The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation
Open accessAbstract
Matrix metalloproteinases (MMPs) form a family of enzymes that mediate multiple functions both in the tissue destruction and immune responses related to periodontal inflammation. The expression and activity of MMPs in non-inflamed periodontium is low but is drastically enhanced to pathologically elevated levels due to the dental plaque and infection-induced periodontal inflammation. Soft and hard tissue destruction during periodontitis and peri-implantitis are thought to reflect a cascade of events involving bacterial virulence factors/enzymes, pro-inflammatory cytokines, reactive oxygen species and MMPs. However, recent studies suggest that MMPs can also exert anti-inflammatory effects in defence of the host by processing anti-inflammatory cytokines and chemokines, as well as by regulating apoptotic and immune responses. MMP-inhibitor (MMPI)-drugs, such as doxycycline, can be used as adjunctive medication to augment both the scaling and root planing-treatment of periodontitis locally and to reduce inflammation systematically. Furthermore, MMPs present in oral fluids (gingival crevicular fluid (GCF), peri-implant sulcular fluid (PISF), mouth-rinses and saliva) can be utilized to develop new non-invasive, chair/bed-side, point-of-care diagnostics for periodontitis and dental peri-implantitis.
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Cites
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
How Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen
Vogel, W., Gish, G. D., Alves, F., & Pawson, T. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80003-9 · Cited by 1,002
Moilanen, M., Sorsa, T., Stenman, M., Nyberg, P., Lindy, O., Vesterinen, J., Paju, A., Konttinen, Y. T., Stenman, U.-H., & Salo, T. (2003) · Biochemistry · doi:10.1021/bi020582s · Cited by 111
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Cited by
Tjäderhane, L., Buzalaf, M. A. R., Carrilho, M., & Chaussain, C. (2015) · Caries Research · doi:10.1159/000363582 · Cited by 2,306
Self-citationInflammatory and immune pathways in the pathogenesis of periodontal disease
Cekici, A., Kantarci, A., Hasturk, H., & Van Dyke, T. E. (2014) · Periodontology 2000 · doi:10.1111/prd.12002 · Cited by 1,415
“matrix metalloproteinases 8 and 9 (221), resulting in the degradation of the extracellular matrix and the”
BackgroundNazar Majeed, Z., Philip, K., Alabsi, A. M., Pushparajan, S., & Swaminathan, D. (2016) · Disease Markers · doi:10.1155/2016/1804727 · Cited by 107
Gul, S. S., Abdulkareem, A. A., Sha, A. M., & Rawlinson, A. (2020) · Diagnostics · doi:10.3390/diagnostics10100838 · Cited by 87
Ariaans, K., Heussen, N., Schiffer, H., Wienert, A., Plümäkers, B., Rink, L., & Wolfart, S. (2016) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12500 · Cited by 37
Khongkhunthian, S., Kongtawelert, P., Ongchai, S., Pothacharoen, P., Sastraruji, T., Jotikasthira, D., & Krisanaprakornkit, S. (2014) · BMC Oral Health · doi:10.1186/1472-6831-14-107 · Cited by 19
Türkoğlu, O., Barış, N., Tervahartiala, T., Şenarslan, Ö., Sorsa, T., & Atilla, G. (2014) · Journal of Periodontology · doi:10.1902/jop.2013.130346 · Cited by 17
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Metadata
- Authors
- Sorsa, T., Tjäderhane, L., Konttinen, Y. T., Lauhio, A., Salo, T., Lee, H., Golub, L. M., Brown, D. L., & Mäntylä, P.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 38
- Issue
- 5
- Pages
- 306-321
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W1996726306
- Cited by
- 673
- References
- 5
- FWCI
- 24.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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