Effects of probiotic supplementation on oxidative stress indices in women with rheumatoid arthritis: a randomized double-blind clinical trial

Vaghef-Mehrabany, Elnaz; Homayouni-Rad, Aziz; Alipour, Beitullah; Sharif, Sakineh-Khatoun; Vaghef-Mehrabany, Leila; Alipour-Ajiry, Serour

doi:10.1080/07315724.2014.959208

Cited by 88Probiotics and Fermented FoodsAntioxidant Activity and Oxidative StressRheumatoid Arthritis Research and Therapies

Effects of probiotic supplementation on oxidative stress indices in women with rheumatoid arthritis: a randomized double-blind clinical trial

Vaghef-Mehrabany, Elnaz, Homayouni-Rad, Aziz, Alipour, Beitullah, Sharif, Sakineh-Khatoun, Vaghef-Mehrabany, Leila, Alipour-Ajiry, Serour·2016·Journal of the American College of Nutrition

DOI 10.1080/07315724.2014.959208

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Abstract

OBJECTIVE: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that causes great pain and disability and increasing oxidative stress in patients. The objective of the present study was to evaluate the effects of probiotics-live microorganisms with many health benefits, including antioxidant properties-on oxidative stress indices of patients with RA. This study is a secondary analysis from a previously published study Methods: In a randomized double-blind placebo-controlled clinical trial, 46 patients with RA were assigned to one of two groups; patients in the probiotic group received a daily capsule containing 10(8) colony forming units (CFUs) of Lactobacillus casei 01 (L. casei 01), while those in the placebo group took identical capsules containing maltodextrin, for 8 weeks. In the baseline and at the end of the study, anxiety, physical activity levels, and dietary intakes were assessed. Anthropometric parameters, serum malondialdehyde (MDA), total antioxidant capacity (TAC), erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities were measured. RESULTS: There was no significant difference between the two groups for demographic characteristics, anthropometric parameters, physical activity, anxiety levels, or dietary intakes, throughout the course of the study. No significant within- and between-group differences were observed for MDA, TAC, or CAT. SOD activity decreased only in the probiotic group and GPx activity decreased in both study groups (p < 0.05); however, no significant between-group difference was found for these enzymes activities at the end of the study (p > 0.05). CONCLUSION: No significant effect of L. casei 01 supplementation was observed on the oxidative status of patients with RA, compared to placebo.

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8 weeks consumption of capsules containing 108 CFU/g of L. casei by rheumatoid arthritis patients displayed no significant changes in MDA and TAC levels.
“Furthermore, 8 weeks consumption of capsules containing 108 CFU/g of L. casei by the people suffered from rheumatoid arthritis displayed no significant within- and between-group changes in MDA and TAC levels (Vaghef-Mehrabany et al., 2015).”
From Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016) · cites this paper as Vaghef-Mehrabany et al., 2015

[13] Catalase in vitro
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
Guidelines for data processing analysis of the International Physical Activity Questionnaire (IPAQ) - Short and long forms
Sjöström, M., Ainsworth, B., Bauman, A. E., Bull, F., Hamilton-Craig, C., & Sallis, J. F. (2005) · Cited by 1,403 · see citing works
Antioxidative Ability of Lactic Acid Bacteria
Lin, M., & Yen, C.-L. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981149l · Cited by 511 · see citing works
The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis
Tobón, G. J., Youinou, P., & Saraux, A. (2010) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.12.009 · Cited by 485 · see citing works
The microbiome and rheumatoid arthritis
Scher, J. U., & Abramson, S. B. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.121 · Cited by 479 · see citing works
Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases
Loguercio, C., Federico, A., Tuccillo, C., Terracciano, F., D’Auria, M. V., Simone, C. D., & Blanco, C. D. V. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000165671.25272.0f · Cited by 448 · see citing works
Markers of Oxidative Stress in Erythrocytes and Plasma During Aging in Humans
Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.1.10476 · Cited by 444 · see citing works
Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial
Mandel, D. R., Eichas, K., & Holmes, J. (2010) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-10-1 · Cited by 408 · see citing works
Antioxidative Effect of Intestinal Bacteria Bifidobacterium longum ATCC 15708 and Lactobacillus acidophilus ATCC 4356
Lin, M., & Chang, F.-J. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005577330695 · Cited by 384 · see citing works
Redox signalling and the inflammatory response in rheumatoid arthritis
Filippin, L. I., Vercelino, R., Marroni, N. P., & Xavier, R. M. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03634.x · Cited by 328 · see citing works
Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis
Vaghef‐Mehrabany, E., Alipour, B., Rad, A. H., Sharif, S., Jafarabadi, M. A., & Zavvari, S. (2013) · Nutrition · doi:10.1016/j.nut.2013.09.007 · Cited by 312 · see citing works
Self-citation
Antioxidative probiotic fermented goats' milk decreases oxidative stress-mediated atherogenicity in human subjects
Kullisaar, T., Songisepp, E., Mikelsaar, M., Zilmer, K., Vihalemm, T., & Zilmer, M. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003896 · Cited by 295 · see citing works
Antioxidative activities of soymilk fermented with lactic acid bacteria and bifidobacteria
Wang, Y.-C., Yu, R., & Chou, C. (2005) · Food Microbiology · doi:10.1016/j.fm.2005.01.020 · Cited by 278 · see citing works
Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis
Tayşi, S., Polat, F., Gül, M., Sari, R., & Bakan, E. (2001) · Rheumatology International · doi:10.1007/s00296-001-0163-x · Cited by 264 · see citing works
Antioxidant status in rheumatoid arthritis and role of antioxidant therapy
Jaswal, S., Mehta, H. C., Sood, A. K., & Kaur, J. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.08.011 · Cited by 251 · see citing works
Effect of a Probiotic Intake on Oxidant and Antioxidant Parameters in Plasma of Athletes During Intense Exercise Training
Martarelli, D., Verdenelli, M. C., Scuri, S., Cocchioni, M., Silvi, S., Cecchini, C., & Pompei, P. (2011) · Current Microbiology · doi:10.1007/s00284-011-9915-3 · Cited by 209 · see citing works
Alterations of the gut microbiota in high-fat diet mice is strongly linked to oxidative stress
Qiao, Y., Sun, J., Ding, Y., Le, G., & Shi, Y. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4323-6 · Cited by 206 · see citing works
Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis
Kamanlı, A., Nazıroğlu, M., Aydilek, N., & Hacıevlıyagil, C. (2003) · Cell Biochemistry and Function · doi:10.1002/cbf.1055 · Cited by 193 · see citing works
Antioxidant intake, plasma antioxidants and oxidative stress in a randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis
Hagfors, L. N., Leanderson, P., Sköldstam, L., Andersson, J., & Johansson, G. K. (2003) · Nutrition Journal · doi:10.1186/1475-2891-2-5 · Cited by 158 · see citing works
A comparative study of the preventative effects exerted by two probiotics,Lactobacillus reuteriandLactobacillus fermentum, in the trinitrobenzenesulfonic acid model of rat colitis
Perán, L., Sierra, S., Comalada, M., Lara‐Villoslada, F., Bailón, E., Nieto, A., Concha, Á., Olivares, M. M., Zarzuelo, A., Xaus, J., et al. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507257770 · Cited by 155 · see citing works
Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide.
Nunoshiba, T., & Demple, B. (1993) · PubMed · Cited by 151 · see citing works
Activation of the immune system and inflammatory activity in relation to markers of atherothrombotic disease and atherosclerosis in rheumatoid arthritis.
Wållberg‐Jonsson, S., Cvetkovic, J. T., Sundqvist, K., Lefvert, A. K., & Rantapää‐Dahlqvist, S. (2002) · PubMed · Cited by 142 · see citing works
Probiotics Prevent Intestinal Barrier Dysfunction in Acute Pancreatitis in Rats via Induction of Ileal Mucosal Glutathione Biosynthesis
Lutgendorff, F., Nijmeijer, R. M., Sandström, P., Trulsson, L. M., Magnusson, K., Timmerman, H. M., van Minnen, L. P., Rijkers, G. T., Gooszen, H. G., Akkermans, L. M. A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004512 · Cited by 129 · see citing works
The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phosphate in the pathogenesis of rheumatoid arthritis
Kalpakcioglu, B. B., & Şenel, K. (2007) · Clinical Rheumatology · doi:10.1007/s10067-007-0746-3 · Cited by 127 · see citing works
Antioxidative activity of lactic acid bacteria in yogurt
Zhang, S. (2011) · African Journal of Microbiology Research · doi:10.5897/ajmr11.997 · Cited by 122 · see citing works
Faecal microbial flora and disease activity in rheumatoid arthritis during a vegan diet
Peltonen, R., Nenonen, M., Helve, T., Hänninen, O., Toivanen, P., & Eerola, E. (1997) · Lara D. Veeken · doi:10.1093/rheumatology/36.1.64 · Cited by 121 · see citing works
A comparative study of the preventative effects exerted by three probiotics,Bifidobacterium lactis,Lactobacillus caseiandLactobacillus acidophilus, in the TNBS model of rat colitis
Perán, L., Camuesco, D., Comalada, M., Bailón, E., Henriksson, A., Xaus, J., Zarzuelo, A., & Gálvez, J. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03302.x · Cited by 118 · see citing works
Antiproliferative and anticytotoxic effects of cell fractions and exopolysaccharides from Lactobacillus casei 01
Liu, C., Chu, F.-J., Chou, C., & Yu, R. (2011) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2011.01.005 · Cited by 116 · see citing works
Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis
Lutgendorff, F., Trulsson, L. M., van Minnen, L. P., Rijkers, G. T., Timmerman, H. M., Franzén, L., Gooszen, H. G., Akkermans, L. M. A., Söderholm, J. D., & Sandström, P. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00603.2007 · Cited by 116 · see citing works
Investigation of protein oxidation and lipid peroxidation in patients with rheumatoid arthritis
Başkol, G., Demir, H., Başkol, M., Kılıç, E., Ates, F., Karakükçü, Ç., & Üstdal, M. (2005) · Cell Biochemistry and Function · doi:10.1002/cbf.1257 · Cited by 95 · see citing works
Inadequate Antioxidant Nutrient Intake and Altered Plasma Antioxidant Status of Rheumatoid Arthritis Patients
Bae, S., Kim, S. J., & Sung, M. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719309 · Cited by 92 · see citing works
Assessment of paraoxonase 1 activity and malondialdehyde levels in patients with rheumatoid arthritis
Başkol, G., Demir, H., Başkol, M., Kılıç, E., Ates, F., Koçer, D., & Muhtaroğlu, S. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2005.06.010 · Cited by 92 · see citing works
INTESTINAL FLORA IN EARLY RHEUMATOID ARTHRITIS
Eerola, E., Möttönen, T. T., Hannonen, P., Luukkainen, R., Kantola, I. M., Vuori, K., Tuominen, J., & Toivanen, P. (1994) · Lara D. Veeken · doi:10.1093/rheumatology/33.11.1030 · Cited by 90 · see citing works
Lactobacillus casei and Lactobacillus acidophilus Regulate Inflammatory Pathway and Improve Antioxidant Status in Collagen-Induced Arthritic Rats
Amdekar, S., Singh, V. K., Kumar, A., Sharma, P., & Singh, R. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0034 · Cited by 87 · see citing works
Effect of Daily Consumption of Probiotic Yogurt on Oxidative Stress in Pregnant Women: A Randomized Controlled Clinical Trial
Asemi, Z., Jazayeri, S., Najafi, M., Samimi, M., Mofid, V., Shidfar, F., Shakeri, H., & Esmaillzadeh, A. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000335468 · Cited by 73 · see citing works
Do probiotics act more efficiently in foods than in supplements?
Rad, A. H., Mehrabany, E. V., Alipour, B., Vaghef‐Mehrabany, L., & Javadi, M. (2012) · Nutrition · doi:10.1016/j.nut.2012.01.012 · Cited by 65 · see citing works
Self-citation
Antioxidative and hypocholesterolemic effect ofLactobacillus caseisspcasei(biodefensive properties of lactobacilli)
Kapila, S., Vibha, & Sinha, P. (2006) · Indian Journal of Medical Sciences · doi:10.4103/0019-5359.27220 · Cited by 63 · see citing works
INCREASED BACTERIAL UREASE ACTIVITY IN FAECES IN JUVENILE CHRONIC ARTHRITIS: EVIDENCE OF ALTERED INTESTINAL MICROFLORA?
Malin, M., VERRONEN, P., Mykkänen, H. M., Salminen, S., & Isolauri, E. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.7.689 · Cited by 54 · see citing works
Increasing Antioxidant Activity of Procyanidin Extracts from the Pericarp of Litchi chinensis Processing Waste by Two Probiotic Bacteria Bioconversions
Li, S., Chen, L., Yang, T., Wu, Q., Lv, Z., Xie, B., & Sun, Z. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf305213e · Cited by 53 · see citing works
Rheumatoid arthritis: how well do the theories fit the evidence?
McCulloch, J., Lydyard, P. M., & Rook, G. A. W. (1993) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1993.tb05938.x · Cited by 47 · see citing works
Sensitive and selective determination of glutathione in probiotic bacteria by capillary electrophoresis–laser induced fluorescence
Musenga, A., Mandrioli, R., Bonifazi, P., Kenndler, E., Pompei, A., & Raggi, M. A. (2007) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-006-0980-6 · Cited by 47 · see citing works
The Effect of Daily Consumption of Probiotic and Conventional Yoghurt on Oxidant and Antioxidant Parameters in Plasma of Young Healthy Women
Fabian, & Elmadfa (2007) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.77.2.79 · Cited by 44 · see citing works
Beta-Carotene, Vitamin E, MDA, Glutathione Reductase and Arylesterase Activity Levels in Patients with Active Rheumatoid Arthritis.
Aryaeian, N., Djalali, M., Shahram, F., Jazayeri, S., Chamari, M., & Nazari, S. (2011) · Europe PMC (PubMed Central) · Cited by 31 · see citing works
ACID AND BILE TOLERANCE, ADHESION TO EPITHELIAL CELLS OF PROBIOTIC MICROORGANISMS
Both, E., György, É., Szabó, C. Z. K., Tamás, É., Ábrahám, B., & Lányi, S. (2010) · Cited by 25 · see citing works
Elaboration of method for approach of food's monitoring of chemical safety results in real time.
Литвинова, О. С., Vereshchagin, A. I., & Mikhaylov, N. A. (2009) · Voprosy Pitaniya · Cited by 25 · see citing works
A standard quantitative method to measure acid tolerance of probiotic cells
Chan, E., Lee, P.-P., Pogaku, R., Krishnaiah, K., & Voo, W.-P. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2384-y · Cited by 18 · see citing works
Rheumatoid Arthritis - Etiology, Consequences and Co-Morbidities
LEMMEY, A. B. (2012) · InTech eBooks · doi:10.5772/1303 · Cited by 16 · see citing works
Rheumatoid Arthritis: A Historical and Biopsychosocial Perspective
Zyrianova, Y. (2012) · InTech eBooks · doi:10.5772/26138 · Cited by 7 · see citing works

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Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial
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Gioia, C., Lucchino, B., Tarsitano, M. G., Iannuccelli, C., & Franco, M. D. (2020) · Nutrients · doi:10.3390/nu12051456 · Cited by 303 · see citing works
“Other studies, focusing mainly on metabolic changes associated with probiotics use, did not observe improvement in serum lipids or in oxidative status in RA patients after daily supplementation of Lactobacillus casei 01 [200,201].”
Background
Oxidative Stress in Rheumatoid Arthritis: What the Future Might Hold regarding Novel Biomarkers and Add-On Therapies
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“Accordingly, serum levels of MDA, a marker of lipid peroxidation, have been described as presenting positive correlation with proinflammatory cytokines in RA [28], with reactive oxygen metabolites (ROM) in blood samples also found to be increased in patients with RA and positively correlated with disease activity [61].”
Background
Expression of Concern: Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double‐blind, placebo‐controlled trial
Zamani, B., Golkar, H. R., Farshbaf, S., Emadi‐Baygi, M., Ebrahimi, M. T., Jafari, P., Akhavan, R., Taghizadeh, M., Memarzadeh, M. R., & Asemi, Z. (2016) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12888 · Cited by 220 · see citing works
Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects
Soleimani, A., Mojarrad, M. Z., Bahmani, F., Taghizadeh, M., Ramezani, M., Ebrahimi, M. T., Jafari, P., Esmaillzadeh, A., & Asemi, Z. (2016) · Kidney International · doi:10.1016/j.kint.2016.09.040 · Cited by 215 · see citing works
Effects of prebiotic dietary fibers and probiotics on human health: With special focus on recent advancement in their encapsulated formulations
Shah, B. R., Li, B., Sabbah, H. A., Xu, W., & Mráz, J. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.06.010 · Cited by 138 · see citing works
RETRACTED ARTICLE: The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes
Badehnoosh, B., Karamali, M., Zarrati, M., Jamilian, M., Bahmani, F., Ebrahimi, M. T., Jafari, P., Rahmani, E., & Asemi, Z. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1310193 · Cited by 131 · see citing works
“However, no significant change in MDA and TAC levels was seen following the consumption of capsule containing 10 8 CFU/g of Lactobacillus casei among RA patients for 8 weeks [40].”
Background
Retracted
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Kazemi, A., Soltani, S., Ghorabi, S., Keshtkar, A., Daneshzad, E., Nasri, F., & Mazloomi, S. M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2019.04.004 · Cited by 131 · see citing works
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“Probiotics may be highly beneficial if you have inflammatory arthritis [38,39].”
Background
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Khanna, S., Jaiswal, K. S., & Gupta, B. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00052 · Cited by 127 · see citing works
“(62) Diet group—22 patients—108 CFU of L.”
Background
The effects of probiotic supplementation on metabolic status in type 2 diabetic patients with coronary heart disease
Raygan, F., Rezavandi, Z., Bahmani, F., Ostadmohammadi, V., Mansournia, M. A., Ebrahimi, M. T., Borzabadi, S., & Asemi, Z. (2018) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0353-2 · Cited by 117 · see citing works
“On the other hand, no significant changes in MDA and TAC levels were found following probiotic capsule supplementation containing Lactobacillus casei (108 CFU/g) for 8 weeks in patients with rheumatoid arthritis [34].”
Background
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Mititelu, R. R., Pădureanu, R., Bacanoiu, M. V., Pădureanu, V., Docea, A. O., Călina, D. C., Bărbulescu, A. L., & Bugă, A. M. (2020) · Biomedicines · doi:10.3390/biomedicines8050125 · Cited by 110 · see citing works
The therapeutic effect of probiotics on rheumatoid arthritis: a systematic review and meta-analysis of randomized control trials
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“[52] report insignificant differences in CAT activity and reduced GPx and SOD activity in the Lactobacillus casei 01 group.”
Background
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“In another study, Lactobacillus casei 01 demonstrated no significant impact on the oxidative status in patients with RA characterized by serum malondialdehyde, total antioxidant capacity, erythrocyte superoxide dismutase, and catalase [49].”
Background
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Cannarella, L. A. T., Mari, N. L., de Alcantara, C. C., Iryioda, T. M. V., Costa, N. T., Oliveira, S. R., Lozovoy, M. A. B., Reiche, E. M. V., Dichi, I., & Simão, A. N. C. (2021) · Nutrition · doi:10.1016/j.nut.2021.111282 · Cited by 79 · see citing works
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“casei among patients with RA for 8 weeks was observed((48)).”
Background
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“(80) found no significant changes after 8 weeks of treatment with Lactobacillus casei (L.”
Background
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Heshmati, J., Farsi, F., Shokri, F., Rezaeinejad, M., Almasi‐Hashiani, A., Vesali, S., & Sepidarkish, M. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.049 · Cited by 74 · see citing works
The efficacy of probiotic supplementation in rheumatoid arthritis: a meta-analysis of randomized, controlled trials
Aqaeinezhad Rudbane, S. M., Rahmdel, S., Abdollahzadeh, S. M., Zare, M., Bazrafshan, A., & Mazloomi, S. M. (2018) · Inflammopharmacology · doi:10.1007/s10787-017-0436-y · Cited by 69 · see citing works
Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus
Paul, A. K., Paul, A., Jahan, R., Jannat, K., Bondhon, T. A., Hasan, A., Nissapatorn, V., Pereira, M. D. L., Wilairatana, P., & Rahmatullah, M. (2021) · Microorganisms · doi:10.3390/microorganisms9051070 · Cited by 71 · see citing works
“casei administered over eight weeks did not change the oxidative stress indicators or lipid profiles of RA patients [133,134].”
Background
Efficacy and safety of gut microbiota-based therapies in autoimmune and rheumatic diseases: a systematic review and meta-analysis of 80 randomized controlled trials
Zeng, L., Yang, K., He, Q., Zhu, X., Long, Z., Wu, Y., Chen, J., Li, Y., Zeng, J., Cui, G., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03303-4 · Cited by 70 · see citing works
“The other two trials were recorded as Oscarsson et al. [40, 41], Roman et al. [72, 73], and Kragelund [88, 89], and the other three trials were recorded as Alipour et al. [51–53] for the same reason.”
Result
Nutraceuticals against Oxidative Stress in Autoimmune Disorders
Mannucci, C., Casciaro, M., Sorbara, E. E., Calapai, F., Salvo, E. D., Pioggia, G., Navarra, M., Calapai, G., & Gangemi, S. (2021) · Antioxidants · doi:10.3390/antiox10020261 · Cited by 64 · see citing works
“casei supplementation on the oxidative status of patients with RA were observed [64].”
Background
The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials
Pourrajab, B., Fatahi, S., Sohouli, M. H., Găman, M.-A., & Shidfar, F. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1821166 · Cited by 82 · see citing works
The Effects of Synbiotic Supplementation on Pregnancy Outcomes in Gestational Diabetes
Karamali, M., Nasiri, N., Shavazi, N. T., Jamilian, M., Bahmani, F., Ebrahimi, M. T., & Asemi, Z. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9313-7 · Cited by 65 · see citing works
“casei supplementation for 8 weeks was seen on parameters of oxidative stress of subjects with RA [37].”
Background
Effect of L. acidophilus and B. lactis on blood glucose in women with gestational diabetes mellitus: a randomized placebo-controlled trial
Ebrahimi, F. S., Rad, A. H., Mosen, M., Abbasalizadeh, F., Tabrizi, A., & Khalili, L. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0471-5 · Cited by 61 · see citing works
Is There a Role for Diet in the Therapy of Rheumatoid Arthritis?
Tedeschi, S. K., & Costenbader, K. H. (2016) · Current Rheumatology Reports · doi:10.1007/s11926-016-0575-y · Cited by 57 · see citing works
Probiotic supplementation attenuates hippocampus injury and spatial learning and memory impairments in a cerebral hypoperfusion mouse model
Rahmati, H., Momenabadi, S., Vafaei, A. A., Bandegi, A. R., Mazaheri, Z., & Vakili, A. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04949-7 · Cited by 55 · see citing works
Inflammation and ROS in arthritis: management by Ayurvedic medicinal plants
Prasad, S., Kulshreshtha, A., Lall, R., & Gupta, S. C. (2021) · Food & Function · doi:10.1039/d1fo01078f · Cited by 54 · see citing works
Safety and efficacy of probiotic supplementation in 8 types of inflammatory arthritis: A systematic review and meta-analysis of 34 randomized controlled trials
Zeng, L., Deng, Y., He, Q., Yang, K., Li, J., Wang, X., Liu, H., Zhu, X., & Chen, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.961325 · Cited by 53 · see citing works
Selenium and Autoimmune Diseases: A Review Article
Sahebari, M., Rezaieyazdi, Z., & Khodashahi, M. (2018) · Current Rheumatology Reviews · doi:10.2174/1573397114666181016112342 · Cited by 51 · see citing works
Effects of probiotics and synbiotic supplementation on antioxidant status: A meta-analysis of randomized clinical trials
Roshan, H., Ghaedi, E., Rahmani, J., Barati, M., Najafi, M., Karimzedeh, M., & Nikpayam, O. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.02.003 · Cited by 52 · see citing works
Daily consumption effects of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 on oxidative stress in metabolic syndrome patients
Rezazadeh, L., Alipour, B., Jafarabadi, M. A., Behrooz, M., & Gargari, B. P. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.12.003 · Cited by 47 · see citing works
Self-citation
Does propolis have any effect on rheumatoid arthritis? A review study
Nattagh‐Eshtivani, E., Pahlavani, N., Ranjbar, G., Navashenaq, J. G., Salehi‐Sahlabadi, A., Mahmudiono, T., Shalaby, M. N., Jokar, M. H., Nematy, M., Barghchi, H., et al. (2022) · Food Science & Nutrition · doi:10.1002/fsn3.2684 · Cited by 47 · see citing works
Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation
Martemucci, G., Portincasa, P., Centonze, V., Mariano, M., Khalil, M., & D‘Alessandro, A. G. (2022) · Medicinal Chemistry · doi:10.2174/1573406419666221130162512 · Cited by 44 · see citing works
Prebiotics, Prosynbiotics and Synbiotics: Can They Reduce Plasma Oxidative Stress Parameters? A Systematic Review
Salehi‐Abargouei, A., Ghiasvand, R., & Hariri, M. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-016-9248-4 · Cited by 42 · see citing works
The Effects of Supplementation with Probiotic on Biomarkers of Oxidative Stress in Adult Subjects: a Systematic Review and Meta-analysis of Randomized Trials
Zamani, B., Sheikhi, A., Namazi, N., Larijani, B. A., & Azadbakht, L. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9500-1 · Cited by 42 · see citing works
Rheumatoid arthritis and the intestinal microbiome: probiotics as a potential therapy
Yang, Y., Hong, Q., Zhang, X., & Liu, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331486 · Cited by 40 · see citing works
Effects of Biological Therapies on Molecular Features of Rheumatoid Arthritis
López-Pedrera, C., Barbarroja, N., Patiño-Trives, A. M., Luque-Tévar, M., Collantes‐Estévez, E., Escudero‐Contreras, A., & Pérez‐Sánchez, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239067 · Cited by 42 · see citing works
“Thus, it was described that serum LPO levels are positively correlated with pro-inflammatory cytokines in RA [60].”
Background
Oral–Gut Microbiota, Periodontal Diseases, and Arthritis: Literature Overview on the Role of Probiotics
Ferrillo, M., Giudice, A., Migliario, M., Renò, F., Lippi, L., Calafiore, D., Marotta, N., de Sire, R., Fortunato, L., Ammendolia, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054626 · Cited by 37 · see citing works
Influence of Synbiotics on Selected Oxidative Stress Parameters
Kleniewska, P., & Pawliczak, R. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9315375 · Cited by 37 · see citing works
“However, several studies [11, 30] have shown no significant differences in MDA concentrations after the probiotics application in humans.”
Background
The effect of probiotics on gestational diabetes and its complications in pregnant mother and newborn: A systematic review and meta‐analysis during 2010–2020
Ari, M. M., Teymouri, S., Fazlalian, T., Asadollahi, P., Afifirad, R., Sabaghan, M., Valizadeh, F., Ghanavati, R., & Darbandi, A. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24326 · Cited by 37 · see citing works
Effect of synbiotics and probiotics supplementation on autoimmune diseases: A systematic review and meta-analysis of clinical trials
Askari, G., Ghavami, A., Shahdadian, F., & Moravejolahkami, A. R. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.02.015 · Cited by 36 · see citing works
Relationship between diet and ankylosing spondylitis: A systematic review
Macfarlane, T. V., Abbood, H. M., Pathan, E., Gordon, K., Hinz, J., & Macfarlane, G. J. (2017) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2017.16103 · Cited by 35 · see citing works
Modification of Gut Microbiota in Inflammatory Arthritis: Highlights and Future Challenges
Horta‐Baas, G., Sandoval-Cabrera, A., & Romero‐Figueroa, M. D. S. (2021) · Current Rheumatology Reports · doi:10.1007/s11926-021-01031-9 · Cited by 33 · see citing works
Is butyrate a natural alternative to dexamethasone in the management of CoVID-19?
Kuriakose, N., Patil, P., Bhandary, S. K., Haridas, V. M., Kumari, S., Edachery, S., & Shetty, P. K. (2021) · F1000Research · doi:10.12688/f1000research.51786.1 · Cited by 30 · see citing works
The Use of Lactobacillus casei and Lactobacillus paracasei in Clinical Trials for the Improvement of Human Health
Jones, R. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804024-9.00009-4 · Cited by 30 · see citing works
Comparison of probiotic yogurt and ordinary yogurt consumption on serum Pentraxin3, NT-proBNP, oxLDL, and ApoB100 in patients with chronic heart failure: a randomized, triple-blind, controlled trial
Pourrajab, B., Naderi, N., Janani, L., Mofid, V., Hajahmadi, M., Dehnad, A., & Shidfar, F. (2020) · Food & Function · doi:10.1039/d0fo01014f · Cited by 25 · see citing works
The Efficacy of Antioxidative Stress Therapy on Oxidative Stress Levels in Rheumatoid Arthritis: A Systematic Review and Meta‐analysis of Randomized Controlled Trials
Zeng, L., Yu, G., Yang, K., Li, J., Hao, W., & Chen, H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3302886 · Cited by 24 · see citing works
Lactobacillus rhamnosus reduces CD8+T cell mediated inflammation in patients with rheumatoid arthritis
Tripathy, A., Swain, N., Padhan, P., Raghav, S. K., & Gupta, B. (2023) · Immunobiology · doi:10.1016/j.imbio.2023.152415 · Cited by 20 · see citing works
The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled clinical trial
Pourhabibi‐Zarandi, F., Rafraf, M., Zayeni, H., Jafarabadi, M. A., & Ebrahimi, A. (2024) · Phytotherapy Research · doi:10.1002/ptr.8225 · Cited by 20 · see citing works
Microbiota and arthritis
Bravo‐Blas, A., Wessel, H. M., & Milling, S. W. F. (2016) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000261 · Cited by 19 · see citing works
The effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine: A double‐blind, placebo‐controlled, randomized trial
Ghavami, A., Khorvash, F., Khalesi, S., Heidari, Z., & Askari, G. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104738 · Cited by 18 · see citing works
Effect of probiotic composition on oxidative/antioxidant balance in blood of rats under experimental osteoarthriti
Korotkyi, O., Dvorshchenko, K., Vovk, A., Dranitsina, A. S., Tymoshenko, M., Коt, L., & Остапченко, Л. І. (2019) · The Ukrainian Biochemical Journal · doi:10.15407/ubj91.06.049 · Cited by 18 · see citing works
“Moreover, the bacterial strains are active producers of physiologically active metabolites: vitamins, short-chain fatty acids, antioxidants and immunomodulators, which extends the spectrum of biological effects of PB compositions [58-60].”
Background
A multiple-strain probiotic product provides a better enzymatic antioxidant response in individuals with constipation in a double-blind randomized controlled trial
Araújo, A. D. M., Botelho, P. B., Ribeiro, D. J. S., Magalhães, K. G., Nakano, E. Y., & Arruda, S. F. (2021) · Nutrition · doi:10.1016/j.nut.2021.111225 · Cited by 17 · see citing works
Lactic Acid Bacteria: A Promising Tool for Menopausal Health Management in Women
Chen, Q., Wang, H., Wang, G., Zhao, J., Chen, H., Lu, X., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14214466 · Cited by 17 · see citing works
“casei 01 Clinical trials RA patients RA Decreased SOD and GPx activity [60] L.”
Background
Can Probiotic Supplements Improve Outcomes in Rheumatoid Arthritis?
Schorpion, A., & Kolasinski, S. L. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0696-y · Cited by 16 · see citing works
Oxidative Stress and Chronic Inflammation as Partners in Crime in Interstitial Cystitis/Bladder Pain Syndrome
Janev, A., Zupančič, D., Veranič, P., & Kuret, T. (2025) · Journal of Innate Immunity · doi:10.1159/000546901 · Cited by 14 · see citing works
Food-grade lactic acid bacteria and probiotics as a potential protective tool against erythrotoxic dietary xenobiotics
Cuevas-González, P. F., Peredo-Lovillo, A. G., Castro-López, C., Vallejo‐Córdoba, B., González-Córdova, A. F., Garcia, H. S., & Hernández‐Mendoza, A. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.09.004 · Cited by 14 · see citing works
Benefits of Probiotics in Rheumatic Diseases
Oliviero, F., & Spinella, P. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00157 · Cited by 14 · see citing works
New findings of oxidative stress biomarkers in nutritional research
Kochlik, B., Grune, T., & Weber, D. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000388 · Cited by 13 · see citing works
Exploring the Anti-Inflammatory and Antioxidative Potential of Selenium Nanoparticles Biosynthesized by Lactobacillus casei 393 on an Inflamed Caco-2 Cell Line
Sendani, A. A., Farmani, M., Jahankhani, K., Kazemifard, N., Ghavami, S. B., Houri, H., Ashrafi, F., & Sadeghi, A. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01356-z · Cited by 12 · see citing works
“Various lactobacilli have been identi ﬁ ed as agents that enhance the activity of antioxidant enzymes like catalase (CAT), SOD, and GPx [78, 79].”
Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach
Yu, X., Li, Y., Chen, L., Shen, X., & Zhang, W. (2025) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-025-00957-5 · Cited by 9 · see citing works
Oxidative Stress–Gut Microbiome Crosstalk: Intestinal Redox Imbalance and Probiotics Therapeutic Potential
Barakat, H., Sakr, S. S., Alfheeaid, H. A., Alsaleem, K. A., Alhomaid, R. M., El-Messery, T. M., Ebeid, T. A., & Abdul-Hafeez, E. Y. (2026) · Antioxidants · doi:10.3390/antiox15050533 · Cited by 9 · see citing works
“Gut–kidney axis modulation involves toxin clearance and reduced inflammation, thereby delaying CKD progression [104,105].”
The effect of propolis supplementation on inflammatory factors and oxidative status in women with rheumatoid arthritis: Design and research protocol of a double-blind, randomized controlled
Nattagh‐Eshtivani, E., Jokar, M. H., Tabesh, H., Nematy, M., Safarian, M., Pahlavani, N., Maddahi, M., & Khosravi, M. (2021) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2021.100807 · Cited by 9 · see citing works
Effects of the oral probiotics to control pain and stress disorders of cyclical mastalgia associated with fibrocystic breast changes; a randomised controlled trial
Davoodabadi, A., Rohani, S. H., & Hajian, A. (2021) · International Journal of Surgery Open · doi:10.1016/j.ijso.2021.100358 · Cited by 8 · see citing works
Impact of Gut Microbiota and Probiotics on Rheumatoid Arthritis: A Potential Treatment Challenge
Ajith, T. A., & Anita, B. B. (2025) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.70266 · Cited by 11 · see citing works
Gut microbiome and rheumatoid arthritis: Revisiting the gut-joint axis
Kapoor, B., & Gulati, M. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115503 · Cited by 7 · see citing works
The effects of seven-strain probiotic supplementation on cell adhesion molecules, oxidative stress and antioxidant parameters in patients with traumatic brain injury: a randomised controlled clinical trial
Noshadi, N., Sabet, S. S., Sanaie, S., Mahmoodpoor, A., Tutunchi, H., Naghshi, S., Arefhosseini, S. R., & Ebrahimi‐Mameghani, M. (2025) · British Journal Of Nutrition · doi:10.1017/s0007114524003234 · Cited by 4 · see citing works
Effects of Probiotics on Markers of Oxidative/Nitrosative Stress and Damage Associated with Inflammation in Non-communicable Diseases: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials
Silva, N. S., Cerdeira, C. D., dos Reis, T. M., & Junior, M. R. R. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10710-3 · Cited by 3 · see citing works
Review of Constipation Treatment Methods with Emphasis on Laxative Foods
Abbasalizadeh, S., Ebrahimi, B., Azizi, A., Dargahi, R., Tayebali, M., Ghadim, S. T., Foroumandi, E., Aliasghari, F., Javadi, M., Izadi, A., et al. (2019) · Current Nutrition & Food Science · doi:10.2174/1573401315666191002164336 · Cited by 3 · see citing works
Probiotic Supplementation Attenuates Polystyrene Nanoplastic-Induced Pancreatic Injury through Modulation of Oxidative Stress, Inflammation, and P2X7 Receptor/Caspase-1 Signaling Pathway in Rats
Erbaş, E., Üstündağ, H., Gedikli, S., Gelen, V., Parlak, S. N., Çelebi, D., & Kara, A. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11091-x · Cited by 2 · see citing works
Effects of Probiotics on Markers of Oxidative/Nitrosative Stress and Damage Associated with Inflammation in Non-Communicable Diseases: a Systematic Review and Meta-Analysis of Randomized Placebo-Controlled TrialsPreprint
Silva, N. S., Cerdeira, C. D., dos Reis, T. M., & Rodrigues, M. R. (2025) · Research Square · doi:10.21203/rs.3.rs-5791482/v1 · Cited by 2 · see citing works
The Effects of Different Probiotic Administration on Dexamethasone-Associated Metabolic Effects
Inceu, A.-I., Neag, M. A., Bocșan, I. C., Craciun, A. E., Melincovici, C. S., Muntean, D. M., Militaru, F. C., Onofrei, M. M., Pop, R. M., Gherman, L.-M., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13040739 · Cited by 1 · see citing works
“…observed in a double-blind placebo-controlled clinical trial of patients with rheumatoid arthritis who received Lactobacillus casei 01 probiotics [43]; however, different LP strains showed antioxidant properties in both in vitro and in vivo studies, suggesting that the obtained results could be…”
A Novel Combination of Probiotic Supplements Reduces Gut Permeability, Oxidative Stress, and Inflammation in Undernourished Adults: A Randomized Controlled Trial
Ahmadi‐Khorram, M., Hatami, A., Eskandari, M. H., Afshari, A., Esfehani, A. J., Asghari, P., Nattagh‐Eshtivani, E., & Nematy, M. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71915 · Cited by 1 · see citing works
Modulation of neurotransmitter signaling along the Microbiota–Gut–Brain Axis by prebiotics, probiotics and synbiotics in peptic ulcerative rats
Doghaither, H. A. A., & Khalifa, F. K. (2023) · Medical Science · doi:10.54905/disssi/v27i135/e218ms3018 · Cited by 1 · see citing works
“…of selected Pro bacteria and Pre (with potentially synergistic effects), has been demonstrated to have health benefits, such as immune system regulation and anti-inflammatory (Kazemi et al., 2020), anti-depressant (Vaghef-Mehrabany et al., 2016) and antioxidant effects (Zheng et al., 2019).”
PROBIOTICS IN RHEUMATIC DISEASES: A SYSTEMATIC REVIEW
Гонсалвеш, К., Маседо, Х., Фернандеш, Л., Churilov, L. P., & Карвалью, Ж. Ф. Д. (2023) · Russian Biomedical Research · doi:10.56871/rbr.2023.39.42.011 · Cited by 1 · see citing works
The Challenges of Local Intra-Articular Therapy
Kirdaitė, G., Denkovskij, J., Mieliauskaitė, D., Pachaleva, J., & Bernotienė, E. (2024) · Medicina · doi:10.3390/medicina60111819 · Cited by 1 · see citing works
“Based on previous studies, a positive correlation between lipid peroxidation biomarker malondialdehyde (MDA) and proinflammatory cytokines has been observed in the serum of individuals with RA [129].”
Probiotics against Oxidative Stress
Naji, P., Parvini, F., & Fard, M. A. F. (2024) · Biochemistry · doi:10.5772/intechopen.1005325
Exploring the Potential of Probiotics and Gut Microbiota Modulation in the Management of Rheumatoid Arthritis: A Review of Current Mechanisms and Therapeutic Strategies
Gojare, S. A., Aher, P., Lokhande, R., Game, N., & Khamkar, P. N. (2026) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v16i3.7639
Recent insights into the protective effects of lactic acid bacteria on rheumatoid arthritis
Chen, Y., Long, B., Li, X., Lan, Y., Mu, Y., Wang, C. R., Xia, L., Wang, Q., Gao, J., Peng, M., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108222
Effects of synbiotic supplementation on oxidative stress biomarkers in adults: an updated GRADE-assessed systematic review and meta-analysis of randomized controlled trials
Bideshki, M. V., Nojoumi, M., Behzadi, M., Arefinia, N., Askarpour, H., Sohrabi, Z., Esmailian, M., & Ali‐Hassanzadeh, M. (2026) · Genes & Nutrition · doi:10.1186/s12263-026-00809-9
“Specific strains, such as Lactobacillus casei , Lactobacillus fermentum [83, 84], Bifidobacterium , and Lactococcus , elevate SOD activity and GSH production [85, 86].”
The Effect of Synbiotic Supplementation on Malondialdehyde Levels in Adolescents Exposed to Air Pollution: A Randomized, Single-Blind, Controlled Clinical Trial
Kelishadi, R., Zarean, M., Najafabadi, A. M., Yazdi, M., Poursafa, P., & Heidari‐Beni, M. (2026) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_246_25
“[9,10] Exposure to air pollution might increase MDA levels.”

Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis
Cannarella, L. A. T., Mari, N. L., de Alcantara, C. C., Iryioda, T. M. V., Costa, N. T., Oliveira, S. R., Lozovoy, M. A. B., Reiche, E. M. V., Dichi, I., & Simão, A. N. C. (2021) · Nutrition · doi:10.1016/j.nut.2021.111282 · Cited by 79 · see citing works
Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis
Vaghef‐Mehrabany, E., Alipour, B., Rad, A. H., Sharif, S., Jafarabadi, M. A., & Zavvari, S. (2013) · Nutrition · doi:10.1016/j.nut.2013.09.007 · Cited by 312 · see citing works
Self-citation
The efficacy of probiotic supplementation in rheumatoid arthritis: a meta-analysis of randomized, controlled trials
Aqaeinezhad Rudbane, S. M., Rahmdel, S., Abdollahzadeh, S. M., Zare, M., Bazrafshan, A., & Mazloomi, S. M. (2018) · Inflammopharmacology · doi:10.1007/s10787-017-0436-y · Cited by 69 · see citing works
Effect of probiotic supplementation on disease activity in rheumatoid arthritis patients
Khalifa, A. A., Hany, S. M., Morshedy, N. A., & Elsayed, A. M. (2025) · The Egyptian Rheumatologist · doi:10.1016/j.ejr.2025.04.009 · Cited by 2 · see citing works
Expression of Concern: Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double‐blind, placebo‐controlled trial
Zamani, B., Golkar, H. R., Farshbaf, S., Emadi‐Baygi, M., Ebrahimi, M. T., Jafari, P., Akhavan, R., Taghizadeh, M., Memarzadeh, M. R., & Asemi, Z. (2016) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12888 · Cited by 220 · see citing works

Authors: Vaghef-Mehrabany, E., Homayouni-Rad, A., Alipour, B., Sharif, S.-K., Vaghef-Mehrabany, L., & Alipour-Ajiry, S.
Affiliations: Tabriz University of Medical Sciences (IR)
Corresponding author: Alipour, Beitullah
ORCID: Alipour, Beitullah
Sharif, Sakineh-Khatoun
Venue: Journal of the American College of Nutrition
Publisher: Informa UK Limited
Published: 2015-04-09
Volume: 35
Issue: 4
Pages: 291-299
ISSN: 0731-5724 (ISSN-L)
1541-1087
DOI: 10.1080/07315724.2014.959208
OpenAlex: W2026020979
Cited by: 88
References: 48
Citations by year: 2026: 7 · 2025: 8 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 16 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 11 · 2016: 6
FWCI: 9.81
Type: journal article
Language: en
Open access: closed
Locations: Journal of the American College of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: rheumatoid arthritis, probiotics, Lactobacillus casei, oxidative stress, antioxidant enzymes, malondialdehyde, superoxide dismutase, glutathione peroxidase, catalase, total antioxidant capacity, women
MeSH terms: Adult, Aged, Aged, 80 and over, Antioxidants, Arthritis, Rheumatoid, Catalase, Double-Blind Method, Female, Glutathione Peroxidase, Humans, Lacticaseibacillus casei, Malondialdehyde, Middle Aged, Placebos, Superoxide Dismutase, Oxidative Stress, Probiotics

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Effects of probiotic supplementation on oxidative stress indices in women with rheumatoid arthritis: a randomized double-blind clinical trial

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