Circadian Disruption, Sleep Loss, and Prostate Cancer Risk: A Systematic Review of Epidemiologic Studies
Open accessAbstract
Disruption of the circadian system has been hypothesized to increase cancer risk, either because of direct disruption of the molecular machinery generating circadian rhythms or because of disruption of parameters controlled by the clock such as melatonin levels or sleep duration. This hypothesis has been studied in hormone-dependent cancers among women, but data are sparse about potential effects of circadian disruption on the risk of prostate cancer. This review systematically examines available data evaluating the effects of light at night, sleep patterns, and night shift work on prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 21(7); 1002–11. ©2012 AACR.
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Many physiologically and nutritionally relevant processes in the human body have circadian rhythms, including glycolysis and gluconeogenesis, cholesterol and lipid metabolism, oxidative phosphorylation and detoxification pathways.
“It is known that many physiologically and nutritionally relevant processes in the human body have circadian rhythms, including glycolysis and gluconeogenesis, cholesterol and lipid metabolism, oxidative phosphorylation and detoxification pathways (8,9) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [9]
Disrupted eating patterns, consisting of irregular meals, different frequency of meals, as well as specific clock time of meals, could lead to disruption of the internal body clock.
“Disrupted eating patterns, consisting of irregular meals, different frequency of meals, as well as specific clock time of meals, could lead to disruption of the internal body clock.”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [9]
The amplitude of some metabolic rhythms is reduced in the obese, although this varies from study to study and by hormone.
“Interestingly, it appears that the amplitude of some of these rhythms is reduced in the obese, although this varies from study to study and by hormone (9,53) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [9]
Many nutritionally related processes in the body follow a circadian pattern, such as glucose homeostasis, insulin sensitivity, postprandial response and plasma lipids.
“Many nutritionally related processes in the body follow a circadian pattern, such as glucose homeostasis, insulin sensitivity, postprandial response and plasma lipids (9) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [9]
Disruption of the internal body clock could lead directly to a positive energy balance, which could then lead to metabolic dysfunction.
“This in turn could lead directly to a positive energy balance, which could then lead to metabolic dysfunction.”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [9]
Circadian disruption could also directly lead to a positive energy balance.
“Circadian disruption could also directly lead to a positive energy balance.”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [9]
Disruption of the internal body clock is affected by genetic differences, for example in CLOCK genes.
“It is known that this disruption of the internal body clock is affected by genetic differences, for example in CLOCK genes (9) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [9]
Disruption of the internal body clock could have biochemical and molecular impacts, such as an effect on the circadian responses of glucose and lipids.
“Disruption of the internal body clock could have biochemical and molecular impacts, such as an effect on the circadian responses of glucose and lipids (9) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [9]
Direct nocturnal light exposure suppresses melatonin production and resets the timing of the circadian clock.
“Direct nocturnal light exposure suppresses melatonin production41 and resets the timing of the circadian clock.33,42,43”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [43]
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Cites
Self-Reported and Measured Sleep Duration: How Similar Are They?
Lauderdale, D. S., Knutson, K. L., Yan, L. L., Liu, K., & Rathouz, P. J. (2008) · Epidemiology · doi:10.1097/ede.0b013e318187a7b0 · Cited by 1,565 · see citing works
Brzezinski, A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701163360306 · Cited by 1,549 · see citing works
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,189 · see citing works
Melatonin as a natural ally against oxidative stress: a physicochemical examination
Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,154 · see citing works
Carcinogenicity of shift-work, painting, and fire-fighting
Straif, K., Baan, R., Grosse, Y., Secretan, B., Ghissassi, F. E., Bouvard, V., Altieri, A., Benbrahim-Tallaa, L., & Cogliano, V. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70373-x · Cited by 1,082 · see citing works
Occupation and cancer – follow-up of 15 million people in five Nordic countries
Pukkala, ., Martinsen, J. I., Lynge, E., Gunnarsdóttir, H. K., Sparén, P., Tryggvadóttír, L., Weiderpass, E., & Kjærheim, K. (2009) · Acta Oncologica · doi:10.1080/02841860902913546 · Cited by 717 · see citing works
Night work and risk of breast cancer
Schernhammer, E. S., Kroenke, C. H., Laden, F., & Hankinson, S. E. (2006) · Epidemiology · doi:10.1097/01.ede.0000190539.03500.c1 · Cited by 484 · see citing works
Self-citationNight work and breast cancer risk: A systematic review and meta-analysis
Megdal, S. P., Kroenke, C. H., Laden, F., Pukkala, E., & Schernhammer, E. S. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.05.010 · Cited by 482 · see citing works
Self-citationMelatonin, sleep disturbance and cancer risk
Blask, D. E. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.07.007 · Cited by 452 · see citing works
Kubo, T., Ozasa, K., Mikami, K., Wakai, K., Fujino, Y., Watanabe, Y., Miki, T., Nakao, M., Hayashi, K., Suzuki, K. A. O., et al. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj232 · Cited by 403 · see citing works
Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology
Arendt, J. (1998) · Reviews of Reproduction · doi:10.1530/ror.0.0030013 · Cited by 347 · see citing works
The Durations of Human Melatonin Secretion and Sleep Respond to Changes in Daylength (Photoperiod)
WEHR, T. A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-6-1276 · Cited by 320 · see citing works
Shift work and cancer – considerations on rationale, mechanisms, and epidemiology
Costa, G., Haus, E., & Stevens, R. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2899 · Cited by 241 · see citing works
Rotating Shift Work and Risk of Prostate Cancer
Conlon, M., Lightfoot, N., & Kreiger, N. (2006) · Epidemiology · doi:10.1097/01.ede.0000249519.33978.31 · Cited by 225 · see citing works
Stevens, R. G. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.01.003 · Cited by 225 · see citing works
Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study
Kakizaki, M., Inoue, K., Kuriyama, S., Sone, T., Matsuda‐Ohmori, K., Nakaya, N., Fukudo, S., & Tsuji, I. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604425 · Cited by 216 · see citing works
Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men
Kloog, I., Haim, A., Stevens, R. G., & Portnov, B. A. (2009) · Chronobiology International · doi:10.1080/07420520802694020 · Cited by 215 · see citing works
Circadian gene mPer2 overexpression induces cancer cell apoptosis
Hua, H., Wang, Y., Wan, C., Liu, Y., Zhu, B., Yang, C., Wang, X., Wang, Z., Cornélissen, G., & Franz Halberg, A. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00225.x · Cited by 213 · see citing works
Kolstad, H. A. (2008) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1194 · Cited by 208 · see citing works
Melatonin increases p53 and p21WAFl expression in MCF-7 human breast cancer cells in vitro
Mediavilla, M. D., Cos, S., & Sánchez‐Barceló, E. J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00262-3 · Cited by 190 · see citing works
Cohort Study of Air Canada Pilots: Mortality, Cancer Incidence, and Leukemia Risk
Band, P. R., Le, N. D., Fang, R. S., Deschamps, M., Coldman, A. J., Gallagher, R. P., & Moody, J. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008722 · Cited by 176 · see citing works
Cohort study of cancer risk among male and female shift workers
Schwartzbaum, J., Ahlbom, A., & Feychting, M. (2007) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1150 · Cited by 168 · see citing works
Incidence of cancer among Nordic airline pilots over five decades: occupational cohort study
Pukkala, ., Aspholm, R., Auvinen, A., Eliasch, H., Gundestrup, M., Haldorsen, T., Hammar, N., Hrafnkelsson, J., Kyyrönen, P., Linnersjö, A., et al. (2002) · BMJ · doi:10.1136/bmj.325.7364.567 · Cited by 160 · see citing works
Sainz, R. M., Mayo, J. C., Tan, D., et al. (2004) · The Prostate · doi:10.1002/pros.20155 · Cited by 159 · see citing works
Reduced Cancer Incidence among the Blind
Feychting, M., OsterLund, B., & Ahlbom, A. (1998) · Epidemiology · doi:10.1097/00001648-199809000-00004 · Cited by 156 · see citing works
Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells
Jung-Hynes, B. D., Huang, W., Reiter, R. J., & Ahmad, N. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00767.x · Cited by 137 · see citing works
Melatonin, Sleep, and Shift Work Adaptation
Burch, J. B., Yost, M. G., Johnson, W., & Allen, E. (2005) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000177336.21147.9f · Cited by 135 · see citing works
Anatomy of the healthy worker effect: a critical review.
Wen, C. P., Tsai, S. P., & Gibson, R. L. (1983) · PubMed · Cited by 130 · see citing works
Circadian disruption in experimental cancer processes
Filipski, E., & Lévi, F. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352085 · Cited by 125 · see citing works
Tumor Suppression and Circadian Function
Chen‐Goodspeed, M., & Lee, C. C. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407303387 · Cited by 125 · see citing works
Bartsch, C., Bartsch, H., Schmidt, A., Ilg, S., Bichler, K., & Flüchter, S. (1992) · Clinica Chimica Acta · doi:10.1016/0009-8981(92)90164-l · Cited by 102 · see citing works
Absence of Detectable Melatonin and Preservation of Cortisol and Thyrotropin Rhythms in Tetraplegia1
Zeitzer, J. M., Ayas, N., Shea, S. A., Brown, R., & Czeisler, C. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6647 · Cited by 101 · see citing works
Registry‐based case–control study of cancer in California firefighters
Bates, M. (2007) · American Journal of Industrial Medicine · doi:10.1002/ajim.20446 · Cited by 101 · see citing works
Cancer incidence and mortality among flight personnel: a meta-analysis.
Ballard, T. J., Lagorio, S., Angelis, G. D., & Verdecchia, A. (2000) · PubMed · Cited by 94 · see citing works
Mortality and cancer incidence in a cohort of commercial airline pilots.
Band, P. R., Spinelli, J. J., Ng, V., Moody, J., & Gallagher, R. P. (1990) · PubMed · Cited by 92 · see citing works
Buja, A., Lange, J. H., Perissinotto, E., et al. (2005) · Toxicology and Industrial Health · doi:10.1191/0748233705th238oa · Cited by 87 · see citing works
Charles, L. E. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg044 · Cited by 85 · see citing works
Absence of Detectable Melatonin and Preservation of Cortisol and Thyrotropin Rhythms in Tetraplegia
Zeitzer, J. M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.6.2189 · Cited by 83 · see citing works
Siu, S., Lau, K. W., Tam, P. C., & Shiu, S. Y. W. (2002) · The Prostate · doi:10.1002/pros.10098 · Cited by 80 · see citing works
The role of polymorphisms in circadian pathway genes in breast tumorigenesis
Dai, H., Zhang, L., Cao, M., Song, F., Zheng, H., Zhu, X., Wei, Q., Zhang, W., & Chen, K. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1231-2 · Cited by 79 · see citing works
Antiproliferative action of melatonin on human prostate cancer LNCaP cells.
Moretti, R. M., Marelli, M. M., Maggi, R., Dondi, D., Motta, M., & Limonta, P. (2000) · Oncology Reports · doi:10.3892/or.7.2.347 · Cited by 78 · see citing works
Total visual blindness is protective against breast cancer
Flynn‐Evans, E. E., Stevens, R. G., Tabandeh, H., Schernhammer, E. S., & Lockley, S. W. (2009) · Cancer Causes & Control · doi:10.1007/s10552-009-9405-0 · Cited by 77 · see citing works
Self-citationGrowth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cells
Marelli, M. M., Limonta, P., Maggi, R., Motta, M., & Moretti, R. M. (2000) · The Prostate · doi:10.1002/1097-0045(20001101)45:3 · Cited by 76 · see citing works
Bartsch, C., Bartsch, H., Flüchter, S., Attanasio, A. F., & Gupta, D. (1985) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1985.tb00633.x · Cited by 73 · see citing works
Introduction to artificial neural networks for physicians: Taking the lid off the black box
Rodvold, D. M., McLeod, D. G. R., Brandt, J. M., Snow, P. B., & Murphy, G. P. (2001) · The Prostate · doi:10.1002/1097-0045(200101)46:1 · Cited by 72 · see citing works
Mortality Among US Commercial Pilots And Navigators
Nicholas, J. S., Lackland, D. T., Dosemeci, M., Mohr, L. C., Dunbar, J. B., Grosche, B., & Hoel, D. G. (1998) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-199811000-00008 · Cited by 72 · see citing works
Kubo, T., Oyama, I., Nakamura, T., Kunimoto, M., Kadowaki, K., Otomo, H., Fujino, Y., Fujimoto, N., Matsumoto, T., & Matsuda, S. (2011) · International Journal of Urology · doi:10.1111/j.1442-2042.2010.02714.x · Cited by 70 · see citing works
British Airways flightdeck mortality study, 1950-1992.
Irvine, D., & Davies, D. M. (1999) · PubMed · Cited by 68 · see citing works
Shiu, S. Y. W., Law, I. C., Lau, K. W., et al. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00074.x · Cited by 68 · see citing works
Xi, S. C., Tam, P. C., Brown, G. M., Pang, S. F., & Shiu, S. Y. W. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.d01-64.x · Cited by 63 · see citing works
Cervical spinal cord lesions disrupt the rhythm in human melatonin excretion.
Kneisley, L. W., Moskowitz, M. A., & Lynch, H. G. (1978) · PubMed · Cited by 62 · see citing works
Occupational risk factors and prostate cancer in U.S. Blacks and Whites
Krstev, S., Baris, D., Stewart, P. A., Dosemeci, M., Swanson, G. M., Greenberg, R. S., Schoenberg, J. B., Schwartz, A. G., Liff, J. M., & Hayes, R. B. (1998) · American Journal of Industrial Medicine · doi:10.1002/(sici)1097-0274(199811)34:5 · Cited by 60 · see citing works
Visual impairment and cancer: a population-based cohort study in Finland
Pukkala, ., Verkasalo, P. K., Ojamo, M., & Rudanko, S. (1999) · Cancer Causes & Control · doi:10.1023/a:1008897317401 · Cited by 55 · see citing works
Pukkala, ., Ojamo, M., Rudanko, S., et al. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9005-6 · Cited by 53 · see citing works
Nguyen, H.-L., Zucker, S., Zarrabi, K. K., et al. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0033 · Cited by 45 · see citing works
Occupational Cohort Studies: The Influence of Design Characteristics on the Healthy Worker Effect
Meijers, J. M. M., Swaen, G. M. H., Volovics, A., et al. (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.4.970 · Cited by 42 · see citing works
Hormonal interactions in human prostate tumor LNCaP cells
Lupowitz, Z., & Zisapel, N. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00164-2 · Cited by 39 · see citing works
DOES BLINDNESS PROTECT AGAINST CANCERS?
Hann, R. A. (1998) · Epidemiology · doi:10.1097/00001648-199809000-00002 · Cited by 33 · see citing works
Toma, J. G., Amerongen, H. M., Hennes, S. C., et al. (1987) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1987.tb00870.x · Cited by 21 · see citing works
Defense Meteorological Satellite Program
Curtis, J. A., & Adams, L. J. (1987) · IEEE Aerospace and Electronic Systems Magazine · doi:10.1109/maes.1987.5005348 · Cited by 15 · see citing works
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Kecklund, G., & Axelsson, J. (2016) · BMJ · doi:10.1136/bmj.i5210 · Cited by 1,195 · see citing works
The Circadian Clock and Human Health
Roenneberg, T., & Merrow, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.011 · Cited by 1,004 · see citing works
Crosstalk between the circadian clock circuitry and the immune system
Cermakian, N., Lange, T., Golombek, D., Sarkar, D., Nakao, A., Shibata, S., & Mazzoccoli, G. (2013) · Chronobiology International · doi:10.3109/07420528.2013.782315 · Cited by 279 · see citing works
Hakim, F., Wang, Y., Zhang, S. X. L., Zheng, J., Yolcu, E. S., Carreras, A., Khalyfa, A., Shirwan, H., Almendros, I., & Gozal, D. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3014 · Cited by 206 · see citing works
Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts
Gu, F., Han, J., Laden, F., Pan, A., Caporaso, N. E., Stampfer, M. J., Kawachi, I., Rexrode, K. M., Willett, W. C., Hankinson, S. E., et al. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.10.018 · Cited by 202 · see citing works
Self-citationDuration, timing and quality of sleep are each vital for health, performance and safety
Czeisler, C. A. (2015) · Sleep Health · doi:10.1016/j.sleh.2014.12.008 · Cited by 156 · see citing works
Pot, G. K., Almoosawi, S., & Stephen, A. M. (2016) · Proceedings of the Nutrition Society · doi:10.1017/s0029665116000239 · Cited by 134 · see citing works
The Pineal Gland from Development to Function
Sapède, D., & Cau, E. (2013) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416021-7.00005-5 · Cited by 102 · see citing works
Trudel-Fitzgerald, C., Zhou, E. S., Poole, E. M., Zhang, X., Michels, K. B., Eliassen, A. H., Chen, W. Y., Holmes, M. D., Tworoger, S. S., & Schernhammer, E. S. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.85 · Cited by 98 · see citing works
Self-citationFerguson, A., Lyall, L. M., Ward, J., Strawbridge, R. J., Cullen, B., Graham, N., Niedzwiedz, C. L., Johnston, K. J. A., MacKay, D., Biello, S. M., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.08.004 · Cited by 70 · see citing works
The association between shift work and health: A review
Itani, O., & Kaneita, Y. (2016) · Sleep and Biological Rhythms · doi:10.1007/s41105-016-0055-9 · Cited by 19 · see citing works
- Authors
- Sigurdardottir, L. G., Valdimarsdottir, U. A., Fall, K., Rider, J. R., Lockley, S. W., Schernhammer, E., & Mucci, L. A.
- Affiliations
- Authors' Affiliations: 1Center of Public Health Sciences, 2Faculty of Medicine, University of Iceland; 3The Icelandic Cancer Society, Reykjavik, Iceland; 4Clinical Epidemiology Unit, Örebro University Hospital and Örebro University, Örebro, Sweden; 5Department of Epidemiology, Harvard School of Public Health; 6Channing Laboratory, Harvard Medical School; 7Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital; and 8Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts
- Brigham and Women's Hospital (US)
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2012-07-01
- Volume
- 21
- Issue
- 7
- Pages
- 1002-1011
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- PMC
- PMC3392423
- OpenAlex
- W2015611130
- Cited by
- 162
- References
- 60
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 5 · 2023: 13 · 2022: 13 · 2021: 10 · 2020: 10 · 2019: 13 · 2018: 12 · 2017: 14 · 2016: 16 · 2015: 14 · 2014: 15 · 2013: 11 · 2012: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Funders
- National Center for Research Resources (UL1RR025758)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Keywords
- circadian rhythm disruption, prostate cancer risk, sleep deprivation, light at night, night shift work, melatonin, sleep duration, circadian clock, hormone-dependent tumors
- MeSH terms
- Animals, Humans, Male, Prostatic Neoplasms, Risk Factors, Work Schedule Tolerance, Sleep Disorders, Circadian Rhythm
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