The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Multiple Signaling Pathways Converge on the Cbfa1/Runx2 Transcription Factor to Regulate Osteoblast Differentiation
Open accessAbstract
The Cbfa1/Runx2 transcription factor is essential for osteoblast differentiation. However, levels of Runx2 are often not well correlated with its transcriptional activity suggesting that this factor must be activated either by covalent modification or through interactions with other nuclear components. Runx2 is phosphorylated and activated by the mitogen-activated protein kinase (MAPK) pathway. This pathway is stimulated in at least two ways: by binding of type I collagen to alpha2beta1 integrins on the osteoblast surface and by treatment of cells with the osteogenic growth factor, FGF2. Protein kinase A (PKA) also may phosphorylate/activate Runx2 under certain conditions. Runx2 activity also is enhanced by factors known to stimulate specific signal transduction pathways such as PTH/PTHrP (signals through PKA and PKC pathways) and BMPs (Signal through Smad proteins). Interactions with Runx2 are complex involving both binding of distinct components such as AP-1 factors and Smads to separate sites on DNA, direct interactions between Runx2 and AP-1/Smad factors and MAPK or PKA-dependent Runx2 phosphorylation. These findings suggest that Runx2 plays a central role in coordinating multiple signals involved in osteoblast differentiation.
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Cites
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Otto, F., Thornell, A. P., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G. W. H., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,814
Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia
Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80260-3 · Cited by 1,522
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
Ducy, P., Schinke, T., & Karsenty, G. (2000) · Science · doi:10.1126/science.289.5484.1501 · Cited by 1,120
Lee, K.-S., Kim, H.-J., Li, Q.-L., Chi, X.-Z., Ueta, C., Komori, T., Wozney, J. M., Kim, E.-G., Choi, J.-Y., Ryoo, H.-M., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8783-8792.2000 · Cited by 865
Construction of adenovirus vectors through Cre-lox recombination
Hardy, S., Kitamura, M., Harris-Stansil, T., Dai, Y., & Phipps, M. L. (1997) · Journal of Virology · doi:10.1128/jvi.71.3.1842-1849.1997 · Cited by 789
The roles of FGFs in the early development of vertebrate limbs
Martin, G. R. (1998) · Genes & Development · doi:10.1101/gad.12.11.1571 · Cited by 648
MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1
Xiao, G., Jiang, D., Thomas, P., Benson, M. D., Guan, K., Karsenty, G., & Franceschi, R. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4453 · Cited by 552
Self-citationNugent, M. A., & Iozzo, R. V. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00123-5 · Cited by 547
Xiao, G., Gopalakrishnan, R., Jiang, D., Reith, E., Benson, M. D., & Franceschi, R. T. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.101 · Cited by 456
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Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
Self-citationGe, C., Xiao, G., Jiang, D., & Franceschi, R. T. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610046 · Cited by 507
Self-citationCalcium phosphate surfaces promote osteogenic differentiation of mesenchymal stem cells
Müller, P., Bulnheim, U., Diener, A., Lüthen, F., Teller, M., Klinkenberg, E., Neumann, H., Nebe, B., Liebold, A., Steinhoff, G., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00103.x · Cited by 269
Zhong, L., Zhao, J., Huang, L., Liu, Y., Pang, X., Zhan, K., Li, S., Xue, Q., Pan, X., & Deng, L. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1316 · Cited by 43
Metadata
- Authors
- Franceschi, R. T., Xiao, G., Jiang, D., Gopalakrishnan, R., Yang, S., & Reith, E.
- Venue
- Connective Tissue Research
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 44
- Issue
- 1
- Pages
- 109-116
- ISSN
- 0300-8207 (ISSN-L)
- 1607-8438
- OpenAlex
- W2113442798
- Cited by
- 256
- References
- 30
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Franceschi, R. T., Xiao, G., Jiang, D., Gopalakrishnan, R., Yang, S., & Reith, E. (2003). Multiple Signaling Pathways Converge on the Cbfa1/Runx2 Transcription Factor to Regulate Osteoblast Differentiation. Connective Tissue Research. https://doi.org/10.1080/03008200390152188
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