Differentiation between the two types of amiodarone-associated thyrotoxicosis using duplex and amplitude doppler sonography
Abstract
Purpose: To evaluate the usefulness of Doppler parameters in the differentiation between the two types of amiodarone-associated thyrotoxicosis (AAT). Material and Methods: One hundred thirty-seven individuals were selected at our institution. They were divided into four groups: 84 normal subjects (N), 30 euthyroids taking amiodarone (A), 14 AAT type 1 patients (AAT1), and nine AAT type 2 patients (AAT2). Each AAT type was classified according to 131 I uptake and clinical outcome. Blindly, the resistance and pulsatility indexes (RI, PI), systolic peak velocity, and color pixel density (CPD) were calculated. Results: AAT1 had greater CPD than AAT2 ( P = 0.02). The latter group had similar vascularization to the N and A groups ( P = 0.45). The area under the receiver operating characteristic (ROC) curve showed that systolic peak velocity in the inferior thyroid arteries and CPD were the best parameters in the differentiation between AAT type 1 and AAT type 2 (Az = 0.83 and 0.84, respectively). Impedance indexes were useless. Conclusion: Our results demonstrate that objective tests such as systolic peak velocities in the thyroid arteries and CPD are reliable parameters for differentiating between the two types of AAT.
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Several studies have shown that increased vascularity on CFDS may be seen in patients with type 1, but not type 2 AIT.
“Several studies have shown that increased vascularity on CFDS may be seen in patients with type 1, but not type 2 AIT (599-601).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [601]
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- Authors
- Macedo, T. A. A., Chammas, M. C., Jorge, P. T., Souza, L. P., Farage, L., Watanabe, T., Santos, V. A., & Cerri, G. G.
- Affiliations
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Corresponding author
- Macedo, T. A. A.
- Venue
- Acta Radiologica
- Publisher
- SAGE Publications
- Published
- 2007-05
- Volume
- 48
- Issue
- 4
- Pages
- 412-421
- ISSN
- 0284-1851 (ISSN-L)
- 1600-0455
- OpenAlex
- W2158187533
- Cited by
- 24
- References
- 21
- Citations by year
- 2023: 1 · 2021: 3 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Radiologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- duplex ultrasound, inferior thyroid artery, peak systolic velocity, resistance index, pulsatility index, thyroid vascularization, differential diagnosis
- MeSH terms
- Adult, Aged, Aged, 80 and over, Amiodarone, Anti-Arrhythmia Agents, Atrial Fibrillation, Blood Flow Velocity, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Prospective Studies, Pulsatile Flow, ROC Curve, Thyroid Gland, Thyrotoxicosis, Vascular Resistance, Ultrasonography, Doppler, Color, Ultrasonography, Doppler, Duplex, Ventricular Premature Complexes, Area Under Curve
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