Effects of Oral Resveratrol Supplementation on Glycogen Replenishment and Mitochondria Biogenesis in Exercised Human Skeletal Muscle
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The present study aimed to investigate the effect of oral resveratrol supplementation on the key molecular gene expressions involved in mitochondria biogenesis and glycogen resynthesis in human skeletal muscle. Nine young male athletes participated in the single-blind and crossover designed study. All subjects completed a 4-day resveratrol and placebo supplement in a randomized order while performing a single bout of cycling exercise. Immediately after the exercise challenge, the subjects consumed a carbohydrate (CHO) meal (2 g CHO/Kg body mass) with either resveratrol or placebo capsules. Biopsied muscle samples, blood samples and expired gas samples were obtained at 0 h and 3 h after exercise. The muscle samples were measured for gene transcription factor expression by real-time PCR for glucose uptake and mitochondria biogenesis. Plasma glucose, insulin, glycerol, non-esterified fatty acid concentrations and respiratory exchange ratio were analyzed during post-exercise recovery periods. The results showed that the muscle glycogen concentrations were higher at 3 h than at 0 h; however, there were no difference between resveratrol trial and placebo trial. There were no significantly different concentrations in plasma parameters between the two trials. Similarly, no measured gene expressions were significant between the two trials. The evidence concluded that the 4-day oral resveratrol supplementation did not improve post-exercise muscle glycogen resynthesis and related glucose uptake and mitochondrial biosynthesis gene expression in men.
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The optimal dose of resveratrol remains elusive in clinical practice, as insufficient effect of resveratrol treatment has been reported in some studies.
“Despite the array of studies demonstrating beneficial effects of resveratrol in metabolic disorders, optimal dose of resveratrol remains elusive in clinical practice, as insufficient effect of resveratrol treatment has been reported in some studies [90].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [90]
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- Authors
- Huang, C.-C., Liu, C.-C., Tsao, J.-P., Hsu, C.-L., & Cheng, I.-S.
- Affiliations
- National Taipei University of Nursing and Health Science (TW)
- National Taichung University of Education (TW)
- Chung Shan Medical University Hospital (TW)
- Corresponding author
- Hsu, Chin-Lin
- Cheng, I-Shiung
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-12-02
- Volume
- 12
- Issue
- 12
- Pages
- 3721
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7760965
- OpenAlex
- W3107018184
- Cited by
- 16
- References
- 46
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Changhua Christian Hospital
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- resveratrol, oral supplementation, mitochondrial biogenesis, glucose uptake, post-exercise recovery, carbohydrate intake, physical activity, gene expression, athletes, insulin, respiratory exchange ratio
- MeSH terms
- Resveratrol, Blood Glucose, Energy Metabolism, Glycogen, Humans, Insulin, Male, Mitochondria, RNA, Messenger, Exercise, Single-Blind Method, Muscle, Skeletal, Dietary Supplements, Young Adult
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