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Gelatin nanoparticles by two step desolvation a new preparation method, surface modifications and cell uptake
Abstract
A new two-step desolvation method for manufacturing gelatin nanoparticles was developed. After the first desolvation step, the low molecular gelatin fractions present in the supernatant were removed by decanting. The high molecular fractions present in the sediment were redesolved and then desolvated again at pH 2.5 in the second step. The resulting particles can then be easily purified by centrifugation and redispersion. The different fractions obtained during the process were analysed by gel permeation chromatography (GPC). Based on these results, it can be concluded that the molecular weight of gelatin has a decisive influence on the stability of the manufactured gelatin nanoparticles. In addition, two fluorescent dyes (Texasred and fluoresceinamine) were coupled to the nanoparticles for cell uptake studies. The fluorescent nanoparticles showed a high uptake into monocytes/macrophages.
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Cited by
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Ferreira, A. M., Gentile, P., Chiono, V., & Ciardelli, G. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.06.014 · Cited by 938
Imaging macrophages with nanoparticles
Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials · doi:10.1038/nmat3780 · Cited by 809
A review: using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals
Li, Z., Jiang, H., Xu, C., & Gu, L. (2015) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2014.05.010 · Cited by 376
Yang, X.-J., Wang, F.-Q., Lu, C.-B., Zou, J.-W., Hu, J.-B., Yang, Z., Sang, H.-X., & Zhang, Y. (2020) · Biomedical Materials · doi:10.1088/1748-605x/ab8720 · Cited by 28
“First, gelatin NPs were prepared using a two-step coagulation method as described in previous research [22].”
Metadata
- Authors
- C. J. Coester, K. L.
- Venue
- Journal of Microencapsulation
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 17
- Issue
- 2
- Pages
- 187-193
- ISSN
- 0265-2048 (ISSN-L)
- 1464-5246
- OpenAlex
- W2152952586
- Cited by
- 415
- References
- 0
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- C. J. Coester, K. L. (2000). Gelatin nanoparticles by two step desolvation a new preparation method, surface modifications and cell uptake. Journal of Microencapsulation. https://doi.org/10.1080/026520400288427
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
