated linoleic acid supplementation (8 weeks at 3.8 g/d) resulted in higher muscle glycogen post-exercise and post-recovery compared with control.
“Muscle glycogen higher post-exercise and post-recovery in CLA trial than”
From Postexercise muscle glycogen resynthesis in humans. (2017) · cites this paper as Tsao et al. 2015 (107)
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Postexercise muscle glycogen resynthesis in humans.
Burke, L. M., van Loon, L. J. C., & Hawley, J. A. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00860.2016 · Cited by 242 · see citing works
Naderi, A., Rothschild, J. A., Santos, H. O., Hamidvand, A., Koozehchian, M. S., Ghazzagh, A., Berjisian, E., & Podlogar, T. (2025) · Sports Medicine · doi:10.1007/s40279-025-02213-6 · Cited by 43 · see citing works
“…most commonly studied in the context of body composition, humans have also shown an increase in post-exercise muscle GLUT4 protein expression and post-exercise muscle glycogen resynthesis rates following 8 weeks of 3.8 g ⋅ day −1 of trans -10 cis -12 and cis -9 trans -11 CLA supplementation [184].”
InfluentialCraven, J., Desbrow, B., Sabapathy, S., Bellinger, P., McCartney, D., & Irwin, C. (2021) · Sports Medicine - Open · doi:10.1186/s40798-020-00297-0 · Cited by 24 · see citing works
Huang, C.-C., Liu, C.-C., Tsao, J.-P., Hsu, C.-L., & Cheng, I.-S. (2020) · Nutrients · doi:10.3390/nu12123721 · Cited by 16 · see citing works
Self-citation
- Authors
- Tsao, J.-P., Liao, S.-F., Korivi, M., Hou, C.-W., Kuo, C.-H., Wang, H.-F., & Cheng, I.-S.
- Affiliations
- Fu Jen Catholic University (TW)
- Changhua Christian Hospital (TW)
- University of Taipei (TW)
- Hungkuang University (TW)
- National Taichung University of Education (TW)
- Corresponding author
- Korivi, Mallikarjuna
- Cheng, I-Shiung
- ORCID
- Venue
- Journal of Sports Sciences
- Publisher
- Informa UK Limited
- Published
- 2014-11-11
- Volume
- 33
- Issue
- 9
- Pages
- 915-923
- ISSN
- 0264-0414 (ISSN-L)
- 1466-447X
- OpenAlex
- W2009298181
- Cited by
- 17
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Sports Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- conjugated linoleic acid, glycogen resynthesis, skeletal muscle, post-exercise recovery, glucose transporter type 4, Akt signaling, glucose tolerance, fat oxidation, free fatty acids, glycerol, dietary supplementation, cycling exercise
- MeSH terms
- Blood Glucose, Fatty Acids, Nonesterified, Glycogen, Homeostasis, Humans, Insulin, Male, Pulmonary Ventilation, Exercise, Protein Serine-Threonine Kinases, Muscle, Skeletal, Cross-Over Studies, Dietary Supplements, Linoleic Acids, Conjugated, Glucose Transport Proteins, Facilitative, Glucose Transporter Type 4, Young Adult
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