Cited by 293SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesAnimal Virus Infections Studies

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A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

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Hasan, Anwarul, Paray, Bilal Ahamad, Hussain, Arif, Qadir, Fikry Ali, Attar, Farnoosh, Aziz, Falah Mohammad, Sharifi, Majid, Derakhshankhah, Hossein, Rasti, Behnam, Mehrabi, Masoumeh, Shahpasand, Koorosh, Saboury, Ali Akbar, Falahati, Mojtaba·2021·Journal of Biomolecular Structure and Dynamics

DOI 10.1080/07391102.2020.1754293PMC PMC7189411

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Abstract

The widespread antigenic changes lead to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically different from the previous circulating species. Angiotensin-converting enzyme-2 (ACE-2) is one of the most important receptors on the cell membrane of the host cells (HCs) which its interaction with spike protein (SP) with a furin-cleavage site results in the SARS-CoV-2 invasion. Hence, in this review, we presented an overview on the interaction of ACE-2 and furin with SP. As several kinds of CoVs, from various genera, have at their S1/S2 binding site a preserved site, we further surveyed the role of furin cleavage site (FCS) on the life cycle of the CoV. Furthermore, we discussed that the small molecular inhibitors can limit the interaction of ACE-2 and furin with SP and can be used as potential therapeutic platforms to combat the spreading CoV epidemic. Finally, some ongoing challenges and future prospects for the development of potential drugs to promote targeting specific activities of the CoV were reviewed. In conclusion, this review may pave the way for providing useful information about different compounds involved in improving the effectiveness of CoV vaccine or drugs with minimum toxicity against human health.Communicated by Ramaswamy H. Sarma.

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Authors: Hasan, A., Paray, B. A., Hussain, A., Qadir, F. A., Attar, F., Aziz, F. M., Sharifi, M., Derakhshankhah, H., Rasti, B., Mehrabi, M., Shahpasand, K., Saboury, A. A., & Falahati, M.
Affiliations: Qatar University (QA)
King Saud University (SA)
Manipal Academy of Higher Education, Dubai (AE)
Salahaddin University-Erbil (IQ)
Standard Research Institute (IR)
Islamic Azad University, Tehran (IR)
Kermanshah University of Medical Sciences (IR)
Islamic Azad University, Lahijan Branch (IR)
Royan Institute (IR)
University of Tehran (IR)
Corresponding author: Hasan, Anwarul
Falahati, Mojtaba
ORCID: Hasan, Anwarul
Hussain, Arif
Qadir, Fikry Ali
Sharifi, Majid
Derakhshankhah, Hossein
Rasti, Behnam
Shahpasand, Koorosh
Saboury, Ali Akbar
Falahati, Mojtaba
Venue: Journal of Biomolecular Structure and Dynamics
Publisher: Informa UK Limited
Published: 2020-04-22
Volume: 39
Issue: 8
Pages: 3025-3033
ISSN: 0739-1102 (ISSN-L)
1538-0254
DOI: 10.1080/07391102.2020.1754293
PMC: PMC7189411
OpenAlex: W3015385976
Cited by: 293
References: 84
Citations by year: 2026: 3 · 2025: 9 · 2024: 18 · 2023: 24 · 2022: 40 · 2021: 83 · 2020: 115
FWCI: 3.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Biomolecular Structure and Dynamics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Qatar University QSpace (Qatar University) (submittedVersion)
Funders: Qatar Foundation (GCC-2017-005, NPRP10-120-170-211)
Fonds National de la Recherche Luxembourg
Qatar University (GCC-2017-005)
Qatar National Research Fund (NPRP10, NPRP10-120-170-211, GCC-2017-005)
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Keywords: SARS-CoV-2, spike protein, furin cleavage site, angiotensin-converting enzyme 2, viral entry, host cell receptors, S1/S2 cleavage, small molecule inhibitors, antiviral drug discovery, coronavirus vaccines
MeSH terms: Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Angiotensins, Humans, Furin, Spike Glycoprotein, Coronavirus

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A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

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