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Cited by 84Gut microbiota and healthNutritional Studies and DietMicrobial Metabolites in Food Biotechnology

Gut microbiota and cardiometabolic outcomes: influence of dietary patterns and their associated components

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Wong, Julia MW·2014·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.113.071639
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Abstract

Many dietary patterns have been associated with cardiometabolic risk reduction. A commonality between these dietary patterns is the emphasis on plant-based foods. Studies in individuals who consume vegetarian and vegan diets have shown a reduced risk of cardiovascular events and incidence of diabetes. Plant-based dietary patterns may promote a more favorable gut microbial profile. Such diets are high in dietary fiber and fermentable substrate (ie, nondigestible or undigested carbohydrates), which are sources of metabolic fuel for gut microbial fermentation and, in turn, result in end products that may be used by the host (eg, short-chain fatty acids). These end products may have direct or indirect effects on modulating the health of their host. Modulation of the gut microbiota is an area of growing interest, and it has been suggested to have the potential to reduce risk factors associated with chronic diseases. Examples of dietary components that alter the gut microbial composition include prebiotics and resistant starches. Emerging evidence also suggests a potential link between interindividual differences in the gut microbiota and variations in physiology or predisposition to certain chronic disease risk factors. Alterations in the gut microbiota may also stimulate certain populations and may assist in biotransformation of bioactive components found in plant foods. Strategies to modify microbial communities may therefore provide a novel approach in the treatment and management of chronic diseases.

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Authors
Wong, J. M.
Affiliations
Boston Children's Hospital (US)
Corresponding author
Wong, Julia MW
ORCID
Wong, Julia MW
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2014-07
Volume
100
Pages
369S-377S
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.113.071639
OpenAlex
W2103938780
Cited by
84
References
11
Citations by year
2026: 5 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 14 · 2016: 10 · 2015: 7 · 2014: 2
FWCI
4.49
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
gut microbiota, cardiometabolic risk, dietary habits, plant-based diet, vegetarian diet, vegan diet, dietary fiber, short-chain fatty acids, prebiotics, resistant starch, cardiovascular disease, diabetes mellitus, chronic disease prevention
MeSH terms
Cardiovascular Diseases, Diabetes Mellitus, Diet, Dietary Carbohydrates, Dietary Fiber, Fermentation, Humans, Diet, Vegetarian, Gastrointestinal Tract, Microbiota

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