Antiinflammatory activities of lactoferrin

Conneely, Orla M.

doi:10.1080/07315724.2001.10719173

Cited by 205Infant Nutrition and HealthAntimicrobial Peptides and ActivitiesImmune Response and Inflammation

Antiinflammatory activities of lactoferrin

Conneely, Orla M.·2001·Journal of the American College of Nutrition

DOI 10.1080/07315724.2001.10719173

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Abstract

Lactoferrin is a non-heme iron binding glycoprotein produced during lactation and by epithelial cells at mucosal surfaces. The protein is a prominent component of the first line of mammalian host defense and its expression is upregulated in response to inflammatory stimuli. In this paper, the antibacterial and immune modulatory properties of lactoferrin that contribute to host defense are reviewed. In addition, the results of recent preclinical and clinical studies demonstrating that lactoferrin acts as an inhibitor of dermal inflammatory cytokine production are summarized. The results indicate that lactoferrin may act as a potent anti-inflammatory protein at local sites of inflammation including the respiratory and gastrointestinal tracts.

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Authors: Conneely, O. M.
Affiliations: Baylor College of Medicine (US)
Corresponding author: Conneely, Orla M.
Venue: Journal of the American College of Nutrition
Publisher: Informa UK Limited
Published: 2001-10
Volume: 20
Issue: sup5
Pages: 389S-395S
ISSN: 0731-5724 (ISSN-L)
1541-1087
DOI: 10.1080/07315724.2001.10719173
OpenAlex: W2019081576
Cited by: 205
References: 84
Citations by year: 2026: 3 · 2025: 9 · 2024: 10 · 2023: 16 · 2022: 13 · 2021: 13 · 2020: 3 · 2019: 12 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 13
FWCI: 0.50
Type: journal article
Language: en
Open access: closed
Locations: Journal of the American College of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: lactoferrin, anti-inflammatory activity, host defense, antibacterial activity, immunomodulation, inflammatory cytokines, skin inflammation, respiratory tract, gastrointestinal tract, iron-binding glycoprotein, mucosal immunity
MeSH terms: Animals, Anti-Inflammatory Agents, Dermatitis, Gastrointestinal Diseases, Humans, Lactoferrin, Safety, Cytokines, Treatment Outcome, Immunity, Mucosal

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Antiinflammatory activities of lactoferrin

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