Evaluation of systemic levels of neutrophilic enzymes in patients with hypertension and chronic periodontitis
Abstract
BACKGROUND: Inflammation stimulates neutrophils to release their enzymes into the extracellular matrix. The aim of the present study is to investigate the serum levels of matrix metalloproteinase (MMP)-8, MMP-9, tissue inhibitor of MMP (TIMP)-1, myeloperoxidase (MPO), and neutrophil elastase (NE) in patients with hypertension and chronic periodontitis (CP). METHODS: A total of 95 patients were included in the study. Patients were categorized into three groups: healthy control (n = 29), hypertensive control (n = 32), and hypertensive CP (n = 34). Periodontal parameters were recorded, and serum samples were collected from each participant. Serum MMP-8, MMP-9, TIMP-1, MPO, and NE levels in circulation were assessed by enzyme-linked immunosorbent assay. RESULTS: The hypertensive CP group had significantly higher serum MMP-8, MMP-9, and NE levels than the healthy control group (P <0.05). All study groups had similar serum TIMP-1 levels (P >0.05). Significantly higher serum MPO levels were detected in patients with hypertension and CP than healthy controls and hypertensive controls (P <0.05); however, the difference in serum MPO levels was not significant between the healthy controls and hypertensive controls (P >0.05). There was no significant difference in MMP-8/TIMP-1 ratio among the study groups (P >0.05). MMP-9/TIMP-1 ratio was significantly higher in patients with hypertension and CP than healthy controls (P <0.05). CONCLUSIONS: The presence of hypertension along with CP has a considerable effect on serum neutrophilic enzyme levels, except TIMP-1. However, the levels of these enzymes do not seem to be affected by the presence of hypertension only. Further studies including patients who have only CP might help illuminate the effect of CP on these enzymes in patients with hypertension.
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Circulating levels of MMP-8, MMP-9, myeloperoxidase and neutrophil elastase were increased in patients with hypertension and periodontitis but not in controls.
“The authors observed that circulating levels of matrix metalloproteinases (MMP)-8, MMP-9, myeloperoxidase and neutrophil elastase (NE) were increased in patients with hypertension and periodontitis but not in the controls.”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [55]
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- Authors
- Türkoğlu, O., Barış, N., Tervahartiala, T., Şenarslan, Ö., Sorsa, T., & Atilla, G.
- Affiliations
- Ege University (TR)
- Dokuz Eylül University (TR)
- University of Helsinki (FI)
- Corresponding author
- Türkoğlu, Oya
- Venue
- Journal of Periodontology
- Publisher
- Wiley
- Published
- 2014-07
- Volume
- 85
- Issue
- 7
- Pages
- 908-916
- ISSN
- 0022-3492 (ISSN-L)
- 1943-3670
- OpenAlex
- W2110778170
- Cited by
- 17
- References
- 59
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Periodontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- hypertension, chronic periodontitis, matrix metalloproteinase-8, MMP-9, TIMP-1, myeloperoxidase, neutrophil elastase, serum biomarkers, MMP-9/TIMP-1 ratio, periodontal inflammation
- MeSH terms
- Adult, Dental Plaque Index, Female, Humans, Hypertension, Male, Middle Aged, Peroxidase, Neutrophils, Periodontal Index, Periodontal Pocket, Case-Control Studies, Periodontal Attachment Loss, Leukocyte Elastase, Tissue Inhibitor of Metalloproteinase-1, Matrix Metalloproteinase 9, Matrix Metalloproteinase 8, Chronic Periodontitis
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