Formulation and in vitro Evaluation of pH-Sensitive Cross-linked Xanthan Gum-Grafted Acrylic Acid Copolymer for Controlled Delivery of Perindopril Erbumine (PE)
Abstract
A novel xanthan gum-co-acrylic acid superabsorbent hydrogel composite was formulated by free radical polymerization reaction of acrylic acid on xanthan gum. Effect of variables like dynamic swelling ratio, equilibrium swelling ratio, drug loading and drug release was investigated. Swelling ratio increases with decrease in crosslinker concentration. Drug release studies were conducted in pH 7.4 and 0.1N HCl. In acidic environment, drug release was low whereas it was sustained release in alkaline. XG4 showed significant swelling and drug release up to 24 hr. Physicochemical evaluation also confirmed it was optimized formulation. Hence XG4-co-AA was optimized for once daily dose of Perindopril Erbumine.
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The formulation retained its stability for three months under the prescribed conditions.
“it means the formulation retained its stability for three months under prescribed conditions as reported earlier for hydrogels (Ijaz et al., 2018;Ijaz et al., 2019)”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Ijaz et al., 2018
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- Authors
- Ijaz, H., Tulain, U. R., & Qureshi, J.
- Affiliations
- University of Sargodha (PK)
- Bahauddin Zakariya University (PK)
- Corresponding author
- Tulain, Ume Ruqia
- Venue
- Polymer-Plastics Technology and Engineering
- Publisher
- Informa UK Limited
- Published
- 2017-12-13
- Volume
- 57
- Issue
- 5
- Pages
- 459-470
- ISSN
- 0360-2559 (ISSN-L)
- 1525-6111
- OpenAlex
- W2619978610
- Cited by
- 24
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 3
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Polymer-Plastics Technology and Engineering (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Polymer-Based Agricultural Enhancements
- Keywords
- xanthan gum, acrylic acid, superabsorbent hydrogels, pH-responsive drug delivery, perindopril erbumine, polymer networks, sustained drug release, swelling ratio, drug loading, radical polymerization, composite hydrogels
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