Sensitivity to change and responsiveness of the Stroke and Aphasia Quality-of-Life Scale (SAQOL) in a Singapore stroke population
Abstract
Background: The health-related quality of life (HRQoL) of people with aphasia (PWA) in Singapore is unknown.Aims: To compare outcomes between stroke survivors with and without aphasia in Singapore and examine the sensitivity and responsiveness to change of the Stroke and Aphasia QOL Scale (SAQOL-39g) and its Singapore (Mandarin) variant, SAQOL-CSg.Methods & Procedures: A longitudinal cohort study was conducted with stroke survivors with and without aphasia. Participants underwent a series of questionnaires at 3 and 12 months post-stroke including SAQOL-39g/SAQOL-CSg, Barthel Index, Modified Rankin Scale (MRS), Mini Mental State Examination, Frontal Assessment Battery, Center for Epidemiologic Studies Depression Scale and the EQ-5D. The following data analyses were conducted: comparison of stroke outcomes between participants with and without aphasia, computation of floor and ceiling effects, calculation of effect sizes (ESs) to determine sensitivity to change and estimation of minimally important differences (MIDs) for examining responsiveness.Outcomes & Results: A total of 78 participants (29.5% female, 29.5% PWA, mean age 64.1 years) completed all the assessments on both occasions. At 12 months post-stroke, PWA had higher levels of disability on the MRS (Mann–Whitney U = 294.5, p < 0.01) and reported significantly lower quality of life on the SAQOL-39g/SAQOL-CSg (U = 349, p < 0.01) and the EQ-5D index (U = 447, p < 0.05). In terms of sensitivity to change, the SAQOL-39g/SAQOL- 35CSg showed a small degree of improvement for the entire sample (ES, r = 0.22) but change was only significant for participants without aphasia. MID estimates for improvement were 0.21 on the SAQOL-39g/SAQOL-CSg and 0.17 on the EQ-5D index.Conclusions: PWA reported poorer HRQoL even when physical function was comparable. SAQOL-39g/SAQOL-CSg was found to have adequate sensitivity to change (i.e., reflect at least small change) up to 12 months post-stroke. MID estimates of the SAQOL-39g/SAQOL-CSg may assist in the interpretation of changes in scores in the clinical setting.
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To achieve 80% power to detect an effect size of at least .50 with a random-effects model, outcome measures with cumulative within-group sample sizes below 100 or used in fewer than 10 studies were excluded.
“To have a power of .80 to detect an effect size of ≥.50 using a random-effects model, outcome measures with cumulative sample sizes across within group studies < than 100 were excluded and/or if the measure was used in less than < 10 studies.25”
From Benchmarks of Significant Change After Aphasia Rehabilitation (2019) · cites this paper as [25]
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Benchmarks of Significant Change After Aphasia Rehabilitation
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- Authors
- Guo, Y. E., Togher, L., Power, E., Heard, R., Luo, N., Yap, P., & Koh, G. C. H.
- Affiliations
- The University of Sydney (AU)
- National University of Singapore (SG)
- Khoo Teck Puat Hospital (SG)
- Corresponding author
- Guo, Yiting Emily
- Venue
- Aphasiology
- Publisher
- Informa UK Limited
- Published
- 2016-12-03
- Volume
- 31
- Issue
- 4
- Pages
- 427-446
- ISSN
- 0268-7038 (ISSN-L)
- 1464-5041
- OpenAlex
- W2559552889
- Cited by
- 19
- References
- 57
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Aphasiology (publishedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Funders
- University of Sydney (Faculty Postgraduate Funding)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Keywords
- aphasia, stroke survivors, health-related quality of life, sensitivity to change, responsiveness, minimally important difference, floor and ceiling effects, stroke disability, post-stroke depression, frontal lobe dysfunction
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