The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Calcium, Dairy Products and Osteoporosis
Abstract
Osteoporosis is a multifactorial disorder in which nutrition plays a role but does not account for the totality of the problem. 139 papers published since 1975 and describing studies of the relationship of calcium intake and bone health are briefly analyzed. Of 52 investigator-controlled calcium intervention studies, all but two showed better bone balance at high intakes, or greater bone gain during growth, or reduced bone loss in the elderly, or reduced fracture risk. This evidence firmly establishes that high calcium intakes promote bone health. Additionally, three-fourths of 86 observational studies were also positive, indicating that the causal link established in investigator-controlled trials can be found in free-living subjects as well. The principal reason for failure to find an association in observational studies is the weakness of the methods available for estimating long-term calcium intake. While most of the investigator-controlled studies used calcium supplements, six used dairy sources of calcium; all were positive. Most of the observational studies were based on dairy calcium also, since at the time the studies were done, higher calcium intakes meant higher dairy intakes. All studies evaluating the issue reported substantial augmentation of the osteoprotective effect of estrogen by high calcium intakes. Discussion is provided in regard to the multifactorial complexity of osteoporotic response to interventions and to the perturbing effect in controlled trials of the bone remodeling transient, as well as about how inferences can validly be drawn from the various study types represented in this compilation.
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Citations
Cites
Risk Factors for Hip Fracture in White Women
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Heaney, R. P. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650091003 · Cited by 286 · cited 2×
“To determine whether or not it actually does, it is necessary to begin the measurement of rate of bone loss after the transient has fully expressed itself [163], not from start of treatment.”
BackgroundSelf-citationEvidence for efficacy of drugs affecting bone metabolism in preventing hip fracture.
Kanis, J. A., Johnell, O., Gullberg, B., Allander, E., Dilşen, G., Gennari, C., Lopes Vaz, A. A., Lyritis, G. P., Mazzuoli, G., & Miravet, L. (1992) · BMJ · doi:10.1136/bmj.305.6862.1124 · Cited by 285
Cited by
Sex Steroids and the Construction and Conservation of the Adult Skeleton
Riggs, B. L., Khosla, S., & Melton, L. J. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0465 · Cited by 1,846
The Bare Bones of Sex: Part 1—Sex and Gender
Fausto‐Sterling, A. (2005) · Signs: Journal of Women in Culture and Society · doi:10.1086/424932 · Cited by 437
Calcium supplementation in clinical practice: a review of forms, doses, and indications
Straub, D. A. (2007) · Nutrition in Clinical Practice · doi:10.1177/0115426507022003286 · Cited by 374
Feskanich, D., Willett, W. C., & Colditz, G. A. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.504 · Cited by 358
Osteoporosis: the role of micronutrients
Nieves, J. W. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.1232 · Cited by 343
Effects of caffeine on bone and the calcium economy
Heaney, R. P. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00094-7 · Cited by 211
Self-citationThe effects of dairy and dairy derivatives on the gut microbiota: a systematic literature review
Aslam, H., Marx, W., Rocks, T., Loughman, A., Chandrasekaran, V., Ruusunen, A., Dawson, S. L., West, M., Mullarkey, E., Pasco, J. A., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1799533 · Cited by 170
Nutritional management of lactose intolerance: the importance of diet and food labelling
Facioni, M. S., Raspini, B., Pivari, F., Dogliotti, E., & Cena, H. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02429-2 · Cited by 164
Osteoporosis prevention and nutrition
Tucker, K. L. (2009) · Current Osteoporosis Reports · doi:10.1007/s11914-009-0020-5 · Cited by 151
Houston, D. K., Stevens, J., Cai, J., & Haines, P. S. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.515 · Cited by 135
Zhu, K., & Prince, R. L. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0248-6 · Cited by 106
Estrogen Deficiency, Postmenopausal Osteoporosis, and Age-Related Bone Loss
Khosla, S., & Pacifici, R. (2013) · Osteoporosis · doi:10.1016/b978-0-12-415853-5.00046-7 · Cited by 31
Ayo-Yusuf, O., & Olutola, B. (2014) · Nigerian Journal of Clinical Practice · doi:10.4103/1119-3077.127542 · Cited by 27
Metadata
- Authors
- Heaney, R. P.
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2000-04
- Volume
- 19
- Issue
- sup2
- Pages
- 83S-99S
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W2097950610
- Cited by
- 619
- References
- 3
- FWCI
- 22.77
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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