The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Complex disease, gender and epigenetics
Open accessAbstract
Gender differences in susceptibility to complex disease such as asthma, diabetes, lupus, autism and major depression, among numerous other disorders, represent one of the hallmarks of non-Mendelian biology. It has been generally accepted that endocrinological differences are involved in the sexual dimorphism of complex disease; however, specific molecular mechanisms of such hormonal effects have not been elucidated yet. This paper will review evidence that sex hormone action may be mediated via gene-specific epigenetic modifications of DNA and histones. The epigenetic modifications can explain sex effects at DNA sequence polymorphisms and haplotypes identified in gender-stratified genetic linkage and association studies. Hormone-induced DNA methylation and histone modification changes at specific gene regulatory regions may increase or reduce the risk of a disease. The epigenetic interpretation of sexual dimorphism fits well into the epigenetic theory of complex disease, which argues for the primary pathogenic role of inherited and/or acquired epigenetic misregulation rather than DNA sequence variation. The new experimental strategies, especially the high throughput microarray-based epigenetic profiling, can be used for testing the epigenetic hypothesis of gender effects in complex diseases.
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Cites
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“05 (113) COMT RS4680, RS4680, RS737865 Female Pv0.”
Cited by
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
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Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
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Sex differences in Parkinson’s disease
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Early Life Nutrition, Epigenetics and Programming of Later Life Disease
Vickers, M. (2014) · Nutrients · doi:10.3390/nu6062165 · Cited by 366
Metadata
- Authors
- Kaminsky, Z., Wang, S., & Petronis, A.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 38
- Issue
- 8
- Pages
- 530-544
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2013909104
- Cited by
- 209
- References
- 8
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
