Imaging macrophages with nanoparticles

Weissleder, Ralph; Nahrendorf, Matthias; Pittet, Mikael J.

doi:10.1038/nmat3780

Cited by 810Nanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic Nanoparticles

Imaging macrophages with nanoparticles

Weissleder, Ralph, Nahrendorf, Matthias, Pittet, Mikael J.·2014·Nature Materials

DOI 10.1038/nmat3780

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Abstract

Nanomaterials have much to offer, not only in deciphering innate immune cell biology and tracking cells, but also in advancing personalized clinical care by providing diagnostic and prognostic information, quantifying treatment efficacy and designing better therapeutics. This Review presents different types of nanomaterial, their biological properties and their applications for imaging macrophages in human diseases, including cancer, atherosclerosis, myocardial infarction, aortic aneurysm, diabetes and other conditions. We anticipate that future needs will include the development of nanomaterials that are specific for immune cell subsets and can be used as imaging surrogates for nanotherapeutics. New in vivo imaging clinical tools for noninvasive macrophage quantification are thus ultimately expected to become relevant to predicting patients' clinical outcome, defining treatment options and monitoring responses to therapy.

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The liver and spleen typically cope relatively well with high SPION accumulation, which can be explained at least in part by the fact that the liver is the main storage organ for iron in the body.
“These organs typically cope relatively well with high SPION accumulation, which can be explained – at least in part – by the fact that the liver is main storage organ for iron in the body [132].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [132]
Macrophage infiltration can serve as a biomarker for the stage and progression of cardiovascular disorders such as atherosclerosis.
“Macrophage infiltration can be used as a biomarker in several pathological conditions. It can for instance provide information on the stage and progression of cardiovascular disorders, such as atherosclerosis [169, 170].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [169]
N1177 showed approximately 100-fold higher resolution than conventional CT scans and is being clinically tested in human subjects.
“Approximately 100-fold higher resolution than conventional computed tomography scans showed promise, and this approach is being clinically tested for application in human subjects.152”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [152]

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Authors: Weissleder, R., Nahrendorf, M., & Pittet, M. J.
Affiliations: Harvard University (US)
Massachusetts General Hospital (US)
Corresponding author: Weissleder, Ralph
ORCID: Weissleder, Ralph
Nahrendorf, Matthias
Venue: Nature Materials
Publisher: Springer Science and Business Media LLC
Published: 2014-01-23
Volume: 13
Issue: 2
Pages: 125-138
ISSN: 1476-1122 (ISSN-L)
1476-4660
DOI: 10.1038/nmat3780
OpenAlex: W2092877053
Cited by: 809
References: 183
Citations by year: 2026: 25 · 2025: 31 · 2024: 36 · 2023: 51 · 2022: 61 · 2021: 67 · 2020: 80 · 2019: 64 · 2018: 90 · 2017: 105 · 2016: 90 · 2015: 79 · 2014: 28 · 2013: 1
FWCI: 8.63
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Materials (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Keywords: macrophages, nanomaterials, macrophage targeting, tumor imaging, atherosclerosis, myocardial infarction, aortic aneurysm, diabetes mellitus, inflammation, innate immunity, cell tracking, non-invasive imaging, nanotherapeutics
MeSH terms: Humans, Inflammation, Macrophages, Nanoparticles, Cell Tracking

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