The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Decreased responsiveness to reward in depression
Abstract
We have interpreted the literature showing left anterior hypoactivation in depression as reflecting a decrease in approach-related motivation and behaviour among depressed subjects. In support of this model, we have previously demonstrated a decreased responsiveness to reward in subclinically depressed dysphoric subjects. The current study was designed to replicate and extend those findings. Clinically depressed subjects who met DSM-IV criteria for major depression were compared to a group of nondepressed control subjects on a verbal memory task under three monetary payoff conditions: neutral, reward, and punishment. Although control subjects changed their pattern of responding in both the reward and punishment conditions, relative to the neutral condition, so as to maximise their earnings, depressed subjects did not do so during reward. The two groups did not differ during the punishment condition. These findings provide additional evidence of a decreased responsiveness to reward in depressed individuals, and are consistent with the hypothesis that the left prefrontal hypoactivation observed in depression reflects a deficit in approach-related behaviour.
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“Behavioral studies have reliably found that individuals with MDD show a blunted response to a range of rewarding stimuli [203-205].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [203]
Citations
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The Psychobiology of Depression and Resilience to Stress: Implications for Prevention and Treatment
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Metadata
- Authors
- Henriques, J. B., & Davidson, R. J.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Cognition & Emotion
- Publisher
- Informa UK Limited
- Published
- 2000-09
- Volume
- 14
- Issue
- 5
- Pages
- 711-724
- ISSN
- 0269-9931 (ISSN-L)
- 1464-0600
- OpenAlex
- W2137750408
- Cited by
- 399
- References
- 38
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 17 · 2023: 9 · 2022: 23 · 2021: 18 · 2020: 17 · 2019: 18 · 2018: 17 · 2017: 28 · 2016: 19 · 2015: 19 · 2014: 29 · 2013: 24 · 2012: 21
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cognition & Emotion (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- depression, reward responsiveness, punishment, approach motivation, monetary rewards, major depressive disorder
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