A review: using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals

Atomic Force Microscope

Binnig, G. K., Quate, C. F., & Gerber, C. (1986) · Physical Review Letters · doi:10.1103/physrevlett.56.930 · Cited by 14,795 · see citing works

Self-Assembly at All Scales

Whitesides, G. M., & Grzybowski, B. A. (2002) · Science · doi:10.1126/science.1070821 · Cited by 7,457 · see citing works

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · see citing works

Antioxidant properties of phenolic compounds

Rice-Evans, C. A., Miller, N., & Paganga, G. (1997) · Trends in Plant Science · doi:10.1016/s1360-1385(97)01018-2 · Cited by 4,407 · see citing works

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works

Transmission Electron Microscopy

Williams, D. B., & Carter, C. B. (2009) · Springer eBooks · doi:10.1007/978-0-387-76501-3 · Cited by 4,004 · see citing works

Antioxidant activity of plant extracts containing phenolic compounds

Kähkönen, M. P., Hopia, A. I., Vuorela, H. J., Rauha, J.-P., Pihlaja, K., Kujala, T. S., & Heinonen, M. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990146l · Cited by 3,854 · see citing works

Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art

Müller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,759 · see citing works

Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis

Rejman, J., Oberle, V., Zuhorn, I. S., & Hoekstra, D. (2004) · Biochemical Journal · doi:10.1042/bj20031253 · Cited by 2,872 · see citing works

Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer

Cai, Y., Luo, Q., Sun, M., & Corke, H. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.09.047 · Cited by 2,823 · see citing works

Chemical studies of anthocyanins: A review

Ovando, A. C., Pacheco-Hernández, M. D. L., Páez-Hernández, M. E., Rodríguez, J. A., & Galán-Vidal, C. A. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.09.001 · Cited by 2,562 · see citing works

Directed Self-Assembly of Nanoparticles

Grzelczak, M., Vermant, J., Furst, E. M., & Liz‐Marzán, L. M. (2010) · ACS Nano · doi:10.1021/nn100869j · Cited by 2,219 · see citing works

Endocytosis of nanomedicines

Sahay, G., Alakhova, D. Y., & Kabanov, A. V. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.036 · Cited by 2,181 · see citing works

Formation and stability of nano-emulsions

Tadros, T. F., Izquierdo, P., Esquena, J., & Solans, C. (2003) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2003.10.023 · Cited by 2,040 · see citing works

Dietary phenolics: chemistry, bioavailability and effects on health

Crozier, A., Jaganath, I. B., & Clifford, M. N. (2009) · Natural Product Reports · doi:10.1039/b802662a · Cited by 2,002 · see citing works

Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates

Filipe, V., Hawe, A., & Jiskoot, W. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0073-2 · Cited by 1,885 · see citing works

Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine

Frankel, E. N., German, J. B., Kinsella, J. E., Parks, E. J., & Kanner, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)90206-v · Cited by 1,646 · see citing works

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

Ensign, L. M., Cone, R. A., & Hanes, J. S. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.009 · Cited by 1,646 · see citing works

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

Singh, B. N., Shankar, S., & Srivastava, R. K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.093 · Cited by 1,603 · see citing works

Barrier properties of mucus

Cone, R. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.008 · Cited by 1,459 · see citing works

Bitter taste, phytonutrients, and the consumer: a review

Drewnowski, A., & Gomez-Carneros, C. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.6.1424 · Cited by 1,366 · see citing works

Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach

des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305 · see citing works

Food protein-based materials as nutraceutical delivery systems

Chen, L., Remondetto, G. E., & Subirade, M. (2006) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2005.12.011 · Cited by 1,159 · see citing works

Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones

Setchell, K. D. R. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1333s · Cited by 1,137 · see citing works

Bioavailability of resveratrol

Walle, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05842.x · Cited by 1,051 · see citing works

Isoflavone Content in Commercial Soybean Foods

Wang, H., & Murphy, P. A. (1994) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00044a016 · Cited by 1,004 · see citing works

Bioavailability of Pure Isoflavones in Healthy Humans and Analysis of Commercial Soy Isoflavone Supplements

Setchell, K. D. R., Brown, N. M., Desai, P. B., Zimmer-Nechemias, L., Wolfe, B., Brashear, W. T., Kirschner, A. S., Cassidy, A., & Heubi, J. E. (2001) · Journal of Nutrition · doi:10.1093/jn/131.4.1362s · Cited by 974 · see citing works

Soy Isoflavone Aglycones Are Absorbed Faster and in Higher Amounts than Their Glucosides in Humans

Izumi, T., Osawa, S., Obata, A., Tobe, K., Saito, M., Kataoka, S., Kikuchi, M., Piskuła, M. K., & Kubota, Y. (2000) · Journal of Nutrition · doi:10.1093/jn/130.7.1695 · Cited by 959 · see citing works

Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF- κ B Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF- κ B Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages

Hämäläinen, M., Nieminen, R. M., Vuorela, P. M., Heinonen, M., & Moilanen, E. (2007) · Mediators of Inflammation · doi:10.1155/2007/45673 · Cited by 946 · see citing works

Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules.

Schnitzer, J. E., Oh, P., Pinney, E., & Allard, J. F. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.5.1217 · Cited by 918 · see citing works

Inhibition of human LDL oxidation by resveratrol

Frankel, E. N., Waterhouse, A. L., & Kinsella, J. E. (1993) · The Lancet · doi:10.1016/0140-6736(93)92472-6 · Cited by 889 · see citing works

Endocytosis by Random Initiation and Stabilization of Clathrin-Coated Pits

Ehrlich, M., Boll, W., van Oijen, A. M., Hariharan, R., Chandran, K., Nibert, M. L., & Kirchhausen, T. L. (2004) · Cell · doi:10.1016/j.cell.2004.08.017 · Cited by 888 · see citing works

Bioavailability of nanoparticles in nutrient and nutraceutical delivery

Acosta, E. (2008) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2008.01.002 · Cited by 875 · see citing works

Virus entry by macropinocytosis

Mercer, J., & Helenius, A. (2009) · Nature Cell Biology · doi:10.1038/ncb0509-510 · Cited by 814 · see citing works

Substrate-specific activation of sirtuins by resveratrol

Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500655200 · Cited by 745 · see citing works

Preparation and characterization of zein/chitosan complex for encapsulation of α-tocopherol, and its in vitro controlled release study

Luo, Y., Zhang, B., Whent, M., Yu, L. L., & Wang, Q. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.02.020 · Cited by 682 · see citing works

Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells

Das, R. K., Kasoju, N., & Bora, U. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.05.009 · Cited by 642 · see citing works

Minimising oil droplet size using ultrasonic emulsification

Leong, T. S. H., Wooster, T. J., Kentish, S. E., & Ashokkumar, M. (2009) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2009.02.008 · Cited by 637 · see citing works

Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment

Ma, X., Wu, Y., Jin, S., Tian, Y., Zhang, X., Zhao, Y., Yu, L., & Liang, X. (2011) · ACS Nano · doi:10.1021/nn202155y · Cited by 631 · see citing works

Antidiabetic effects of quercetin in streptozocin-induced diabetic rats

Vessal, M., Hemmati, M., & Vasei, M. (2003) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(03)00140-6 · Cited by 625 · see citing works

Chemopreventive Agent Resveratrol, a Natural Product Derived From Grapes, Triggers CD95 Signaling-Dependent Apoptosis in Human Tumor Cells

Clement, M., Hirpara, J. L., Chawdhury, S.-H., & Pervaiz, S. (1998) · Blood · doi:10.1182/blood.v92.3.996 · Cited by 611 · see citing works

Absorption, metabolism and health effects of dietary flavonoids in man

Hollman, P., & Katan, M. (1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)88045-6 · Cited by 609 · see citing works

The bioavailability and absorption of anthocyanins: Towards a better understanding

McGhie, T. K., & Walton, M. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700092 · Cited by 606 · see citing works

Research Strategies for Safety Evaluation of Nanomaterials. Part VI. Characterization of Nanoscale Particles for Toxicological Evaluation

Powers, K. W., Brown, S. C., Krishna, V. B., Wasdo, S. C., Moudgil, B. M., & Roberts, S. M. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj099 · Cited by 606 · see citing works

Targeting of nanoparticles to the clathrin-mediated endocytic pathway

Harush-Frenkel, O., Debotton, N., Benita, S., & Altschuler, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.135 · Cited by 564 · see citing works

Polymeric proanthocyanidins from grape skins

Souquet, J., Cheynier, V., Brossaud, F., & Moutounet, M. (1996) · Phytochemistry · doi:10.1016/0031-9422(96)00301-9 · Cited by 522 · see citing works

Procyanidin dimer B2 [epicatechin-(4β-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa

Holt, R. R., Lazarus, S. A., Sullards, M. C., Zhu, Q. Y., Schramm, D. D., Hammerstone, J. F., Fraga, C. G., Schmitz, H. H., & Keen, C. L. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.798 · Cited by 517 · see citing works

The mouth‐feel properties of grape and apple proanthocyanidins in a wine‐like medium

Vidal, S., Francis, I. L., Guyot, S., Marnet, N., KWIATKOWSKI, M. J., Gawel, R., Cheynier, V., & Waters, E. J. (2003) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.1394 · Cited by 507 · see citing works

More Effective Nanomedicines through Particle Design

Wang, J., Byrne, J. D., Napier, M. E., & DeSimone, J. M. (2011) · Small · doi:10.1002/smll.201100442 · Cited by 474 · see citing works

Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin

Day, A. J., Mellon, F. A., Barron, D., Sarrazin, G., Morgan, M. R. A., & Williamson, G. (2001) · Free Radical Research · doi:10.1080/10715760100301441 · Cited by 472 · see citing works

Dynamics of Endocytosis and Exocytosis of Poly(D,L-Lactide-co-Glycolide) Nanoparticles in Vascular Smooth Muscle Cells

Panyam, J., & Labhasetwar, V. D. (2003) · Pharmaceutical Research · doi:10.1023/a:1022219003551 · Cited by 467 · see citing works

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

Tang, B. C., Dawson, M., Lai, S. K., Wang, Y.-Y., Suk, J. S., Yang, M., Zeitlin, P., Boyle, M. P., Fu, J., & Hanes, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905998106 · Cited by 453 · see citing works

Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy.

Mukerjee, A., & Vishwanatha, J. K. (2009) · PubMed · Cited by 441 · see citing works

Stability of Green Tea Catechins

Zhu, Q. Y., Zhang, A., Tsang, D., Huang, Y., & Chen, Z. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9706080 · Cited by 438 · see citing works

Comparison of scanning electron microscopy, dynamic light scattering and analytical ultracentrifugation for the sizing of poly(butyl cyanoacrylate) nanoparticles

Bootz, A., Vogel, V., Schubert, D., & Kreuter, J. (2003) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00193-0 · Cited by 431 · see citing works

Co-pigmentation of anthocyanins in plant tissues and its effect on color

ASEN, S., Stewart, R. N., & Norris, K. H. (1972) · Phytochemistry · doi:10.1016/s0031-9422(00)88467-8 · Cited by 426 · see citing works

Gelatin nanoparticles by two step desolvation a new preparation method, surface modifications and cell uptake

C. J. Coester, K. L. (2000) · Journal of Microencapsulation · doi:10.1080/026520400288427 · Cited by 415 · see citing works

Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production

Martı́nez, J., & Moreno, J. J. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00380-9 · Cited by 410 · see citing works

Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death

Chen, C., Yu, R., Owuor, E. D., & Kong, A.-N. T. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02975249 · Cited by 403 · see citing works

Bitterness and astringency of flavan-3-ol monomers, dimers and trimers

Peleg, H., Gacon, K., Schlich, P., & Noble, A. C. (1999) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(199906)79:8 · Cited by 402 · see citing works

Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting

Frey, A., Giannasca, K. T., Weltzin, R., Giannasca, P. J., Reggio, H., Lencer, W. I., & Neutra, M. R. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1045 · Cited by 401 · see citing works

Flavonol Profiles ofVitis viniferaRed Grapes and Their Single-Cultivar Wines

Castillo-Muñoz, N., Gómez‐Alonso, S., García‐Romero, E., & Hermosín‐Gutiérrez, I. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062800k · Cited by 395 · see citing works

Absorption and Metabolism of Anthocyanins in Elderly Women after Consumption of Elderberry or Blueberry

Prior, R. L., Wu, X., & Cao, G. (2002) · Journal of Nutrition · doi:10.1093/jn/132.7.1865 · Cited by 393 · see citing works

The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro

Borchard, G., Lueβen, H. L., de Boer, A. G., Verhoef, J. C., Lehr, C., & Junginger, H. E. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00146-8 · Cited by 393 · see citing works

Role of Phenolic Compounds in the Physiology of Plant Diseases and Disease Resistance

Farkas, G. L., & Kiraaly, Z. (1962) · Journal of Phytopathology · doi:10.1111/j.1439-0434.1962.tb02005.x · Cited by 388 · see citing works

Soy Isoflavones and Cancer Prevention

Sarkar, F. H., & Li, Y. (2003) · Cancer Investigation · doi:10.1081/cnv-120023773 · Cited by 385 · see citing works

Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening

Yeh, T.-H., Hsu, L.-W., Tseng, M. T., Lee, P., Sonjae, K., Ho, Y., & Sung, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.056 · Cited by 381 · see citing works

Transport of Proanthocyanidin Dimer, Trimer, and Polymer Across Monolayers of Human Intestinal Epithelial Caco-2 Cells

Déprez, S., Mila, I., Huneau, J., Tomé, D., & Scalbert, A. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601317203503 · Cited by 379 · see citing works

Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport

Behrens, I., Pena, A. I. V., Alonso, M. J., & Kissel, T. (2002) · Pharmaceutical Research · doi:10.1023/a:1019854327540 · Cited by 373 · see citing works

Stability of Tea Polyphenol (−)-Epigallocatechin-3-gallate and Formation of Dimers and Epimers under Common Experimental Conditions

Sang, S., Lee, M., Hou, Z., Ho, C., & Yang, C. S. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0519055 · Cited by 372 · see citing works

Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects

Kanaze, F. I., Bounartzi, M. I., Georgarakis, M., & Niopas, I. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602543 · Cited by 372 · see citing works

Air Pollution, Ultrafine and Nanoparticle Toxicology: Cellular and Molecular Interactions

Stone, V., Johnston, H. J., & Clift, M. J. D. (2007) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2007.909005 · Cited by 367 · see citing works

Zein nanoparticles produced by liquid–liquid dispersion

Zhong, Q., & Jin, M. (2009) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2009.06.015 · Cited by 363 · see citing works

Antiplatelet activity of synthetic and natural resveratrol in red wine.

Bertelli, A., Giovannini, L., Giannessi, D., MIGLIORI, M., Bernini, W., Fregoni, M., & Bertelli, A. A. A. (1995) · PubMed · Cited by 361 · see citing works

Nanoparticles Synthesized from Soy Protein: Preparation, Characterization, and Application for Nutraceutical Encapsulation

Teng, Z., Luo, Y., & Wang, Q. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205238x · Cited by 358 · see citing works

Sorting it out

Traub, L. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200309175 · Cited by 352 · see citing works

ANTHOCYANINS AS FOOD COLORANTS ?A REVIEW

Jackman, R. L., Yada, R. Y., Tung, M. A., & Speers, R. A. (1987) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.1987.tb00123.x · Cited by 343 · see citing works

Strawberry Anthocyanins Are Recovered in Urine as Glucuro- and Sulfoconjugates in Humans

Felgines, C., Talavéra, S., Texier, O., Lamaison, J., Gonthier, M., Scalbert, A., & Rémésy, C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1296 · Cited by 337 · see citing works

Bottom-up strategy of materials fabrication: a new trend in nanotechnology of soft materials

Shimomura, M., & Sawadaishi, T. (2001) · Current Opinion in Colloid & Interface Science · doi:10.1016/s1359-0294(00)00081-9 · Cited by 333 · see citing works

Biopharmaceutical Parameters to Consider in Order to Alter The Fate of Nanocarriers After Oral Delivery

Roger, E., Lagarce, F., Garcion, E., & Benoît, J. (2010) · Nanomedicine · doi:10.2217/nnm.09.110 · Cited by 324 · see citing works

The “French paradox” and beyond: neuroprotective effects of polyphenols1,2 1Guest editor: Arthur Cederbaum 2This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury.” The full list of papers may be found on the homepage of the journal.

Sun, A. Y., Simonyi, Á., & Sun, G. Y. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00803-6 · Cited by 315 · see citing works

Flavanones in Citrus fruit: Structure–antioxidant activity relationships

Majo, D. D., Giammanco, M., Guardia, M. L., Tripoli, E., Giammanco, S., & Finotti, E. (2005) · Food Research International · doi:10.1016/j.foodres.2005.05.001 · Cited by 314 · see citing works

Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity

Kim, T. H., Jiang, H. H., Youn, Y. S., Park, C. W., Tak, K. K., Lee, S., Kim, H., Jon, S., Chen, X. S., & Lee, K. C. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.10.041 · Cited by 293 · see citing works

Piceid, the Major Resveratrol Derivative in Grape Juices

Romero‐Pérez, A. I., Ibern-Gómez, M., Lamuela-Raventós, R. M., & de la Torre-Boronat, M. C. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981024g · Cited by 287 · see citing works

Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review)

WU, J. M., Wang, Z., Hsieh, T., Bruder, J. L., Zou, J., & Huang, Y. (2001) · International Journal of Molecular Medicine · doi:10.3892/ijmm.8.1.3 · Cited by 285 · see citing works

Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood–brain barrier

Chang, J., Jallouli, Y., Kroubi, M., Yuan, X.-B., Feng, W., Kang, C., Pu, P., & Betbeder, D. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.04.035 · Cited by 280 · see citing works

Subcellular compartment targeting of layered double hydroxide nanoparticles

Xu, Z. P., Niebert, M., Porazik, K., Walker, T. L., Cooper, H. M., Middelberg, A. P. J., Gray, P. P., Bartlett, P. F., & Lu, G. Q. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.021 · Cited by 279 · see citing works

Bioavailability of Ferulic Acid

Bourne, L., & Rice-Evans, C. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9681 · Cited by 275 · see citing works

Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway

Lai, S. K., Hida, K., Man, S. T., Chen, C., Machamer, C. E., Schroer, T. A., & Hanes, J. S. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.02.021 · Cited by 264 · see citing works

The effect of physical barriers and properties on the oral absorption of particulates

Norris, D. A. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00037-4 · Cited by 261 · see citing works

Quercetin potentiates insulin secretion and protects INS‐1 pancreatic β‐cells against oxidative damage via the ERK1/2 pathway

Youl, E., Bardy, G., Magous, R., Cros, G. H., Sejalon, F., Virsolvy, A., Richard, S., Quignard, J., Gross, R., Petit, P., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00910.x · Cited by 259 · see citing works

General method for extraction of blueberry anthocyanins and identification using high performance liquid chromatography–electrospray ionization-ion trap-time of flight-mass spectrometry

Barnes, J. S., Nguyen, H. P., Shen, S., & Schug, K. A. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.04.032 · Cited by 259 · see citing works

Design of Estradiol Loaded PLGA Nanoparticulate Formulations: A Potential Oral Delivery System for Hormone Therapy

Hariharan, S., Bhardwaj, V., Bala, I., Sitterberg, J., Bakowsky, U., & Ravi Kumar, M. N. V. (2006) · Pharmaceutical Research · doi:10.1007/s11095-005-8418-y · Cited by 257 · see citing works

Engineering of Dendrimer Surfaces to Enhance Transepithelial Transport and Reduce Cytotoxicity

Jevprasesphant, R., Penny, J. I., Attwood, D., McKeown, N. B., & D’Emanuele, A. (2003) · Pharmaceutical Research · doi:10.1023/a:1026166729873 · Cited by 256 · see citing works

Factors Affecting the Bioavailability of Soy Isoflavones in Humans after Ingestion of Physiologically Relevant Levels from Different Soy Foods

Cassidy, A., Brown, J. E., Hawdon, A., Faughnan, M. S., King, L. J., Millward, J., Zimmer-Nechemias, L., Wolfe, B., & Setchell, K. D. R. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.45 · Cited by 256 · see citing works

Novel biomarkers of the metabolism of caffeic acid derivatives in vivo

Rechner, A. R., Spencer, J. P. E., Kuhnle, G., Hahn, U., & Rice-Evans, C. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00506-8 · Cited by 255 · see citing works

Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution

Vllasaliu, D., Exposito-Harris, R., Heras, Á., Casettari, L., Garnett, M. C., Illum, L., & Stolnik, S. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.08.020 · Cited by 253 · see citing works

Opening of Epithelial Tight Junctions and Enhancement of Paracellular Permeation by Chitosan: Microscopic, Ultrastructural, and Computed-Tomographic Observations

Sonaje, K., Chuang, E., Lin, K., Yen, T., Su, F.-Y., Tseng, M. T., & Sung, H. (2012) · Molecular Pharmaceutics · doi:10.1021/mp200572t · Cited by 253 · see citing works

Flavonoids of Leguminous Plants: Structure, Biological Activity, and Biosynthesis

Aoki, T., Akashi, T., & Ayabe, S. (2000) · Journal of Plant Research · doi:10.1007/pl00013958 · Cited by 246 · see citing works

Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro

Wang, Z.-J., Huang, Y. C., Zou, J., Cao, K., Xu, Y., & Wu, J. (2002) · International Journal of Molecular Medicine · doi:10.3892/ijmm.9.1.77 · Cited by 245 · see citing works

Bioavailability challenges associated with development of anti-cancer phenolics

Gao, S., & Hu, M. (2010) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955710791384081 · Cited by 242 · see citing works

Cellular Uptake and Efflux of the Tea Flavonoid (-)Epicatechin-3-gallate in the Human Intestinal Cell Line Caco-2

Vaidyanathan, J. B., & Walle, T. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054296 · Cited by 242 · see citing works

Delphinidin, an Anthocyanidin in Pigmented Fruits and Vegetables, Protects Human HaCaT Keratinocytes and Mouse Skin Against UVB-Mediated Oxidative Stress and Apoptosis

Afaq, F., Syed, D. N., Malik, A., Hadi, N., Sarfaraz, S., Kweon, M., Khan, N., Zaid, M. I. A., & Mukhtar, H. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700510 · Cited by 239 · see citing works

Procyanidin B1 Is Detected in Human Serum after Intake of Proanthocyanidin-rich Grape Seed Extract

Atsushi, S. A. N. O., Yamakoshi, J., Tokutake, S., Tobe, K., Kubota, Y., & Kikuchi, M. (2003) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.67.1140 · Cited by 227 · see citing works

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease

Strathearn, K. E., Yousef, G. G., Grace, M. H., Roy, S. L., Tambe, M. A., Ferruzzi, M. G., Wu, Q.-L., Simon, J. E., Lila, M. A., & Rochet, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.047 · Cited by 226 · see citing works

Phenolic compounds and antioxidant properties of different grape cultivars grown in China

Xu, C., Zhang, Y., Cao, L., & Lu, J. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.09.042 · Cited by 225 · see citing works

Permeation enhancer effect of chitosan and chitosan derivatives: Comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells

Sadeghi, A. M. M., Dorkoosh, F. A., Avadi, M. R., Weinhold, M. X., BAYAT, A., Delié, F., Gurny, R., Larijani, B. A., Rafiee‐Tehrani, M., & Junginger, H. E. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.03.004 · Cited by 223 · see citing works

Absorption of Hydroxycinnamates in Humans after High-Bran Cereal Consumption

Kern, S. M., Bennett, R. N., Mellon, F. A., Kroon, P. A., & García‐Conesa, M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0302299 · Cited by 214 · see citing works

Induction of Hepatic Antioxidant Enzymes by Phenolic Acids in Rats Is Accompanied by Increased Levels of Multidrug Resistance–Associated Protein 3 mRNA Expression

Yeh, C., & Yen, G. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.11 · Cited by 213 · see citing works

Suppression of Wnt Signaling by the Green Tea Compound (–)-Epigallocatechin 3-Gallate (EGCG) in Invasive Breast Cancer Cells

Kim, J., Zhang, X., Rieger‐Christ, K., Summerhayes, I. C., Wazer, D. E., Paulson, K. E., & Yee, A. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513378200 · Cited by 203 · see citing works

Suppression of Multiple Scattering by Photon Cross-correlation Techniques

Schätzel, K. (1991) · Journal of Modern Optics · doi:10.1080/09500349114551951 · Cited by 199 · see citing works

Epicatechin and Catechin are O-Methylated and Glucuronidated in the Small Intestine

Kuhnle, G., Spencer, J. P. E., Schroeter, H., Shenoy, B., Debnam, E. S., Srai, S. K., Rice-Evans, C. A., & Hahn, U. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3701 · Cited by 199 · see citing works

Phenolic Signals in Cohabitation: Implications for Plant Development

Lynn, D. G., & Chang, M. (1990) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.pp.41.060190.002433 · Cited by 199 · see citing works

Unique Uptake and Transport of Isoflavone Aglycones by Human Intestinal Caco-2 Cells: Comparison of Isoflavonoids and Flavonoids

Murota, K., Shimizu, S., Miyamoto, S., Terao, J., Izumi, T., Obata, A., & Kikuchi, M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.7.1956 · Cited by 197 · see citing works

Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model

Xiao-juan, T., Yang, X., Yang, X., & Wang, K. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.09.023 · Cited by 196 · see citing works

Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model

Zhang, L., Zheng, Y., Chow, M. S. S., & Zuo, Z. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.08.020 · Cited by 189 · see citing works

Procyanidin Dimers A1, A2, and B2 Are Absorbed without Conjugation or Methylation from the Small Intestine of Rats

Appeldoorn, M. M., Vincken, J., Gruppen, H., & Hollman, P. C. H. (2009) · Journal of Nutrition · doi:10.3945/jn.109.106765 · Cited by 188 · see citing works

Oral Absorption and Bioavailability of Tea Catechins

Zhu, M., Chen, Y., & Li, R. C. (2000) · Planta Medica · doi:10.1055/s-2000-8599 · Cited by 185 · see citing works

In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer

Boyer, J., Brown, D. L., & Liu, R. H. (2005) · Nutrition Journal · doi:10.1186/1475-2891-4-1 · Cited by 176 · see citing works

Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles

Duan, J., Zhang, Y., Han, S., Chen, Y., Li, B., Liao, M., Chen, W., Deng, X., Zhao, J., & Huang, B. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.08.033 · Cited by 175 · see citing works

Fabrication, characterization, and cytotoxicity evaluation of cranberry procyanidins-zein nanoparticles

Zou, T., Li, Z., Percival, S. S., Bonard, S., & Gu, L. (2011) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2011.10.002 · Cited by 174 · see citing works

Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets

Rotchés-Ribalta, M., Andrés‐Lacueva, C., Estruch, R., Escribano, E., & Urpí-Sardà, M. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.08.001 · Cited by 173 · see citing works

Identification of 14 Quercetin Phase II Mono- and Mixed Conjugates and Their Formation by Rat and Human Phase II in Vitro Model Systems

van der Woude, H., Boersma, M. G., Vervoort, J. J. M., & Rietjens, I. M. C. M. (2004) · Chemical Research in Toxicology · doi:10.1021/tx049826v · Cited by 173 · see citing works

INHIBITION OF LUNG CANCER CELL GROWTH BY QUERCETIN GLUCURONIDES VIA G2/M ARREST AND INDUCTION OF APOPTOSIS

Yang, J., Hsia, T., Kuo, H., Chao, P.-D. L., Chou, C., Wei, Y., & Chung, J. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.005280 · Cited by 164 · see citing works

Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells

Kim, H. R., Gil, S., Andrieux, K., Nicolas, V., Appel, M., Chacun, H., Desmaële, D., Taran, F., Georgin, D., & Couvreur, P. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6390-x · Cited by 163 · see citing works

Development of gelatin nanoparticles with biotinylated EGF conjugation for lung cancer targeting

Tseng, C.-L., Wang, T.-W., Dong, G., Wu, S. Y.-H., Young, T., Shieh, M., Lou, P., & Lin, F. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.05.006 · Cited by 160 · see citing works

Significance of wine and resveratrol in cardiovascular disease: French paradox revisited.

Vidavalur, R., Otani, H., Singal, P. K., & Maulik, N. (2006) · PubMed Central · Cited by 155 · see citing works

(B) Mechanisms of peptide and protein absorption

Nellans, H. N. (1991) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(91)90013-3 · Cited by 153 · see citing works

Flavonoid metabolites in human plasma and urine after the consumption of red onions: analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection

Mullen, W., Boitier, A., Stewart, A. J., & Crozier, A. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.08.117 · Cited by 149 · see citing works

Matrix-loaded biodegradable gelatin nanoparticles as new approach to improve drug loading and delivery

Ofokansi, K. C., Winter, G., Fricker, G., & Coester, C. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.04.008 · Cited by 149 · see citing works

Comparison on phenolic compounds in Vitis vinifera cv. Cabernet Sauvignon wines from five wine-growing regions in China

Li, Z., Pan, Q., Jin, Z.-M., Mu, L., & Duan, C. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.08.039 · Cited by 145 · see citing works

Gallic acid and hydrolysable tannins are formed in birch leaves from an intermediate compound of the shikimate pathway

Ossipov, V. I., Salminen, J., Ossipova, S., Haukioja, E., & Pihlaja, K. (2002) · Biochemical Systematics and Ecology · doi:10.1016/s0305-1978(02)00081-9 · Cited by 144 · see citing works

Preparation and Characterization of Nanoparticles Based on Hydrophobic Alginate Derivative as Carriers for Sustained Release of Vitamin D3

Li, Q., Liu, C., Huang, Z., & Xue, F.-F. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1020347 · Cited by 142 · see citing works

Novel Technology for the Preparation of Self-Assembled Catechin/Gelatin Nanoparticles and Their Characterization

Chen, Y.-C., Yu, S.-H., Tsai, G., Tang, D.-W., Mi, F., & Peng, Y.-P. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1005116 · Cited by 135 · see citing works

Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats

Bishayee, A., Mbimba, T., Thoppil, R. J., Háznagy‐Radnai, E., Sipos, P., Darvesh, A. S., Folkesson, H. G., & Hohmann, J. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.09.001 · Cited by 134 · see citing works

Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound

Labrecque, L. G. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi024 · Cited by 132 · see citing works

A Lipid Receptor Sorts Polyomavirus from the Endolysosome to the Endoplasmic Reticulum to Cause Infection

Qian, M., Cai, D., Verhey, K. J., & Tsai, B. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000465 · Cited by 124 · see citing works

Macromolecules as safe penetration enhancers for hydrophilic drugs—a fiction?

Junginger, H. E., & Verhoef, J. C. (1998) · Pharmaceutical Science & Technology Today · doi:10.1016/s1461-5347(98)00100-x · Cited by 124 · see citing works

Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma

Longo, L., Platini, F., Scardino, A., Alabiso, O., Vasapollo, G., & Tessitore, L. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0361 · Cited by 123 · see citing works

The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis

Li, W. S., Chen, C., Ye, C., Wei, T., Zhao, Y., Lao, F., Chen, Z., Meng, H., Gao, Y., Yuan, H. Y., et al. (2008) · Nanotechnology · doi:10.1088/0957-4484/19/14/145102 · Cited by 120 · see citing works

Uptake of Quercetin and Quercetin 3-Glucoside from Whole Onion and Apple Peel Extracts by Caco-2 Cell Monolayers

Boyer, J., Brown, D. L., & Liu, R. H. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030733d · Cited by 120 · see citing works

Suppression of multiple scattering by photon cross-correlation techniques

Pusey, P. N. (1999) · Current Opinion in Colloid & Interface Science · doi:10.1016/s1359-0294(99)00036-9 · Cited by 116 · see citing works

Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption

Fagerholm, U., & Lennernäs, H. (1995) · European Journal of Pharmaceutical Sciences · doi:10.1016/0928-0987(95)00027-b · Cited by 115 · see citing works

EGCG blocks tumor promoter-induced MMP-9 expression via suppression of MAPK and AP-1 activation in human gastric AGS cells.

Kim, H. S., Kim, M. H., Jeong, M. H., Hwang, Y. S., Lim, S. H., Shin, B. A., Ahn, B. W., & Jung, Y. D. (2004) · PubMed · Cited by 114 · see citing works

Cellular entry of nanoparticles via serum sensitive clathrin-mediated endocytosis, and plasma membrane permeabilization

Rappoport, J. Z., Smith, Giroud, Wiggins, Mazzolin, & Dyson (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s29334 · Cited by 111 · see citing works

Bioavailability of dietary (poly)phenols: a study with ileostomists to discriminate between absorption in small and large intestine

Borges, G., Lean, M. E. J., Roberts, S. A., & Crozier, A. (2013) · Food & Function · doi:10.1039/c3fo60024f · Cited by 109 · see citing works

Polyplexes Traffic through Caveolae to the Golgi and Endoplasmic Reticulum en Route to the Nucleus

Reilly, M. J., Larsen, J. D., & Sullivan, M. O. (2012) · Molecular Pharmaceutics · doi:10.1021/mp200583d · Cited by 109 · see citing works

Anthocyanins from Black Soybean Seed Coats Inhibit UVB-Induced Inflammatory Cylooxygenase-2 Gene Expression and PGE2 Production through Regulation of the Nuclear Factor-κB and Phosphatidylinositol 3-Kinase/Akt Pathway

Tsoyi, K., Park, H. B., Kim, Y. M., Chung, J. I., Shin, S. C., Lee, W. S., Seo, H. G., Lee, J. H., Chang, K. C., & Kim, H. J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801345c · Cited by 105 · see citing works

Human Serum Albumin as an Antioxidant in the Oxidation of (−)-Epigallocatechin Gallate: Participation of Reversible Covalent Binding for Interaction and Stabilization

Ishii, T., Ichikawa, T., Minoda, K., Kusaka, K., Ito, S., Suzuki, Y., Akagawa, M., Mochizuki, K., Goda, T., & Nakayama, T. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100600 · Cited by 103 · see citing works

Influence of Growing Season on Phenolic Compounds and Antioxidant Properties of Grape Berries from Vines Grown in Subtropical Climate

Xu, C., Zhang, Y., Zhu, L., Huang, Y., & Lu, J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf104157z · Cited by 96 · see citing works

Fabrication of Self-Assembled (−)-Epigallocatechin Gallate (EGCG) Ovalbumin–Dextran Conjugate Nanoparticles and Their Transport across Monolayers of Human Intestinal Epithelial Caco-2 Cells

Li, Z., & Gu, L. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404621f · Cited by 96 · see citing works

Internalization of poly( D , L ‐1actic acid) nanoparticles by isolated human leukocytes and analysis of plasma proteins adsorbed onto the particles

Leroux, J., Gravel, P., Balant, L., Volet, B., Anner, B. M., Allémann, É., Doelker, É., & Gurny, R. (1994) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820280410 · Cited by 94 · see citing works

Albumin stabilizes (–)‐epigallocatechin gallate in human serum: Binding capacity and antioxidant property

Bae, M., Ishii, T., Minoda, K., Kawada, Y., Ichikawa, T., Mori, T., Kamihira, M., & Nakayama, T. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800274 · Cited by 89 · see citing works

Cellular uptake mechanism and knockdown activity of siRNA-loaded biodegradable DEAPA-PVA-g-PLGA nanoparticles

Benfer, M., & Kissel, T. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.10.021 · Cited by 86 · see citing works

Transport of Cranberry A-Type Procyanidin Dimers, Trimers, and Tetramers across Monolayers of Human Intestinal Epithelial Caco-2 Cells

Ou, K., Percival, S. S., Zou, T., Khoo, C., & Gu, L. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2040912 · Cited by 84 · see citing works

Dynamics of clathrin and adaptor proteins during endocytosis.

Rappoport, J., Kemal, S., Benmerah, A., & Simon, S. (2006) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00160.2006 · Cited by 83 · see citing works

Quercetin Attenuates TNF-Induced Inflammation in Hepatic Cells by Inhibiting the NF-κB Pathway

Granado‐Serrano, A. B., Martín, M. Á., Bravo, L., Goya, L., & Ramos, S. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.661513 · Cited by 82 · see citing works

Inhibitory Effect and Mechanisms of an Anthocyanins- and Anthocyanidins-Rich Extract from Purple-Shoot Tea on Colorectal Carcinoma Cell Proliferation

Hsu, C., Shih, Y.-T., Lin, B., Chiu, C.-F., & Lin, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204619n · Cited by 81 · see citing works

Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites

Takumi, H., Nakamura, H., Simizu, T., Harada, R., Kometani, T., Nadamoto, T., Mukai, R., Murota, K., Kawai, Y., & Terao, J. (2012) · Food & Function · doi:10.1039/c2fo10224b · Cited by 80 · see citing works

Curcumin Loaded Fibrinogen Nanoparticles for Cancer Drug Delivery

Rejinold, N. S., Muthunarayanan, M., Chennazhi, K. P., Nair, S. V., & Jayakumar, R. (2011) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2011.1320 · Cited by 78 · see citing works

The use of deoxycholic acid to enhance the oral bioavailability of biodegradable nanoparticles

Samstein, R. M., Perica, K., Balderrama, F., Look, M., & Fahmy, T. M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.10.026 · Cited by 77 · see citing works

Protective Effects of Anthocyanins against Amyloid β-Peptide-Induced Damage in Neuro-2A Cells

Shih, P., Wu, C., Yeh, C., & Yen, G. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103822h · Cited by 75 · see citing works

EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-γ: Role of JAK/STAT1 signaling and implications for HIV-associated dementia

Giunta, B. N., Obregon, D. F., Hou, H., Zeng, J., Sun, N., Nikolic, V., Ehrhart, J. C., Shytle, R. D., Fernandez, F., & Tan, J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.057 · Cited by 75 · see citing works

Fabrication of nanoparticles using partially purified pomegranate ellagitannins and gelatin and their apoptotic effects

Li, Z., Percival, S. S., Bonard, S., & Gu, L. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000528 · Cited by 71 · see citing works

Mechanistic studies on the uptake and intracellular trafficking of novel cyclodextrin transfection complexes by intestinal epithelial cells

Neill, M. J. O., Guo, J., Byrne, C. J., Darcy, R., & O’Driscoll, C. M. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.04.021 · Cited by 71 · see citing works

Caveolae and the Regulation of Endocytosis

Kiss, A. L. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-1222-9_2 · Cited by 69 · see citing works

Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7)

Devi, P. S., Kumar, M. S., & Das, S. M. (2011) · International Journal of Breast Cancer · doi:10.4061/2011/891481 · Cited by 68 · see citing works

Chromium nanoparticle exhibits higher absorption efficiency than chromium picolinate and chromium chloride in Caco‐2 cell monolayers

Zha, L., Xu, Z., Wang, M. ‐., & Linbo, G. U. (2007) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2007.00718.x · Cited by 63 · see citing works

Soy isoflavones sensitize cancer cells to radiotherapy

Hillman, G. G., & Singh‐Gupta, V. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.039 · Cited by 62 · see citing works

Caveolae-mediated endocytosis of biocompatible gold nanoparticles in living Hela cells

Hao, X. F., Wu, J., Shan, Y., Cai, M., Shang, X. C., Jiang, J., & Wang, H. (2012) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/24/16/164207 · Cited by 61 · see citing works

Curcumin-loaded into PLGA nanoparticles

Luz, P. P., Magalhães, L. G., Pereira, A. C., Cunha, W. R., Rodrigues, V., & Silva, M. L. A. E. (2011) · Parasitology Research · doi:10.1007/s00436-011-2527-9 · Cited by 61 · see citing works

Cyanidin‐3‐glucoside ameliorates ethanol neurotoxicity in the developing brain

Ke, Z., Liu, Y., Wang, X., Fan, Z., Chen, G., Xu, M., Bower, K. A., Frank, J. A., Ou, X., Shi, X., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22689 · Cited by 57 · see citing works

Specific permeability modulation of intestinal paracellular pathway by chitosan-poly(isobutylcyanoacrylate) core-shell nanoparticles

Bravo‐Osuna, I., Vauthier, C., Chacun, H., & Ponchel, G. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.12.012 · Cited by 56 · see citing works

Effects of Mass Ratio, pH, Temperature, and Reaction Time on Fabrication of Partially Purified Pomegranate Ellagitannin−Gelatin Nanoparticles

Li, Z., & Gu, L. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200024d · Cited by 52 · see citing works

Thiolated chitosan nanoparticles: transfection study in the Caco-2 differentiated cell culture

Martien, R., Loretz, B., Sandbichler, A. M., & Bernkop‐Schnürch, A. (2008) · Nanotechnology · doi:10.1088/0957-4484/19/04/045101 · Cited by 52 · see citing works

Mechanistic Insights into LDL Nanoparticle-Mediated siRNA Delivery

Jin, H., Lovell, J. F., Chen, J., Lin, Q., Ding, L., Ng, K. K., Pandey, R. K., Manoharan, M., Zhang, Z., & Zheng, G. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200233n · Cited by 52 · see citing works

Gelatin/tannin complex nanospheres via molecular assembly

Yi, K., Cheng, G., & Xing, F. (2006) · Journal of Applied Polymer Science · doi:10.1002/app.22416 · Cited by 51 · see citing works

Optimization on anthocyanins extraction from wine grape skins using orthogonal test design

Li, Z., Pan, Q., Cui, X., & Duan, C. (2010) · Food Science and Biotechnology · doi:10.1007/s10068-010-0147-2 · Cited by 50 · see citing works

Selenium- or quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgen-receptor activity

Morris, J. D. H., Pramanik, R., Zhang, X., Carey, A., Ragavan, N., MARTIN, F., & MUIR, G. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.07.037 · Cited by 50 · see citing works

Moderate Red Wine and Grape Juice Consumption Modulates the Hydrolysis of the Adenine Nucleotides and Decreases Platelet Aggregation in Streptozotocin-Induced Diabetic Rats

Schmatz, R., Mann, T. R., Spanevello, R. M., Machado, M. M., Zanini, D., Pimentel, V. C., Stefanello, N., Martins, C. C., Cardoso, A. M., Bagatini, M. D., et al. (2012) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-012-9407-5 · Cited by 49 · see citing works

Chitosan/PLGA Particles for Controlled Release of α-Tocopherol in The GI Tract Via Oral Administration

Murugeshu, A., Astete, C. E., Leonardi, C., Morgan, T. W., & Sabliov, C. M. (2011) · Nanomedicine · doi:10.2217/nnm.11.44 · Cited by 48 · see citing works

Anthocyanin‐rich Fractions of Blackberry Extracts Reduce UV‐induced Free Radicals and Oxidative Damage in Keratinocytes

Murapa, P., Dai, J., Chung, M. T., Mumper, R. J., & D'Orazio, J. A. (2011) · Phytotherapy Research · doi:10.1002/ptr.3510 · Cited by 46 · see citing works

Development of (−)-epigallocatechin-3-gallate (EGCG)-loaded enteric microparticles with intestinal mucoadhesive property

Onoue, S., Ochi, M., & Yamada, S. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.03.020 · Cited by 43 · see citing works

Up-Regulation of Human Prostaglandin Reductase 1 Improves the Efficacy of Hydroxymethylacylfulvene, an Antitumor Chemotherapeutic Agent

Yu, X. Y., Erzinger, M. M., Pietsch, K. E., Cervoni-Curet, F. N., Whang, J., Niederhuber, J. E., & Sturla, S. J. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.195768 · Cited by 43 · see citing works

Black currant phytoconstituents exert chemoprevention of diethylnitrosamine‐initiated hepatocarcinogenesis by suppression of the inflammatory response

Bishayee, A., Thoppil, R. J., Mandal, A., Darvesh, A. S., Ohanyan, V. A., Meszaros, J. G., Háznagy‐Radnai, E., Hohmann, J., & Bhatia, D. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.21860 · Cited by 40 · see citing works

Effect of the co-occurring components from green tea on the intestinal absorption and disposition of green tea polyphenols in Caco-2 monolayer model

Zhang, L., Chow, M. S. S., & Zuo, Z. (2005) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.1.0005 · Cited by 31 · see citing works

A Comparison of the Effect of Chitosan and Chitosan-Coated Vesicles on Monolayer Integrity and Permeability Across Caco-2 and 16HBE14o-Cells

Kudsiova, L., & Lawrence, M. J. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21262 · Cited by 30 · see citing works

Anti-inflammatory effect of O-methylated flavonol 2-(3,4-dihydroxy-phenyl)-3,5-dihydroxy-7-methoxy-chromen-4-one obtained from Cassia sophera Linn in rats

Mondal, A., Rajalingam, D., & Maity, T. K. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.01.021 · Cited by 28 · see citing works

In‐gel detection and study of the role of flavonol 3‐glucosidase in the bitter taste generation in tartary buckwheat

Suzuki, T., Honda, Y., Funatsuki, W., & Nakatsuka, K. (2004) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.1865 · Cited by 27 · see citing works

Nanopowder Characterization: Challenges and Future Directions

Jillavenkatesa, A., & Kelly, J. F. (2002) · Journal of Nanoparticle Research · doi:10.1023/a:1021689007419 · Cited by 25 · see citing works

Permeation of Hesperidin Glycosides Across Caco-2 Cell Monolayers Via the Paracellular Pathway

Kim, M., Kometani, T., Okada, S., & SHIMUZU, M. (1999) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.63.2183 · Cited by 25 · see citing works

Resveratrol suppresses prostaglandin F2α-induced osteoprotegerin synthesis in osteoblasts: Inhibition of the MAP kinase signaling

Kuroyanagi, G., Tokuda, H., Matsushima‐Nishiwaki, R., Kondo, A., Mizutani, J., Kozawa, O., & Otsuka, T. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.12.002 · Cited by 21 · see citing works

Epigallocatechin gallate induces telomere fragmentation in HeLa and 293 but not in MRC-5 cells

Li, W., Li, Q., & Tan, Z. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.09.024 · Cited by 21 · see citing works

Fabrication of self‐assembled (‐)‐epigallocatechin gallate (EGCG) ovalbumin‐dextran conjugate nanoparticles and their transport across monolayers of human intestinal epithelial Caco‐2 cells (1044.1)

Li, Z., & Gu, L. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.1044.1 · Cited by 10 · see citing works

Using quantum dots to visualize clathrin associations

Ogunkoya, Y. O., Nickel, B., GAY, V. L., & Murray, S. (2009) · Biotechnic & Histochemistry · doi:10.1080/10520290902881967 · Cited by 6 · see citing works

Analysis of chemical interactions of (−)-epigallocatechin-3-gallate, a major green tea polyphenol, with commonly-consumed over-thecounter drugs

Kim, M., & Hong, J. (2010) · Food Science and Biotechnology · doi:10.1007/s10068-010-0078-y · Cited by 4 · see citing works

Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

Zhang, Y.-J., Gan, R.-Y., Li, S., Zhou, Y., Li, A.-N., Xu, D.-P., & Li, H.-B. (2015) · Molecules · doi:10.3390/molecules201219753 · Cited by 1,369 · see citing works

Role of the Encapsulation in Bioavailability of Phenolic Compounds

Grgić, J., Šelo, G., Planinić, M., Tišma, M., & Bucić‐Kojić, A. (2020) · Antioxidants · doi:10.3390/antiox9100923 · Cited by 409 · see citing works

Improving the bioavailability of phenolic compounds by loading them within lipid-based nanocarriers

Esfanjani, A. F., Assadpour, E., & Jafari, S. M. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.04.002 · Cited by 406 · see citing works

A Brief Overview on Antioxidant Activity Determination of Silver Nanoparticles

Bedlovičová, Z., Strapáč, I., Baláž, M., & Salayová, A. (2020) · Molecules · doi:10.3390/molecules25143191 · Cited by 388 · see citing works

Functionality of Food Components and Emerging Technologies

Galanakis, C. M. (2021) · Foods · doi:10.3390/foods10010128 · Cited by 397 · see citing works

Engineering polyphenols with biological functions via polyphenol-protein interactions as additives for functional foods

Li, Y., He, D., Li, B., Lund, M. N., Xing, Y., Wang, Y., Li, F., Cao, X., Liu, Y., Chen, X., et al. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.02.009 · Cited by 324 · see citing works

Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals

McClements, D. J. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.08.004 · Cited by 322 · see citing works

Applications of chitosan nanoparticles to enhance absorption and bioavailability of tea polyphenols: A review

Liang, J., Yan, H., Puligundla, P., Gao, X., Zhou, Y., & Wan, X. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2017.01.041 · Cited by 304 · see citing works

Synthesis, characterization, bioactivity and potential application of phenolic acid grafted chitosan: A review.

Liu, J., Pu, H.-M., Liu, S., Kan, J., & Jin, C. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.07.014 · Cited by 279 · see citing works

Microencapsulation of bioactives for food applications

Días, M. I., Ferreira, I. C. F. R., & Barreiro, M. F. (2015) · Food & Function · doi:10.1039/c4fo01175a · Cited by 294 · see citing works

Encapsulation and delivery of food ingredients using starch based systems.

Zhu, F. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.02.101 · Cited by 265 · see citing works

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

Yang, B., Dong, Y., Wang, F., & Zhang, Y. (2020) · Molecules · doi:10.3390/molecules25204613 · Cited by 280 · see citing works

Food macromolecule based nanodelivery systems for enhancing the bioavailability of polyphenols

Hu, B., Liu, X., Zhang, C., & Zeng, X. (2016) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.11.004 · Cited by 252 · see citing works

Advances in nutraceutical delivery systems: From formulation design for bioavailability enhancement to efficacy and safety evaluation

Gonçalves, R. F. S., Martins, J. T., Duarte, C. M. M., Vicente, A. A., & Pinheiro, A. C. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.06.011 · Cited by 242 · see citing works

Natural phytochemicals and probiotics as bioactive ingredients for functional foods: Extraction, biochemistry and protected-delivery technologies

da Silva, B. V., Barreira, J. C. M., & Oliveira, M. B. P. P. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2015.12.007 · Cited by 248 · see citing works

Assembly of kafirin/carboxymethyl chitosan nanoparticles to enhance the cellular uptake of curcumin

Xiao, J., Nian, S., & Huang, Q. (2015) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2015.05.012 · Cited by 236 · see citing works

Bioavailability enhancement of EGCG by structural modification and nano-delivery: A review

Dai, W., Ruan, C., Zhang, Y., Wang, J., Han, J., Shao, Z., Sun, Y., & Liang, J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103732 · Cited by 224 · see citing works

The delivery of sensitive food bioactive ingredients: Absorption mechanisms, influencing factors, encapsulation techniques and evaluation models.

Bao, C., Jiang, P., Chai, J., Jiang, Y.-M., Li, D., Bao, W., Liu, B.-X., Liu, B., Norde, W., & Li, Y. (2019) · Food Research International · doi:10.1016/j.foodres.2019.02.024 · Cited by 193 · see citing works

Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art

Costanzo, A. D., & Angelico, R. (2019) · Molecules · doi:10.3390/molecules24112155 · Cited by 220 · see citing works

Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends

Choudhury, H., Pandey, M., Chin, P. X., Phang, Y. L., Cheah, J. Y., Ooi, S. C., Mak, K., Pichika, M. R., Kesharwani, P., Hussain, Z., et al. (2018) · Drug Delivery and Translational Research · doi:10.1007/s13346-018-0552-2 · Cited by 210 · see citing works

Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds

Domínguez-Avila, J. A., Wall‐Medrano, A., Rodríguez, G. R. V., Chen, C. ‐. O., Salazar‐López, N. J., Robles‐Sánchez, M., & González-Aguilar, G. A. (2017) · Food & Function · doi:10.1039/c6fo01475e · Cited by 207 · see citing works

Improving Resveratrol Bioaccessibility Using Biopolymer Nanoparticles and Complexes: Impact of Protein–Carbohydrate Maillard Conjugation

Davidov‐Pardo, G., Pérez-Ciordia, S., Arroyo, R. M., & McClements, D. J. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00777 · Cited by 203 · see citing works

Phytosomes as an Emerging Nanotechnology Platform for the Topical Delivery of Bioactive Phytochemicals

Alharbi, W. S., Almughem, F. A., Almehmady, A. M., Jarallah, S. J., Alsharif, W. K., Alzahrani, N. M., & Alshehri, A. A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091475 · Cited by 204 · see citing works

Delivery of synergistic polyphenol combinations using biopolymer-based systems: Advances in physicochemical properties, stability and bioavailability

Zhang, L. H., McClements, D. J., Wei, Z., Wang, G., Liu, X., & Liu, F. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1630358 · Cited by 186 · see citing works

Encapsulation of resveratrol in biopolymer particles produced using liquid antisolvent precipitation. Part 2: Stability and functionality

Joye, I. J., Davidov‐Pardo, G., & McClements, D. J. (2015) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2015.02.038 · Cited by 182 · see citing works

Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems

Chen, Z., Farag, M. A., Zhong, Z., Zhang, C., Yang, Y. P., Wang, S., & Wang, Y. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113870 · Cited by 173 · see citing works

The Signaling Pathways, and Therapeutic Targets of Antiviral Agents: Focusing on the Antiviral Approaches and Clinical Perspectives of Anthocyanins in the Management of Viral Diseases

Pour, P. M., Fakhri, S., Asgary, S., Farzaei, M. H., & Echeverría, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01207 · Cited by 168 · see citing works

Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction

Hassan, F.-U., Arshad, M. A., Ebeid, H. M., Rehman, M. S.-U., Khan, M. S., Shahid, S., & Yang, C. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.575801 · Cited by 160 · see citing works

Nanosuspensions of poorly water-soluble drugs prepared by bottom-up technologies

Du, J., Li, X., Zhao, H., Zhou, Y., Wang, L., Tian, S., & Wang, Y. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.09.021 · Cited by 146 · see citing works

Plant extracts as green reductants for the synthesis of silver nanoparticles: lessons from chemical synthesis

Khan, M., Shaik, M. R., Adil, S. F., Khan, S. T., Al‐Warthan, A., Siddiqui, M. R. H., Tahir, M. N., & Tremel, W. (2018) · Dalton Transactions · doi:10.1039/c8dt01152d · Cited by 150 · see citing works

The intelligent delivery systems for bioactive compounds in foods: Physicochemical and physiological conditions, absorption mechanisms, obstacles and responsive strategies

Chai, J., Jiang, P., Wang, P., Jiang, Y., Li, D., Bao, W., Liu, B., Liu, B., Zhao, L., Norde, W., et al. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.06.003 · Cited by 142 · see citing works

Ultrasound-assisted preparation of different nanocarriers loaded with food bioactive ingredients

Koshani, R., & Jafari, S. M. (2019) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2019.06.005 · Cited by 140 · see citing works

Flavonoids mediated ‘Green’ nanomaterials: A novel nanomedicine system to treat various diseases – Current trends and future perspective

Sathishkumar, P., Gu, F. L., Zhan, Q., Palvannan, T., & Yusoff, A. R. M. (2017) · Materials Letters · doi:10.1016/j.matlet.2017.08.078 · Cited by 137 · see citing works

Nanocarriers transport across the gastrointestinal barriers: The contribution to oral bioavailability via blood circulation and lymphatic pathway

Wang, D., Jiang, Q., Dong, Z., Meng, T., Hu, F., Wang, J., & Yuan, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115130 · Cited by 140 · see citing works

Polysaccharide-based nano-delivery systems for encapsulation, delivery, and pH-responsive release of bioactive ingredients

Meng, Y., Qiu, C., Li, X., McClements, D. J., Sang, S., Jiao, A., & Jin, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2105800 · Cited by 135 · see citing works

Mutlifunctional nanoparticles prepared from arginine-modified chitosan and thiolated fucoidan for oral delivery of hydrophobic and hydrophilic drugs

Chen, C.-H., Lin, Y., Wu, S., & Mi, F. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.03.080 · Cited by 130 · see citing works

Silver nanoparticles (AgNPs) biosynthesized using pod extract of Cola nitida enhances antioxidant activity and phytochemical composition of Amaranthus caudatus Linn

Azeez, L. A., Lateef, A., & Adebisi, S. A. (2017) · Applied Nanoscience · doi:10.1007/s13204-017-0546-2 · Cited by 129 · see citing works

Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation

Feng, Y., Sun, C., Yuan, Y., Zhu, Y., Wan, J., Firempong, C. K., Omari‐Siaw, E., Xu, Y., Pu, Z., Yu, J., et al. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.01.081 · Cited by 119 · see citing works

Zein-polysaccharide nanoparticles as matrices for antioxidant compounds: A strategy for prevention of chronic degenerative diseases

Tapia‐Hernández, J. A., Rodríguez‐Félix, F., Juárez, J., Ruíz‐Cruz, S., Robles-García, M. Á., Borboa‐Flores, J., Wong‐Corral, F. J., Cinco-Moroyoqui, F. J., Castro‐Enríquez, D. D., & Del‐Toro‐Sánchez, C. L. (2018) · Food Research International · doi:10.1016/j.foodres.2018.05.036 · Cited by 119 · see citing works

Protein-polyphenol particles for delivering structural and health functionality

Foegeding, E. A., Plundrich, N. J., Schneider, M., Campbell, C. L., & Lila, M. A. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2017.05.024 · Cited by 119 · see citing works

UPLC-ESI-Q-TOF-MS/MS Characterization of Phenolics from Crataegus monogyna and Crataegus laevigata (Hawthorn) Leaves, Fruits and their Herbal Derived Drops (Crataegutt Tropfen)

Karar, M. G. E., & Kuhnert, N. (2016) · Journal of Chemical Biology & Therapeutics · doi:10.4172/2572-0406.1000102 · Cited by 115 · see citing works

Adsorption mechanism of polyphenols onto starch nanoparticles and enhanced antioxidant activity under adverse conditions

Liu, C., Ge, S., Yang, J., Xu, Y., Zhao, M., Xiong, L., & Sun, Q. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.08.036 · Cited by 109 · see citing works

Phenolic Compounds and Its Bioavailability

Ferreira, I. C. F. R., Martins, N. A., & Barros, L. (2017) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2016.12.004 · Cited by 109 · see citing works

Nanoemulsions: An emerging platform for increasing the efficacy of nutraceuticals in foods

Zhang, R., Zhang, Z., & McClements, D. J. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111202 · Cited by 109 · see citing works

Metaloxide Nanomaterials and Nanocomposites of Ecological Purpose

Dontsova, T. A., Нагірняк, С. В., & Astrelin, I. M. (2019) · Journal of Nanomaterials · doi:10.1155/2019/5942194 · Cited by 108 · see citing works

A review of molecular mechanisms involved in anticancer and antiangiogenic effects of natural polyphenolic compounds

Abbaszadeh, H., Keikhaei, B., & Mottaghi, S. (2019) · Phytotherapy Research · doi:10.1002/ptr.6403 · Cited by 107 · see citing works

A Comprehensive Review of the Potential Use of Green Tea Polyphenols in the Management of COVID-19

Tallei, T. E., Fatimawali, F., Niode, N. J., Idroes, R., Zidan, B. M. R. M., Mitra, S., Çeli̇k, İ., Nainu, F., Ağagündüz, D., Emran, T. B., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/7170736 · Cited by 107 · see citing works

Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds

Conte, R., Marturano, V., Peluso, G., Calarco, A., & Cerruti, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040709 · Cited by 105 · see citing works

Monoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer

Wathoni, N., Puluhulawa, L. E., Joni, I. M., Muchtaridi, M., Mohammed, A. F. A., Elamin, K. M., Milanda, T., & Gozali, D. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2120566 · Cited by 107 · see citing works

In-vivo sustained release of nanoencapsulated ferulic acid and its impact in induced diabetes

Panwar, R., Raghuwanshi, N., Srivastava, A., Sharma, A. K., & Pruthi, V. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.06.055 · Cited by 103 · see citing works

Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols

Puligundla, P., Mok, C., Ko, S., Liang, J., & Recharla, N. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.04.023 · Cited by 102 · see citing works

Stable emulsion produced from casein and soy polysaccharide compacted complex for protection and oral delivery of curcumin

Xu, G., Wang, C., & Yao, P. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2017.05.010 · Cited by 101 · see citing works

Phytochemicals as potent modulators of autophagy for cancer therapy

Moosavi, M. A., Haghi, A., Rahmati, M., Taniguchi, H., Mocan, A., Echeverría, J., Gupta, V. K., Tzvetkov, N. T., & Atanasov, A. G. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.02.030 · Cited by 100 · see citing works

Anthocyanins from jussara (Euterpe edulis Martius) extract carried by calcium alginate beads pre-prepared using ionic gelation

Carvalho, A. G. D. S., Machado, M. T. D. C., Barros, H. D. D. F. Q., Cazarin, C. B. B., Maróstica, M. R., & Hubinger, M. D. (2019) · Powder Technology · doi:10.1016/j.powtec.2019.01.016 · Cited by 101 · see citing works

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

Mahmoud, K. Y., Swidan, S. A., El-Nabarawi, M. A., & Teaima, M. H. M. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01309-9 · Cited by 106 · see citing works

Enhancement of the permeability and activities of epigallocatechin gallate by quaternary ammonium chitosan/fucoidan nanoparticles

Huang, T., Ho, Y., Tsai, T.-N., Tseng, C., Lin, C., & Mi, F. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116312 · Cited by 99 · see citing works

Nutraceutical nanodelivery; an insight into the bioaccessibility/bioavailability of different bioactive compounds loaded within nanocarriers

Dima, C. V., Assadpour, E., Dima, Ş., & Jafari, S. M. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1792409 · Cited by 99 · see citing works

Evaluating the effect of chitosan layer on bioaccessibility and cellular uptake of curcumin nanoemulsions

da Silva, H. D. M., Beldíková, E., Poejo, J., Abrunhosa, L., Serra, T., Duarte, C. M. M., Brányik, T., Cerqueira, M. Â., Pinheiro, A. C., & Vicente, A. A. (2018) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2018.09.007 · Cited by 98 · see citing works

Research progress of polyphenols in nanoformulations for antibacterial application

Liu, C., Dong, S., Wang, X., Xu, H., Liu, C., Yang, X., Wu, S., Jiang, X., Kan, M., & Xu, C. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100729 · Cited by 98 · see citing works

A critical review on grape polyphenols for neuroprotection: Strategies to enhance bioefficacy

Zhao, D., Simon, J. E., & Wu, Q. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1546668 · Cited by 99 · see citing works

Production of self-assembling acylated ovalbumin nanogels as stable delivery vehicles for curcumin

Hu, G., Batool, Z., Cai, Z., Liu, Y., Ma, M., Sheng, L., & Jin, Y. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.129635 · Cited by 95 · see citing works

Morphology and Characteristics of Starch Nanoparticles Self-Assembled via a Rapid Ultrasonication Method for Peppermint Oil Encapsulation

Liu, C., Li, M., Ji, N., Liu, J., Xiong, L., & Sun, Q. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02938 · Cited by 94 · see citing works

Stilbenoids: A Natural Arsenal against Bacterial Pathogens

Mattio, L. M., Catinella, G., Dallavalle, S., & Pinto, A. (2020) · Antibiotics · doi:10.3390/antibiotics9060336 · Cited by 98 · see citing works

Antioxidant Capacity of Anthocyanin Pigments

Martı́n, J., Kuskoski, E. M., Sánchez, M. J. N., & Asuero, A. G. (2017) · InTech eBooks · doi:10.5772/67718 · Cited by 89 · see citing works

Nanoencapsulation of anthocyanins-loaded β-lactoglobulin nanoparticles: Characterization, stability, and bioavailability in vitro

Salah, M., Mansour, M., Zogona, D., & Xu, X. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109635 · Cited by 88 · see citing works

Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance

Vladu, A. F., Ficai, D., Ene, A., & Ficai, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810244 · Cited by 88 · see citing works

Physicochemical properties and bioavailability comparison of two quercetin loading zein nanoparticles with outer shell of caseinate and chitosan

Zhou, J.-F., Zheng, G., Wang, W., Yin, Z., Chen, J., Li, J., & Zhang, Q. (2021) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.106959 · Cited by 86 · see citing works

Preparation, characterization and biological activity of proanthocyanidin-chitosan nanoparticles

Ding, Z., Mo, M., Zhang, K., Bi, Y., & Kong, F. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.08.010 · Cited by 86 · see citing works

The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review

Razavi-Azarkhiavi, K., Iranshahy, M., Sahebkar, A., Shirani, K., & Karimi, G. (2016) · Nutrition and Cancer · doi:10.1080/01635581.2016.1187280 · Cited by 86 · see citing works

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Contardi, M., Lenzuni, M., Fiorentini, F., Summa, M., Bertorelli, R., Suarato, G., & Athanassiou, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070999 · Cited by 91 · see citing works

Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance

Hussain, Y., Mirzaei, S., Ashrafizadeh, M., Zarrabi, A., Hushmandi, K., Khan, H. Z., & Daglia, M. (2021) · Cancers · doi:10.3390/cancers13071602 · Cited by 84 · see citing works

Anthocyanins: Modified New Technologies and Challenges

Lin, Y., Li, C., Shi, L., & Wang, L. (2023) · Foods · doi:10.3390/foods12071368 · Cited by 84 · see citing works

Construction of food-grade pH-sensitive nanoparticles for delivering functional food ingredients

Xiong, K., Zhou, L., Wang, J., Ma, A., Fang, D., Xiong, L., & Sun, Q. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.12.019 · Cited by 83 · see citing works

Natural Macromolecules as Carriers for Essential Oils: From Extraction to Biomedical Application

Stevanović, Z. D., Sieniawska, E., Głowniak, K., Obradović, N. S., & Pajić‐Lijaković, I. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00563 · Cited by 83 · see citing works

Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts

Fernandes, F., Dias-Teixeira, M., Delerue-Matos, C. M., & Grosso, C. (2021) · Nanomaterials · doi:10.3390/nano11030563 · Cited by 81 · see citing works

Utilization of Nanotechnology to Improve the Application and Bioavailability of Phytochemicals Derived from Waste Streams

McClements, D. J., & Öztürk, B. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c03020 · Cited by 81 · see citing works

From waste to health: sustainable exploitation of grape pomace seed extract to manufacture antioxidant, regenerative and prebiotic nanovesicles within circular economy

Manca, M. L., Casula, E., Marongiu, F., Bacchetta, G., Sarais, G., Zaru, M., Escribano‐Ferrer, E., Peris, J., Usach, I., Fais, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-71191-8 · Cited by 79 · see citing works

Flavonoids: Food associations, therapeutic mechanisms, metabolism and nanoformulations

Kaushal, N., Singh, M., & Sangwan, R. S. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111442 · Cited by 78 · see citing works

In vitro inhibition of pancreatic α-amylase by spherical and polygonal starch nanoparticles

Jiang, S., Li, M., Chang, R., Xiong, L., & Sun, Q. (2017) · Food & Function · doi:10.1039/c7fo01381g · Cited by 78 · see citing works

A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy

Abedini, E., Khodadadi, E., Zeinalzadeh, E., Moaddab, S. R., Asgharzadeh, M., Mehramouz, B., Dao, S., & Kafil, H. S. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/8866311 · Cited by 77 · see citing works

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Zhang, H., Wu, F., Li, Y., Yang, X., Huang, J., Lv, T., Zhang, Y., Chen, J., Chen, H., Gao, Y., et al. (2016) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.7.178 · Cited by 77 · see citing works

Green tea polyphenols-derived hybrid materials in manufacturing, environment, food and healthcare

Xu, C., Zhou, S., Song, H., Hu, H., Yang, Y., Zhang, X., Ma, S., Feng, X., Pan, Y., Gong, S., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101990 · Cited by 76 · see citing works

Insight into the potential application of polyphenol-rich dietary intervention in degenerative disease management

Quero, J., Mármol, I., Cerrada, E., & Rodriguez‐Yoldi, M. J. (2020) · Food & Function · doi:10.1039/d0fo00216j · Cited by 77 · see citing works

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

Panwar, R., Sharma, A. K., Kaloti, M., Dutt, D., & Pruthi, V. (2015) · Applied Nanoscience · doi:10.1007/s13204-015-0502-y · Cited by 75 · see citing works

Nanoscale Delivery System for Nutraceuticals: Preparation, Application, Characterization, Safety, and Future Trends

Chen, J., & Hu, L. (2019) · Food Engineering Reviews · doi:10.1007/s12393-019-09208-w · Cited by 74 · see citing works

Fabrication and characterization of dihydromyricetin encapsulated zein-caseinate nanoparticles and its bioavailability in rat

Sun, C., Su, H., Zheng, G., Wang, W., Yuan, E., & Zhang, Q. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127245 · Cited by 74 · see citing works

Application of muscadine grape (Vitis rotundifolia Michx.) pomace extract to reduce carcinogenic acrylamide

Xu, C., Yağız, Y., Marshall, S. M., Li, Z., Simonne, A., Lu, J., & Marshall, M. R. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.02.133 · Cited by 73 · see citing works

Bioavailability and Kinetics of the Antihypertensive Casein-Derived Peptide HLPLP in Rats

Sánchez‐Rivera, L., Arés, I., Miralles, B., Ruiz, J. Á. G., Recio, I., Martínez-Larrañaga, M. R., Anadón, A., & Martínez, M. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5035256 · Cited by 69 · see citing works

Preparation and Characterization of Rutin-loaded Nanophytosomes

Hooresfand, Z., Ghanbarzadeh, S., & Hamishehkar, H. (2015) · Pharmaceutical Sciences · doi:10.15171/ps.2015.29 · Cited by 69 · see citing works

The influence of food matrix on the stability and bioavailability of phytochemicals: A comprehensive review

Mishra, A. K., Singh, R., Rawat, H., Kumar, V., Jagtap, C., & Jain, A. (2023) · Food and Humanity · doi:10.1016/j.foohum.2023.12.010 · Cited by 67 · see citing works

Enhancement of Antifungal Activity of Juglone (5-Hydroxy-1,4-naphthoquinone) Using a Poly( d , l -lactic-co-glycolic acid) (PLGA) Nanoparticle System

Arasoğlu, T., Mansuroğlu, B., Derman, S., Gumus, B., KOÇYİĞİT, B., Acar, T., & Kocaçalışkan, İ. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b03309 · Cited by 65 · see citing works

Stability and structural characteristics of amylopectin nanoparticle-binding anthocyanins in Aronia melanocarpa

Tong, Y., Deng, H., Kong, Y., Tan, C., Chen, J., Wan, M., Wang, M., Yan, T., Meng, X., & Li, L. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125687 · Cited by 63 · see citing works

Impact of nanotechnology on the oral delivery of phyto-bioactive compounds

Nsairat, H., Lafi, Z., Al-Sulaibi, M., Gharaibeh, L. F., & Alshaer, W. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136438 · Cited by 66 · see citing works

High dispersity, stability and bioaccessibility of curcumin by assembling with deamidated zein peptide

Li, L., & Yao, P. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126577 · Cited by 62 · see citing works

Role of Moringa oleifera on Green Synthesis of Metal/Metal Oxide Nanomaterials

Jadhav, V. R., Bhagare, A. M., Ali, I. H., Dhayagude, A. C., Lokhande, D. D., Aher, J. S., Jameel, M., & Dutta, M. (2022) · Journal of Nanomaterials · doi:10.1155/2022/2147393 · Cited by 61 · see citing works

Improving Flavonoid Bioaccessibility using an Edible Oil-Based Lipid Nanoparticle for Oral Delivery

Ban, C., Park, S. J., Lim, S., Choi, S. J., & Choi, Y. J. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b01495 · Cited by 61 · see citing works

Ultrasound-reinforced encapsulation of proanthocyanidin by chitosan-chondroitin sulfate nanosystem

Yu, Z., Yu, D., Dong, J., & Xia, W. (2022) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2022.107872 · Cited by 57 · see citing works

Bioavailability Enhancement of Astilbin in Rats through Zein–Caseinate Nanoparticles

Zheng, D., & Zhang, Q. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00018 · Cited by 57 · see citing works

Ginkgo biloba extracts-loaded starch nano-spheres: Preparation, characterization, and in vitro release kinetics

Wang, T., Wu, C., Fan, G., Li, T., Gong, H., & Cao, F. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.08.012 · Cited by 56 · see citing works

Fabrication, characterization and evaluation of myricetin adsorption onto starch nanoparticles

Xia, W., Zheng, B., Li, T., Lian, F., Lin, Y., & Liu, R. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116848 · Cited by 56 · see citing works

Advances in research on interactions between polyphenols and biology-based nano-delivery systems and their applications in improving the bioavailability of polyphenols

Zhang, Z., Qiu, C., Li, X., McClements, D. J., Jiao, A., Wang, J., & Jin, Z. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.08.009 · Cited by 125 · see citing works

Improving absorption and bioactivities of phytochemicals using protein/polysaccharide nanoparticle delivery systems

Zheng, T. (2022) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3-dgt4-hy86 · Cited by 2 · see citing works

Applications of chitosan nanoparticles to enhance absorption and bioavailability of tea polyphenols: A review

Liang, J., Yan, H., Puligundla, P., Gao, X., Zhou, Y., & Wan, X. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2017.01.041 · Cited by 304 · see citing works

Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals

Wang, S. F., Su, R., Nie, S., Sun, M., Zhang, J., Wu, D., & Moustaïd‐Moussa, N. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.10.002 · Cited by 532 · see citing works

Biopolymer nanoparticles: a strategy to enhance stability, bioavailability, and biological effects of phenolic compounds as functional ingredients

Nishimoto‐Sauceda, D., Robles, L. E. R., & Antunes‐Ricardo, M. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11512 · Cited by 93 · see citing works