Modulation of Bone Formation and Resorption Using a Novel Zoledronic Acid Loaded Gelatin Nanoparticles Integrated Porous Titanium Scaffold: An In Vitro and In Vivo Study
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Abstract Osteoporotic bone defects are a major challenge in clinics for bone regeneration. With the condition of osteoporosis, excessive bone absorption and impaired osteogenesis result in unexpectedly long healing procedures for defects. In order to simultaneously enhance bone formation and reduce bone resorption, a polydopamine-coated porous titanium scaffold was designed, to be integrated with anti-catabolic drug zoledronic acid nanoparticles (ZOL loaded gelatin NPs), which was able to achieve a local sustained release of ZOL as expected. The in vitro study demonstrated that extracts of the composite scaffolds would stimulate osteoblast differentiation; they also inhibited osteoclastogenesis at a ZOL loading concentration of 50 μmol l−1. In the subsequent in vivo study, the composite scaffolds were implanted into ovariectomy-induced osteoporotic rabbits suffering from femoral condyles defects. The results indicated that the composite scaffolds without ZOL loaded gelatin NPs only induced callus formation, mainly at the interface margin between the implant and bone, whereas the composite scaffolds with ZOL loaded gelatin NPs were capable of further enhancing osteogenesis and bone growth into the scaffolds. Moreover, the research proved that the promoting effect was optimal at a ZOL loading concentration of 50 μmol l−1. In summary, the present research indicated that a new type of porous titanium scaffold integrated with ZOL loaded gelatin NPs inherited a superior biocompatibility and bone regeneration capability. It would be an optimal alternative for the reconstruction of osteoporosis-related defects compared to a traditional porous titanium implant; in other words, the new type of scaffold offers a new effective and practical procedure option for patients suffering from osteoporotic bone defects.
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Using bisphosphonates can increase integration of scaffolds with surrounding bone tissue by increasing bone growth.
“Using of bisphosphonates is considered, as one of the applicable methods that can be increased the integration of scaffolds with the surrounding bone tissue by increasing bone growth, for example, Zoledronic acid (ZA), which is a member of this group. (Yang et al., 2020).”
From Osteogenesis Improvement of Gelatin-Based Nanocomposite Scaffold by Loading Zoledronic Acid (2022) · cites this paper as Yang et al., 2020
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- Authors
- Yang, X.-J., Wang, F.-Q., Lu, C.-B., Zou, J.-W., Hu, J.-B., Yang, Z., Sang, H.-X., & Zhang, Y.
- Affiliations
- Xijing Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Corresponding author
- Sang, Hong-xun
- Zhang, Yang
- ORCID
- Zhang, Yang
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2020-07-22
- Volume
- 15
- Issue
- 5
- Pages
- 055013
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- OpenAlex
- W3015095969
- Cited by
- 28
- References
- 45
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 3
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biomedical Materials (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81902185)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- zoledronic acid, gelatin nanoparticles, porous titanium scaffolds, bone regeneration, osteoporosis, bone formation, bone resorption, osteogenic differentiation, osteoclastogenesis inhibition, polydopamine coating, sustained drug release, ovariectomy-induced osteoporosis, femoral condyle defect
- MeSH terms
- Zoledronic Acid, Animals, Biocompatible Materials, Bone and Bones, Bone Regeneration, Bone Resorption, Cell Adhesion, Cell Differentiation, Female, Gelatin, Osteoclasts, Osteogenesis, Osteoporosis, Rabbits, Titanium, Porosity, Cell Proliferation, Nanoparticles, Tissue Scaffolds, Static Electricity, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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