Aetiology of hyperthyroidism in Canada and Wales.
Open accessAbstract
A retrospective, comparative review of 100 consecutive new outpatients presenting with hyperthyroidism in Cardiff, South Wales, and in Toronto, Canada, was performed. The aim was to quantify the causes of hyperthyroidism with particular emphasis on the prevalence of viral thyroiditis and "silent" thyroiditis. The proportional morbidity of Graves' disease (approximately 70%) was similar in the two groups. Toxic multinodular goitre and toxic adenoma (Plummers' disease) occurred significantly more frequently in Cardiff (25% v 8%), whereas thyroiditis predominated in Toronto (17% v 1%).
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Painless thyroiditis caused by lymphocytic inflammation occurs with different frequency depending on the population studied: 0.5% in Denmark, 6% in Toronto, and 22% in Wisconsin.
“in Denmark it accounted for only 0.5% of thyrotoxic patients, but it was 6% of patients in Toronto and 22% of patients in Wisconsin (16)(17)(18).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [17]
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- Authors
- Williams, I., Ankrett, V. O., Lazarus, J. H., & Volpe, R.
- Affiliations
- University Hospital of Wales (GB)
- ORCID
- Venue
- Journal of Epidemiology and Community Health
- Publisher
- BMJ
- Published
- 1983-09
- Volume
- 37
- Issue
- 3
- Pages
- 245-248
- ISSN
- 0141-7681 (ISSN-L)
- 0143-005X
- 1470-2738
- PMC
- PMC1052301
- OpenAlex
- W2012275811
- Cited by
- 45
- References
- 23
- Citations by year
- 2025: 1 · 2022: 2 · 2020: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Epidemiology & Community Health (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- hyperthyroidism, etiology, Graves' disease, viral thyroiditis, silent thyroiditis, toxic multinodular goiter, toxic adenoma, Plummer's disease, thyroiditis, cross-national comparison, Cardiff, Toronto
- MeSH terms
- Adenoma, Adolescent, Adult, Aged, Child, Female, Goiter, Nodular, Graves Disease, Humans, Hyperthyroidism, Male, Middle Aged, Ontario, Thyroid Neoplasms, Thyroiditis, Wales
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