The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Soy Isoflavones—Benefits and Risks from Nature’s Selective Estrogen Receptor Modulators (SERMs)
Abstract
Phytoestrogens have become one of the more topical areas of interest in clinical nutrition. These non-nutrient bioactive compounds are ubiquitous to the plant kingdom and possess a wide range of biological properties that contribute to the many different health-related benefits reported for soy foods and flaxseeds--two of the most abundant dietary sources of phytoestrogens. Reviewed is the recent knowledge related to their pharmacokinetics and clinical effects, focusing mainly on isoflavones that are found in high concentrations in soy foods. Arguments are made for considering soy isoflavones as natural selective estrogen receptor modulators (SERMs) based upon recent data of their conformational binding to estrogen receptors. Rebuttal is made to several key and important issues related to the recent concerns about the safety of soy and its constituent isoflavones. This article is not intended to be a comprehensive review of the literature but merely highlight recent research with key historical perspectives.
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Citations
Cites
Meta-Analysis of the Effects of Soy Protein Intake on Serum Lipids
Anderson, J. W., Johnstone, B. M., & Cook-Newell, M. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508033330502 · Cited by 2,048
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514267 · Cited by 1,216
Phytoestrogens. Friends or foes?
Barrett, J. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104478 · Cited by 68
Cited by
Setchell, K. D. R., Brown, N. M., & Lydeking-Olsen, E. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.12.3577 · Cited by 1,209
Self-citationMeta-analysis of the effects of soy protein containing isoflavones on the lipid profile
Zhan, S., & Ho, S. C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.397 · Cited by 499
Proposal for a dietary “phytochemical index”
McCarty, M. F. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2002.11.004 · Cited by 166
Kang, X., Zhang, Q., Wang, S., Huang, X., & Jin, S. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.091298 · Cited by 141
Wong, J. M. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.071639 · Cited by 84
Metadata
- Authors
- Setchell, K. D. R.
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2001-10
- Volume
- 20
- Issue
- sup5
- Pages
- 354S-362S
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W1971930482
- Cited by
- 354
- References
- 3
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Setchell, K. D. R. (2001). Soy Isoflavones—Benefits and Risks from Nature’s Selective Estrogen Receptor Modulators (SERMs). Journal of the American College of Nutrition. https://doi.org/10.1080/07315724.2001.10719168
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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