Cited by 25Stress Responses and CortisolAdrenal Hormones and DisordersNeuroendocrine regulation and behavior

The hypothalamo–pituitary–adrenal axis in major affective disorder: a review

Christensen, Maj Vinberg, Kessing, Lars Vedel·2001·Nordic Journal of Psychiatry

Abstract

This paper reviews studies of the hypothalamo-pituitary-adrenal (HPA)-axis activity in patients with affective disorders. It is concluded that, despite methodological drawbacks in most studies, dysregulation of the HPA axis seems to be a consistent finding in a proportion of patients with affective disorder. The HPA axis is a complex neuroendocrine network with multiple integrated levels of control, and it is likely that the dysregulation involves abnormalities at several sites within the axis. At present, it is not clear whether the abnormalities are related to the affective episodes only or to the disorder itself. There is a need for prospective studies of larger samples of patients to be followed during successive affective episodes with a combination of measurements of the HPA-axis activity and brain imaging.

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Registry

Crossref · 10.1080/080394801317080873

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47 of 47 references verified0 citation errors · 0 not checkable

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  • Hypercortisolemia has been consistently found in depressed adults.

    “Hypercortisolemia has been consistently found in depressed adults (Christensen & Kessing, 2001; Gillespie & Nemeroff, 2005), and has been examined as a potential predictor of various outcomes (e.g., treatment response; Ribeiro et al., 1993) as well as one cause of the brain structural anomalies observed in depressed patients (Videbech & Ravnkilde, 2004).”

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Authors
Christensen, M. V., & Kessing, L. V.
Affiliations
Hvidovre Hospital (DK)
Venue
Nordic Journal of Psychiatry
Published
2001-01
Volume
55
Issue
5
Pages
359-363
ISSN
  • 0029-1455 (ISSN-L)
  • 0803-9488
  • 1502-4725
OpenAlex
W2033493592
Cited by
25
References
47
Citations by year
2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Nordic Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
hypothalamic-pituitary-adrenal axis, mood disorders, HPA axis dysregulation, neuroendocrine regulation, depression, bipolar disorder, stress response, neuroimaging
MeSH terms
Dexamethasone, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Psychological, Mood Disorders

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