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Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development
Open accessAbstract
The extracellular signal–regulated kinase (ERK)–mitogen-activated protein kinase (MAPK) pathway provides a major link between the cell surface and nucleus to control proliferation and differentiation. However, its in vivo role in skeletal development is unknown. A transgenic approach was used to establish a role for this pathway in bone. MAPK stimulation achieved by selective expression of constitutively active MAPK/ERK1 (MEK-SP) in osteoblasts accelerated in vitro differentiation of calvarial cells, as well as in vivo bone development, whereas dominant-negative MEK1 was inhibitory. The involvement of the RUNX2 transcription factor in this response was established in two ways: (a) RUNX2 phosphorylation and transcriptional activity were elevated in calvarial osteoblasts from TgMek-sp mice and reduced in cells from TgMek-dn mice, and (b) crossing TgMek-sp mice with Runx2+/− animals partially rescued the hypomorphic clavicles and undemineralized calvaria associated with Runx2 haploinsufficiency, whereas TgMek-dn; Runx2+/− mice had a more severe skeletal phenotype. This work establishes an important in vivo function for the ERK–MAPK pathway in bone that involves stimulation of RUNX2 phosphorylation and transcriptional activity.
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Metadata
- Authors
- Ge, C., Xiao, G., Jiang, D., & Franceschi, R. T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-02-26
- Volume
- 176
- Issue
- 5
- Pages
- 709-718
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2108281583
- Cited by
- 507
- References
- 50
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- green
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