The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men
Abstract
The incidence rates of cancers in men differ by countries of the world. We compared the incidence rates of three of the most common cancers (prostate, lung, and colon) in men residing in 164 different countries with the population-weighted light at night (LAN) exposure and with several developmental and environmental indicators, including per capita income, percent urban population, and electricity consumption. The estimate of per capita LAN exposure was a novel aspect of this study. Both ordinary least squares (OLS) and spatial error (SE) regression models were used in the analysis. We found a significant positive association between population exposure to LAN and incidence rates of prostate cancer, but no such association with lung cancer or colon cancer. The prostate cancer result is consistent with a biological theory and a limited number of previous studies of circadian disruption and risk. The LAN-prostate cancer connection is postulated to be due to suppression of melatonin and/or disruption of clock gene function. An analysis holding other variables at average values across the 164 countries yielded a risk of prostate cancer in the highest LAN-exposed countries 110% higher than in the lowest LAN exposed countries. This observed association is a necessary condition for a potentially large effect of LAN on risk of prostate cancer. However, it is not sufficient due to potential confounding by factors that increase the risk of prostate cancer and are also associated with LAN among the studied countries.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Epidemiological studies have revealed that individuals who work night-shifts are at higher risk for developing cancer (Hansen, 2001; Kloog et al., 2009; Megdal et al., 2005; Schernhammer et al., 2006; Schernhammer et al., 2001; Viswanathan et al., 2007) or display poorer cancer prognosis (Lis et al., 2003).”
From Circadian Rhythm Disruption Promotes Lung Tumorigenesis (2016) · cites this paper as Kloog et al., 2009
Citations
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077
Global Cancer Statistics, 2002
Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.2.74 · Cited by 18,710
Ecological Correlations and the Behavior of Individuals
Robinson, W. S. (1950) · American Sociological Review · doi:10.2307/2087176 · Cited by 4,547
Estimating the world cancer burden: Globocan 2000
Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2001) · International Journal of Cancer · doi:10.1002/ijc.1440 · Cited by 3,718
GeoDa : An Introduction to Spatial Data Analysis
Anselin, L., Syabri, I., & Kho, Y. (2005) · Geographical Analysis · doi:10.1111/j.0016-7363.2005.00671.x · Cited by 2,666
Cancer burden in the year 2000. The global picture
Parkin, D. M., Bray, F. I., & Devesa, S. S. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00267-2 · Cited by 2,169
Krieger, N. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf068 · Cited by 1,185
The changing global patterns of female breast cancer incidence and mortality
Bray, F., McCarron, P., & Parkin, D. M. (2004) · Breast Cancer Research · doi:10.1186/bcr932 · Cited by 1,006
Night-Shift Work and Risk of Colorectal Cancer in the Nurses' Health Study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I. I., Fuchs, C. S., & Colditz, G. A. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.11.825 · Cited by 837
Christianity and Democracy: The Global Picture
Berger, P. L. (2004) · Journal of democracy · doi:10.1353/jod.2004.0022 · Cited by 689
Research works printed but not linked: 2
- Anisimov V N, 2006, Neuro. Endocrinol. Lett., 27, 35
- Hulshof K F, 1991, Eur. J. Clin. Nutr., 45, 441
Cited by
Sorted by citations
Remote sensing of night lights: A review and an outlook for the future
Noam Levin, A., Kyba, C. C. M., Zhang, Q., de Miguel, A. S., Román, M. O., Li, X., Portnov, B. A., Molthan, A., Jechow, A., Miller, S. D., et al. (2019) · Remote Sensing of Environment · doi:10.1016/j.rse.2019.111443 · Cited by 869
Self-citationLimiting the impact of light pollution on human health, environment and stellar visibility
Falchi, F., Cinzano, P., Elvidge, C. D., Keith, D. M., & Haim, A. (2011) · Journal of Environmental Management · doi:10.1016/j.jenvman.2011.06.029 · Cited by 631
“…the production of the pineal hormone melatonin, and since melatonin is an oncostatic or anti-carcinognenic agent, lower levels in blood may encourage the growth of some type of cancers (Glickman et al., 2002; Stevens et al., 2007; Kloog et al., 2008, 2009; Bullough et al., 2006; Haim et al., 2010).”
BackgroundSelf-citationCircadian Rhythm Disruption Promotes Lung Tumorigenesis
Papagiannakopoulos, T., Bauer, M. R., Davidson, S. M., Heimann, M., Subbaraj, L., Bhutkar, A., Bartlebaugh, J., Vander Heiden, M. G., & Jacks, T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.001 · Cited by 557
“Circadian rhythm disruption through shift work has been linked to increased cancer risk in multiple types of cancer (Hansen, 2001; Kloog et al., 2009; Schernhammer et al., 2001, 2006).”
InfluentialCho, Y.-M., Ryu, S., Lee, B. R., Kim, K., Lee, E., & Choi, J. W. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1073158 · Cited by 490
“Kloog and colleagues used the DMSP data in their ecological studies to show that the ALAN level increased the risk of breast cancer in women and of prostate cancer in men; these results were independent of other cancers, including lung cancer (Kloog et al., 2008, 2009, 2010).”
BackgroundMethodThe Effects of Light at Night on Circadian Clocks and Metabolism
Fonken, L. K., & Nelson, R. J. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1051 · Cited by 494
Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice
Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D., & Fu, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010995 · Cited by 286
“Epidemiological studies have revealed that human night-shift workers show an increased risk of breast, colon, lung, endometrial and prostate cancer, hepatocellular carcinoma and non-Hodgkin’s lymphoma [7,8,9,10,11,12].”
BackgroundAssociations between chronotype, morbidity and mortality in the UK Biobank cohort
Knutson, K. L., & von Schantz, M. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1454458 · Cited by 275
“Lower levels of melatonin have been associated with greater insulin resistance (Reutrakul et al. 2018), increased risk of diabetes (Mcmullan et al. 2013) and breast and prostate cancer (Kloog et al. 2009; Kloog et al. 2010).”
BackgroundThe circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251
Night Work and the Risk of Cancer Among Men
Parent, M.-E., El-Zein, M., Rousseau, M.-C., Pintos, J., & Siemiatycki, J. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws318 · Cited by 243
“(35) found a significant positive association between light-at-night exposure and prostate cancer but not lung or colon cancer.”
BackgroundGarcía-Saenz, A., de Miguel, A. S., Espinosa, A., Valentín, A., Aragonés, N., Llorca, J., Amiano, P., Martín, V., Guevara, M., Capelo, R., et al. (2018) · Environmental Health Perspectives · doi:10.1289/ehp1837 · Cited by 206
“…the spectrum of nighttime lighting emissions, di ff erent studies used this source of information to link the ALAN intensities captured by DMSP-OLS with incidence rates of breast and prostate cancer and found a signi fi cant positive association (Kloog et al. 2009, 2010; Keshet-Sitton et al. 2017).”
Aubé, M., Roby, J., & Kocifaj, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067798 · Cited by 220
“ALAN may be associated with an increased risk of breast cancer [15], [16], [17], [18], [19], [20], prostate and colorectal cancer [21], [22], and may also cause obesity [23], [24], diabetes [25] and depression [26].”
BackgroundCircadian nature of immune function
Logan, R. W., & Sarkar, D. K. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.039 · Cited by 196
“…lymphoma (Lahti et al., 2008), breast (Davis et al., 2001; Hansen, 2001; Schernhammer et al., 2001), endometrial (Viswanathan and Schernhammer, 2009), prostate (Conlon et al., 2007; Kloog et al., 2009; Kubo et al., 2006), and colon (Kloog et al., 2009; Schernhammer et al., 2003) cancers.”
Enhancing circadian clock function in cancer cells inhibits tumor growth
Kießling, S., Beaulieu-Laroche, L., Blum, I. D., Landgraf, D., Welsh, D. K., Storch, K.-F., Labrecque, N., & Cermakian, N. (2017) · BMC Biology · doi:10.1186/s12915-017-0349-7 · Cited by 182
Night shift work, chronotype and prostate cancer risk in the MCC‐ S pain case‐control study
Papantoniou, K., Castaño‐Vinyals, G., Espinosa, A., Aragonés, N., Pérez‐Gómez, B., Burgos, J., Gómez‐Acebo, I., Llorca, J., Peiró, R., Jiménez‐Moleón, J. J., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29400 · Cited by 175
“Finally, an ecological study showed that only prostate cancer among all tumors examined, was significantly correlated with light at night levels provided by satellites at the country level.(36) We found increased prostate cancer risk among night shift workers, particularly for high risk tumors, suggesting a possible a…”
BackgroundEndocrine Effects of Circadian Disruption
Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170
“Nighttime light levels also codistribute with breast cancer incidents (122).”
BackgroundClock Genes and Clock-Controlled Genes in the Regulation of Metabolic Rhythms
Mazzoccoli, G., Pazienza, V., & Vinciguerra, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.658127 · Cited by 173
“Epidemiological studies have found that there is an increase in the incidence of pathologies, such as cancer, cardiovascular disease, and metabolic syndrome, in shift- and night workers (Karlsson et al., 2001; Kloog et al., 2009; Schernammer et al., 2001).”
BackgroundChronic Shift-Lag Alters the Circadian Clock of NK Cells and Promotes Lung Cancer Growth in Rats
Logan, R. W., Zhang, C., Murugan, S., O’Connell, S., Levitt, D., Rosenwasser, A. M., & Sarkar, D. K. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102715 · Cited by 166
“Several large-scale epidemiological studies on rotating shiftworkers have reported that working during the night is a major risk factor for several types of cancer, including non-Hodgkin’s lymphoma (1) and breast (2–4), endometrial (5), prostate (6, 7), and colon (8, 9) cancers.”
BackgroundSigurdardottir, L. G., Valdimarsdottir, U. A., Fall, K., Rider, J. R., Lockley, S. W., Schernhammer, E., & Mucci, L. A. (2012) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0116 · Cited by 162
“The studies addressedvarious proxies of circadian disruption: light at night distribution (41), sleep duration (37), rotating shift work (38–40, 42), and occupations likely to include night shift work, such as firefighters (47, 50), policemen (50), public safety workers (46), waiters (46), and airline pilots (35, 36,…”
BackgroundInfluentialMolecular Links between the Circadian Clock and the Cell Cycle
Farshadi, E. A., van der Horst, G. T. J., & Chaves, I. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.04.003 · Cited by 164
Circadian gene variants in cancer
Kettner, N. M., Katchy, C. A., & Fu, L. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.914808 · Cited by 147
Nighttime light level co-distributes with breast cancer incidence worldwide
Kloog, I., Stevens, R. G., Haim, A., & Portnov, B. A. (2010) · Cancer Causes & Control · doi:10.1007/s10552-010-9624-4 · Cited by 159
Self-citationCross-talk between the circadian clock and the cell cycle in cancer
Soták, M., Sumová, A., & Pácha, J. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.892296 · Cited by 157
Smolensky, M. H., Sackett-Lundeen, L. L., & Portaluppi, F. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1072002 · Cited by 158
“, 2015) and PC of men (Kloog et al., 2009), especially in Western countries.”
BackgroundDoes artificial light-at-night exposure contribute to the worldwide obesity pandemic?
Rybnikova, N. A., Haim, A., & Portnov, B. A. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.255 · Cited by 146
Self-citationARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer
Mazzoccoli, G., Pazienza, V., Panza, A., Valvano, M. R., Benegiamo, G., Vinciguerra, M., Andriulli, A., & Piepoli, A. (2011) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-011-1126-6 · Cited by 140
Mazzoccoli, G., Panza, A., Valvano, M. R., Palumbo, O., Carella, M., Pazienza, V., Biscaglia, G., Tavano, F., Sebastiano, P. D., Andriulli, A., et al. (2011) · Chronobiology International · doi:10.3109/07420528.2011.615182 · Cited by 132
“…of bodily temporal organization, defined as circadian disruption, is considered a cancer risk factor, and an increased incidence of various cancers has been reported in shiftworkers by epidemiological studies (Erren et al., 2011; IARC, 2010; Kloog et al., 2009; Schernhammer et al., 2001, 2003).”
BackgroundWalker, W. H., Borniger, J. C., Gaudier-Diaz, M. M., Hecmarie Meléndez-Fernández, O., Pascoe, J. L., Courtney DeVries, A., & Nelson, R. J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0430-4 · Cited by 129
Metabolic rivalry: circadian homeostasis and tumorigenesis
Kinouchi, K., & Sassone‐Corsi, P. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0291-9 · Cited by 128
Red is the new black: how the colour of urban skyglow varies with cloud cover
Kyba, C. C. M., Ruhtz, T., Fischer, J., & Hölker, F. (2012) · Monthly Notices of the Royal Astronomical Society · doi:10.1111/j.1365-2966.2012.21559.x · Cited by 119
“…et al. 1980; Salmon et al. 1995), it has been demonstrated that scattered skyglow has ecological impacts (Moore et al. 2000), and the potential for a connection between the level of urban lighting and some human cancers is under investigation (Kloog et al. 2008, 2009; Kantermann & Roenneberg 2009).”
BackgroundRotating Night-Shift Work and Lung Cancer Risk Among Female Nurses in the United States
Schernhammer, E. S., Feskanich, D., Liang, G., & Han, J. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kwt155 · Cited by 112
Walker, W. H., Bumgarner, J. R., Walton, J. C., Liu, J. A., Meléndez‐Fernández, O. H., Nelson, R. J., & DeVries, A. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249360 · Cited by 115
Assessing Light Pollution in China Based on Nighttime Light Imagery
Jiang, W., He, G., Long, T., Wang, C., Ni, Y., & Ma, R. (2017) · Remote Sensing · doi:10.3390/rs9020135 · Cited by 104
A case-referent study: light at night and breast cancer risk in Georgia
Bauer, S. E., Wagner, S. E., Burch, J., Bayakly, R. A., & Vena, J. E. (2013) · International Journal of Health Geographics · doi:10.1186/1476-072x-12-23 · Cited by 102
“Two previous studies investigated the link between levels of LAN and cancer incidence, but no association with lung cancer was reported [9,12].”
BackgroundRacial disparities in prostate cancer among black men: epidemiology and outcomes
Chowdhury-Paulino, I. M., Ericsson, C. I., Vince, R., Spratt, D. E., George, D. J., & Mucci, L. A. (2021) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-021-00451-z · Cited by 101
Light at Night and Breast Cancer Risk Among California Teachers
Hurley, S. E., Goldberg, D. E., Nelson, D. O., Hertz, A., Horn‐Ross, P. L., Bernstein, L., & Reynolds, P. (2014) · Epidemiology · doi:10.1097/ede.0000000000000137 · Cited by 105
Circadian Disruption and Prostate Cancer Risk: An Updated Review of Epidemiological Evidences
Wendeu-Foyet, M. G., & Menegaux, F. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-1030 · Cited by 101
“those male cancers for 164 countries (49).”
Work Schedule, Sleep Duration, Insomnia, and Risk of Fatal Prostate Cancer
Gapstur, S. M., Diver, W. R., Stevens, V. L., Carter, B. D., Teras, L. R., & Jacobs, E. J. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.10.033 · Cited by 96
Lyytimäki, J. M. (2013) · Ecosystem Services · doi:10.1016/j.ecoser.2012.12.001 · Cited by 97
“Disruption of natural circadian rhythmicity caused by artificial light may lead to several health effects, such as elevated risk of breast or prostate cancer, obesity, depression, diabetes and sleep disorders (Kloog et al., 2009; Stevens et al., 2007).”
BackgroundSvechkina, A., Portnov, B. A., & Trop, T. (2020) · Landscape Ecology · doi:10.1007/s10980-020-01053-1 · Cited by 96
“…association between short Table 1 List of publications by research topic Research subject* Outcome analyzed Publications Humans (15) Cancer Kloog et al. (2008, 2009, 2010), Bauer et al. (2013); Hurley et al. (2014), Rybnikova et al. (2015), Al-Naggar et al. (2016), Rybnikova et al.…”
BackgroundSelf-citationmiR-34a-dependent overexpression of Per1 decreases cholangiocarcinoma growth
Han, Y., Meng, F., Venter, J. K., Wu, N., Wan, Y., Standeford, H. A., Francis, H., Meininger, C. J., Greene, J. F., Trzeciakowski, J. P., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.024 · Cited by 96
“In humans, circadian disruption increases the susceptibility to cancer development including hepatocellular carcinoma, lung, pancreatic, prostate and colorectal cancer [25-27].”
Light-at-Night-Induced Circadian Disruption, Cancer and Aging
Anisimov, V. N., Vinogradova, I. A., Панченко, А. В., Popovich, I. G., & Zabezhinski, M. A. (2013) · Current Aging Science · doi:10.2174/1874609811205030002 · Cited by 95
Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers
Menéndez-Menéndez, J., & Martínez‐Campa, C. (2018) · International Journal of Endocrinology · doi:10.1155/2018/3271948 · Cited by 90
“The countries with higher levels of nocturnal light yielded a higher risk of prostate cancer [93].”
BackgroundMelatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation
Santoro, R., Marani, M., Blandino, G., Muti, P. C., & Strano, S. (2011) · Oncogene · doi:10.1038/onc.2011.469 · Cited by 88
Seasonal population estimates based on night-time lights
Stathakis, D. N., & Baltas, P. (2017) · Computers Environment and Urban Systems · doi:10.1016/j.compenvurbsys.2017.12.001 · Cited by 85
Night-Time Light Dynamics during the Iraqi Civil War
Li, X., Liu, S., Jendryke, M., Li, D., & Wu, C. (2018) · Remote Sensing · doi:10.3390/rs10060858 · Cited by 84
“Moreover, night-time light images have also played an important role in mapping light pollution [34–36] and evaluating its impact on human health [37,38].”
BackgroundDoes the Modern Urbanized Sleeping Habitat Pose a Breast Cancer Risk?
Kloog, I., Portnov, B. A., Rennert, H. S., & Haim, A. (2010) · Chronobiology International · doi:10.3109/07420528.2010.531490 · Cited by 89
Self-citationMiro, C., Docimo, A., Barrea, L., Verde, L., Cernea, S., Šojat, A. S., Marina, L., Docimo, G., Colao, A., Dentice, M., et al. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.03.003 · Cited by 85
Remote sensing of human beings – a perspective from nighttime light
Li, D., Zhao, X., & Li, X. (2016) · Geo-spatial Information Science · doi:10.1080/10095020.2016.1159389 · Cited by 81
“Kloog et al. (2009) analyzed the correlation between the incidences of prostate cancer, lung cancer, colon rectal cancer, and light pollution intensity in the global male group by combining the use of medical survey data and DMSP/OLS nighttime light data.”
MethodClock genes: Their role in colorectal cancer
Karantanos, T. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i8.1986 · Cited by 79
IS LIGHT-AT-NIGHT A HEALTH RISK FACTOR OR A HEALTH RISK PREDICTOR?
Kantermann, T., & Roenneberg, T. (2009) · Chronobiology International · doi:10.3109/07420520903223984 · Cited by 76
“The causal chain of the LAN hypothesis is often argued based on correlations in epidemiological data, such as that cancer rates correlate with the degree of light pollution (Pauley, 2004), which has been linked to health problems via the LAN hypothesis (Kloog et al., 2008, 2009).”
BackgroundMonitoring Trends in Light Pollution in China Based on Nighttime Satellite Imagery
Han, P., Huang, J., Li, R., Wang, L., Hu, Y., Wang, J., & Huang, W. (2014) · Remote Sensing · doi:10.3390/rs6065541 · Cited by 76
Nadybal, S. M., Collins, T. W., & Grineski, S. E. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109959 · Cited by 84
“…imagery found strong associations between ambient light at night and breast cancer in women (Kloog et al., 2008; Rybnikova et al., 2015) and prostate cancer in men (Kloog et al., 2009; Rybnikova et al., 2017), adjusting for variables such as income, urbanicity, and electricity consumption.”
Light-Mediated Perturbations of Circadian Timing and Cancer Risk: A Mechanistic Analysis
Reiter, R. J., Tan, D. X., Erren, T. C., Fuentes‐Broto, L., & Paredes, S. D. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352026 · Cited by 76
Outdoor artificial light at night and human health: A review of epidemiological studies
Bożejko, M., Tarski, I., & Małodobra-Mazur, M. (2022) · Environmental Research · doi:10.1016/j.envres.2022.115049 · Cited by 71
Exposure to artificial light at night: A common link for obesity and cancer?
Muscogiuri, G., Poggiogalle, E., Barrea, L., Tarsitano, M. G., Garifalos, F., Liccardi, A., Pugliese, G., Savastano, S., Colao, A., Colao, A., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.06.007 · Cited by 67
Association Between Outdoor Light-at-night Exposure and Colorectal Cancer in Spain
García-Saenz, A., de Miguel, A. S., Espinosa, A., Costas, L., Aragonés, N., Tonne, C. C., Moreno, V. R., Pérez‐Gómez, B., Valentín, A., Pollán, M., et al. (2020) · Epidemiology · doi:10.1097/ede.0000000000001226 · Cited by 68
An association between clock genes and clock‐controlled cell cycle genes in murine colorectal tumors
Soták, M., Polidarová, L., Ergang, P., Sumová, A., & Pácha, J. (2012) · International Journal of Cancer · doi:10.1002/ijc.27760 · Cited by 66
EPIGENETIC EFFECTS OF SHIFTWORK ON BLOOD DNA METHYLATION
Bollati, V., Baccarelli, A., Sartori, S., Tarantini, L., Motta, V., Rota, F., & Costa, G. (2010) · Chronobiology International · doi:10.3109/07420528.2010.490065 · Cited by 68
“More recently, the International Agency on Research on Cancer (IARC) has classified “shiftwork that involves circadian disruption” as “probably carcinogenic to humans” (Group 2A) on the basis of “limited evidence in humans for the carcinogenicity of shift-work that involves nightwork,” and “sufficient evidence in expe…”
Unawareness in environmental protection: The case of light pollution from traffic
Lyytimäki, J. M., Tapio, P., & Assmuth, T. W. (2011) · Land Use Policy · doi:10.1016/j.landusepol.2011.10.002 · Cited by 65
A Supernova at 50 pc: Effects on the Earth's Atmosphere and Biota
Melott, A. L., Thomas, B. C., Kachelrieß, M., SEMIKOZ, D. V., & Overholt, A. C. (2017) · The Astrophysical Journal · doi:10.3847/1538-4357/aa6c57 · Cited by 61
“Nighttime exposure to artificial lighting has been linked to cancers in animals, including rats (Vinogradova et al. 2009) and humans, including breast cancer (Stevens 2009; Schernhammer et al. 2001) and prostate cancer (Kloog et al. 2009).”
BackgroundGurubhagavatula, I., Barger, L. K., Barnes, C. M., Basner, M., Boivin, D. B., Dawson, D. E., Drake, C. L., Flynn‐Evans, E. E., Mysliwiec, V., Patterson, P. D., et al. (2021) · SLEEP · doi:10.1093/sleep/zsab161 · Cited by 68
Gurubhagavatula, I., Barger, L. K., Barnes, C. M., Basner, M., Boivin, D. B., Dawson, D. E., Drake, C. L., Flynn‐Evans, E. E., Mysliwiec, V., Patterson, P. D., et al. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9512 · Cited by 75
Matsumoto, C. S., Almeida, L. O., Guimarães, D. M., Martins, M. D., Papagerakis, P., Papagerakis, S. M., Leopoldino, A. M., CASTILHO, R. M., & SQUARIZE, C. H. (2016) · Oncotarget · doi:10.18632/oncotarget.9877 · Cited by 58
“Indeed, increased incidence of prostate cancer was also found in individuals living in countries with high light exposure at night [44] and those who sleep less [45-47].”
BackgroundJiang, P., Xu, C., Zhang, P., Ren, J., Mageed, F., Wu, X., Chen, L., Zeb, F., Feng, Q., & Li, S. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4758 · Cited by 55
“Previous epidemiological studies have revealed that individuals working night shifts are at higher risk of developing cancer or exhibit poorer cancer prognosis (3-5).”
BackgroundRybnikova, N., Haim, A., & Portnov, B. A. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1043369 · Cited by 51
“Instead, we calculated national averages of ALAN by population weighing using the calculation approach similar to that used by Kloog and co-authors (Kloog et al., 2009, 2010).”
MethodSelf-citationImpacts of home lighting on human health
Ticleanu, C. (2021) · Lighting Research & Technology · doi:10.1177/14771535211021064 · Cited by 50
Circadian clock circuitry in colorectal cancer
Mazzoccoli, G. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i15.4197 · Cited by 47
Light pollution as a factor in breast and prostate cancer
Lamphar, H. A. S., Kocifaj, M., Limón-Romero, J., Paredes-Tavares, J., Diba, C. S., Mego, M., Prado, N. J., Baez-Lopez, Y. A., & Diez, E. R. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.150918 · Cited by 47
Circadian clock synchrony and chronotherapy opportunities in cancer treatment
Damato, A. R., & Herzog, E. D. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.07.017 · Cited by 45
Tam, C. W., & Shiu, S. Y. W. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00890.x · Cited by 44
“Of note, a significant positive association between population exposure to light at night and incidence rates of prostate cancer has been shown recently [14].”
BackgroundLan, T., Shao, G., Tang, L., Xu, Z., Zhu, W., & Liu, L. (2021) · IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing · doi:10.1109/jstars.2021.3060038 · Cited by 44
Circadian Time-Dependent Tumor Suppressor Function of Period Genes
Yang, X., Wood, P. A., Ansell, C. M., & Hrushesky, W. J. M. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352083 · Cited by 45
Kim, K. Y., Lee, E., Kim, Y. J., & Kim, J. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1259241 · Cited by 40
“Moreover, a strong positive relationship between age-standardized incidence of prostate cancer and ALAN levels was found in a study of the global distribution of ALAN and cancer, with no relationship found for other cancers (Kloog et al., 2009).”
BackgroundSky Quality Meter and satellite correlation for night cloud-cover analysis at astronomical sites
Cavazzani, S., Ortolani, S., Bertolo, A., Binotto, R., Fiorentin, P., B, G. C. A., Saviane, I., & Zitelli, V. (2020) · Monthly Notices of the Royal Astronomical Society · doi:10.1093/mnras/staa416 · Cited by 39
“…(Kyba et al., 2015) as evidenced by the growing interest from scientists in fields of astronomy (Patat et al., 2008; Puschnig et al., 2014; Zhang et al., 2016), ecology, biology (Holker et al., 2010; Gaston et al., 2013; Manfrin et al., 2017) and medicine (Kloog et al., 2009; Stevens et al. 2013).”
BackgroundTesting the Light-at-Night (LAN) Theory for Breast Cancer Causation
Stevens, R. G. (2011) · Chronobiology International · doi:10.3109/07420528.2011.606945 · Cited by 38
Self-citationKatamune, C., Koyanagi, S., Shiromizu, S., Matsunaga, N., Shimba, S., Shibata, S., & Ohdo, S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.706481 · Cited by 38
“These epidemiological findings are also supported by animal studies in which repetitive changes in the light-dark cycle facilitate the growth of implanted tumors (8, 9).”
BackgroundIndividual Variations in Serum Melatonin Levels through Time: Implications for Epidemiologic Studies
Nogueira, L., Sampson, J. N., Chu, L. W., Yu, K. F., Andriole, G. L., Church, T. R., Stanczyk, F. Z., Koshiol, J. E., & Hsing, A. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083208 · Cited by 38
“Circadian disruption, is mostly measured by shift work in epidemiologic studies, and is associated with several cancers [3–5] including prostate [6–11], breast [12– 41], endometrium [16], ovarian [42], and colorectum [43], as well as non-Hodgkin lymphoma [44].”
BackgroundRybnikova, N. A., & Portnov, B. A. (2016) · International Journal of Remote Sensing · doi:10.1080/01431161.2016.1246778 · Cited by 37
“…satellite images raises a question whether the association between ALAN exposure and its health outcomes, detected by previous studies (cf. inter alia Kloog et al. 2009, 2010; Hurley et al. 2014; Rybnikova, Haim, and Portnov 2015), alters if higher-resolution ALAN images are used in the analysis.”
BackgroundMethodSelf-citationLight pollution: Is there an Environmental Kuznets Curve?
Ngarambe, J., Lim, H. S., & Kim, G. (2018) · Sustainable Cities and Society · doi:10.1016/j.scs.2018.07.018 · Cited by 37
Do malignant cells sleep at night?
Cortés‐Hernández, L. E., Eslami‐S, Z., Dujon, A. M., Giraudeau, M., Újvári, B., Frédéric Thomas, A., & Alix‐Panabières, C. (2020) · Genome biology · doi:10.1186/s13059-020-02179-w · Cited by 36
Tetteh, M. O., Darko, A., Chan, A. P. C., Jafari, A., Brilakis, I., Chen, W., Nani, G., & Yevu, S. K. (2022) · Energy and Buildings · doi:10.1016/j.enbuild.2022.112532 · Cited by 35
Sørensen, T. B., Wilson, R., Gregson, J., Shankar, B., Dangour, A. D., & Kinra, S. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-036213 · Cited by 36
Circadian rhythm and sleep influences on digestive physiology and disorders
Vaughn, B. V., Rotolo, S., & Roth, H. L. (2014) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s44806 · Cited by 37
Light Pollution and Impact of Light Pollution
Rajkhowa, R. (2014) · Cited by 32
Wu, J., Tu, Y., Chen, Z., & Yu, B. (2022) · Remote Sensing · doi:10.3390/rs14225695 · Cited by 31
The circadian clock and cancer: links between circadian disruption and disease Pathology
Fekry, B., & Eckel‐Mahan, K. L. (2022) · The Journal of Biochemistry · doi:10.1093/jb/mvac017 · Cited by 32
Impact of Exposure to Dim Light at Night on Sleep in Female and Comparison with Male Subjects
Cho, C., Yoon, H., Kang, S., Kim, L., Lee, E., & Lee, H. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.03.17 · Cited by 31
Analyzing trend in artificial light pollution pattern in India using NTL sensor's data
Kumar, P., Rehman, S., Sajjad, H., Tripathy, B. R., Rani, M., & Singh, S. K. (2018) · Urban Climate · doi:10.1016/j.uclim.2018.12.005 · Cited by 30
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application
Megerian, M. F., Kim, J., Badreddine, J., Hong, S. H., Ponsky, L. E., Shin, J. I., & Ghayda, R. A. (2022) · Aging and Disease · doi:10.14336/ad.2022.1010 · Cited by 31
“An ecological study that involved 164 countries examined the relationship between exposure to light at night and the risk of several types of cancer including prostate cancer [23, 24].”
BackgroundRybnikova, N. A., Haim, A., & Portnov, B. A. (2016) · Archives of Environmental & Occupational Health · doi:10.1080/19338244.2016.1169980 · Cited by 30
“According to the second potential impact mechanism, humans, being involved in nighttime activities enabled by ALAN, may suffer from daily rhythm disruption, leading to increased susceptibility to various hormone-dependent diseases, including PC.”
BackgroundMethodInfluentialSelf-citationDim Light at Night Exposure Induces Cold Hyperalgesia and Mechanical Allodynia in Male Mice
Bumgarner, J. R., Walker, W. H., Liu, J. A., Walton, J. C., & Nelson, R. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.022 · Cited by 29
“In humans, LAN exposure is correlated with an increased risk for breast and prostate cancers, depression in the elderly population, and obesity (Davis et al., 2001; Kloog et al., 2009; Obayashi et al., 2013; McFadden et al., 2014).”
BackgroundLi, M., Chen, Z., Jiang, T., Yang, X., Du, Y., Liang, J., Wang, L., Xi, J., Lin, M. Y., & Feng, M. (2021) · Journal of Cancer · doi:10.7150/jca.52454 · Cited by 27
“Changes and disruptions of circadian rhythms in humans significantly impinged on the increasing risk of tumorigenesis [27,28].”
BackgroundJones, B. A. (2018) · Journal of Environmental Economics and Management · doi:10.1016/j.jeem.2018.01.002 · Cited by 27
Datta, S., Samanta, D., Tiwary, B. K., Chaudhuri, A. G., & Chakrabarti, N. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.03.015 · Cited by 25
Gabinet, N. M., & Portnov, B. A. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1886111 · Cited by 25
“…(Krishnan and Collop 2006; Reyner and Horne 1995), age (Ohayon et al. 2004; Reyner and Horne 1995) and different health dysfunctions (Barone and MennaBarreto 2011; Blask et al. 2005; Garcia-Saenz et al. 2018; Hurley et al. 2014; Kloog et al. 2008, 2009; Luyster et al. 2012; Newman et al. 2001).”
BackgroundSelf-citationGreen, A., Cohen‐Zion, M., Haim, A., & Dagan, Y. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1387555 · Cited by 26
“Longterm alterations of these rhythms due to ALAN exposure have been shown to be associated with high risk of cancer (Kloog et al., 2009; Stevens et al., 2104; Yang et al., 2014), altered metabolic Table 2.”
BackgroundSelf-citationCircadian genes and risk of prostate cancer in the prostate cancer prevention trial
Chu, L. W., Till, C., Yang, B., Tangen, C. M., Goodman, P. J., Yu, K. F., Zhu, Y. L., Han, S. S., Hoque, A. M., Ambrosone, C. B., et al. (2018) · Molecular Carcinogenesis · doi:10.1002/mc.22770 · Cited by 26
A laboratory study of the psychological impact of light pollution in national parks
Benfield, J. A., Nutt, R. J., Taff, B. D., Miller, Z. D., Costigan, H. J., & Newman, P. (2018) · Journal of Environmental Psychology · doi:10.1016/j.jenvp.2018.06.006 · Cited by 26
Katamune, C., Koyanagi, S., Hashikawa, K.-I., Kusunose, N., Akamine, T., Matsunaga, N., & Ohdo, S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004942 · Cited by 27
Are some melanomas caused by artificial light?
Kvaskoff, M., & Weinstein, P. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.03.010 · Cited by 25
“Recent evidence also suggests that the LAN theory may be applicable for other neoplasms such as prostate cancer [16–21], endometrial cancer [22–24], and possibly colon cancer [25].”
Background
Metadata
- Authors
- Kloog, I., Haim, A., Stevens, R. G., & Portnov, B. A.
- Affiliations
- University of Haifa (IL)
- UConn Health (US)
- Corresponding author
- Portnov, Boris A.
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 2009-01
- Volume
- 26
- Issue
- 1
- Pages
- 108-125
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2164074733
- Cited by
- 215
- References
- 58
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 14 · 2022: 11 · 2021: 27 · 2020: 22 · 2019: 9 · 2018: 15 · 2017: 13 · 2016: 17 · 2015: 10 · 2014: 15 · 2013: 11 · 2012: 12
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- light at night, artificial light exposure, prostate cancer, colon cancer, lung cancer, cancer incidence, circadian rhythm disruption, melatonin suppression, clock genes, per capita income, urbanization, electricity consumption, cross-national comparison, confounding
- MeSH terms
- Circadian Rhythm, Colonic Neoplasms, Electricity, Humans, Light, Lung Neoplasms, Male, Prostatic Neoplasms, Risk Factors, Urban Population, Global Health, Incidence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
