Endocrine Effects of Circadian Disruption

Bedrosian, Tracy A.; Fonken, Laura K.; Nelson, Randy J.

doi:10.1146/annurev-physiol-021115-105102

Cited by 170Circadian rhythm and melatoninSleep and Work-Related FatigueImpact of Light on Environment and Health

Endocrine Effects of Circadian Disruption

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Bedrosian, Tracy A., Fonken, Laura K., Nelson, Randy J.·2016·Annual Review of Physiology

DOI 10.1146/annurev-physiol-021115-105102

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Abstract

Disruption of circadian rhythms, provoked by artificial lighting at night, inconsistent sleep-wake schedules, and transmeridian air travel, is increasingly prevalent in modern society. Desynchrony of biological rhythms from environmental light cycles has dramatic consequences for human health. In particular, disrupting homeostatic oscillations in endocrine tissues and the hormones that these tissues regulate can have cascading effects on physiology and behavior. Accumulating evidence suggests that chronic disruption of circadian organization of endocrine function may lead to metabolic, reproductive, sleep, and mood disorders. This review discusses circadian control of endocrine systems and the consequences of distorting rhythmicity of these systems.

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Misalignment between the sleep-awake, fasting-feeding cycles, and the light-dark cycle disrupts natural oscillations of glucose, lipid metabolism, and blood pressure, eventually increasing risk of type 2 diabetes and cardiovascular disease.
“The resulting misalignment between the sleep-awake, fasting-feeding cycles, and the light-dark cycle subsequently disrupts the natural oscillations of physiologic processes such as glucose, lipid metabolism, and blood pressure, eventually manifesting itself as heightened risk of developing type 2 diabetes and cardiovascular disease (1–4).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [3]

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Effects of Suprachiasmatic Transplants on Circadian Rhythms of Neuroendocrine Function in Golden Hamsters**This work was supported by NIH Grants MH-44132, KO2-MH-00914, and F32-HD-07673. A preliminary report of this research was presented at the 23rd Annual Meeting of the Society for Neuroscience (Neurosci Abstr 19:236.17, 1993).
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A Melatonin Rhythm Persists in Rat Pineals in Darkness1
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Background
Effects of Suprachiasmatic Transplants on Circadian Rhythms of Neuroendocrine Function in Golden Hamsters
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Spontaneous Abortions Among Finnish Flight Attendants
Aspholm, R., Lindbohm, M.-L., Paakkulainen, H., Taskinen, H., Nurminen, T., & Tiitinen, A. (1999) · Journal of Occupational & Environmental Medicine · doi:10.1097/00043764-199906000-00015 · Cited by 58 · see citing works
Impaired leukocyte trafficking and skin inflammatory responses in hamsters lacking a functional circadian system
Prendergast, B. J., Cable, E. J., Patel, P. N., Pyter, L. M., Onishi, K. G., Stevenson, T. J., Ruby, N. F., & Bradley, S. P. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.02.007 · Cited by 49 · see citing works
Effects of exercise timing on sleep architecture and nocturnal blood pressure in prehypertensives
Collier, S. R., Fairbrother, K. R., Cartner, B. W., Alley, J., Curry, C. D., Dickinson, D., & Morris, D. (2014) · Vascular Health and Risk Management · doi:10.2147/vhrm.s73688 · Cited by 48 · see citing works
Dim Light at Night Increases Immune Function in Nile Grass Rats, a Diurnal Rodent
Fonken, L. K., Haim, A., & Nelson, R. J. (2012) · Chronobiology International · doi:10.3109/07420528.2011.635831 · Cited by 48 · see citing works
Self-citation
Estrous Cycles in the Mouse: Relative Influence of Continuous Light and the Presence of a Male1
Campbell, C. S., Ryan, K. D., & Schwartz, N. B. (1976) · Biology of Reproduction · doi:10.1095/biolreprod14.3.292 · Cited by 47 · see citing works
Potential animal models of seasonal affective disorder
Workman, J. L., & Nelson, R. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.08.005 · Cited by 46 · see citing works
Self-citation
Effectiveness of evening phototherapy for insomnia is reduced by bright daytime light exposure
Zeitzer, J. M., Friedman, L., & Yesavage, J. A. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2011.02.005 · Cited by 44 · see citing works
Bedtime misalignment and progression of breast cancer
Hahm, B., Jo, B., Dhabhar, F. S., Palesh, O. G., Aldridge-Gerry, A. A., Bajestan, S. N., Neri, E., Nouriani, B., Spiegel, D., & Zeitzer, J. M. (2013) · Chronobiology International · doi:10.3109/07420528.2013.842575 · Cited by 42 · see citing works
Pronounced Inflammatory Response to Endotoxaemia during Nighttime: A Randomised Cross-Over Trial
Alamili, M., Bendtzen, K., Lykkesfeldt, J., Rosenberg, J., & Gögenür, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087413 · Cited by 39 · see citing works
Melatonin prevents pancreatic β‐cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress
Park, J., Shim, H. M., Na, A., Bae, K., Bae, J., Im, S., Cho, H., & Song, D. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12106 · Cited by 39 · see citing works
Pharmacological Interventions for Sleepiness and Sleep Disturbances Caused by Shift Work
Liira, J., Verbeek, J. H. A. M., & Ruotsalainen, J. H. (2015) · JAMA · doi:10.1001/jama.2014.18422 · Cited by 39 · see citing works
Working night shifts affects surgeons' biological rhythm
Amirian, I., Andersen, L. T., Rosenberg, J., & Gögenür, I. (2015) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2014.09.035 · Cited by 38 · see citing works
Mice Show Circadian Rhythms of Blood Pressure During Each Wake-Sleep State
Bastianini, S., Silvani, A., Berteotti, C., Martire, V. L., & Zoccoli, G. (2012) · Chronobiology International · doi:10.3109/07420528.2011.635231 · Cited by 33 · see citing works
A placebo-controlled study of three agomelatine dose regimens (10mg, 25mg, 25–50mg) in patients with major depressive disorder
Kennedy, S. H., Аведисова, А. С., Giménez-Montesinos, N., Belaïdi, C., & de, B. C. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.01.006 · Cited by 28 · see citing works
Shift work at young age is associated with elevated long-term cortisol levels and body mass index
Manenschijn, L., Kruysbergen, R., de Jong, F. H., Koper, J. W., Lamberts, S. W. J., & van Rossum, E. F. C. (2012) · 15th International & 14th European Congress of Endocrinology · Cited by 28 · see citing works
Shifts of the hormonal rhythms of melatonin and cortisol after a 4 h bright‐light pulse in different diurnal types
Griefahn, B., Künemund, C., & Robens, S. (2006) · Chronobiology International · doi:10.1080/07420520600650679 · Cited by 22 · see citing works
Photoperiod-dependent effects of neuronal nitric oxide synthase inhibition on aggression in Siberian hamsters
Bedrosian, T. A., Fonken, L. K., Demas, G. E., & Nelson, R. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.011 · Cited by 20 · see citing works
Self-citation
Circadian function in cancer: Regulating the DNA damage response
Ramsey, M. R., & Ellisen, L. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107319108 · Cited by 11 · see citing works
Real life trumps laboratory in matters of public health
Zeitzer, J. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500717112 · Cited by 9 · see citing works
Forced entrainment by using light therapy, modafinil and melatonin in a sighted patient with non-24-hour sleep-wake disorder
Lee, D. K., & Shin, W. C. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.09.020 · Cited by 4 · see citing works

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Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030 · see citing works
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Biological Rhythm and Chronotype: New Perspectives in Health
Montaruli, A., Castelli, L., Mulè, A., Scurati, R., Esposito, F., Galasso, L., & Roveda, E. (2021) · Biomolecules · doi:10.3390/biom11040487 · Cited by 366 · see citing works
Circadian disruption: what do we actually mean?
Vetter, C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14255 · Cited by 333 · see citing works
Impacts of Artificial Light at Night on Biological Timings
Gaston, K. J., Davies, T. W., Nedelec, S. L., & Holt, L. (2017) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-110316-022745 · Cited by 305 · see citing works
Endocrine Crosstalk Between Skeletal Muscle and the Brain
Delezie, J., & Handschin, C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00698 · Cited by 270 · see citing works
The genetics of circadian rhythms, sleep and health
Jagannath, A., Taylor, L., Wakaf, Z., Vasudevan, S. R., & Foster, F. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx240 · Cited by 258 · see citing works
Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health
Almoosawi, S., Vingeliene, S., Gachon, F., Voortman, T., Palla, L., Johnston, J. D., Van Dam, R. M., Darimont, C., & Karagounis, L. G. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy070 · Cited by 247 · see citing works
Circadian rhythms disrupted by light at night and mistimed food intake alter hormonal rhythms and metabolism
Meléndez-Fernández, O. H., Liu, J. A., & Nelson, R. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043392 · Cited by 227 · see citing works
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A Review of Human Physiological Responses to Light: Implications for the Development of Integrative Lighting Solutions
Vetter, C., Pattison, P. M., Houser, K. W., Herf, M., Phillips, A. J. K., Wright, K. P., Skene, D. J., Brainard, G. C., Boivin, D. B., & Glickman, G. L. (2021) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2021.1872383 · Cited by 226 · see citing works
Circadian regulation of depression: A role for serotonin
Daut, R., & Fonken, L. (2019) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2019.04.003 · Cited by 196 · see citing works
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Exposure to Artificial Light at Night and the Consequences for Flora, Fauna, and Ecosystems
Falcón, J., Torriglia, A., Attia, D., Viénot, F., Gronfier, C., Béhar‐Cohen, F., Martinsons, C., & Hicks, D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.602796 · Cited by 222 · see citing works
When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis
Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 198 · see citing works
Role of chronotype in dietary intake, meal timing, and obesity: a systematic review
Teixeira, G. P., Guimarães, K. C., Soares, A. G. N. S., Marqueze, E. C., Moreno, C. R. D. C., Mota, M. C., & Crispim, C. A. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac044 · Cited by 147 · see citing works
Artificial light at night disrupts sleep in female great tits (Parus major) during the nestling period, and is followed by a sleep rebound
Raap, T., Pinxten, R., & Eens, M. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.04.100 · Cited by 113 · see citing works
Genetic and epigenomic mechanisms of mammalian circadian transcription
Papazyan, R., Zhang, Y., & Lazar, M. A. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3324 · Cited by 112 · see citing works
Building Evidence for Health: Green Buildings, Current Science, and Future Challenges
Cedeño-Laurent, J. G., Williams, A. A., MacNaughton, P., Cao, X., Eitland, E. S., Spengler, J. D., & Allen, J. G. (2018) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031816-044420 · Cited by 109 · see citing works
Development of the circadian system in early life: maternal and environmental factors
Wong, S. D., Wright, K. P., Spencer, R. L., Vetter, C., Hicks, L. M., Jenni, O. G., & LeBourgeois, M. K. (2022) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-022-00294-0 · Cited by 106 · see citing works
Melatonin effects on bone: Implications for use as a therapy for managing bone loss
Munmun, F., & Witt‐Enderby, P. A. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12749 · Cited by 100 · see citing works
Spectral Tuning of White Light Allows for Strong Reduction in Melatonin Suppression without Changing Illumination Level or Color Temperature
Souman, J. L., Borra, T., de Goijer, I., Schlangen, L. J. M., Vlaskamp, B. N. S., & Lucassen, M. P. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418784041 · Cited by 96 · see citing works
Accelerometer-Derived Sleep Onset Timing and Cardiovascular Disease Incidence: A UK Biobank Cohort Study
Nikbakhtian, S., Reed, A. B., Obika, B. D., Morelli, D., Cunningham, A. C., Aral, M., & Plans, D. (2021) · European Heart Journal - Digital Health · doi:10.1093/ehjdh/ztab088 · Cited by 96 · see citing works
Artificial light at night affects body mass but not oxidative status in free-living nestling songbirds: an experimental study
Raap, T., Casasole, G., Costantini, D., AbdElgawad, H., Asard, H., Pinxten, R., & Eens, M. (2016) · Scientific Reports · doi:10.1038/srep35626 · Cited by 94 · see citing works
The Circadian Clock Is a Key Driver of Steroid Hormone Production in Drosophila
Cara, F. D., & King‐Jones, K. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.004 · Cited by 80 · see citing works
Enhancing precision in human neuroscience
Nebe, S., Reutter, M., Baker, D. H., Bölte, J., Domes, G., Gamer, M., Gärtner, A., Gießing, C., Gurr, C., Hilger, K., et al. (2023) · eLife · doi:10.7554/elife.85980 · Cited by 75 · see citing works
OUP accepted manuscript
Li, S., Shui, K., Zhang, Y. W., Lv, Y., Deng, W., Ullah, S., Zhang, L., & Xue, Y. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1028 · Cited by 72 · see citing works
Neither artificial light at night, anthropogenic noise nor distance from roads are associated with oxidative status of nestlings in an urban population of songbirds
Casasole, G., Raap, T., Costantini, D., AbdElgawad, H., Asard, H., Pinxten, R., & Eens, M. (2017) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2017.05.003 · Cited by 68 · see citing works
Hub-organized parallel circuits of central circadian pacemaker neurons for visual photoentrainment in Drosophila
Li, M.-T., Cao, L.-H., Xiao, N., Tang, M., Deng, B., Tian, Y., Yoshii, T., & Luo, D.-G. (2018) · Nature Communications · doi:10.1038/s41467-018-06506-5 · Cited by 68 · see citing works
Corticosteroid resistance in asthma: Cellular and molecular mechanisms
Caramori, G., Nucera, F., Mumby, S. E., Bello, F. L., & Adcock, I. M. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100969 · Cited by 65 · see citing works
Indefinite
Walker, M. L. (2022) · doi:10.1093/oso/9780190072865.001.0001 · Cited by 65 · see citing works
Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies
Codoñer‐Franch, P., Gombert, M., Martı́nez-Raga, J., & Cénit, M. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087579 · Cited by 69 · see citing works
Exposure to Air Pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics
Palanivel, R., Vinayachandran, V., Biswal, S. S., Deiuliis, J. A., Padmanabhan, R., Park, B., Gangwar, R. S., Durieux, J., Cara, E. A., Das, L. M., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101728 · Cited by 63 · see citing works
Circadian disruption and cancer- and treatment-related symptoms
Amidi, A., & Wu, L. M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1009064 · Cited by 63 · see citing works
Modeling Strengthens Molecular Link between Circadian Polymorphisms and Major Mood Disorders
Liberman, A. R., Halitjaha, L., Ay, A. A., & Ingram, K. K. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418764540 · Cited by 59 · see citing works
Sleep Disruption Exacerbates and Prolongs the Inflammatory Response to Traumatic Brain Injury
Tapp, Z. M., Kumar, J. E., Witcher, K. G., Atluri, R. R., Velasquez, J., O’Neil, S. M., Dziabis, J. E., Bray, C. E., Sheridan, J. F., Godbout, J. P., et al. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7010 · Cited by 53 · see citing works
Disruptive effects of light pollution on sleep in free-living birds: Season and/or light intensity-dependent?
Raap, T., Sun, J., Pinxten, R., & Eens, M. (2017) · Behavioural Processes · doi:10.1016/j.beproc.2017.08.011 · Cited by 53 · see citing works
Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research
Lucas, R. J., Allen, A. E., Brainard, G. C., Brown, T. M., Dauchy, R. T., Didikoğlu, A., Do, M. T. H., Gaskill, B. N., Hattar, S. S., Hawkins, P., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002535 · Cited by 55 · see citing works
Self-citation
Traumatic stress and the circadian system: neurobiology, timing and treatment of posttraumatic chronodisruption
Agorastos, A., & Olff, M. (2020) · European Journal of Psychotraumatology · doi:10.1080/20008198.2020.1833644 · Cited by 53 · see citing works
Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters
Petkau, N., Budak, H., Zhou, X., Oster, H., & Gregor Eichele, C. (2019) · eLife · doi:10.7554/elife.43235 · Cited by 46 · see citing works
Circadian control of neuroendocrine function: implications for health and disease
Gotlieb, N., Moeller, J., & Kriegsfeld, L. J. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.11.001 · Cited by 43 · see citing works
The menstrual cycle associated with insomnia in newly employed nurses performing shift work: a 12-month follow-up study
Kang, W., Jang, K.-H., Lim, H., Ahn, J., & Park, W.-J. (2018) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-018-1371-y · Cited by 42 · see citing works
Integration of Circadian and Metabolic Control of Reproductive Function
Evans, M. C., & Anderson, G. M. (2018) · Endocrinology · doi:10.1210/en.2018-00691 · Cited by 41 · see citing works
Clocks, Rhythms, Sex, and Hearts: How Disrupted Circadian Rhythms, Time-of-Day, and Sex Influence Cardiovascular Health
Meléndez‐Fernández, O. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2021) · Biomolecules · doi:10.3390/biom11060883 · Cited by 41 · see citing works
Self-citation
Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure
Hirayama, J., Hattori, A., Takahashi, A., Furusawa, Y., Tabuchi, Y., Shibata, M., Nagamatsu, A., Yano, S., Maruyama, Y., Matsubara, H., et al. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12834 · Cited by 41 · see citing works
Spinal Cord Injury in Rats Disrupts the Circadian System
Gaudet, A. D., Fonken, L. K., Ayala, M. T., Bateman, E. M., Schleicher, W. E., Smith, E. J., D’Angelo, H. M., Maier, S. F., & Watkins, L. R. (2018) · eNeuro · doi:10.1523/eneuro.0328-18.2018 · Cited by 40 · see citing works
Self-citation
Artificial light pollution: Shifting spectral wavelengths to mitigate physiological and health consequences in a nocturnal marsupial mammal
Dimovski, A. M., & Robert, K. A. (2018) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.2163 · Cited by 40 · see citing works
Dim light at night impairs recovery from global cerebral ischemia
Fonken, L. K., Bedrosian, T. A., Zhang, N., Weil, Z. M., DeVries, A. C., & Nelson, R. J. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.02.008 · Cited by 39 · see citing works
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Chronotype and cardio metabolic health in obesity: does nutrition matter?
Muscogiuri, G., Barrea, L., Aprano, S., Framondi, L., Matteo, R. D., Altieri, B., Laudisio, D., Pugliese, G., Savastano, S., & Colao, A. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1885017 · Cited by 36 · see citing works
Artificial light at night alters activity, body mass, and corticosterone level in a tropical anuran
Secondi, J., Mondy, N., Gippet, J. M. W., Touzot, M., Gardette, V., Guillard, L., & Lengagne, T. (2021) · Behavioral Ecology · doi:10.1093/beheco/arab044 · Cited by 36 · see citing works
Assessing the effects of artificial light at night on biodiversity across latitude – Current knowledge gaps
Secondi, J., Davranche, A., Théry, M., Mondy, N., & Lengagne, T. (2019) · Global Ecology and Biogeography · doi:10.1111/geb.13037 · Cited by 34 · see citing works
Skipping Breakfast for 6 Days Delayed the Circadian Rhythm of the Body Temperature without Altering Clock Gene Expression in Human Leukocytes
Ogata, H., Horie, M., Kayaba, M., Tanaka, Y., Ando, A., Park, I., Zhang, S., Yajima, K., Shoda, J., Omi, N., et al. (2020) · Nutrients · doi:10.3390/nu12092797 · Cited by 34 · see citing works
Central Circadian Clock Regulates Energy Metabolism
Ding, G., Gong, Y., Eckel-Mahan, K. L., & Sun, Z. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-13-1286-1_5 · Cited by 33 · see citing works
Parental Exposure to Dim Light at Night Prior to Mating Alters Offspring Adaptive Immunity
Cissé, Y. M., Russart, K. L. G., & Nelson, R. J. (2017) · Scientific Reports · doi:10.1038/srep45497 · Cited by 32 · see citing works
Self-citation
Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder
Wang, H. B., Tahara, Y., Luk, S. H. C., Kim, Y.-S., Hitchcock, O. N., Kaswan, Z. A. M., Kim, Y. I., Block, G. D., Ghiani, C. A., Loh, D. H., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105064 · Cited by 32 · see citing works
Association between light exposure and metabolic syndrome in a rural Brazilian town
Benedito‐Silva, A. A., Evans, S., Mendes, J. V., Castro, J., Gonçalves, B. D. S. B., Ruiz, F. S., Beijamini, F., Evangelista, F. S., Vallada, H., Krieger, J. E., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238772 · Cited by 31 · see citing works
Environmental disruption of reproductive rhythms
Moralia, M.-A., Quignon, C., Simonneaux, M., & Simonneaux, V. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100990 · Cited by 32 · see citing works
Melatonin and Vascular Function
Mendes, L., Queiroz, M., & Sena, C. M. (2024) · Antioxidants · doi:10.3390/antiox13060747 · Cited by 31 · see citing works
Wavelength-specific artificial light disrupts molecular clock in avian species: A power-calibrated statistical approach
Yang, Y., Liu, Q., Wang, T., & Pan, J. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114206 · Cited by 31 · see citing works
Daily rewiring of a neural circuit generates a predictive model of environmental light
Song, B. J., Sharp, S. J., & Rogulja, D. (2021) · Science Advances · doi:10.1126/sciadv.abe4284 · Cited by 28 · see citing works
Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors
Lassi, M., Tomar, A., Comas-Armangué, G., Vogtmann, R., Dijkstra, D. J., Corujo, D., Gerlini, R., Darr, J., Scheid, F., Rozman, J., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg6424 · Cited by 30 · see citing works
Food in synchrony with melatonin and corticosterone relieves constant light disturbed metabolism
Báez‐Ruíz, A., Guerrero‐Vargas, N. N., Cázarez‐Márquez, F., Sabath, E., Basualdo, M. D. C., Salgado‐Delgado, R., Escobar, C., & Buijs, R. M. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0370 · Cited by 27 · see citing works
Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice
Fan, X., Chen, D., Wang, Y., Tan, Y., Zhao, H., Jing, Z., Li, Y., Guo, X., Qiu, H., & Gu, Y. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00025.2021 · Cited by 26 · see citing works
Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders
Marco, E. M., Velarde, E., Llorente, R., & Laviola, G. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_419 · Cited by 25 · see citing works
Disruptions of Circadian Rhythms and Thrombolytic Therapy During Ischemic Stroke Intervention
Liu, J. A., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.675732 · Cited by 23 · see citing works
Self-citation
Causal Association Between Subtypes of Excessive Daytime Sleepiness and Risk of Cardiovascular Diseases
Goodman, M. O., Dashti, H. S., Lane, J. M., Windred, D. P., Burns, A. C., Jones, S. E., Sofer, T., Purcell, S., Zhu, X., Ollila, H. M., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.030568 · Cited by 23 · see citing works
Spinal Cord Injury in Rats Dysregulates Diurnal Rhythms of Fecal Output and Liver Metabolic Indicators
Gaudet, A. D., Fonken, L. K., Ayala, M. T., D’Angelo, H. M., Smith, E. J., Bateman, E. M., Schleicher, W. E., Maier, S. F., & Watkins, L. R. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.6101 · Cited by 23 · see citing works
Self-citation
Current Insights into Optimal Lighting for Promoting Sleep and Circadian Health: Brighter Days and the Importance of Sunlight in the Built Environment
Fernandez, F. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s251712 · Cited by 26 · see citing works
The effect of cycled lighting in the intensive care unit on sleep, activity and physiological parameters: A pilot study
Engwall, M., Fridh, I., Jutengren, G., Bergbom, I., Sterner, A., & Lindahl, B. (2017) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2017.01.009 · Cited by 22 · see citing works
The Chronobiology of Hormone Administration: “Doctor, What Time Should I Take My Medication?”
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Authors: Bedrosian, T. A., Fonken, L. K., & Nelson, R. J.
Affiliations: Salk Institute for Biological Studies (US)
University of Colorado Boulder (US)
The Ohio State University (US)
ORCID: Bedrosian, Tracy A.
Fonken, Laura K.
Nelson, Randy J.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2016-02-10
Volume: 78
Issue: 1
Pages: 109-131
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev-physiol-021115-105102
OpenAlex: W2137252045
Cited by: 170
References: 187
Citations by year: 2026: 7 · 2025: 16 · 2024: 14 · 2023: 16 · 2022: 30 · 2021: 21 · 2020: 16 · 2019: 10 · 2018: 19 · 2017: 11 · 2016: 8 · 2015: 2
FWCI: 1.45
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords: circadian rhythm disruption, endocrine system, artificial light at night, transmeridian travel, metabolic disorders, reproductive disorders, sleep disorders, mood disorders, biological rhythms
MeSH terms: Animals, Circadian Rhythm, Endocrine System, Humans, Lighting, Sleep

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Endocrine Effects of Circadian Disruption

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