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Cited by 414

The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.

Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans

Open access
Mahmoudi, Keon, Bouras, Alexandros, Bozec, Dominique, Ivkov, Robert, Hadjipanayis, Constantinos·2018·International Journal of Hyperthermia

Abstract

Hyperthermia therapy (HT) is the exposure of a region of the body to elevated temperatures to achieve a therapeutic effect. HT anticancer properties and its potential as a cancer treatment have been studied for decades. Techniques used to achieve a localised hyperthermic effect include radiofrequency, ultrasound, microwave, laser and magnetic nanoparticles (MNPs). The use of MNPs for therapeutic hyperthermia generation is known as magnetic hyperthermia therapy (MHT) and was first attempted as a cancer therapy in 1957. However, despite more recent advancements, MHT has still not become part of the standard of care for cancer treatment. Certain challenges, such as accurate thermometry within the tumour mass and precise tumour heating, preclude its widespread application as a treatment modality for cancer. MHT is especially attractive for the treatment of glioblastoma (GBM), the most common and aggressive primary brain cancer in adults, which has no cure. In this review, the application of MHT as a therapeutic modality for GBM will be discussed. Its therapeutic efficacy, technical details, and major experimental and clinical findings will be reviewed and analysed. Finally, current limitations, areas of improvement, and future directions will be discussed in depth.

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Metadata

Authors
Mahmoudi, K., Bouras, A., Bozec, D., Ivkov, R., & Hadjipanayis, C.
Venue
International Journal of Hyperthermia
Published
2018-02-06
Volume
34
Issue
8
Pages
1316-1328
ISSN
  • 0265-6736 (ISSN-L)
  • 1464-5157
OpenAlex
W2790388651
Cited by
414
References
114
FWCI
14.82
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans. https://app.cochat.ai/papers/10.1080/02656736.2018.1430867
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Mahmoudi, K., Bouras, A., Bozec, D., Ivkov, R., & Hadjipanayis, C. (2018). Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans. International Journal of Hyperthermia. https://doi.org/10.1080/02656736.2018.1430867

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.